Humanizing Animal Models: A Key to Autoimmune Diabetes Treatment

Human CD3 Transgenic Mice: Preclinical Testing of Antibodies Promoting Immune Tolerance

(2011) C. Kuhn et al.   Science Translational Medicine

Developing combination immunotherapies for type 1 diabetes: recommendations from the ITN-JDRF Type 1 Diabetes Combination Therapy Assessment Group

(2010) J. B. Matthews et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass

(2010) B. Keymeulen et al.   DIABETOLOGIA

Epidemiology of Type 1 Diabetes

(2010) David M. Maahs et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Immune therapy for type 1 diabetes mellitus—what is unique about anti-CD3 antibodies?

(2010) Lucienne Chatenoud   Nature Reviews Endocrinology

The Environmental Determinants of Diabetes in the Young (TEDDY) Study

(2009)   Annals of the New York Academy of Sciences

TSH receptor autoantibodies

(2009) Krzysztof Michalek et al.   AUTOIMMUNITY REVIEWS

Transient Epstein-Barr virus reactivation in CD3 monoclonal antibody-treated patients

(2009) B. Keymeulen et al.   BLOOD

Treatment of patients with new onset Type 1 diabetes with a single course of anti-CD3 mAb teplizumab preserves insulin production for up to 5 years

(2009) Kevan C. Herold et al.   CLINICAL IMMUNOLOGY

Regulatory T cells and inhibitory cytokines in autoimmunity

(2009) Maria Bettini et al.   CURRENT OPINION IN IMMUNOLOGY

Anti-CD3 mAbs for treatment of type 1 diabetes

(2009) Adam Kaufman et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Genetic-induced Variations in the GAD65 T-cell Repertoire Governs Efficacy of Anti-CD3/GAD65 Combination Therapy in New-onset Type 1 Diabetes

(2009) Damien Bresson et al.   MOLECULAR THERAPY