Article
Infectious Diseases
Jie Qin, Chengyun Zou, Jianmin Tao, Tian Wei, Li Yan, Yufei Zhang, Haiying Wang
Summary: This study aimed to investigate the prevalence, clinical manifestations, antimicrobial resistance, risk factors, and outcomes of carbapenem-resistant Pseudomonas aeruginosa (CRPA) infection in elderly inpatients. The study found high rates of CRPA and multidrug-resistant P. aeruginosa (MDR PA) among hospitalized elderly patients. The analysis of antimicrobial susceptibility emphasized the importance of antimicrobial stewardship and infection control in hospitals. The identified risk factors can aid in identifying high-risk patients and guiding alternate empiric treatment.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Infectious Diseases
Fangfang Yuan, Weiqiang Xiao, Xiaokun Wang, Yuewen Fu, Xudong Wei
Summary: The study aimed to analyze the clinical characteristics and prognostic risk factors of carbapenem-resistant Pseudomonas aeruginosa (CRPA) bloodstream infections in patients with hematologic malignancies. Medical records and drug susceptibility data of patients with hematologic malignancies complicated by CRPA bloodstream infections were retrospectively analyzed. The results showed that patients with hematologic neoplasms had high mortality from CRPA bloodstream infections, and admission to the intensive care unit, higher Pitt bacteremia score, and granulocyte deficiency at discharge were independently associated with higher mortality. Early anti-infective treatment with ceftazidime-avibactam or polymyxin B may improve the clinical prognosis of patients.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Immunology
Anthony Sophonsri, Corey Kelsom, Mimi Lou, Paul Nieberg, Annie Wong-Beringer
Summary: The study found that patients coinfected with CRKP and another carbapenem-resistant pathogen have more significant morbidity and require longer hospital stays compared to those with CRKP monoinfection. Empiric therapy targeting both CRKP and carbapenem-resistant Pseudomonas aeruginosa may be beneficial for at-risk patients with pneumonia.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Infectious Diseases
Tomasz Bogiel, Malgorzata Prazynska, Joanna Kwiecinska-Pirog, Agnieszka Mikucka, Eugenia Gospodarek-Komkowska
Summary: The study compared the frequency of selected enzymatic virulence factor genes among non-duplicated carbapenem-resistant P. aeruginosa isolates, finding a higher prevalence of alkaline protease gene and a 37.4% detection rate for neuraminidase-1 gene. Significant differences in the prevalence of lasB and nan1 were observed between MBL-positive and MBL-negative strains.
Article
Immunology
Marco Falcone, Giusy Tiseo, Sergio Carbonara, Andrea Marino, Giovanni Di Caprio, Anna Carretta, Alessandra Mularoni, Michele Fabiano Mariani, Alberto Enrico Maraolo, Riccardo Scotto, Lidia Dalfino, Lorenzo Corbo, Margherita Macera, Alice Annalisa Medaglia, Maria Luca d'Errico, Claudia Gioe, Christian Sgroi, Rosa Fontana Del Vecchio, Giancarlo Ceccarelli, Antonio Albanese, Calogero Buscemi, Simona Talamanca, Giammarco Raponi, Giuseppe Foti, Giulio De Stefano, Antonina Franco, Carmelo Iacobello, Salvatore Corrao, Uccio Morana, Filippo Pieralli, Ivan Gentile, Teresa Santantonio, Antonio Cascio, Nicola Coppola, Bruno Cacopardo, Alessio Farcomeni, Mario Venditti, Francesco Menichetti
Summary: Carbapenem-resistance in gram-negative bacilli is associated with increased mortality in patients with bloodstream infections, with the highest risk seen in patients infected with MBL-producing CRE.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Weichun Huang, Xiaoshu Wei, Guifeng Xu, Xingyu Zhang, Xing Wang
Summary: This study aimed to determine the epidemiology, risk factors, and clinical outcomes of carbapenem-resistant Pseudomonas aeruginosa (CRPA) infections among critically ill pediatric patients in a large tertiary pediatric hospital in China. The study found that risk factors for CRPA infection included a hospitalization length of >28 days, invasive operations, and blood transfusion. Conversely, a birth weight >= 2,500 g and breast nursing were protective factors against CRPA infections. Platelet < 100 x 10(9)/L and serum urea <3.2 mmol/L were independent predictors of mortality due to P. aeruginosa infection.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Infectious Diseases
Xianzhen Wei, Linlin Li, Meng Li, Hongjie Liang, Yu He, Shan Li
Summary: This study aimed to explore the risk factors for carbapenem-resistant Pseudomonas aeruginosa bloodstream infection and identify the risk factors for the outcomes of patients with PA-BSI. The study found that previous exposure to carbapenem was an independent risk factor for CRPA-BSI, while CRPA was not an independent risk factor for negative outcomes among PA-BSI patients.
INFECTION AND DRUG RESISTANCE
(2023)
Review
Public, Environmental & Occupational Health
Andrea C. Buchler, Selvi N. Shahab, Juliette A. Severin, Margreet C. Vos, Anne F. Voor In ' T. Holt
Summary: This systematic review aimed to summarize outbreak investigations (OI) performed after the detection of carbapenem-resistant Pseudomonas aeruginosa (CRPA) in healthcare settings. The study found significant variations in the components of OI in both epidemic and endemic settings. Further research is needed to develop guidance on when and how to best perform OI.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2023)
Article
Infectious Diseases
Juan Chen, Qiqiang Liang, Shuo Ding, Yongshan Xu, Yanting Hu, Jingyu Chen, Man Huang
Summary: This retrospective observational study evaluated the efficacy of ceftazidime-avibactam (CAZ/AVI) for treating carbapenem-resistant Pseudomonas aeruginosa (CRPA) infection in lung transplant recipients. The study found that CAZ/AVI therapy showed good clinical and microbiological efficacy in this population, with high survival rates.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Infectious Diseases
Kai Yang, Tingting Xiao, Qingyi Shi, Yunying Zhu, Jing Ye, Yanzi Zhou, Yonghong Xiao
Summary: The study revealed that Pseudomonas aeruginosa bloodstream infections result in a significant economic burden, with significant differences in socioeconomic losses between carbapenem-resistant and carbapenem-susceptible strains. The direct and indirect economic burdens, as well as disability-adjusted life years loss caused by carbapenem-resistant Pseudomonas aeruginosa bloodstream infections, were significantly higher than those caused by susceptible strains.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2021)
Review
Public, Environmental & Occupational Health
Lijuan Guo, Hui Xu, Zhigang Yue
Summary: This study investigated the resistance profiles of wound-isolated Pseudomonas aeruginosa to antimicrobial agents among Chinese burn patients. The results showed an increasing trend of resistance and the highest resistance to gentamicin. Effective stewardship programs should be established to optimize treatment options for burn patients.
ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE
(2022)
Article
Microbiology
Luke Diorio-Toth, Sidra Irum, Robert F. Potter, Meghan A. Wallace, Muhammad Arslan, Tehmina Munir, Saadia Andleeb, Carey-Ann D. Burnham, Gautam Dantas
Summary: This study used whole-genome sequencing to determine the genotypic mechanisms of beta-lactam resistance in Pseudomonas aeruginosa clinical isolates from three hospitals in Pakistan. The study found that carbapenem resistance was associated with the acquisition of metallo-beta-lactamases or extended-spectrum beta-lactamases and mutations in the porin gene. Furthermore, isolates with multiple resistance mechanisms showed significantly higher levels of imipenem resistance compared to isolates with a single resistance mechanism.
MICROBIOLOGY SPECTRUM
(2022)
Article
Microbiology
Yun-Qi Song, Su Min Kyung, Suji Kim, Gun Kim, So Yeong Lee, Han Sang Yoo
Summary: Pseudomonas aeruginosa is a major pathogen in nosocomial infections, which are difficult to handle due to its biofilm-forming ability and carbapenem resistance. Antimicrobial peptides, such as RP557, have shown effectiveness in inhibiting biofilms. Our study assessed the effectiveness of RP557 on carbapenem-resistant P. aeruginosa planktonic cells and biofilms, providing a potential treatment option for carbapenem-resistant P. aeruginosa infection. This treatment could be helpful in managing severe nosocomial infections caused by carbapenem-resistant bacteria and improving patients' survival rates.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Christian M. Gill, Elif Aktas, Wadha Alfouzan, Lori Bourassa, Adrian Brink, Carey-Ann D. Burnham, Rafael Canton, Yehuda Carmeli, Marco Falcone, Carlos Kiffer, Anna Marchese, Octavio Martinez, Spyros Pournaras, Harald Seifert, Abrar K. Thabit, Maria Virginia Villegas, Lars F. Westblade, David P. Nicolau
Summary: In this study, high in vitro potency of ceftazidime and cefepime among carbapenem-resistant Pseudomonas aeruginosa isolates was found, with 6 g/day required to achieve optimal pharmacodynamic profiles. These findings should be considered in the clinical setting and for the application of CLSI susceptibility breakpoints.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Review
Infectious Diseases
Eric Reid, Ryan W. Walters, Christopher J. Destache
Summary: The meta-analyses demonstrate that FQ monotherapy significantly improves survival in PA bacteremia and shows similar rates of bacteriological eradication in pneumonia and skin and soft tissue infection caused by PA compared to BL monotherapy. Further research is needed to provide meaningful clinical recommendations.
Article
Pharmacology & Pharmacy
Shouquan Wu, Yu Wang, Miaomiao Zhang, Minggui Wang, Jian-Qing He
Article
Immunology
Shouquan Wu, Minggui Wang, Yu Wang, Miaomiao Zhang, Jian-Qing He
MICROBIAL PATHOGENESIS
(2019)
Article
Biotechnology & Applied Microbiology
Guo Chen, Lan Luo, Miao-Miao Zhang, Shou-Quan Wu, Yu Wang, Andrew J. Sandford, Jian-Qing He
BIOMED RESEARCH INTERNATIONAL
(2019)
Review
Infectious Diseases
Meng Zhang, Miao Xue, Jian-qing He
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2020)
Review
Pharmacology & Pharmacy
Meng Zhang, Shou-quan Wu, Jian-qing He
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
(2019)
Article
Biochemistry & Molecular Biology
Shouquan Wu, Yu Wang, Miaomiao Zhang, Minggui Wang, Jian-Qing He
Article
Biotechnology & Applied Microbiology
Shouquan Wu, Xiangmin Liu, Yu Wang, Miaomiao Zhang, Minggui Wang, Jian-Qing He
Review
Pharmacology & Pharmacy
Meng Zhang, Jian-qing He
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2020)
Article
Pharmacology & Pharmacy
Guiyi Ji, Weiwei Huang, Jianqing He
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
(2020)
Article
Medical Laboratory Technology
Jingcan Wu, Shouquan Wu, Qianqian Liu, Yu Wang, Guiyi Ji, Andrew J. Sandford, Jian-Qing He
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2020)
Article
Pharmacology & Pharmacy
Mingjin Yang, Yan Zhang, Hong Cheng, Zhibo Xu, Jianqing He
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Shouquan Wu, Xiangmin Liu, Ling Chen, Yu Wang, Miaomiao Zhang, Minggui Wang, Jian-Qing He
BIOSCIENCE REPORTS
(2020)
Article
Respiratory System
Miaomiao Zhang, Guo Chen, Yu Wang, Shou-Quan Wu, Andrew J. Sandford, Jian-Qing He
BMC PULMONARY MEDICINE
(2020)
Article
Multidisciplinary Sciences
Shouquan Wu, Ming-Gui Wang, Yu Wang, Jian-Qing He
SCIENTIFIC REPORTS
(2019)
Article
Multidisciplinary Sciences
Yu Wang, Xi Xiang, Wei-Wei Huang, Andrew J. Sandford, Shou-Quan Wu, Miao-Miao Zhang, Ming-Gui Wang, Guo Chen, Jian-Qing He
SCIENTIFIC REPORTS
(2019)