Quantifying Crosstalk Among Interferon- , Interleukin-12, and Tumor Necrosis Factor Signaling Pathways Within a TH1 Cell Model

Timescale analysis of rule-based biochemical reaction networks

(2011) David J. Klinke et al.   BIOTECHNOLOGY PROGRESS

Quantitative events determine the differentiation and function of helper T cells

(2011) Anne O'Garra et al.   NATURE IMMUNOLOGY

In Vivo Systems Analysis Identifies Spatial and Temporal Aspects of the Modulation of TNF- -Induced Apoptosis and Proliferation by MAPKs

(2011) K. S. Lau et al.   Science Signaling

Differentiation of Effector CD4 T Cell Populations

(2010) Jinfang Zhu et al.   Annual Review of Immunology

Signal Transduction Networks in Cancer: Quantitative Parameters Influence Network Topology

(2010) D. J. Klinke   CANCER RESEARCH

Classic and contemporary approaches to modeling biochemical reactions

(2010) W. W. Chen et al.   GENES & DEVELOPMENT

Inferring relevant control mechanisms for interleukin-12 signaling in naïve CD4+ T cells

(2010) Stacey D Finley et al.   IMMUNOLOGY AND CELL BIOLOGY

Networks Inferred from Biochemical Data Reveal Profound Differences in Toll-like Receptor and Inflammatory Signaling between Normal and Transformed Hepatocytes

(2010) Leonidas G. Alexopoulos et al.   MOLECULAR & CELLULAR PROTEOMICS

Mechanisms Underlying Lineage Commitment and Plasticity of Helper CD4+ T Cells

(2010) J. J. O'Shea et al.   SCIENCE

The Mammalian MAPK/ERK Pathway Exhibits Properties of a Negative Feedback Amplifier

(2010) O. E. Sturm et al.   Science Signaling

Arginine Usage in Mycobacteria-Infected Macrophages Depends on Autocrine-Paracrine Cytokine Signaling

(2010) J. E. Qualls et al.   Science Signaling

The Balance of WNT and FGF Signaling Influences Mesenchymal Stem Cell Fate During Skeletal Development

(2010) T. Maruyama et al.   Science Signaling

An empirical Bayesian approach for model-based inference of cellular signaling networks

(2009) David J Klinke   BMC BIOINFORMATICS

Digital Signaling and Hysteresis Characterize Ras Activation in Lymphoid Cells

(2009) Jayajit Das et al.   CELL

Scalable analysis of flow cytometry data using R/Bioconductor

(2009) David J. Klinke et al.   CYTOMETRY PART A

Sequential Polarization and Imprinting of Type 1 T Helper Lymphocytes by Interferon-γ and Interleukin-12

(2009) Edda G. Schulz et al.   IMMUNITY

Negative feedback control of the autoimmune response through antigen-induced differentiation of IL-10–secreting Th1 cells

(2009) Leona Gabryšová et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Temporal Induction Pattern of STAT4 Target Genes Defines Potential for Th1 Lineage-Specific Programming

(2009) S. R. Good et al.   JOURNAL OF IMMUNOLOGY

Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis

(2009) Sabrina L. Spencer et al.   NATURE

The Systems Biology Graphical Notation

(2009) Nicolas Le Novère et al.   NATURE BIOTECHNOLOGY

Modulating Temporal Control of NF-κB Activation: Implications for Therapeutic and Assay Selection

(2008) David J. Klinke et al.   BIOPHYSICAL JOURNAL

Separate endocytic pathways regulate IL-5 receptor internalization and signaling

(2008) Jonathan T. Lei et al.   JOURNAL OF LEUKOCYTE BIOLOGY