The selective post-translational processing of transcription factor Nrf1 yields distinct isoforms that dictate its ability to differentially regulate gene expression

Proteasome-Mediated Processing of Nrf1 Is Essential for Coordinate Induction of All Proteasome Subunits and p97

(2014) Zhe Sha et al.   CURRENT BIOLOGY

The C-Terminal Domain of Nrf1 Negatively Regulates the Full-Length CNC-bZIP Factor and Its Shorter Isoform LCR-F1/Nrf1β; Both Are Also Inhibited by the Small Dominant-Negative Nrf1γ/δ Isoforms that Down-Regulate ARE-Battery Gene Expression

(2014) Yiguo Zhang et al.   PLoS One

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

(2014) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition

(2014) Senthil K Radhakrishnan et al.   eLife

Nuclear factor-erythroid 2-related factor 1 regulates expression of proteasome genes in hepatocytes and protects against endoplasmic reticulum stress and steatosis in mice

(2013) Candy S. Lee et al.   FEBS Journal

The Casein Kinase 2-Nrf1 Axis Controls the Clearance of Ubiquitinated Proteins by Regulating Proteasome Gene Expression

(2013) Yoshiki Tsuchiya et al.   MOLECULAR AND CELLULAR BIOLOGY

The membrane-topogenic vectorial behaviour of Nrf1 controls its post-translational modification and transactivation activity

(2013) Yiguo Zhang et al.   Scientific Reports

A Proteasome Inhibitor-stimulated Nrf1 Protein-dependent Compensatory Increase in Proteasome Subunit Gene Expression Reduces Polycomb Group Protein Level

(2012) Sivaprakasam Balasubramanian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Live Cell Imaging of Protein Dislocation from the Endoplasmic Reticulum

(2012) Yongwang Zhong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity

(2012) S Chowdhry et al.   ONCOGENE

Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction

(2011) Akira Kobayashi et al.   GENES TO CELLS

The Fbw7 Tumor Suppressor Regulates Nuclear Factor E2-related Factor 1 Transcription Factor Turnover through Proteasome-mediated Proteolysis

(2011) Madhurima Biswas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dual Regulation of the Transcriptional Activity of Nrf1 by  -TrCP- and Hrd1-Dependent Degradation Mechanisms

(2011) Y. Tsuchiya et al.   MOLECULAR AND CELLULAR BIOLOGY

The Nrf1 CNC-bZIP Protein Is Regulated by the Proteasome and Activated by Hypoxia

(2011) Nikolai L. Chepelev et al.   PLoS One

Loss of nuclear factor E2-related factor 1 in the brain leads to dysregulation of proteasome gene expression and neurodegeneration

(2011) C. S. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specific SKN-1/Nrf Stress Responses to Perturbations in Translation Elongation and Proteasome Activity

(2011) Xuan Li et al.   PLoS Genetics

Identification of topological determinants in the N-terminal domain of transcription factor Nrf1 that control its orientation in the endoplasmic reticulum membrane

(2010) Yiguo Zhang et al.   BIOCHEMICAL JOURNAL

Basic Leucine Zipper Protein Cnc-C Is a Substrate and Transcriptional Regulator of the Drosophila 26S Proteasome

(2010) K. B. Grimberg et al.   MOLECULAR AND CELLULAR BIOLOGY

Transcription Factor Nrf1 Mediates the Proteasome Recovery Pathway after Proteasome Inhibition in Mammalian Cells

(2010) Senthil K. Radhakrishnan et al.   MOLECULAR CELL

Proteasomal Degradation Is Transcriptionally Controlled by TCF11 via an ERAD-Dependent Feedback Loop

(2010) Janos Steffen et al.   MOLECULAR CELL

Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease

(2010) G. P. Sykiotis et al.   Science Signaling

Lipid-Dependent Membrane Protein Topogenesis

(2009) William Dowhan et al.   Annual Review of Biochemistry

Targeted disruption of nuclear factor erythroid-derived 2-like 1 in osteoblasts reduces bone size and bone formation in mice

(2009) Jonghyun Kim et al.   PHYSIOLOGICAL GENOMICS

Interaction and conformational dynamics of membrane-spanning protein helices

(2009) Dieter Langosch et al.   PROTEIN SCIENCE

Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents

(2009) Larry G. Higgins et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Targeting NRF2 signaling for cancer chemoprevention

(2009) Mi-Kyoung Kwak et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The Nrf1 CNC/bZIP protein is a nuclear envelope-bound transcription factor that is activated by t-butyl hydroquinone but not by endoplasmic reticulum stressors

(2008) Yiguo Zhang et al.   BIOCHEMICAL JOURNAL

Nrf1 and Nrf2 Play Distinct Roles in Activation of Antioxidant Response Element-dependent Genes

(2008) Makiko Ohtsuji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Nrf3 Transcription Factor Is a Membrane-bound Glycoprotein Targeted to the Endoplasmic Reticulum through Its N-terminal Homology Box 1 Sequence

(2008) Yiguo Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

One step at a time: endoplasmic reticulum-associated degradation

(2008) Shruthi S. Vembar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY