Article
Ophthalmology
Lara Buhl, Stephan Thurau, Christoph Kern
Summary: Through a retrospective cohort study, we found that the 0.19-mg fluocinolone acetonide implant showed effectiveness in treating noninfectious uveitis in standard clinical practice. Additionally, administering high-dose corticosteroids before FAi can benefit patients with increased baseline uveitis activity.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Review
Ophthalmology
Yi Hsuan Li, Shiuh-Liang Hsu, Shwu-Jiuan Sheu
Summary: Uveitic macular edema is a common cause of visual impairment in uveitis, with corticosteroids remaining as the main treatment option, but nonsteroidal immunomodulators and biologic agents are gaining popularity. Local therapy options, including intraocular delivery and sustained releasing implants, are being developed and evaluated in clinical trials to manage cystoid macular edema in uveitis.
ASIA-PACIFIC JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Oren Tomkins-Netzer, Susan L. Lightman, Alyce E. Burke, Elizabeth A. Sugar, Lyndell L. Lim, Glenn J. Jaffe, Michael M. Altaweel, John H. Kempen, Janet T. Holbrook, Douglas A. Jabs
Summary: The study found that nearly all uveitic macular edema can resolve with sufficient time and treatment, but relapse is common. Eyes with resolved macular edema had better visual acuity results, suggesting that controlling inflammation and resolving edema may be important treatment targets.
Article
Ophthalmology
Mustafa Iftikhar, Chen Dun, Oliver D. Schein, Flora Lum, Fasika Woreta
Summary: This study aimed to determine the incidence, risk factors, and visual outcomes of cystoid macular edema (CME) after cataract surgery in the United States. The study found that the incidence of CME was low, but there were significant outcome disparities that warrant further exploration.
Review
Ophthalmology
Abdus Samad Ansari, Zain Amir, Gwyn S. Williams
Summary: Treatment of JIA-associated uveitis often requires long-term corticosteroids or immunosuppressive agents. In complex cases, the 0.19 mg fluocinolone acetonide implant may provide a safe and effective alternative for prolonged intravitreal administration.
OPHTHALMOLOGY AND THERAPY
(2021)
Review
Medicine, Research & Experimental
Xue Wu, Mengying Tao, Ling Zhu, Ting Zhang, Ming Zhang
Summary: Non-infectious uveitis (NIU) is an eye disorder characterized by inflammation, primarily affecting people of working age. Accurate diagnosis and targeted treatment are crucial for improving patient prognosis.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Ophthalmology
S. Pockar, I Leal, R. Chhabra, Np Jones, Lr Steeples
Summary: This retrospective observational study evaluated the efficacy and safety of 0.19 mg fluocinolone acetonide insert (FAi) in the treatment of chronic noninfectious uveitis (NIU). The results showed that FAi effectively improved the condition and maintained stable visual acuity.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Ophthalmology
Ankush Kawali, Ram Snehith, Vivek Singh, Srinivasan Sanjay, Padmamalini Mahendradas, Rohit Shetty
Summary: The study demonstrated that topical interferon therapy is effective in treating pseudophakic cystoid macular edema (P-CME), reducing the risk of relapse in some patients. Patients showed significant improvement in central macular thickness after using topical IFN therapy, with no serious side effects noted.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2021)
Letter
Ophthalmology
Tianyu Tao, Daquan He, Xuening Peng, Zhaohao Huang, Wenru Su
Summary: This study retrospectively followed up two BU patients with a history of BS for 2 and 10 years, respectively, and found that upadacitinib successfully treated BU, improving visual acuity, controlling intraocular inflammation, and resolving macular edema in both patients. One female patient showed mildly abnormal blood test results and slight liver enzyme elevation after 6 months of upadacitinib treatment, but no serious adverse events were reported in either patient during follow-up. Upadacitinib may be an important future option for managing recurrent and recalcitrant cases of BU, especially in patients with chronic ocular inflammation and macular edema resistant to conventional therapies.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Review
Ophthalmology
Hillary C. Stiefel, Laura J. Kopplin, Thomas Albini, Michael Chang, Sravanthi Vegunta, Eric B. Suhler
Summary: The retrospective study examined data from seven patients, showing that pegylated interferon alfa-2A can improve inflammatory cystoid macular edema and also contribute to visual improvement. While some patients had to discontinue treatment due to side effects, the majority of patients showed sustained significant effects with low-dose continuous treatment.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2021)
Letter
Ophthalmology
Alfredo Adan, Aina Moll-Udina, Julio Ramirez, Victor Llorenc
Summary: This case report describes a 26-year-old female patient with cystoid macular edema (CME) secondary to juvenile idiopathic arthritis (JIA)-associated uveitis. Treatment with TCZ-SC led to improvement in symptoms, resolution of inflammation, and a decrease in central foveal thickness.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2021)
Review
Ophthalmology
Thiago Jose Muniz Machado Mazzeo, Raimunda Cristina Mendonca Freire, Cleide Guimaraes Machado, Andre Marcelo Vieira Gomes, Andre Luiz Land Curi
Summary: The aim of this article is to comprehensively review the current role of pars plana vitrectomy in uveitis and its structural complications. The study was based on a comprehensive literature search on relevant articles. Therapeutic vitrectomy can aid in the treatment of uveitic structural complications, although visual outcomes may be unpredictable. Additionally, diagnostic vitrectomy is a valuable tool for assessing and diagnosing uveitis.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Review
Ophthalmology
Andrea York Tiang Teo, Bjorn Kaijun Betzler, Keith Low Qie Hua, Elizabeth Jiahui Chen, Vishali Gupta, Rupesh Agrawal
Summary: This review provides an update on the clinical presentation, etiologies, complications, and treatment options in intermediate uveitis. It affects all age groups with no gender predominance and has varied etiologies. Various treatment options are currently used in practice.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Ophthalmology
Anne Studsgaard, Kare Orts Clemmensen, Mette Slot Nielsen
Summary: The study suggests that intravitreal treatment with 0.19 mg FAi may be considered in selected patients with chronic non-infectious uveitic CME. This treatment is safe, even in selected glaucoma patients, and may reduce or discontinue local or systemic anti-inflammatory treatment.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Engineering, Biomedical
Jyoti Prakash Medhi, S. R. Nirmala, Simantika Choudhury, Samarendra Dandapat
Summary: This paper presents an automated algorithm for detecting macular edema and cyst segmentation, which enhances OCT analysis with efficient speckle noise removal and variational boundary detection.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2023)
Letter
Rheumatology
Pedro M. Machado, Martin Schaefer, Anja Strangfeld, Laure Gossec, Milena Gianfrancesco, Saskia Lawson-Tovey, Elsa F. Mateus, Loreto Carmona, Kimme L. Hyrich, Philip C. Robinson, Jinoos Yazdany
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Letter
Rheumatology
Martin Schaefer, Anja Strangfeld, Kimme L. Hyrich, Loreto Carmona, Milena Gianfrancesco, Saskia Lawson-Tovey, Elsa F. Mateus, Laure Gossec, Philip C. Robinson, Jinoos Yazdany, Pedro M. Machado
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Letter
Rheumatology
Kimme L. Hyrich, Martin Schaefer, Anja Strangfeld, Loreto Carmona, Laure Gossec, Elsa F. Mateus, Saskia Lawson-Tovey, Milena Gianfrancesco, Philip C. Robinson, Jinoos Yazdany, Pedro M. Machado
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Ophthalmology
Noemi Guemes-Villahoz, David Diaz-Valle, Alex Fonollosa, Maria Jimenez-Santos, Carlos Narvaez-Palazon, Alfredo Adan
Summary: Epiretinal membrane (ERM) is a common complication of uveitis and can lead to vision loss. While there have been only two case reports in the scientific literature depicting spontaneous regression of inflammation-associated ERM, spontaneous separation is a rare but possible event.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Rheumatology
Alejandro Balsa, Maria Jesus Garcia de Yebenes, Loreto Carmona
Summary: In patients with rheumatoid arthritis (RA), the prevalence of treatment adherence is 59.1%, and is influenced by factors such as treatment prescribed, patient perception of treatment, receipt of information on treatment adaptation, and physician perception of patient trust. Psychological, communicational, and logistic factors have a greater impact on treatment adherence in RA than sociodemographic or clinical factors.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Pedro M. Machado, Saskia Lawson-Tovey, Anja Strangfeld, Elsa F. Mateus, Kimme L. Hyrich, Laure Gossec, Loreto Carmona, Ana Rodrigues, Bernd Raffeiner, Catia Duarte, Eric Hachulla, Eric Veillard, Eva Strakova, Gerd R. Burmester, Gozde Kubra Yardimci, Jose A. Gomez-Puerta, Julija Zepa, Lianne Kearsley-Fleet, Ludovic Trefond, Maria Cunha, Marta Mosca, Martina Cornalba, Martin Soubrier, Nicolas Roux, Olivier Brocq, Patrick Durez, Richard Conway, Tiphaine Goulenok, Johannes W. J. Bijlsma, Iain B. McInnes, Xavier Mariette
Summary: The study included 5121 participants from 30 countries, with 90% having I-RMD and 10% having NI-RMD. The majority of patients received the Pfizer/BioNTech vaccine. Breakthrough infections were rare, with 0.7% in I-RMD patients and 1.1% in NI-RMD patients. Adverse events were reported in 37% of cases, with serious AEs in 0.5%. This study concludes that the safety profiles of SARS-CoV-2 vaccines in patients with I-RMD were reassuring.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Jose B. Nergon, Maria A. Lopez-Olivo, Loreto Carmona, Robin Christensen, Francesca Ingegnoli, Natalia Zamora, Jorge I. Gamez-Nava, Laura Gonzalez-Lopez, Vibeke Strand, Niti Goel, Tiffany Westrich-Robertson, Maria E. Suarez-Almazor
Summary: This study aimed to identify patient-centered domains with long-term relevance to people with rheumatoid arthritis (RA). Semi-structured individual cognitive interviews were conducted with RA patients from five different countries. Six main themes were identified, including living with symptoms and functional limitations, lack of participation, partner and family issues, risk of damage to vital organs, coping strategies, and healthcare concerns. These domains are seldom measured in longitudinal registries and should be considered in patient-centered longitudinal studies.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Cell Biology
Barbara Burgos-Blasco, Beatriz Vidal-Villegas, Isabel Collado-Vincueria, Ana Maria Soria-Garcia, Ricardo Cuina-Sardina, Rosalia Mendez-Fernandez, David Diaz-Valle, Mayte Arino-Gutierez
Summary: This study reports the clinical results on the use of frozen corneas stored in Eusol-C as emergency tectonic grafts. The corneas were stored at -78 degrees C for an average of 6.9 months. The study found that long-term preservation of donor corneas in Eusol-C at -78 degrees C is a viable technique to meet the needs of emergency grafts.
CELL AND TISSUE BANKING
(2023)
Review
Rheumatology
Goncalo Boleto, Alvise Berti, Peter A. Merkel, Sibel Zehra Aydin, Haner Direskeneli, Christian Dejaco, Leslie C. Hassett, Loreto Carmona, Sofia Ramiro, O. M. E. R. A. C. T. Vasculitis Working Grp OMERACT Vasculitis Working Grp
Summary: This study systematically reviewed the measurement properties of outcome instruments used in large-vessel vasculitis (LVV). Out of the 3534 articles identified, 13 met the criteria, addressing 12 instruments. The Indian Takayasu Clinical Activity Score (ITAS) and the Disease Extent Index-Takayasu (DEI-Tak) showed the most adequate measurement properties for disease activity/damage in TA, while specific instruments for GCA and validated patient-reported outcomes for both GCA and TA were lacking.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Ophthalmology
Lara Borrego-Sanz, Laura Morales-Fernandez, Federico Saenz-Frances San Baldomero, David Diaz Valle, Esperanza Pato Cour, Rosalia Mendez Fernandez, Julian Garcia Feijoo, Luis Rodriguez Rodriguez
Summary: Differences in corneal biomechanical properties were found between patients with non-infectious uveitis and healthy subjects.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Oncology
Pilar Perez-Garcia, Barbara Burgos-Blasco, Veronica Gomez-Calleja, Beatriz Vidal-Villegas, Rosalia Mendez-Fernandez, Jose Antonio Gegundez-Fernandez, David Diaz-Valle
Summary: The efficacy and safety of 5-fluorouracil as a second-line treatment for conjunctival intraepithelial neoplasia refractive to interferon alpha-2b were reported. 5-fluorouracil treatment resulted in complete remission of the lesions in both cases without relapse. Fewer side effects were observed compared to other available alternatives.
JOURNAL OF ONCOLOGY PHARMACY PRACTICE
(2023)
Article
Ophthalmology
Alejandro Gomez-Gomez, Alfredo Madrid-Garcia, Lara Borrego-Sanz, Paula Alvarez-Hernandez, Pedro Arriola-Villalobos, Ines Perez-Sancristobal, Jose M. Benitez del Castillo, Rosalia Mendez-Fernandez, Esperanza Pato-Cour, David Diaz-Valle, Luis Rodriguez-Rodriguez
Summary: This study aimed to identify factors affecting the response rate to immunosuppressive drugs (ISDs) in patients with non-infectious uveitis (NIU). The results showed that uveitic macular edema at prescription and a higher oral corticosteroid dose in the year before ISD prescription were associated with a lower hazard for achieving good therapeutic response (GTR). On the other hand, prescribing cyclosporine and previous use of multiple ISDs were associated with higher GTR rates.
OPHTHALMOLOGY AND THERAPY
(2023)
Article
Ophthalmology
Barbara Burgos-Blasco, David Diaz-Valle, Daniela Rego-Lorca, Pilar Perez-Garcia, Virginia Puebla-Garcia, Jose Ignacio Fernandez-Vigo, Jose Manuel Benitez-del-Castillo, Jose Antonio Gegundez-Fernandez
Summary: The efficacy of topical insulin eye drops in reducing corneal staining and improving symptoms of refractory dry eye disease was evaluated in this retrospective case series. The results showed that topical insulin was a promising treatment option for patients with epithelial damage in dry eye disease.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Rheumatology
Teresa Oton, Loreto Carmona, Jose Luis Andreu
Summary: This study assessed the experience and needs of patients receiving MTX treatment through an online survey. The results showed that patients were not satisfied with the quality of information provided by clinics and had a demand for more and better-quality written or web-based information.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Rheumatology
Patricia Moya Alvarado, Juan Jose de Agustin de Oro, Maria Aparicio Espinar, Eulalia Armengol Perez, Noemi Busquets Perez, Loreto Carmona, Enrique Casado Burgos, Teresa Clavaguera Poch, Andrea Cuervo Aguilera, Eugenio De Miguel Mendieta, Paula Estrada Alarcon, Elisabet Garcia Casares, Susana Holgado Perez, Berta Magallares Lopez, Melania Martinez Morillo, Lourdes Mateo Soria, Carmen Moragues Pastor, Mireia Moreno Martinez-Losa, Andres Ponce Fernandez, Manel Pujol Busquets, Julio Ramirez Garcia, Delia Reina Sanz, Meritxell Salles Lizarzaburu, Pilar Santo Panero, Elena Sirvent Alierta, Marta Valls Roc, Hector Corominas Macias
Summary: The interobserver reliability of MASEI was evaluated in this multicenter study, and it was found to have high overall reliability. The reliability slightly improved after training and educational programs, but the correlation was weak in the assessment of the plantar aponeursis and triceps tendon.
RHEUMATOLOGY INTERNATIONAL
(2022)
Article
Rheumatology
Walter P. Maksymowych, Nele Herregods, Nisha Varma, Arthur B. Meyers, Jennifer Stimec, Andrea S. Doria, Nikolay Tzaribachev, Tarimobo M. Otobo, Marion A. van Rossum, Joel Paschke, Stephanie Wichuk, Robert G. Lambert
Summary: This study aimed to investigate whether systematic calibration improves the scoring proficiency of JAMRIS-SIJ and whether contrast-enhancement enhances its performance. The results showed that calibrated readers achieved greater reliability in scoring specific inflammatory and structural lesions. Sensitivity and reliability for scoring inflammatory lesions were higher on fluid-sensitive sequences compared to contrast-enhanced sequences. Therefore, systematic calibration should be implemented before using JAMRIS-SIJ in clinical trials, and it is unlikely that contrast-enhanced MRI will improve the performance of this method.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2024)
Article
Rheumatology
L. van Ouwerkerk, S. A. Bergstra, T. D. Maarseveen, T. W. J. Huizinga, R. Knevel, C. F. Allaart
Summary: This study evaluated whether the initial use of glucocorticoid (GC) bridging in RA patients leads to a higher probability of long-term GC and bDMARD use. The results showed that patients who initially started GC had a higher risk of later GC use, but the risk of bDMARD use was not significantly increased.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2024)
Article
Rheumatology
ShuangHua Liu, YiMei Tan, WeiDong Huang, HongSheng Luo, BingCheng Pan, Shuan Wu
Summary: This study assessed the cardiovascular safety of zoledronic acid in the treatment of primary osteoporosis. The results showed that in women with primary osteoporosis, zoledronic acid may increase the risk of atrial fibrillation and arrhythmias, but the cardiovascular risk in men with osteoporosis is uncertain.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2024)
