Article
Clinical Neurology
Karl-Heinz Nenning, Olivia Fosleitner, Ernst Schwartz, Michelle Schwarz, Victor Schmidbauer, Gudrun Geisl, Christian Widmann, Susanne Pirker, Christoph Baumgartner, Daniela Prayer, Ekaterina Pataraia, Lisa Bartha-Doering, Georg Langs, Gregor Kasprian, Silvia B. Bonelli
Summary: The study found significant differences in connectivity between left and right TLE patients compared to healthy controls. Left TLE showed widespread impairment of task-positive language networks, while right TLE showed less pronounced alterations. Particularly, right TLE exhibited altered connectivity for cortical regions associated with the default mode network (DMN).
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Oliver C. Kiersnowski, Gavin P. Winston, Lorenzo Caciagli, Emma Biondetti, Maha Elbadri, Sarah Buck, John S. Duncan, John S. Thornton, Karin Shmueli, Sjoerd B. Vos
Summary: Using quantitative susceptibility mapping (QSM) and transverse relaxation rate (R2*), we investigated brain alterations in patients with temporal lobe epilepsy (TLE) compared to healthy controls (HC). We found significant changes in susceptibility and R2* in various brain regions, indicating selective loss of neurons and iron redistribution in the hippocampi, increased iron content in the thalamus and putamen, and correlations with disease severity and cognitive test scores.
HUMAN BRAIN MAPPING
(2023)
Article
Health Care Sciences & Services
Sung Chul Lim, Juhee Oh, Bo Young Hong, Seong Hoon Lim
Summary: Temporal lobe epilepsy (TLE) is a network disorder of the brain, characterized by hippocampal dysfunction. This study found significant changes in the volumes of the amygdala, hippocampus, and thalamus in patients with left TLE and hippocampal sclerosis (HS), while no abnormal diffusion properties associated with volume reduction were found in specific brain regions of patients with right TLE and HS.
Article
Pharmacology & Pharmacy
Soumil Dey, Aparna Banerjee Dixit, Manjari Tripathi, Ramesh Sharanappa Doddamani, Mehar Chand Sharma, Sanjeev Lalwani, Poodipedi Sarat Chandra, Jyotirmoy Banerjee
Summary: The study identified that levels of kynurenic acid were reduced and quinolinic acid levels were raised in the hippocampus of patients with MTLE-HS, along with abnormal glutamatergic activities. Altered metabolism of tryptophan-kynurenine pathway metabolites in the hippocampus could contribute to hyperglutamatergic tone in patients with MTLE-HS.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Biology
Iman Beheshti, Daichi Sone, Norihide Maikusa, Yukio Kimura, Yoko Shigemoto, Noriko Sato, Hiroshi Matsuda
Summary: This study demonstrates that combining DIR data with machine-learning algorithms can effectively distinguish normal individuals from epileptic subjects and accurately identify the laterality of the focus side in MRI-negative TLE patients.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Neurosciences
Shengkun Yu, Yifei Gu, Tianyu Wang, Long Mu, Haiyang Wang, Shi Yan, Aoweng Wang, Jiabin Wang, Li Liu, Hong Shen, Meng Na, Zhiguo Lin
Summary: This study revealed the molecular mechanisms of neuronal apoptosis in hippocampal sclerosis of intractable temporal lobe epilepsy patients through RNA sequencing and ceRNA network analysis, establishing a ceRNA network of lncRNA-mediated neuronal apoptosis in HS-TLE.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Christophe E. de Bezenac, Guleed Adan, Bernd Weber, Simon S. Keller
Summary: Before surgery, patients with mTLE showed an increased BrainAGE of more than 7 years compared to controls. However, surgery was associated with a mean BrainAGE reduction of 5 years, regardless of complete seizure freedom. Patients with left mTLE showed BrainAGE values more similar to controls post-surgery, indicating a lateralization effect.
Article
Behavioral Sciences
Bulent Guven, Asli Ece Cilliler
Summary: Approximately half of patients with HS-MTLE had headaches, with about one third reporting migraine type headaches. This highlights the potential pathogenetic role of HS in the development of headaches, especially migraines, in patients with epilepsy. Further studies are necessary to determine if accompanying headaches, particularly migraine attacks, could be determining factors for HS-MTLE, and if they have a lateralizing value for HS.
EPILEPSY & BEHAVIOR
(2021)
Review
Clinical Neurology
Yuming Li, Peiwen Liu, Qiuxing Lin, Dong Zhou, Dongmei An
Summary: This study conducted a systematic review and meta-analysis to evaluate the seizure and memory outcomes of temporal lobe epilepsy with different hippocampal sclerosis subtypes. The results showed no significant difference in seizure freedom and improved outcome between different subtypes, and the long-term seizure outcome and memory impairment remained controversial.
Article
Clinical Neurology
Ali A. Asadi-Pooya, Mohsen Farazdaghi
Summary: This study investigated the characteristics of patients with MRI-negative temporal lobe epilepsy (TLE) and compared them with patients with hippocampal sclerosis (HS)-TLE, non-HS structural TLE, and dual pathology. The findings suggest that MRI-negative TLE is not a homogeneous group and may not be a distinct entity from other forms of TLE. With advanced imaging technologies, the underlying pathologies of MRI-negative TLE may be revealed.
ACTA NEUROLOGICA BELGICA
(2023)
Article
Clinical Neurology
Wenbiao Xiao, Zhiquan Yang, Xiaoxin Yan, Li Feng, Lili Long, Tian Tu, Na Deng, Wenjuan Chen, Bo Xiao, Hongyu Long, Yi Zeng
Summary: This study investigated proteomic alterations in the DG region of TLE-HS patients and found that differentially expressed proteins were enriched in areas such as synaptic vesicle, mitochondrion, and cell-cell adhesion. A key protein module related to oxidative phosphorylation was also identified.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Hong Li, Fang Ding, Cong Chen, Peiyu Huang, Jingjing Xu, Zhong Chen, Shuang Wang, Minming Zhang
Summary: This study investigated the relationship between memory impairment and modular alterations in the hippocampal network of TLE patients. The results showed significant differences in modular properties between TLE-MD and TLE-MI patients in two distinct states, with dynamic modularity features having unique advantages in discriminating between the two memory phenotypes.
HUMAN BRAIN MAPPING
(2022)
Article
Clinical Neurology
Mengyi Guo, Jing Wang, Zhonghua Xiong, Xiongfei Wang, Yujiao Yang, Yifan Zhang, Chongyang Tang, Jing Zhang, Yuguang Guan, Fan Chen, Kun Yao, Pengfei Teng, Jian Zhou, Feng Zhai, Detlev Boison, Guoming Luan, Tianfu Li
Summary: Mesial temporal lobe epilepsy without hippocampal sclerosis (no-HS MTLE) patients have resistance to antiepileptic drugs, difficulties in precise seizure location, and poor surgical outcomes. This study found maladaptive changes in adenosine metabolism and neuronal pathology in no-HS MTLE patients, suggesting potential new therapeutic targets.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2023)
Article
Behavioral Sciences
Tamires Araujo Zanao, Tatila Martins Lopes, Brunno Machado de Campos, Clarissa Lin Yasuda, Fernando Cendes
Summary: The study revealed significant differences in DMN FC patterns among the control group, right-HS group, left-HS group, and MRI-negative group. The right-HS group exhibited increased FC in DMN-related areas in the left hemisphere, while the MRI-negative group showed more FC increases compared to the left-HS group, potentially indicating engagement in a compensatory system.
EPILEPSY & BEHAVIOR
(2021)
Review
Behavioral Sciences
Thato Mary Mokhothu, Kazumasa Zen Tanaka
Summary: Temporal Lobe Epilepsy (TLE) is characterized by focal brain hyperexcitability, leading to abnormal neuronal discharge and seizures. The hippocampus, known for its high excitability, is often the focus of TLE and is associated with high-frequency oscillations (HFOs) as a marker. However, distinguishing pathological HFOs from non-pathological ones and understanding their role in disease development remain challenging in research.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Endocrinology & Metabolism
Andreas Stadlbauer, Thomas M. Kinfe, Max Zimmermann, Ilker Eyuepoglu, Nadja Brandner, Michael Buchfelder, Moritz Zaiss, Arnd Doerfler, Sebastian Brandner
Summary: Functional magnetic resonance imaging (fMRI) is widely used for preoperative localization of eloquent cortical areas. However, lesion-induced impairment of neurovascular coupling (NVC) may result in false-negative fMRI results. This study investigated the physiological factors impacting NVC and found that perilesional hypoxia and reduced vascular perfusion and architecture were associated with lesion-induced impairment of NVC. A novel physiologic MRI approach was developed for preoperative risk assessment to prevent severe postoperative functional deficits.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Editorial Material
Clinical Neurology
Thomas Kinfe, Michael Buchfelder, Andreas Stadlbauer
EXPERT REVIEW OF NEUROTHERAPEUTICS
(2021)
Review
Clinical Neurology
Martin Nuessel, Melanie Hamperl, Anna Maslarova, Shafqat R. Chaudhry, Julia Kohn, Andreas Stadlbauer, Michael Buchfelder, Thomas Kinfe
Summary: The review focused on the use of burst and conventional motor cortex stimulation for chronic pain, particularly in patients with central post-stroke pain. While burstMCS showed promising results in reducing post-stroke pain, further large-scale sham-controlled trials are recommended to determine its utility compared to cMCS.
Article
Cell Biology
Krista Mineia Wartchow, Benjamin Schmid, Philipp Tripal, Andreas Stadlbauer, Michael Buchfelder, Carlos-Alberto Goncalves, Andrea Kleindienst
Summary: The study demonstrates that treatment with a cAMP analog/activator reduces GB growth and invasion.
Article
Oncology
Fengjuan Fan, Stefano Malvestiti, Sonia Vallet, Judith Lind, Jose Manuel Garcia-Manteiga, Eugenio Morelli, Qinyue Jiang, Anja Seckinger, Dirk Hose, Hartmut Goldschmidt, Andreas Stadlbauer, Chunyan Sun, Heng Mei, Martin Pecherstorfer, Latifa Bakiri, Erwin F. Wagner, Giovanni Tonon, Martin Sattler, Yu Hu, Pierfrancesco Tassone, Dirk Jaeger, Klaus Podar
Summary: This study demonstrates a significant correlation between JunB and angiogenic factors in MM, independent of hypoxia. JunB plays a dual role as a mediator of MM cell survival, proliferation, drug resistance, and also promotes angiogenesis in the BM microenvironment. These findings suggest targeting JunB as a potential strategy in MM therapy.
Article
Radiology, Nuclear Medicine & Medical Imaging
Elisabeth Heynold, Max Zimmermann, Nirjhar Hore, Michael Buchfelder, Arnd Doerfler, Andreas Stadlbauer, Natalia Kremenevski
Summary: The study evaluated a physiological MRI approach that showed significant differences in the pathophysiology of GB and BM, and has potential to noninvasively distinguish these two brain tumors using this method.
MOLECULAR IMAGING AND BIOLOGY
(2021)
Article
Oncology
Andreas Stadlbauer, Stefan Oberndorfer, Gertraud Heinz, Max Zimmermann, Thomas M. Kinfe, Arnd Doerfler, Michael Buchfelder, Natalia Kremenevski, Franz Marhold
Summary: Anaplastic gliomas (AG) are aggressive primary brain tumors that affect young adults. This study found that physiological MRI biomarkers can help detect pathophysiological changes before radiological recurrence of IDH-mutated AG, with intensifying hypoxia and upregulation of neovascularization activity preceding recurrence. These findings may lead to the development of new MRI imaging modalities and tailored therapy options for recurrent AG patients.
Correction
Oncology
Fengjuan Fan, Stefano Malvestiti, Sonia Vallet, Judith Lind, Jose Manuel Garcia-Manteiga, Eugenio Morelli, Qinyue Jiang, Anja Seckinger, Dirk Hose, Hartmut Goldschmidt, Andreas Stadlbauer, Chunyan Sun, Heng Mei, Martin Pecherstorfer, Latifa Bakiri, Erwin F. Wagner, Giovanni Tonon, Martin Sattler, Yu Hu, Pierfrancesco Tassone, Dirk Jaeger, Klaus Podar
Article
Clinical Neurology
Andreas Stadlbauer, Gertraud Heinz, Stefan Oberndorfer, Max Zimmermann, Thomas M. Kinfe, Michael Buchfelder, Arnd Doerfler, Natalia Kremenevski, Franz Marhold
Summary: This study demonstrated the diagnostic performance of physiological MRI biomarkers for detecting recurrence of IDH-mutant WHO grade 3 glioma, with a focus on microvascular features and tissue oxygen tension as early signs of neovascularization activity, providing valuable information for early detection of recurrence.
Review
Biochemistry & Molecular Biology
Shafqat R. Chaudhry, Andreas Stadlbauer, Michael Buchfelder, Thomas M. Kinfe
Summary: Studies show that melatonin plays a crucial role in sleep, pain, and immunometabolism, with potential adjunct effects in neurostimulation therapies. However, current research on these relationships is mainly experimental, lacking specific evaluations concerning neurostimulation therapy.
Article
Multidisciplinary Sciences
Sebastian Brandner, Simon Aicher, Sarah Schroeter, Izabela Swierzy, Thomas M. Kinfe, Michael Buchfelder, Anna Maslarova, Andreas Stadlbauer
Summary: Assessing the release and re-uptake of glutamate in the brain is crucial for understanding its role in normal brain function and neurological disorders. This study used fluorescent nanosensors to image glutamate transients in human cortical brain slices obtained from epilepsy surgery patients. The results showed that the nanosensor signals were in agreement with the stimulation electrode position and electrical stimulation dynamics. Pharmacological manipulation of glutamate release and reuptake also affected the nanosensor signals. This study demonstrates the potential of fluorescent nanosensors in detecting neuronal activity in human brain slices with high spatiotemporal precision.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Andreas Stadlbauer, Franz Marhold, Stefan Oberndorfer, Gertraud Heinz, Michael Buchfelder, Thomas M. Kinfe, Anke Meyer-Base
Summary: The pretreatment diagnosis of contrast-enhancing brain tumors is challenging due to their similar appearance on MRI. This study combined machine learning algorithms with a physiological MRI technique to develop a radiophysiomics approach for the classification of brain tumors. The results showed that radiophysiomics could be helpful in the clinical routine diagnosis of contrast-enhancing brain tumors, but further automation using deep neural networks is required.
Review
Clinical Neurology
Martin Nuessel, Yining Zhao, Constantin Knorr, Martin Regensburger, Andreas Stadlbauer, Michael Buchfelder, Alessandro del Vecchio, Thomas Kinfe
Summary: Chronic pain is a burden for patients and society, and conventional therapies have limited effectiveness. Reversible deep brain stimulation, stereotactic radiosurgery, and magnetic resonance-guided focused ultrasound are potential treatment options for modulating the affective pain network. However, heterogeneity in observation periods, stimulation patterns, lesioning techniques, and chronic pain etiology limit the evidence and comparative analysis.
Article
Biochemistry & Molecular Biology
Andreas Stadlbauer, Gertraud Heinz, Franz Marhold, Anke Meyer-Baese, Oliver Ganslandt, Michael Buchfelder, Stefan Oberndorfer
Summary: Glioblastoma and brain metastasis have similar appearances in conventional MRI, making their differentiation a major challenge in clinical neurooncology. This study shows that the combination of radiomic features and deep convolutional neural networks can effectively support the pre-therapeutic differentiation of these brain tumors.
Article
Medicine, General & Internal
Laszlo Barany, Nirjhar Hore, Andreas Stadlbauer, Michael Buchfelder, Sebastian Brandner
Summary: This study aimed to compare the performance of a deep-learning-based image segmentation with manual segmentation for predicting the topography of white matter tracts on T1-weighted MR images. After reconstructing the corticospinal tract using deterministic diffusion tensor imaging, a segmentation model was trained and evaluated. The results showed that the algorithm performed well in predicting the topography of the corticospinal pathway on T1-weighted images in healthy subjects.
