Article
Chemistry, Multidisciplinary
Mariia Pushina, Andrej Penavic, Sepideh Farshbaf, Pavel Anzenbacher
Summary: The developed dual chromophore sensors in this study can accurately monitor glucose levels in urine, successfully classify nine different sugars, and quantitatively determine important carbohydrates without the need for sample pretreatment.
Article
Chemistry, Analytical
Haiqin Li, Xiaoyuan Wang, Xiaochun Li, Hua-Zhong Yu
Summary: This study demonstrated a smartphone-based pH determination technique that uses digital image analysis of commercial test strips to accurately determine pH values, achieving a measurement accuracy of 0.05 pH units. The performance of the Smart-pH-Reader system was validated with multiple real-world samples, showing consistent results with standard pH meters, and is envisioned as a simple, portable, and accurate pH determination tool for various fields such as environmental monitoring and medical diagnosis.
ANALYTICAL CHEMISTRY
(2021)
Article
Engineering, Electrical & Electronic
Monica Yumnam, Diganta Hatiboruah, Rahul Mishra, K. Sathyaseelan, Pabitra Nath, Poonam Mishra
Summary: We developed a cost-effective and user-friendly smartphone-based sensor with a PANI label to monitor the freshness of fish fillets during storage. The sensor was calibrated using a standard ammonia solution and validated with conventional techniques. The PANI label made the sensor specific for detecting fish spoilage and a strong correlation was found with traditional freshness indicators. A web application was developed for evaluating fish fillet quality based on the sensor's findings.
SENSORS AND ACTUATORS A-PHYSICAL
(2023)
Article
Chemistry, Applied
Mei Yang, Xiaodong Zhai, Xiaowei Huang, Zhihua Li, Jiyong Shi, Qi Li, Xiaobo Zou, Maurizio Battino
Summary: In this study, 6 beers from Tsingtao Brewery were analyzed using colorimetric GC-MS and sensor array (CSA). The study identified volatile compounds in the beers and discriminated them using multivariate analysis, demonstrating that CSA could be used for rapid and non-destructive determination of beer quality.
Article
Chemistry, Applied
Medena Noikham, Chawallak Sriwiphasathit, Khatcharin Siriwong, Tirayut Vilaivan
Summary: A series of D-pi-A fluorescent styryl pyrene probes were synthesized through the Wittig reaction, and the introduction of electron-withdrawing substituents resulted in solvent-dependent intramolecular charge transfer and solvatochromic properties. The nitro and aldehyde substituents exhibited remarkable sensitivity to environment polarity.
Article
Cell Biology
Gloria B. Kim, Jens Fritsche, Sebastian Bunk, Andrea Mahr, Felix Unverdorben, Kevin Tosh, Hong Kong, Colby R. Maldini, Chui Lau, Sriram Srivatsa, Shuguang Jiang, Joshua Glover, Derek Dopkin, Carolyn X. Zhang, Heiko Schuster, Daniel J. Kowalewski, Valentina Goldfinger, Martina Ott, David Fuhrmann, Maike Baues, Hans Boesmueller, Christoph Schraeder, Gisela Schimmack, Colette Song, Franziska Hoffgaard, Michael Roemer, Chih-Chiang Tsou, Martin Hofmann, Thomas Treiber, Meike Hutt, Leonie Alten, Maike Jaworski, Amir Alpert, Sarah Missel, Carsten Reinhardt, Harpreet Singh, Oliver Schoor, Steffen Walter, Claudia Wagner, Dominik Maurer, Toni Weinschenk, James L. Riley
Summary: By analyzing a large number of tumor and normal tissue samples using immunopeptidomics, a highly expressed tumor antigen in multiple solid cancers was identified. Further research discovered that by enhancing the affinity, this specific TCR can be transduced into T cells and eliminate tumors in vivo.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Chemistry, Analytical
Ruoxuan Jiang, Dan Lin, Qianru Zhang, Lingfei Li, Liang Yang
Summary: A novel fluorescent sensing platform was developed for rapid and sensitive detection of residual antibiotics, which exhibited a unique color response to NFX with high sensitivity and rapid response time. The platform has great potential for on-site and quantitative analysis of NFX, providing an effective pathway for rapid visual antibiotics detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Cell Biology
Fredrick J. Rosario, Amy Catherine Kelly, Madhulika B. Gupta, Theresa L. Powell, Laura Cox, Thomas Jansson
Summary: The study demonstrates that mTORC2 signaling regulates gene expression in trophoblast cells, including those related to inflammation, micronutrient transport, and angiogenesis. This reveals novel links between mTOR signaling and multiple placental functions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Liangren Chen, Youquan Xu, Yinfeng Liu, Jing Wang, Jianwen Chen, Xiaohua Chang, Yutian Zhu
Summary: In this study, a flexible and transparent sensor with interlocked square column arrays containing Ag nanoparticles (AgNPs), citric acid (CA), and poly(vinyl alcohol) (PVA) was designed, inspired by the interlocked biological geometry of human skin. This sensor exhibited multisensory capabilities for pressure, temperature, and humidity. The interlocked AgNPs/CA/PVA sensor demonstrated high sensitivity, low detection limit, fast response, and outstanding stability as a flexible pressure sensor. Additionally, it also acted as a temperature and humidity sensor with high resolution and real-time detection capability.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Electrical & Electronic
Shen Wang, Yinya Li, Guoqing Qi, Andong Sheng
Summary: This article investigates the sensor selection and deployment strategies for target localization with range-only measurements in 2-D space. Instead of using conventional sensor selection methods, an approach of selecting the subset of all sensors based on the optimal sensor-target geometry is proposed to improve the target localization performance. An efficient algorithm for sensor selection is developed and an optimal deployment strategy is proposed to further improve localization accuracy.
IEEE SENSORS JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Panpan Mou, Lingyu Song, Shuo Zhou, Jinfeng Wang, Zhimei Yuan, Jinglin Hong, Rouyi Wang, Xianbo Zhang, Guosong Chen, Liming Huang
Summary: This study proposes a new equation for calculating alkalinity and develops a mix and measure method for determination of alkalinity. The method is more efficient than traditional titration methods and the portable detection system offers accurate and precise results. The findings are significant for industrial control and environmental monitoring.
Article
Engineering, Electrical & Electronic
Zeren Li, Lulu Zhang, Yunze Cai, Hideya Ochiai
Summary: This paper proposes an information-quality-based sensor selection method with estimation feedback for maneuvering target tracking in uncertain wireless sensor networks (WSNs). The GPB1-UIF algorithm with estimation feedback is presented and an information-quality metric framework is proposed for sensor selection. The proposed approach outperforms previous methods in simulation results.
IEEE SENSORS JOURNAL
(2022)
Article
Genetics & Heredity
Zhigang Jia, Xiujun Zhang
Summary: In this work, a novel method called DDTG is presented to improve the accuracy of causality determination in gene regulatory network (GRN) inference by dissecting downstream target genes. The method determines the topology and hierarchy of GRNs using mutual information and conditional mutual information, and the regulatory directions of GRNs using Taylor formula-based regression. The method is validated on benchmark GRNs and outperforms popular GRN inference methods.
FRONTIERS IN GENETICS
(2022)
Article
Chemistry, Multidisciplinary
Joseph W. Shane, Lauren E. Shearer, John N. Richardson, Jeb S. Kegerreis
Summary: This paper describes the use of an inexpensive, commercially available sensor to reliably and accurately measure alcohol concentrations in kombucha across a variety of undergraduate chemistry laboratory courses. Procedures and assessment data are also provided for two courses: an introductory course for nonchemistry majors and upper-division analytical chemistry. The alcohol content of multiple commercial kombucha samples were determined, and students submitted final reports using appropriate scientific writing aligned with precise learning objectives.
JOURNAL OF CHEMICAL EDUCATION
(2023)
Article
Engineering, Aerospace
Zhao Li, Yidi Wang, Wei Zheng, Xin Song
Summary: The accuracy of space debris orbit determination can be greatly improved by observing it with two space-based optical sensors simultaneously. Optimizing sensor pointings to maximize the length of the double coverage arc is key to this observation. The proposed sensor scheduling method based on the double coverage probability (DCP) provides a longer double coverage arc and higher orbit determination accuracy compared to the traditional method.
Article
Biochemistry & Molecular Biology
Duyen H. T. Nguyen, Robert H. Utama, Kristel C. Tjandra, Panthipa Suwannakot, Eric Y. Du, Maria Kavallaris, Richard D. Tilley, J. Justin Gooding
Summary: This study develops a synthetic hydrogel with ionic cross-linking to rapidly create hydrogels. The mechanical stiffness of the hydrogel can be tuned by varying the number of charged ionic groups, the length of the polymer arms, and the polymer concentration. It is demonstrated as an extracellular matrix mimic for 3D in vitro cell models.
Article
Chemistry, Applied
Hongrui Cheng, Song Chen, Min Li, Yongfeng Lu, Haixin Chen, Xiao Fang, Haijiang Qiu, Wensong Wang, Cheng Jiang, Yuanhui Zheng
Summary: This article introduces a universal method for the fabrication of a carbon-dot@silica composite with ultralong lifetime, high phosphorescence quantum efficiency, excellent luminescence stability, and dual-color phosphorescence emission. The triplet excited states of carbon dots are stabilized by the rigid network of silica and the stable covalent bonding between carbon dots and silica. The carbon-dot@silica exhibit ultralong lifetimes of 1.33 s and 0.38 s under excitation at 254 nm and 365 nm, respectively. Moreover, the phosphorescence color of the carbon-dot@silica can change from cyan to yellow when the exciting wavelength switches from 254 nm to 365 nm. The obtained carbon-dot@silica also show outstanding characteristics of anti-photobleaching and phosphorescence stability in an aqueous solution. Based on the unique phosphorescent properties of the carbon-dot@silica, a stable and dual-color phosphorescence security label is designed for advanced information encryption.
Article
Chemistry, Physical
Samuel V. Somerville, Peter B. O'Mara, Tania M. Benedetti, Soshan Cheong, Wolfgang Schuhmann, Richard D. Tilley, J. Justin Gooding
Summary: Enzymes with multiple active sites and control over the solution environment enable the formation of complex products from simple reactants. We mimic this concept using nanoparticles to facilitate the electro-chemical carbon dioxide reduction reaction. By altering the rate of CO2 delivery, the activity of the CO producing site, and the applied potential, we show that stable nanoparticles with lower CO formation activity can produce greater amounts of hydrocarbon products. This highlights the importance of the local solution environment and the stability of the catalyst in cascade reactions.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Multidisciplinary Sciences
Lucy Gloag, Agus R. Poerwoprajitno, Soshan Cheong, Zeno R. Ramadhan, Tadafumi Adschiri, J. Justin Gooding, Richard D. Tilley
Summary: In this study, hierarchical nanostructures with nanosized gold cores and nickel branches were successfully synthesized. The dimensions and morphology of these 3D structures were controlled by tuning in each synthetic step. These materials, which have high surface area, high conductivity, and surfaces that can be chemically modified, are ideal electrocatalyst supports. Coating with nickel-iron oxyhydroxide further enhanced their activity and stability for oxygen evolution reaction. This work introduces a synthetic concept to produce a new type of high-performing electrocatalyst support.
Article
Chemistry, Multidisciplinary
Samuel V. V. Somerville, Qinyu Li, Johanna Wordsworth, Sina Jamali, Mohammad Reza Eskandarian, Richard D. D. Tilley, J. Justin Gooding
Summary: Nanozymes mimic the selectivity of enzymes by utilizing features such as control over the arrangement of atoms in the active site and the placement of the active site down a nanoconfined substrate channel. The implementation of enzyme-inspired features has shown improvements in both activity and selectivity of nanoparticles for various catalytic and sensing applications. Controlled active sites on metal nanoparticle surfaces can be achieved through changing the composition of the surface metal or immobilizing single atoms on a metal substrate. Molecular frameworks and unique diffusional environments further enhance selectivity, while nanoconfined substrate channels offer additional control over selectivity through modifying the solution environment and transport of reactants and products.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Analytical
Danielle Bennett, Xueqian Chen, Gregory J. Walker, Sacha Stelzer-Braid, William D. Rawlinson, D. Brynn Hibbert, Richard D. Tilley, J. Justin Gooding
Summary: Plasmonic nanoparticles in dimer format are used for single molecule sensing, where the interaction with hairpin DNA leads to a shift in localized surface plasmon resonance. Spectroscopy may detect this shift, but point-of-care devices require a faster analysis method. By using dark-field imaging and digital analysis, the plasmonic resonance shift of thousands of dimer structures can be measured in minutes. The challenge is separating dimers from non-specifically bound clusters to achieve accurate results. The LAB-based classifier algorithm demonstrated the highest accuracy for this digital separation.
ANALYTICAL CHEMISTRY
(2023)
Correction
Chemistry, Analytical
Danielle Bennett, Xueqian Chen, Gregory J. Walker, Milad Mehdipour, Sacha Stelzer-Braid, William D. Rawlinson, D. Brynn Hibbert, Richard D. Tilley, J. Justin Gooding
ANALYTICAL CHEMISTRY
(2023)
Editorial Material
Chemistry, Analytical
Eric Bakker, Philippe Buhlmann, J. Justin Gooding, Robert E. Gyurcsanyi, Ernoe Pretsch
Article
Materials Science, Biomaterials
Panthipa Suwannakot, Stephanie Nemec, Newton Gil Peres, Eric Y. Du, Kristopher A. Kilian, Katharina Gaus, Maria Kavallaris, J. Justin Gooding
Summary: Synthetic hydrogels are widely used to mimic the extracellular matrix (ECM) and the physical and biochemical cues observed in natural ECM proteins. Researchers have developed an electrostatically crosslinked PEG-based hydrogel system to create high-throughput 3D in vitro models of the cancer environment. This hydrogel system can be degraded by breaking the interaction between oppositely charged polymer chains.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Biophysics
Ying Yang, Sanjun Fan, James A. Webb, Yuanqing Ma, Jesse Goyette, Xueqian Chen, Katharina Gaus, Richard D. Tilley, Justin Gooding
Summary: This study presents an electrochemical approach to reversible fluorescence switching of enhanced green fluorescent proteins (EGFP) on indium tin oxide coated glass. The method allows efficient switching between bright (ON) and dim (OFF) states at the single molecule level. The electrochemical fluorescence switching is fast, reversible, and can be incorporated into advanced fluorescence microscopy.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Biophysics
Daniel E. Hagness, Ying Yang, Richard D. Tilley, J. Justin Gooding
Summary: Affinity biosensors play a crucial role in various areas of human health, such as clinical diagnosis and pharmaceuticals, by utilizing specific binding between target analytes and biological ligands. Electrokinetic phenomena have been investigated as a viable option to improve the performance of affinity biosensors for higher sensitivity and lower detection limit.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Analytical
Seyedyousef Arman, Vinicius R. R. Goncales, Ying Yang, Richard D. D. Tilley, Katharina Gaus, J. Justin Gooding
Summary: This study explores a dual optical and electrical biosensor based on cells, which provides insights into cellular events. The fabrication steps and electrical characterization of microelectrodes are described. Initial experiments show that the ability of indium tin oxide (ITO) to detect biological cells at the electrode-cell layer interface mainly depends on the size of the sensing area. The impact of conductivity on the real-time impedance signal during cell adhesion on different substrates is also explored.
Editorial Material
Chemistry, Multidisciplinary
J. Justin Gooding, Jean-Francois Masson
Article
Cell Biology
Marina Ulanova, Lucy Gloag, Andre Bongers, Chul-Kyu Kim, Hong Thien Kim Duong, Ha Na Kim, John Justin Gooding, Richard D. Tilley, Joanna Biazik, Wei Wen, Perminder S. Sachdev, Nady Braidy, Alexander E. Kalyuzhny
Summary: Nanoparticle-based magnetic contrast agents have been developed for early non-invasive diagnosis of Alzheimer's disease (AD) using magnetic resonance imaging (MRI). This study developed a biocompatible magnetic nanoparticle targeted to amyloid beta (A beta) plaques to enhance the sensitivity of T2-weighted MRI for imaging of amyloid pathology in AD. The nanoparticles showed no significant cytotoxicity and were able to bind to amyloid species. The study provides promising preliminary results for the development of a targeted non-invasive method for early AD diagnosis using contrast-enhanced MRI.
Review
Chemistry, Analytical
Seyedyousef Arman, Richard D. Tilley, J. Justin Gooding
Summary: This article reviews the development of cellular impedance biosensors, electrochemical impedance spectroscopy, and the general principles and terms associated with the cell-electrode interface. This family of techniques provides real-time quantitative and sensitive information on cell responses to stimuli with high temporal resolution, and their applications in cell biology are illustrated with various examples. The current state of the field, its limitations, possible solutions, and the potential benefits of developing biosensors are discussed.