The inositol phosphatase SHIP2 enables sustained ERK activation downstream of FGF receptors by recruiting Src kinases

Proteomic analyses of signalling complexes associated with receptor tyrosine kinase identify novel members of fibroblast growth factor receptor 3 interactome

(2018) Lukas Balek et al.   CELLULAR SIGNALLING

Protein Tyrosine Phosphatase Receptor Type G (PTPRG) Controls Fibroblast Growth Factor Receptor (FGFR) 1 Activity and Influences Sensitivity to FGFR Kinase Inhibitors

(2018) Michal Kostas et al.   MOLECULAR & CELLULAR PROTEOMICS

Fibroblasts derived from patients with opsismodysplasia display SHIP2-specific cell migration and adhesion defects

(2017) Somadri Ghosh et al.   HUMAN MUTATION

Insulin-like growth factor (IGF) axis in cancerogenesis

(2017) Aldona Kasprzak et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Statins do not inhibit the FGFR signaling in chondrocytes

(2017) B. Fafilek et al.   OSTEOARTHRITIS AND CARTILAGE

One reporter for in-cell activity profiling of majority of protein kinase oncogenes

(2017) Iva Gudernova et al.   eLife

Novel compound heterozygous mutations in inositol polyphosphate phosphatase-like 1 in a family with severe opsismodysplasia

(2016) Cori Feist et al.   CLINICAL DYSMORPHOLOGY

New Functions of the Inositol Polyphosphate 5-Phosphatases in Cancer

(2016) Christophe Erneux et al.   CURRENT PHARMACEUTICAL DESIGN

SHIP2 controls plasma membrane PI(4,5)P2 thereby participating in the control of cell migration in 1321 N1 glioblastoma cells

(2016) William's Elong Edimo et al.   JOURNAL OF CELL SCIENCE

INPPL1 gene mutations in opsismodysplasia

(2016) Anaïs Fradet et al.   JOURNAL OF HUMAN GENETICS

A second locus for schneckenbecken dysplasia identified by a mutation in the gene encodinginositol polyphosphate phosphatase-like 1(INPPL1)

(2015) Hane Lee et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Nosology and classification of genetic skeletal disorders: 2015 revision

(2015) Luisa Bonafe et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Fibroblast growth factor and canonical WNT/β-catenin signaling cooperate in suppression of chondrocyte differentiation in experimental models of FGFR signaling in cartilage

(2015) Marcela Buchtova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Fibroblast growth factor signaling in skeletal development and disease

(2015) David M. Ornitz et al.   GENES & DEVELOPMENT

Multikinase activity of fibroblast growth factor receptor (FGFR) inhibitors SU5402, PD173074, AZD1480, AZD4547 and BGJ398 compromises the use of small chemicals targeting FGFR catalytic activity for therapy of short-stature syndromes

(2015) Iva Gudernova et al.   HUMAN MOLECULAR GENETICS

Fibroblast surface-associated FGF-2 promotes contact-dependent colorectal cancer cell migration and invasion through FGFR-SRC signaling and integrin αvβ5-mediated adhesion

(2015) Sarah Knuchel et al.   Oncotarget

Opsismodysplasia resulting from an insertion mutation in the SH2 domain, which destabilizes INPPL1

(2014) Bing Li et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

CHOPCHOP: a CRISPR/Cas9 and TALEN web tool for genome editing

(2014) Tessa G. Montague et al.   NUCLEIC ACIDS RESEARCH

Photoactivation Approaches Reveal a Role for Rab11 in FGFR4 Recycling and Signalling

(2014) Ellen M. Haugsten et al.   TRAFFIC

FGFR2 Gene Amplification in Gastric Cancer Predicts Sensitivity to the Selective FGFR Inhibitor AZD4547

(2013) L. Xie et al.   CLINICAL CANCER RESEARCH

Rational design and synthesis of 4-substituted 2-pyridin-2-ylamides with inhibitory effects on SH2 domain-containing inositol 5′-phosphatase 2 (SHIP2)

(2013) Yoshinori Ichihara et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The paradox of FGFR3 signaling in skeletal dysplasia: Why chondrocytes growth arrest while other cells over proliferate

(2013) Pavel Krejci   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Derivation of novel human ground state naive pluripotent stem cells

(2013) Ohad Gafni et al.   NATURE

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

RSK2 regulates endocytosis of FGF receptor 1 by phosphorylation on serine 789

(2013) B Nadratowska-Wesolowska et al.   ONCOGENE

Endocytosis and Cancer

(2013) I. Mellman et al.   Cold Spring Harbor Perspectives in Biology

Exome Sequencing Identifies INPPL1 Mutations as a Cause of Opsismodysplasia

(2012) Céline Huber et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Whole-Genome Analysis Reveals that Mutations in Inositol Polyphosphate Phosphatase-like 1 Cause Opsismodysplasia

(2012) Jennifer E. Below et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Reactivation of Mitogen-activated Protein Kinase (MAPK) Pathway by FGF Receptor 3 (FGFR3)/Ras Mediates Resistance to Vemurafenib in Human B-RAF V600E Mutant Melanoma

(2012) Vipin Yadav et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fibroblast growth factors and their receptors in cancer

(2011) Jørgen Wesche et al.   BIOCHEMICAL JOURNAL

IGF-1R signaling in chondrocytes modulates growth plate development by interacting with the PTHrP/Ihh pathway

(2011) Yongmei Wang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

FGFR3 signaling induces a reversible senescence phenotype in chondrocytes similar to oncogene-induced premature senescence

(2010) Pavel Krejci et al.   BONE

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

Frequent and Focal FGFR1 Amplification Associates with Therapeutically Tractable FGFR1 Dependency in Squamous Cell Lung Cancer

(2010) J. Weiss et al.   Science Translational Medicine

De-regulated FGF receptors as therapeutic targets in cancer

(2009) Victoria Knights et al.   PHARMACOLOGY & THERAPEUTICS

Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins

(2008) Noriko Gotoh   CANCER SCIENCE

FGFR3 promotes synchondrosis closure and fusion of ossification centers through the MAPK pathway

(2008) T. Matsushita et al.   HUMAN MOLECULAR GENETICS