Model System to Define Pharmacokinetic Requirements for Antimalarial Drug Efficacy

Altered temporal response of malaria parasites determines differential sensitivity to artemisinin

(2013) N. Klonis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Outwitting Evolution: Fighting Drug-Resistant TB, Malaria, and HIV

(2012) Daniel E. Goldberg et al.   CELL

Global malaria mortality between 1980 and 2010: a systematic analysis

(2012) Christopher JL Murray et al.   LANCET

Effect of Half-Life on the Pharmacodynamic Index of Zanamivir against Influenza Virus Delineated by a Mathematical Model

(2011) Ashley N. Brown et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Artemisinin resistance in Plasmodium falciparum is associated with an altered temporal pattern of transcription

(2011) Sachel Mok et al.   BMC GENOMICS

Global response of Plasmodium falciparum to hyperoxia: a combined transcriptomic and proteomic approach

(2011) Marylin Torrentino-Madamet et al.   MALARIA JOURNAL

Ex vivo susceptibility of Plasmodium falciparum isolates from Dakar, Senegal, to seven standard anti-malarial drugs

(2011) Bécaye Fall et al.   MALARIA JOURNAL

Chemical Genomic Profiling for Antimalarial Therapies, Response Signatures, and Molecular Targets

(2011) J. Yuan et al.   SCIENCE

Proof of Concept: A PhRMA Position Paper With Recommendations for Best Practice

(2010) M E Cartwright et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Thousands of chemical starting points for antimalarial lead identification

(2010) Francisco-Javier Gamo et al.   NATURE

Chemical genetics of Plasmodium falciparum

(2010) W. Armand Guiguemde et al.   NATURE

Spiroindolones, a Potent Compound Class for the Treatment of Malaria

(2010) M. Rottmann et al.   SCIENCE

Artemisinin Resistance inPlasmodium falciparumMalaria

(2009) Arjen M. Dondorp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Transient Potent BCR-ABL Inhibition Is Sufficient to Commit Chronic Myeloid Leukemia Cells Irreversibly to Apoptosis

(2008) Neil P. Shah et al.   CANCER CELL

A Murine Model of falciparum-Malaria by In Vivo Selection of Competent Strains in Non-Myelodepleted Mice Engrafted with Human Erythrocytes

(2008) Iñigo Angulo-Barturen et al.   PLoS One

A Genetically Hard-Wired Metabolic Transcriptome in Plasmodium falciparum Fails to Mount Protective Responses to Lethal Antifolates

(2008) Karthikeyan Ganesan et al.   PLoS Pathogens