Article
Medicine, General & Internal
Nuria Banos, Aleida Castellanos, Giuseppe Barilaro, Francesc Figueras, Gema Lledo, Marta Santana, Gerard Espinosa
Summary: A prospective study was conducted on pregnant women with SLE, antiphospholipid syndrome, or non-criteria obstetric antiphospholipid syndrome to develop a predictive tool for adverse pregnancy outcomes. Baseline characteristics and certain biomarkers were found to be predictive of adverse outcomes, highlighting the need for better biomarkers for pregnant women with autoimmune diseases.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Simona Truglia, Antonella Capozzi, Silvia Mancuso, Valeria Manganelli, Luca Rapino, Gloria Riitano, Serena Recalchi, Serena Colafrancesco, Fulvia Ceccarelli, Tina Garofalo, Cristiano Alessandri, Agostina Longo, Roberta Misasi, Fabrizio Conti, Maurizio Sorice
Summary: Antiphospholipid syndrome (APS) is more common in women than in men, with male patients often exhibiting high levels of IgM anti-cardiolipin antibodies and a higher incidence of arterial thrombosis and myocardial infarction. Gender appears to influence the serological and clinical profiles of APS.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Hematology
Arne Vandevelde, Walid Chayoua, Bas de Laat, Gary W. Moore, Jacek Musial, Stephane Zuily, Denis Wahl, Katrien M. J. Devreese
Summary: The presence of antiphosphatidylserine/prothrombin antibodies (aPS/PT), especially with high antibody titer, is associated with the diagnosis of thrombotic antiphospholipid syndrome (TAPS).
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Hematology
Michael Pham, Giovanni Orsolini, Cynthia Crowson, Melissa Snyder, Rajiv Pruthi, Kevin Moder
Summary: This study aimed to validate the relationship between anti-phosphatidylserine prothrombin antibodies (aPSPT) and lupus anticoagulant (LAC), and determine their sensitivity and specificity in an all-comer population. The results showed that aPSPT had high specificity but lower sensitivity to LAC. These findings further support the potential of aPSPT as a clinical marker for LAC.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Biology
Zemin Lin, Yuting Liu, Li Chen, Shiqi Cao, Yueteng Huang, Xiaoqian Yang, Fenghua Zhu, Wei Tang, Shijun He, Jianping Zuo
Summary: This study revealed the etiology and therapeutic mechanism of antiphospholipid syndrome nephropathy and for the first time demonstrated the therapeutic potential of SM934 in treating this condition.
SCIENCE CHINA-LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Tatiana Reshetnyak, Kamila Nurbaeva, Ivan Ptashnik, Anna Kudriaeva, Alexey Belogurov Jr, Aleksandr Lila, Evgeny Nasonov
Summary: This study aimed to assess the role of neutrophil extracellular traps (NETs) markers, MPO-DNA complex and nucleosomes, in the diagnosis of systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). The study found that levels of MPO-DNA complex were higher in SLE patients and associated with SLE activity and lupus glomerulonephritis. Lower levels of nucleosomes were observed in SLE patients and associated with SLE activity and arthritis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Levi-Dan Azoulay, Marc Pineton de Chambrun, Romaric Larcher, Frederic Pene, Laurent Argaud, Julien Mayaux, Matthieu Jamme, Remi Coudroy, Alexis Mathian, Aude Gibelin, Elie Azoulay, Yacine Tandjaoui-Lambiotte, Auguste Dargent, Francois Beloncle, Jean-Herle Raphalen, Antoine Troger, Nicolas de Prost, Jerome Devaquet, Damien Contou, Samuel Gaugain, Pierre Trouiller, Steven Grange, Stanislas Ledochowski, Jeremie Lemarie, Stanislas Faguer, Vincent Degos, Quentin Moyon, Charles-Edouard Luyt, Mathieu Kerneis, Alain Combes, Zahir Amoura
Summary: This study investigated the prevalence, characteristics, and prognosis of cardiac manifestations in critically-ill patients with thrombotic antiphospholipid syndrome (APS). The results showed that cardiac manifestations were common in these patients and may be associated with a more severe outcome.
JOURNAL OF AUTOIMMUNITY
(2022)
Article
Pediatrics
Lingjuan Liu, Liqun Liu, Lu Zhang, Peng Huang, Xiqiang Dang, Lanjun Shuai, Xingfang Li, Yongzhen Li, Dingan Mao, Xiaochuan Wu, Yan Cao
Summary: Systemic lupus erythematosus (SLE) is an autoimmune disease with complex clinical features. SLE patients are at significantly increased risk of thrombotic events. Antiphospholipid syndrome (APS) is a rare autoimmune disorder characterized by recurrent thrombosis and pregnancy-related complications. This paper reports a school-age patient diagnosed with SLE coexisting with APS, which started with renal contusion and later developed into pulmonary embolism.
FRONTIERS IN PEDIATRICS
(2023)
Article
Rheumatology
Jozelio Freire de Carvalho, Felipe Freire Silva, Yehuda Shoenfeld
Summary: This article describes a rare case of a young patient with cAPS who later developed SLE. Treatment included methylprednisolone, heparin, and immunoglobulin, leading to a good outcome and discharge from the hospital. The patient was later diagnosed with SLE and successfully treated with prednisone, azathioprine, and hydroxychloroquine, currently managing symptoms well with these medications.
Review
Immunology
Xue Peng, Xi Tan, Aiyun Xing
Summary: Antiphospholipid syndrome (APS) is an acquired autoimmune disorder characterized by recurrent thrombosis and pregnancy complications. Obstetrical APS (OAPS) specifically refers to APS in pregnant women. The classification criteria for OAPS have generated discussion due to the possibility of excluding certain patients. This article presents two cases of non-criteria OAPS with severe complications and discusses the diagnosis, treatment, and prognosis of this unusual antenatal event. It also provides an overview of the pathogenetic mechanisms and clinical features of OAPS.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tatiana Reshetnyak, Fariza Cheldieva, Maria Cherkasova, Alexander Lila, Evgeny Nasonov
Summary: This study investigates the role of IgA antibodies to cardiolipin (aCL) and IgA antibodies to beta-2 glycoprotein 1 (anti-beta(2)-GP1) in the development of vascular complications in patients with antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE). The results show that the levels of IgA aCL and IgA anti-beta(2)-GP1 are significantly higher in APS patients compared to SLE patients and the control group. These antibodies are closely associated with thrombosis in APS, demonstrating high specificity but low sensitivity for the diagnosis of APS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Ines Bernardoff, Alexandre Picq, Pierre Loiseau, Thomas Foret, Virginie Dufrost, Thomas Moulinet, Ozan Unlu, Doruk Erkan, Denis Wahl, Stephane Zuily
Summary: This study conducted a systematic review and meta-analysis to evaluate the association of antiphospholipid antibodies (aPL) with autoimmune hemolytic anemia in systemic lupus erythematosus (SLE) patients. The results showed a strong association between the presence of aPL and the occurrence of hemolytic anemia in SLE patients, with lupus anticoagulant and anti beta 2Glycoprotein I antibodies having the highest risk. IgM isotypes also indicated an increased risk of hemolytic anemia in SLE.
AUTOIMMUNITY REVIEWS
(2022)
Article
Hematology
Arne Vandevelde, Jean-Christophe Gris, Gary W. Moore, Jacek Musial, Stephane Zuily, Denis Wahl, Katrien M. J. Devreese
Summary: Currently, the added value of antiphosphatidylserine/prothrombin antibodies testing in the diagnosis of obstetric antiphospholipid syndrome seems limited compared with other antibodies. However, it may be useful in specific subsets of patients.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Review
Medicine, General & Internal
Angelo Claudio Molinari, Tiziano Martini, Laura Banov, Antonella Ierardi, Marzia Leotta, Alessandra Strangio, Rita Carlotta Santoro
Summary: Diagnosis of antiphospholipid syndrome requires clinical criteria and the presence of antiphospholipid antibodies. Lupus anticoagulant is one of the laboratory parameters used to define this condition. Currently, there are various methods available for detecting antiphospholipid antibodies, but detecting lupus anticoagulant is more challenging.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Ariela Hoxha, Daniela Tormene, Elena Campello, Paolo Simioni
Summary: This study conducted a systematic review on the additional treatments used in refractory and high-risk antiphospholipid antibody syndrome (APS) pregnancies. The results showed that combination therapy with IVIG and PEX achieved a 100% live birth rate in refractory APS pregnancies, while Pravastatin, IA, and PEX showed higher live birth rates in high-risk APS pregnancies.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Cyril Gitiaux, Anna Kaminska, Nathalie Boddaert, Giulia Barcia, Sophie Gueden, Sylvie Nguyen The Tich, Pascale De Lonlay, Susana Quijano-Roy, Marie Hully, Yann Pereon, Isabelle Desguerre
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
(2018)
Article
Cardiac & Cardiovascular Systems
Duarte Martins, Caroline Ovaert, Diala Khraiche, Nathalie Boddaert, Damien Bonnet, Francesca Raimondi
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2018)
Article
Clinical Neurology
Julien Puntonet, Volodia Dangouloff-Ros, Raphael Saffroy, Melanie Pages, Felipe Andreiuolo, Jacques Grill, Stephanie Puget, Nathalie Boddaert, Pascale Varlet
JOURNAL OF NEURORADIOLOGY
(2018)
Review
Clinical Neurology
V Dangouloff-Ros, P. Varlet, R. Levy, K. Beccaria, S. Puget, C. Dufour, N. Boddaert
Summary: The study reviews the classical and atypical imaging features of medulloblastomas, emphasizing on advanced MRI techniques, histopathological and molecular subtypes, as well as follow-up modalities. Atypical imaging features have been widely reported, varying according to the age of the patient and histopathological subtype.
Article
Genetics & Heredity
Mara Cavallin, Manuele Mine, Marion Philbert, Nathalie Boddaert, Jean Marie Lepage, Thibault Coste, Vanessa Lopez-Gonzalez, Maria Jose Sanchez-Soler, Maria Juliana Ballesta-Martinez, Ganaelle Remerand, Laurent Pasquier, Agnes Guet, Jamel Chelly, Karine Lascelles, Carol Prieto-Morin, Manoelle Kossorotoff, Elisabeth Tournier Lasserve, Nadia Bahi-Buisson
EUROPEAN JOURNAL OF MEDICAL GENETICS
(2018)
Article
Clinical Neurology
V Dangouloff-Ros, C-J Roux, G. Boulouis, R. Levy, N. Nicolas, C. Lozach, D. Grevent, F. Brunelle, N. Boddaert, O. Naggara
AMERICAN JOURNAL OF NEURORADIOLOGY
(2019)
Article
Clinical Neurology
Klervie Loiselet, Benedetta Ruzzenente, Charles-Joris Roux, Giulia Barcia, Alessandra Pennisi, Isabelle Desguerre, Agnes Rotig, Arnold Munnich, Nathalie Boddaert
Summary: Increased cerebral blood flow, particularly in the striatum, is a distinct characteristic during acute episodes of Leigh syndrome, which may aid in early diagnosis of these episodes, especially in young children experiencing their first attack.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Laureline Berteloot, Thierry Jo Molina, Julie Bruneau, Capucine Picard, Vincent Barlogis, Veronique Secq, Chrystelle Abdo, Nathalie Boddaert, Claude Griscelli, Benedicte Naven, Alain Fischer
Summary: While LTi cells are crucial for the development of most SLOs in humans, there are LTi cell-independent mechanisms for the formation of SLO in the appendix, gut-draining areas, and tertiary lymphoid organs.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Clinical Neurology
P. Benjamin, S. Sudhakar, F. D'Arco, U. Lobel, O. Carney, C-J Roux, N. Boddaert, C. Hemingway, D. Eleftheriou, K. Mankad
Summary: Genetic interferonopathies are a diverse group of disorders caused by dysregulated interferon expression, increasingly recognized in the differential diagnosis of children with recurrent inflammatory phenotypes. Neuroimaging plays a vital role in the diagnosis, and understanding the wide spectrum of neuroimaging features associated with these disorders can aid in earlier diagnosis and treatment strategies.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2022)
Article
Clinical Neurology
J. F. Hak, G. Boulouis, B. Kerleroux, S. Benichi, S. Stricker, F. Gariel, L. Garzelli, P. Meyer, M. Kossorotoff, N. Boddaert, N. Girard, V. Vidal, V. Dangouloff Ros, T. Blauwblomme, O. Naggara
Summary: This study investigates the role of arterial spin-labeling in monitoring the treatment and follow-up of pediatric ruptured brain AVMs. The results suggest that this noninvasive imaging technique can assess treatment response and assist in decision-making for optimal timing of DSA.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2022)
Article
Clinical Neurology
S. Neumane, A. Lesage, V. Dangouloff-Ros, R. Levy, C. -J. Roux, M. P. Robert, D. Bremond-Gignac, N. Boddaert
Summary: The study retrospectively reviewed the MR imaging of 27 children to describe the signal of common pediatric orbital lesions on arterial spin-labeling and evaluate its ability to discriminate malignant from benign masses. The arterial spin-labeling perfusion patterns were classified into homogeneous hypoperfusion, heterogeneous hyperperfusion, and homogeneous intense hyperperfusion. Arterial spin-labeling was found to be valuable in improving the diagnostic confidence of some orbital lesions.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Article
Clinical Neurology
L. Garzelli, E. Shotar, T. Blauwblomme, N. Sourour, Q. Alias, S. Stricker, B. Mathon, M. Kossorotoff, F. Gariel, N. Boddaert, F. Brunelle, P. Meyer, O. Naggara, F. Clarencon, G. Boulouis
AMERICAN JOURNAL OF NEURORADIOLOGY
(2020)
Article
Clinical Neurology
Melanie Pages, Kevin Beccaria, Nathalie Boddaert, Raphael Saffroy, Aurore Besnard, David Castel, Frederic Fina, Doriane Barets, Emilie Barret, Ludovic Lacroix, Franck Bielle, Felipe Andreiuolo, Arnault Tauziede-Espariat, Dominique Figarella-Branger, Stephanie Puget, Jacques Grill, Fabrice Chretien, Pascale Varlet
Article
Genetics & Heredity
C. T. Gordon, A. Tessier, Z. Demir, A. Goldenberg, M. Oufadem, N. Voisin, V. Pingault, T. Bienvenu, S. Lyonnet, L. de Pontual, J. Amiel
Article
Genetics & Heredity
E. M. Jenkinson, J. H. Livingston, M. C. O'Driscoll, I. Desguerre, R. Nabbout, N. Boddaert, G. Soares, M. Goncalves da Rocha, S. D'Arrigo, G. I. Rice, Y. J. Crow
Article
Rheumatology
Walter P. Maksymowych, Nele Herregods, Nisha Varma, Arthur B. Meyers, Jennifer Stimec, Andrea S. Doria, Nikolay Tzaribachev, Tarimobo M. Otobo, Marion A. van Rossum, Joel Paschke, Stephanie Wichuk, Robert G. Lambert
Summary: This study aimed to investigate whether systematic calibration improves the scoring proficiency of JAMRIS-SIJ and whether contrast-enhancement enhances its performance. The results showed that calibrated readers achieved greater reliability in scoring specific inflammatory and structural lesions. Sensitivity and reliability for scoring inflammatory lesions were higher on fluid-sensitive sequences compared to contrast-enhanced sequences. Therefore, systematic calibration should be implemented before using JAMRIS-SIJ in clinical trials, and it is unlikely that contrast-enhanced MRI will improve the performance of this method.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2024)
Article
Rheumatology
L. van Ouwerkerk, S. A. Bergstra, T. D. Maarseveen, T. W. J. Huizinga, R. Knevel, C. F. Allaart
Summary: This study evaluated whether the initial use of glucocorticoid (GC) bridging in RA patients leads to a higher probability of long-term GC and bDMARD use. The results showed that patients who initially started GC had a higher risk of later GC use, but the risk of bDMARD use was not significantly increased.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2024)
Article
Rheumatology
ShuangHua Liu, YiMei Tan, WeiDong Huang, HongSheng Luo, BingCheng Pan, Shuan Wu
Summary: This study assessed the cardiovascular safety of zoledronic acid in the treatment of primary osteoporosis. The results showed that in women with primary osteoporosis, zoledronic acid may increase the risk of atrial fibrillation and arrhythmias, but the cardiovascular risk in men with osteoporosis is uncertain.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2024)