Toll-like receptor 4 contributes to the inhibitory effect of morphine on colonic motility in vitro and in vivo

Circular muscle contraction in the mice rectum plays a key role in morphine-induced constipation

(2014) H. Ono et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Opioid-Induced Constipation: Pathophysiology, Clinical Consequences, and Management

(2014) Lalit Kumar et al.   Gastroenterology Research and Practice

Endogenous Regulation of Visceral Pain via Production of Opioids by Colitogenic CD4+ T Cells in Mice

(2013) Jérôme Boué et al.   GASTROENTEROLOGY

MicroRNA 375 Mediates Palmitate-Induced Enteric Neuronal Damage and High-Fat Diet-Induced Delayed Intestinal Transit in Mice

(2013) Behtash Ghazi Nezami et al.   GASTROENTEROLOGY

Morphine Induces Bacterial Translocation in Mice by Compromising Intestinal Barrier Function in a TLR-Dependent Manner

(2013) Jingjing Meng et al.   PLoS One

Toll-Like Receptor 4 Antagonist Attenuates Intracerebral Hemorrhage–Induced Brain Injury

(2013) Yan-Chun Wang et al.   STROKE

Morphine induced exacerbation of sepsis is mediated by tempering endotoxin tolerance through modulation of miR-146a

(2013) Santanu Banerjee et al.   Scientific Reports

Mu opioid receptor activation modulates Toll like receptor 4 in murine macrophages

(2012) Silvia Franchi et al.   BRAIN BEHAVIOR AND IMMUNITY

Pharmacological characterization of LPS and opioid interactions at the toll-like receptor 4

(2012) CW Stevens et al.   BRITISH JOURNAL OF PHARMACOLOGY

The colonic microbiota in health and disease

(2012) Fergus Shanahan   CURRENT OPINION IN GASTROENTEROLOGY

Gut Microbial Products Regulate Murine Gastrointestinal Motility via Toll-Like Receptor 4 Signaling

(2012) Mallappa Anitha et al.   GASTROENTEROLOGY

Morphine activates neuroinflammation in a manner parallel to endotoxin

(2012) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A role for reactive oxygen species in endotoxin-induced elevation of MOR expression in the nervous and immune systems

(2011) Erik F. Langsdorf et al.   JOURNAL OF NEUROIMMUNOLOGY

Exploring the Neuroimmunopharmacology of Opioids: An Integrative Review of Mechanisms of Central Immune Signaling and Their Implications for Opioid Analgesia

(2011) M. R. Hutchinson et al.   PHARMACOLOGICAL REVIEWS

Dominant role of the MyD88-dependent signaling pathway in mediating early endotoxin-induced murine ileus

(2010) Bettina M. Buchholz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

TAK-242 (Resatorvid), a Small-Molecule Inhibitor of Toll-Like Receptor (TLR) 4 Signaling, Binds Selectively to TLR4 and Interferes with Interactions between TLR4 and Its Adaptor Molecules

(2010) N. Matsunaga et al.   MOLECULAR PHARMACOLOGY

Membrane TLR signaling mechanisms in the gastrointestinal tract during sepsis

(2010) b. m. buchholz et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Interplay between inflammation, immune system and neuronal pathways: Effect on gastrointestinal motility

(2010) Benedicte Y De Winter   WORLD JOURNAL OF GASTROENTEROLOGY

Evidence that opioids may have toll-like receptor 4 and MD-2 effects

(2009) Mark R. Hutchinson et al.   BRAIN BEHAVIOR AND IMMUNITY

Analysis of binding site for the novel small-molecule TLR4 signal transduction inhibitor TAK-242 and its therapeutic effect on mouse sepsis model

(2009) K Takashima et al.   BRITISH JOURNAL OF PHARMACOLOGY

THE NOVEL SELECTIVE TOLL-LIKE RECEPTOR 4 SIGNAL TRANSDUCTION INHIBITOR TAK-242 PREVENTS ENDOTOXAEMIA IN CONSCIOUS GUINEA-PIGS

(2009) Masamune Kuno et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Morphine-induced physiological and behavioral responses in mice lacking G protein-coupled receptor kinase 6

(2009) Kirsten M. Raehal et al.   DRUG AND ALCOHOL DEPENDENCE

Involvement of afferent neurons in the pathogenesis of endotoxin-induced ileus in mice: Role of CGRP and TRPV1 receptors

(2009) Benedicte Y. De Winter et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Toll-like Receptors 3, 4, and 7 Are Expressed in the Enteric Nervous System and Dorsal Root Ganglia

(2009) Isabella Barajon et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Nonhemopoietic Cell TLR4 Signaling Is Critical in Causing Early Lipopolysaccharide-Induced Ileus

(2009) B. M. Buchholz et al.   JOURNAL OF IMMUNOLOGY

Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4)

(2008) Mark R. Hutchinson et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain

(2008) Tomohiro Kawamoto et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Toll-like receptors differentially regulate GPCR kinases and arrestins in primary macrophages

(2008) Katie Loniewski et al.   MOLECULAR IMMUNOLOGY

The Prevalence, Severity, and Impact of Opioid-Induced Bowel Dysfunction: Results of a US and European Patient Survey (PROBE 1)

(2008) Timothy J. Bell et al.   PAIN MEDICINE

The involvement of the μ-opioid receptor in gastrointestinal pathophysiology: Therapeutic opportunities for antagonism at this receptor

(2007) Diane L. DeHaven-Hudkins et al.   PHARMACOLOGY & THERAPEUTICS