Cerebrospinal fluid apolipoprotein E concentration decreases after seizure

Purpose: In epilepsy, Many studies were focus Oil apoE gene polymorphism and found APOE epsilon 4 to be associated with earlier onset of temporal lobe epilepsy. There is not any study about apoE in cerebrospinal fluid (CSF) of epileptic patients, so we detect the CSF-apoE and determine whether it is changed after seizure. Methods: A total of 60 epileptic patients and 28 Subjects wit h no evidence of any neurological diseases were studied. The concentrations of CSF-apoE were detected with enzyme-linked immunosorbent assay. Results: The CSF-apoE levels in epilepsy and control group were 5.78 +/- 12.15 mg/l and 13.60 +/- 12.11 mg/l. and there were statistical difference. In epilepsy group, the CSF-apoE concentration was 6.53 +/- 2.55 mg/l ill male patients, and 4.98 +/- 1.21 mg/l in female. In secondary epilepsy group was 5.06 +/- 1.31 mg/l, and in idiopathic epilepsy was 6.04 +/- 2.34 mg/l. Ill different seizure types groups, including complex partial seizure (CPS), secondarily generalized tonic-clonic seizure (SGTC), generalized tonic-clonic seizure (GTCS), and absence seizure (AS), the mean concentrations of CSF-apoE were 6.62 +/- 3.13 mg/l, 5.21 +/- 1.22 mg/l, 5.00 +/- 1.09 mg/l and 7.25 +/- 1.88 mg/l, respectively. Conclusions: CSF-apoE concentration decreases after seizures, correlated with the gender, etiological factor and seizure types. Crown Copyright (C) 2009 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.