Article
Genetics & Heredity
Qi Li, Chan Zhang, Yujing Cheng, Xin Yang, Wanlu Chen, Kunhua He, Mingwei Chen
Summary: This study found that IL1RL1 genetic variants rs12479210 and rs1420101 are associated with an increased risk of lung cancer in the Chinese Han population. These risk variants may serve as biomarkers for the prevention and treatment of lung cancer.
FRONTIERS IN GENETICS
(2023)
Article
Oncology
Yongqin Yang, Shan Yuan, Shouchun Yan, Kuaini Dong, Yonghui Yang
Summary: This study found that three missense variants in the CYP4B1 gene (rs2297810, rs4646491, and rs2297809) are associated with an increased risk of lung cancer (LC).
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Immunology
Shuyuan Liu, Nannan Liu, Hui Wang, Xinwen Zhang, Yufeng Yao, Shuqiong Zhang, Li Shi
Summary: The study found an association between CCR5 promoter polymorphisms and pulmonary TB and TB progression in the Chinese Han population.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Genetics & Heredity
Yisen Cheng, Qiqi Tang, Yu Li, Xusan Xu, Xiangfan Zhen, Ning Chang, Si Huang, Jieqing Zeng, Fei Luo, Qianqian Ouyang, Liuquan Peng, Guoda Ma, Yajun Wang
Summary: miR-146a SNPs are associated with asthma susceptibility and clinical features in Southern Chinese Han population. rs2910164 C/G genotype increases asthma risk in females, while rs57095329 G/G genotype affects clinical characteristics of males with asthma. Furthermore, these SNPs affect miR-146a levels and structure in asthma patients.
Article
Biochemistry & Molecular Biology
Hanyi Zhang, Siyao Deng, Jiayu Zhang, Guiquan Zhu, Jie Zhou, Wenjing Ye, Qingwei Wang, Yi Wang, Bingwen Zou, Peng Zhang, Shichuan Zhang, Jinyi Lang, Shun Lu
Summary: Genetic variants in genes involved in the LMP1 signaling pathway, particularly the NFKBIA promoter SNP rs2233409, may be moderately associated with the risk of nasopharyngeal carcinoma (NPC). Further studies with larger sample sizes and functional analysis are needed to confirm these findings.
Article
Clinical Neurology
Jiao Huang, Lulu Zhu, Xinyi Zhao, Xulong Wu, Jialei Yang, Bingyi Xu, Zhi Zhao, Lian Gu, Li Su
Summary: This study revealed that lncRNA SERPINB9P1 is downregulated in patients with ischemic stroke, especially in females. Polymorphisms of SERPINB9P1 may influence blood glucose metabolism and coagulation function regulation in ischemic stroke patients.
NEUROLOGICAL SCIENCES
(2022)
Article
Genetics & Heredity
Xia Zhang, Rongfeng Liu
Summary: The study found that six SNPs in the GSDMB, GSDMC, and AIM2 genes were associated with the risk of nonsmall cell lung cancer (NSCLC). The minor alleles of rs8067378, rs2305480, and rs77681114 were associated with a lower risk of NSCLC, while rs2290400 and rs1103577 were associated with an increased risk. These findings provide new insights and risk assessment factors for understanding the development of NSCLC.
FRONTIERS IN GENETICS
(2023)
Article
Genetics & Heredity
Xianglai Liu, Hailing Xie, Zejuan Fu, Qiankun Yao, Tianming Han, Dafei Zhan, Zhan Lin, Hong Zhu
Summary: The study revealed a correlation between MAD1L1 and TSNARE genetic polymorphisms and susceptibility to schizophrenia, suggesting a protective role. Replication experiments in cohorts with larger sample sizes are needed to confirm these findings.
BMC MEDICAL GENOMICS
(2021)
Article
Medicine, General & Internal
Guanghui Tong, Weiwei Tong, Ran He, Zhigang Cui, Sixuan Li, Baosen Zhou, Zhihua Yin
Summary: This study found that rs3200401 in the lncRNA MALAT1 gene is associated with the susceptibility of non-small cell lung cancer and lung squamous cell carcinoma. However, there is no significant association between rs619586 and lung cancer susceptibility. The study also discovered interactions between genes and cigarette smoking.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Haiying Wang, Hui Han, Yongliang Niu, Xiaobo Li, Xintao Du, Qiang Wang
Summary: This study found that certain variants of the LPP gene are associated with increased susceptibility to allergic rhinitis in the Chinese Han population. Additionally, the interaction of LPP polymorphisms with age, gender, and BMI was found to contribute to AR risk.
Article
Medicine, General & Internal
Aifan Li, Tianyi Han, Yongfang Li, Gaiqing Yang, Yuchao Zhang, Yanyang Huang, Baixue Zhou, Guoying Song, Ying He
Summary: This study investigates the relationship between MMP-2,3,9 gene polymorphisms (C1306T, 1612-5A/6A, C-1562T) and ischemic stroke (IS) in the Chinese Han population. The findings suggest that the T allele of MMP-2 may be a protective factor for IS, particularly in the small artery occlusion (SAO) subtype. Conversely, the 5A/5A genotype of MMP-3 may increase the risk of IS, particularly in the large-artery atherosclerosis (LAA) subtype.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2023)
Article
Cell Biology
Fuming Deng, Jinglu Zhao, Wei Jia, Kai Fu, Xiaoyu Zuo, Lihua Huang, Ning Wang, Huiming Xia, Yan Zhang, Wen Fu, Guochang Liu
Summary: GREM1 risk allele rs3743104[G] significantly increases the risk of mild/moderate and severe hypospadias in the Southern Han population, by altering the binding affinity of miR-182 to its gene locus for regulating GREM1 expression. This study provides new evidence for the association of GREM1 rs3743104 with hypospadias susceptibility, and suggests potential for a promising biomarker and further exploration.
Article
Genetics & Heredity
Ning Wang, Rui Tong, Jing Xu, Yanni Tian, Juan Pan, Jiaqi Cui, Huan Chen, Yanqi Peng, Sijia Fei, Shujun Yang, Lu Wang, Juanchuan Yao, Wei Cui
Summary: This study found a significant association between genetic variants in PDX1 and MC4R and T2DM risk in a Chinese Han population, with PDX1-rs9581943 showing a protective effect. Furthermore, genetic polymorphisms may be influenced by factors such as age, sex, BMI, smoking status, and drinking status.
BMC MEDICAL GENOMICS
(2021)
Article
Oncology
Yuxin Wang
Summary: The study revealed that LRRC3B gene polymorphisms were associated with the risk of breast cancer, suggesting that LRRC3B variants might be helpful in predicting breast cancer progression.
FRONTIERS IN ONCOLOGY
(2021)
Article
Orthopedics
Yuan Wang, Yexin Wang, Da Liang, Hongtao Hu, Guangwei Li, Xiaoguang Meng, Bing Zhu, Wei Zhong
Summary: The polymorphisms of the MIR31 host gene (MIR31HG) are associated with the risk of steroid-induced osteonecrosis of the femoral head (SONFH) in the Chinese Han population. Specifically, the rs10965059 polymorphism is correlated with a reduced risk of SONFH in individuals over 40 years old, male populations, and those with bilateral SONFH.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Oncology
Mengmeng Ji, Lingbin Du, Zhimin Ma, Junxing Xie, Yanqian Huang, Xiaoxia Wei, Xiangxiang Jiang, Jing Xu, Rong Yin, Yuzhuo Wang, Juncheng Dai, Guangfu Jin, Lin Xu, Chen Zhu, Zhibin Hu, Hongxia Ma, Meng Zhu, Hongbing Shen
Summary: Elevated CRP levels are associated with a 22% increased risk of lung cancer, with positive associations observed in small cell lung cancer, lung adenocarcinoma, and lung squamous cell carcinoma. However, no genetical association between circulating CRP levels and lung cancer risk was found. Adding CRP to the risk model of lung cancer can improve the model's performance in current smokers.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Biology
Cheng Wang, Mingtao Huang, Congcong Chen, Yuancheng Li, Na Qin, Zijian Ma, Jingyi Fan, Linnan Gong, Hui Zeng, Liu Yang, Xianfeng Xu, Jun Zhou, Juncheng Dai, Guangfu Jin, Zhibin Hu, Hongxia Ma, Fengwei Tan, Hongbing Shen
Summary: The study demonstrated the significant role of adenosine-to-inosine (A-to-I) RNA editing in tumorigenesis of lung adenocarcinoma (LUAD) through evaluating RNA editing sites, consensus clustering, and establishing a model for accurate distinction of a new subtype. The new subtype EC3 was associated with poor prognosis, independent of classic molecular subtype classification based on gene expression or DNA methylation, highlighting the potential application of RNA editing in cancer molecular subtyping and clinical treatment.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Article
Engineering, Multidisciplinary
Yongyue Wei, Jinxing Guan, Xiao Ning, Yuelin Li, Liangmin Wei, Sipeng Shen, Ruyang Zhang, Yang Zhao, Hongbing Shen, Feng Chen
Summary: This study evaluates the global situation of the COVID-19 pandemic from January 2020 to February 2021. The results show that nearly half of the countries and territories in the world have never controlled the epidemic. Among the countries and territories that had once contained the occurrence, nearly half failed to maintain their prevention and control, causing the COVID-19 pandemic to rebound. The study also identifies the countries with an increasing risk of COVID-19 transmission and highlights the association between non-pharmaceutical interventions and global transmission changes.
Letter
Critical Care Medicine
Meng Zhu, Yanqian Huang, Hongxia Ma, Hongbing Shen
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Oncology
Ci Song, Jun Lv, Chengxiao Yu, Meng Zhu, Canqing Yu, Yu Guo, Ling Yang, Yiping Chen, Zhengming Chen, Tao Jiang, Hongxia Ma, Guangfu Jin, Hongbing Shen, Zhibin Hu, Liming Li
Summary: The study found that adhering to a healthy lifestyle can significantly reduce the risk of liver cancer, with a more dramatic protective effect for individuals with hepatitis B surface antigen (HBsAg) positive.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
Sabine Schmid, Mei Jiang, M. Catherine Brown, Aline Fares, Miguel Garcia, Joelle Soriano, Mei Dong, Sera Thomas, Takashi Kohno, Leticia Ferro Leal, Nancy Diao, Juntao Xie, Zhichao Wang, David Zaridze, Ivana Holcatova, Jolanta Lissowska, Beata Swiatkowska, Dana Mates, Milan Savic, Angela S. Wenzlaff, Curtis C. Harris, Neil E. Caporaso, Hongxia Ma, Guillermo Fernandez-Tardon, Matthew J. Barnett, Gary Goodman, Michael P. A. Davies, Monica Perez-Rios, Fiona Taylor, Eric J. Duell, Ben Schoettker, Hermann Brenner, Angeline Andrew, Angela Cox, Alberto Ruano-Ravina, John K. Field, Loic Le Marchand, Ying Wang, Chu Chen, Adonina Tardon, Sanjay Shete, Matthew B. Schabath, Hongbing Shen, Maria Teresa Landi, Brid M. Ryan, Ann G. Schwartz, Lihong Qi, Lori C. Sakoda, Paul Brennan, Ping Yang, Jie Zhang, David C. Christiani, Rui Manuel Reis, Kouya Shiraishi, Rayjean J. Hung, Wei Xu, Geoffrey Liu
Summary: This study developed and tested pragmatic approaches to account for the missing EGFR-mutation-status in epidemiologic datasets of non-small cell lung cancers (NSCLC). By developing a regression model and using restriction and imputation methods, the study successfully evaluated the clinical impact of EGFR-status on NSCLC.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Oncology
Yixuan Meng, Mulong Du, Dongying Gu, Chen Li, Shuwei Li, Qiuyi Zhang, Shuai Ben, Qiuyuan Zhu, Junyi Xin, Zhengdong Zhang, Zhibin Hu, Hongbing Shen, Kewei Jiang, Meilin Wang
Summary: A GWAS meta-analysis identifies a novel genetic risk variant that is associated with colorectal cancer risk and mediates multiple functions involved in colorectal tumorigenesis and progression.
Article
Cell Biology
Lianju Qin, Jing Zhang, Yujie Xiao, Kang Liu, Yugui Cui, Fangyan Xu, Wenkai Ren, Yanggang Yuan, Chunyan Jiang, Song Ning, Xiaoxue Ye, Ming Zeng, Hanyang Qian, Anning Bian, Fan Li, Guang Yang, Shaowen Tang, Zhihong Zhang, Juncheng Dai, Jing Guo, Qiang Wang, Bin Sun, Yifei Ge, Chun Ouyang, Xueqiang Xu, Jing Wang, Yaoyu Huang, Hongqing Cui, Jing Zhou, Meilian Wang, Zhonglan Su, Yan Lu, Di Wu, Jingping Shi, Wei Liu, Li Dong, Yinbing Pan, Baiqiao Zhao, Ying Cui, Xueyan Gao, Zhanhui Gao, Xiang Ma, Aiqin Chen, Jie Wang, Meng Cao, Qian Cui, Li Chen, Feng Chen, Youjia Yu, Qiang Ji, Zhiwei Zhang, Mufeng Gu, Xiaojun Zhuang, Xiaolin Lv, Hui Wang, Yanyan Pan, Ling Wang, Xianrong Xu, Jing Zhao, Xiuqin Wang, Cuiping Liu, Ningxia Liang, Changying Xing, Jiayin Liu, Ningning Wang
Summary: This study reported a case of severe uremic calciphylaxis patient who showed significant improvement after receiving treatment with human amnion-derived mesenchymal stem cells (hAMSCs). The long-term intravenous combined with local treatment of hAMSCs may be a potential regenerative treatment for uremic calciphylaxis.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2022)
Article
Oncology
Xiaoxia Wei, Xiangxiang Jiang, Xu Zhang, Xikang Fan, Mengmeng Ji, Yanqian Huang, Jing Xu, Rong Yin, Yuzhuo Wang, Meng Zhu, Lingbin Du, Juncheng Dai, Guangfu Jin, Lin Xu, Zhibin Hu, Dong Hang, Hongxia Ma
Summary: The study findings suggest that neuroticism is associated with an increased risk of incident lung cancer, and this association is strengthened by genetic susceptibility to lung cancer. Furthermore, there is an interaction between neuroticism and genetic risk.
FRONTIERS IN ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Yuanlin He, Jiajing Luo, Guannan Zhang, Yu Jin, Nanxi Wang, Jinying Lu, Changxian Li, Xiaohuan Guo, Na Qin, Juncheng Dai, Yun Chen
Summary: This study investigated the immune phenotypic characteristics of ILC cells and the role of B cells in the inflammatory differentiation of ILC2 cells in HCC. Dysregulation of ILC cells and enrichment of the ICOS+ ILC2a subset were found in HCC and correlated with poor prognosis. B cells were found to play a role in inflammatory differentiation of ILC2 cells through ICOSL signaling and increased IL-13 production. Targeting ICOS and HSP70 suppressed tumor growth and remodeled the immunosuppressive tumor microenvironment, providing a potential strategy for HCC immunotherapy.
Article
Oncology
Ruyang Zhang, Sipeng Shen, Yongyue Wei, Ying Zhu, Yi Li, Jiajin Chen, Jinxing Guan, Zoucheng Pan, Yuzhuo Wang, Meng Zhu, Junxing Xie, Xiangjun Xiao, Dakai Zhu, Yafang Li, Demetrios Albanes, Maria Teresa Landi, Neil E. Caporaso, Stephen Lam, Adonina Tardon, Chu Chen, Stig E. Bojesen, Mattias Johansson, Angela Risch, Heike Bickeboeller, H-Erich Wichmann, Gadi Rennert, Susanne Arnold, Paul Brennan, James D. McKay, John K. Field, Sanjay S. Shete, Loic Le Marchand, Geoffrey Liu, Angeline S. Andrew, Lambertus A. Kiemeney, Shan Zienolddiny-Narui, Annelie Behndig, Mikael Johansson, Angela Cox, Philip Lazarus, Matthew B. Schabath, Melinda C. Aldrich, Juncheng Dai, Hongxia Ma, Yang Zhao, Zhibin Hu, Rayjean J. Hung, Christopher Amos, Hongbing Shen, Feng Chen, David C. Christiani
Summary: In this study, important gene-gene interactions that influence the risk of non-small cell lung cancer (NSCLC) were identified and enriched in the 5p15.33 and 6p21.32 regions. These findings have the potential to improve lung cancer screening models.
JOURNAL OF THORACIC ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiangxiang Jiang, Na Qin, Tingting Hua, Xiaoxia Wei, Yuancheng Li, Congcong Chen, Linnan Gong, Su Liu, Cheng Wang, Rong Yin, Yue Jiang, Juncheng Dai, Lin Xu, Hongbing Shen, Hongxia Ma
Summary: This study provides a comprehensive characterization of super-enhancers (SEs) in lung adenocarcinoma (LUAD) and emphasizes their clinical significance in LUAD therapy. The findings highlight the different regulatory mechanisms of SEs in cancer compared to normal SEs and their association with crucial tumor-related pathways.
MOLECULAR CARCINOGENESIS
(2022)
Article
Oncology
Dong Hang, Xiaolin Yang, JiaYi Lu, Chong Shen, Juncheng Dai, Xiangfeng Lu, Guangfu Jin, Zhibin Hu, Dongfeng Gu, Hongxia Ma, Hongbing Shen
Summary: This study identified a panel of plasma metabolites associated with hepatocellular carcinoma (HCC) and established a potential model for predicting HCC risk based on metabolites analysis.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Public, Environmental & Occupational Health
Ping Li, Mingjia Yang, Dong Hang, Yongyue Wei, Hongling Di, Hongbing Shen, Zhihong Liu
Summary: Current smoking, high TG, and high SBP were the top three risk factors contributing to CKD burden in China. Increased BMI, DBP, plasma glucose, and decreased HDL-C were also associated with the increase in CKD burden.
JOURNAL OF EPIDEMIOLOGY
(2022)