Teplizumab Induces Human Gut-Tropic Regulatory Cells in Humanized Mice and Patients

Human T cell development in the liver of humanized NOD/SCID/IL-2Rγnull(NSG) mice generated by intrahepatic injection of CD34+ human (h) cord blood (CB) cells

(2011) Bongkum Choi et al.   CLINICAL IMMUNOLOGY

Humoral immune responses in humanized BLT mice immunized with West Nile virus and HIV-1 envelope proteins are largely mediated via human CD5+ B cells

(2011) Subhabrata Biswas et al.   IMMUNOLOGY

Human Natural Regulatory T Cell Development, Suppressive Function, and Postthymic Maturation in a Humanized Mouse Model

(2011) T. Onoe et al.   JOURNAL OF IMMUNOLOGY

Anti-CD3 Therapy Promotes Tolerance by Selectively Depleting Pathogenic Cells while Preserving Regulatory T Cells

(2011) C. Penaranda et al.   JOURNAL OF IMMUNOLOGY

Teplizumab for treatment of type 1 diabetes (Protégé study): 1-year results from a randomised, placebo-controlled trial

(2011) Nicole Sherry et al.   LANCET

Control of TH17 cells occurs in the small intestine

(2011) Enric Esplugues et al.   NATURE

Immunomodulatory therapy to preserve pancreatic β-cell function in type 1 diabetes

(2011) Frank Waldron-Lynch et al.   NATURE REVIEWS DRUG DISCOVERY

Oxidative stress enhances IL-8 and inhibits CCL20 production from intestinal epithelial cells in response to bacterial flagellin

(2010) Sabine M. Ivison et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

A Mouse Model for the Human Pathogen Salmonella Typhi

(2010) Jeongmin Song et al.   Cell Host & Microbe

Anti-TNF Therapy, from Rationale to Standard of Care: What Lessons Has It Taught Us?

(2010) M. Feldmann et al.   JOURNAL OF IMMUNOLOGY

Humanized nonobese diabetic-scid IL2r null mice are susceptible to lethal Salmonella Typhi infection

(2010) S. J. Libby et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Treatment of patients with new onset Type 1 diabetes with a single course of anti-CD3 mAb teplizumab preserves insulin production for up to 5 years

(2009) Kevan C. Herold et al.   CLINICAL IMMUNOLOGY

Remodeling rodent models to mimic human type 1 diabetes

(2009) Matthias von Herrath et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Comparison of human fetal liver, umbilical cord blood, and adult blood hematopoietic stem cell engraftment in NOD-scid/γc−/−, Balb/c-Rag1−/−γc−/−, and C.B-17-scid/bg immunodeficient mice

(2009) Christin M. Lepus et al.   HUMAN IMMUNOLOGY

Cutting Edge: Natalizumab Blocks Adhesion but Not Initial Contact of Human T Cells to the Blood-Brain Barrier In Vivo in an Animal Model of Multiple Sclerosis

(2009) Caroline Coisne et al.   JOURNAL OF IMMUNOLOGY

Highly Sensitive Model for Xenogenic GVHD Using Severe Immunodeficient NOG Mice

(2009) Ryoji Ito et al.   TRANSPLANTATION