Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt- -catenin-mediated intestinal tumor growth and regeneration

Insights into the Role of STAT3 in Human Lymphocyte Differentiation as Revealed by the Hyper-IgE Syndrome

(2014) S. G. Tangye et al.   JOURNAL OF IMMUNOLOGY

Interleukin-11 Is the Dominant IL-6 Family Cytokine during Gastrointestinal Tumorigenesis and Can Be Targeted Therapeutically

(2013) Tracy L. Putoczki et al.   CANCER CELL

A Novel Tankyrase Small-Molecule Inhibitor Suppresses APC Mutation-Driven Colorectal Tumor Growth

(2013) T. Lau et al.   CANCER RESEARCH

The Intestinal Crypt, A Prototype Stem Cell Compartment

(2013) Hans Clevers   CELL

Development of PI3K inhibitors: lessons learned from early clinical trials

(2013) Jordi Rodon et al.   Nature Reviews Clinical Oncology

Overexpression of BMI-1 is associated with poor prognosis in cervical cancer

(2012) Yong-Qing Tong et al.   Asia-Pacific Journal of Clinical Oncology

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties

(2012) Sarah Schwitalla et al.   CELL

Bmi-1 Promotes the Chemoresistance, Invasion and Tumorigenesis of Pancreatic Cancer Cells

(2012) Tao Yin et al.   CHEMOTHERAPY

Non-autonomous crosstalk between the Jak/Stat and Egfr pathways mediates Apc1-driven intestinal stem cell hyperplasia in the Drosophila adult midgut

(2012) J. B. Cordero et al.   DEVELOPMENT

A phase II study of RO4929097 in metastatic colorectal cancer

(2012) Jonathan R. Strosberg et al.   EUROPEAN JOURNAL OF CANCER

A Double-Blind, Placebo-Controlled Trial of Ruxolitinib for Myelofibrosis

(2012) Srdan Verstovsek et al.   NEW ENGLAND JOURNAL OF MEDICINE

Stat3: linking inflammation to epithelial cancer - more than a "gut" feeling?

(2012) Andrew Jarnicki et al.   Cell Division

Absolute requirement for STAT3 function in small-intestine crypt stem cell survival

(2011) J R Matthews et al.   CELL DEATH AND DIFFERENTIATION

STAT3 Expression, Molecular Features, Inflammation Patterns, and Prognosis in a Database of 724 Colorectal Cancers

(2011) Teppei Morikawa et al.   CLINICAL CANCER RESEARCH

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

(2011) Wim de Lau et al.   NATURE

A ‘metastasis-prone’ signature for early-stage mismatch-repair proficient sporadic colorectal cancer patients and its implications for possible therapeutics

(2010) Yi Hong et al.   CLINICAL & EXPERIMENTAL METASTASIS

Focal Adhesion Kinase Is Required for Intestinal Regeneration and Tumorigenesis Downstream of Wnt/c-Myc Signaling

(2010) Gabrielle H. Ashton et al.   DEVELOPMENTAL CELL

p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium

(2010) Alicia M. Cole et al.   EMBO Molecular Medicine

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

Modeling Oncogenic Signaling in Colon Tumors by Multidirectional Analyses of Microarray Data Directed for Maximization of Analytical Reliability

(2010) Magdalena Skrzypczak et al.   PLoS One

The JAK2 Inhibitor AZD1480 Potently Blocks Stat3 Signaling and Oncogenesis in Solid Tumors

(2009) Michael Hedvat et al.   CANCER CELL

gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis

(2009) Julia Bollrath et al.   CANCER CELL

Stat3 Is a Negative Regulator of Intestinal Tumor Progression in ApcMin Mice

(2009) Monica Musteanu et al.   GASTROENTEROLOGY

Expression level of Bmi-1 oncoprotein is associated with progression and prognosis in colon cancer

(2009) Da-wei Li et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Polycomb group protein Bmi1 expression in colon cancers predicts the survival

(2009) Jianjun Du et al.   MEDICAL ONCOLOGY

Prediction and Experimental Validation of Novel STAT3 Target Genes in Human Cancer Cells

(2009) Young Min Oh et al.   PLoS One

Genome-wide discovery of functional transcription factor binding sites by comparative genomics: The case of Stat3

(2009) F. Vallania et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA Replication Stalling Attenuates Tyrosine Kinase Signaling to Suppress S Phase Progression

(2008) Ben J. Shields et al.   CANCER CELL

Deficiency of Mbd2 Attenuates Wnt Signaling

(2008) T. J. Phesse et al.   MOLECULAR AND CELLULAR BIOLOGY

Modelling Myc inhibition as a cancer therapy

(2008) Laura Soucek et al.   NATURE

Crypt stem cells as the cells-of-origin of intestinal cancer

(2008) Nick Barker et al.   NATURE

Bmi1 is expressed in vivo in intestinal stem cells

(2008) Eugenio Sangiorgi et al.   NATURE GENETICS

Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in Apc 716 mice

(2008) T. Fujishita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA