Pharmacogenetics at 50: Genomic Personalization Comes of Age

Comparing Patient-Reported Hospital Adverse Events with Medical Record Review: Do Patients Know Something That Hospitals Do Not?

(2013) Joel S. Weissman et al.   ANNALS OF INTERNAL MEDICINE

Controversies and priorities in amyotrophic lateral sclerosis

(2013) Martin R Turner et al.   LANCET NEUROLOGY

De novo mutations in epileptic encephalopathies

(2013) et al.   NATURE

The changing scene of amyotrophic lateral sclerosis

(2013) Wim Robberecht et al.   NATURE REVIEWS NEUROSCIENCE

Clinical application of exome sequencing in undiagnosed genetic conditions

(2012) Anna C Need et al.   JOURNAL OF MEDICAL GENETICS

Genetic basis of susceptibility to drug-induced liver injury: what have we learned and where do we go from here?

(2012) Thomas J Urban et al.   PHARMACOGENOMICS

Amyotrophic Lateral Sclerosis: Drug Therapy from the Bench to the Bedside

(2012) Mark Bromberg et al.   SEMINARS IN NEUROLOGY

The Emerging Role of Electronic Medical Records in Pharmacogenomics

(2011) R A Wilke et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Inosine Triphosphate Protects Against Ribavirin-Induced Adenosine Triphosphate Loss by Adenylosuccinate Synthase Function

(2011) Yuki Hitomi et al.   GASTROENTEROLOGY

CYP2C19 Genotype, Clopidogrel Metabolism, Platelet Function, and Cardiovascular Events

(2011) Michael V. Holmes et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Boceprevir for Untreated Chronic HCV Genotype 1 Infection

(2011) Fred Poordad et al.   NEW ENGLAND JOURNAL OF MEDICINE

Carbamazepine-Induced Toxic Effects and HLA-B*1502 Screening in Taiwan

(2011) Pei Chen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genomics and Drug Response

(2011) Liewei Wang et al.   NEW ENGLAND JOURNAL OF MEDICINE

HLA-A*3101 and Carbamazepine-Induced Hypersensitivity Reactions in Europeans

(2011) Mark McCormack et al.   NEW ENGLAND JOURNAL OF MEDICINE

Boceprevir for Previously Treated Chronic HCV Genotype 1 Infection

(2011) Bruce R. Bacon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pharmacogenomic characterization of US FDA-approved cytotoxic drugs

(2011) Eric J Peters et al.   PHARMACOGENOMICS

Copy number variants in pharmacogenetic genes

(2011) Yijing He et al.   TRENDS IN MOLECULAR MEDICINE

The BATTLE Trial: Personalizing Therapy for Lung Cancer

(2011) Edward S. Kim et al.   Cancer Discovery

Genetic Variation in IL28B: Impact on Drug Development for Chronic Hepatitis C Infection

(2010) P J Clark et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

How and Why to Screen for CYP2D6 Interindividual Variability in Patients Under Pharmacological Treatments

(2010) Manuela De Gregori et al.   CURRENT DRUG METABOLISM

Interleukin-28B Polymorphism Improves Viral Kinetics and Is the Strongest Pretreatment Predictor of Sustained Virologic Response in Genotype 1 Hepatitis C Virus

(2010) Alexander J. Thompson et al.   GASTROENTEROLOGY

Variants in the ITPA Gene Protect Against Ribavirin-Induced Hemolytic Anemia and Decrease the Need for Ribavirin Dose Reduction

(2010) Alexander J. Thompson et al.   GASTROENTEROLOGY

A Polymorphism Near IL28B Is Associated With Spontaneous Clearance of Acute Hepatitis C Virus and Jaundice

(2010) Hans L. Tillmann et al.   GASTROENTEROLOGY

Genetic Variation in IL28B Is Associated With Chronic Hepatitis C and Treatment Failure: A Genome-Wide Association Study

(2010) Andri Rauch et al.   GASTROENTEROLOGY

IL28B genotype is associated with differential expression of intrahepatic interferon-stimulated genes in patients with chronic hepatitis C

(2010) Thomas J. Urban et al.   HEPATOLOGY

Hepatitis C trials that combine investigational agents with pegylated interferon should be stratified by interleukin-28B genotype

(2010) Alexander J. Thompson et al.   HEPATOLOGY

Clopidogrel and the Reduced-Function CYP2C19 Genetic Variant

(2010) Valentin Fuster et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C

(2010) Jacques Fellay et al.   NATURE

Integrating common and rare genetic variation in diverse human populations

(2010)   NATURE

Uncovering the roles of rare variants in common disease through whole-genome sequencing

(2010) Elizabeth T. Cirulli et al.   NATURE REVIEWS GENETICS

Pharmacogenomics of antihypertensive drugs: Rationale and design of the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) study

(2009) Julie A. Johnson et al.   AMERICAN HEART JOURNAL

Polymorphism of Human Cytochrome P450 2D6 and Its Clinical Significance

(2009) Shu-Feng Zhou   CLINICAL PHARMACOKINETICS

I-SPY 2: An Adaptive Breast Cancer Trial Design in the Setting of Neoadjuvant Chemotherapy

(2009) AD Barker et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis

(2009) Anna C Need et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

ADME pharmacogenetics: current practices and future outlook

(2009) Iris Grossman   Expert Opinion on Drug Metabolism & Toxicology

Association of Cytochrome P450 2C19 Genotype With the Antiplatelet Effect and Clinical Efficacy of Clopidogrel Therapy

(2009) Alan R. Shuldiner   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance

(2009) Dongliang Ge et al.   NATURE

Genetic variation in IL28B and spontaneous clearance of hepatitis C virus

(2009) David L. Thomas et al.   NATURE

Genome-wide association of IL28B with response to pegylated interferon-α and ribavirin therapy for chronic hepatitis C

(2009) Yasuhito Tanaka et al.   NATURE GENETICS

Telaprevir and Peginterferon with or without Ribavirin for Chronic HCV Infection

(2009) Christophe Hézode et al.   NEW ENGLAND JOURNAL OF MEDICINE

Telaprevir with Peginterferon and Ribavirin for Chronic HCV Genotype 1 Infection

(2009) John G. McHutchison et al.   NEW ENGLAND JOURNAL OF MEDICINE

Peginterferon Alfa-2b or Alfa-2a with Ribavirin for Treatment of Hepatitis C Infection

(2009) John G. McHutchison et al.   NEW ENGLAND JOURNAL OF MEDICINE

Data mining on electronic health record databases for signal detection in pharmacovigilance: which events to monitor?

(2009) Gianluca Trifirò et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Association of thymidylate synthase variants with 5-fluorouracil cytotoxicity

(2009) Eric J. Peters et al.   Pharmacogenetics and Genomics

Clopidogrel pharmacogenomics and risk of inadequate platelet inhibition: US FDA recommendations

(2009) Kyle J Ellis et al.   PHARMACOGENOMICS

Secreted proprotein convertase subtilisin/kexin type 9 reduces both hepatic and extrahepatic low-density lipoprotein receptors in vivo

(2008) Robert J. Schmidt et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose

(2008) G. M. Cooper et al.   BLOOD

High Sensitivity of Human Leukocyte Antigen–B*5701 as a Marker for Immunologically Confirmed Abacavir Hypersensitivity in White and Black Patients

(2008) Michael Saag et al.   CLINICAL INFECTIOUS DISEASES

Implications of Pharmacogenomics for Drug Development

(2008) R. J. Kirk et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Genome-wide association studies: past, present and future

(2008) M. I. McCarthy et al.   HUMAN MOLECULAR GENETICS

Genome-wide association studies: potential next steps on a genetic journey

(2008) M. I. McCarthy et al.   HUMAN MOLECULAR GENETICS

Genome-wide association studies for complex traits: consensus, uncertainty and challenges

(2008) Mark I. McCarthy et al.   NATURE REVIEWS GENETICS

SLCO1B1Variants and Statin-Induced Myopathy — A Genomewide Study

(2008)   NEW ENGLAND JOURNAL OF MEDICINE

HLA-B*5701 Screening for Hypersensitivity to Abacavir

(2008) Simon Mallal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pharmacogenetics of hypersensitivity to abacavir: from PGx hypothesis to confirmation to clinical utility

(2008) A R Hughes et al.   PHARMACOGENOMICS JOURNAL

Genetic Mapping in Human Disease

(2008) D. Altshuler et al.   SCIENCE