Review
Biochemistry & Molecular Biology
Julia Nowowiejska, Anna Baran, Iwona Flisiak
Summary: Psoriasis is a common skin disease affecting about 1%-3% of the general population, often accompanied by cardiometabolic disorders. Research indicates that lipid expression and metabolism disorders are more common in psoriatic patients, playing a significant role in the pathogenesis of psoriasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Engineering, Environmental
Matej Zula, Miha Grilc, Blaz Likozar
Summary: This article provides a review of the mechanisms, kinetics, and effects of process conditions on the conversion, selectivity, and catalyst stability in the hydrogenation, hydrocracking, and hydro-deoxygenation reactions of biomass-derived fatty acids. It discusses various steps in the reactions and focuses on non-equilibrium thermodynamic energetics and characteristic modeling approaches.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Nutrition & Dietetics
Cody A. C. Lust, Xinyan Bi, Christiani Jeyakumar Henry, David W. L. Ma
Summary: The study analyzed individual fatty acid reference ranges in 476 middle-aged Singaporean males and females, finding that females had significantly higher concentrations in four types of fatty acids. Participants with fatty acid concentrations above the 95th percentile also showed high risk levels for triglycerides, HDL, LDL, and total cholesterol, indicating potential cardiovascular disease risk.
Article
Cardiac & Cardiovascular Systems
Subodh Verma, Deepak L. Bhatt, Ph Gabriel Steg, Michael Miller, Eliot A. Brinton, Terry A. Jacobson, Nitish K. Dhingra, Steven B. Ketchum, Rebecca A. Juliano, Lixia Jiao, Ralph T. Doyle, Craig Granowitz, C. Michael Gibson, Duane Pinto, Robert P. Giugliano, Matthew J. Budoff, R. Preston Mason, Jean-Claude Tardif, Christie M. Ballantyne
Summary: In patients with a history of coronary artery bypass grafting, treatment with icosapent ethyl in the REDUCE-IT trial led to significant reductions in both first and recurrent ischemic events compared to placebo, with similar safety findings between groups.
Review
Medicine, General & Internal
Reed Mszar, Sarah Bart, Alexander Sakers, Daniel Soffer, Dean G. Karalis
Summary: Hypertriglyceridemia (HTG) is a common medical condition in patients with cardiometabolic risk factors and can increase the risk of atherosclerotic cardiovascular disease (ASCVD) if ignored. Current guidelines recommend clinical evaluation and lifestyle-based interventions to address potential causes of elevated triglyceride (TG) levels. Statin therapy, alone or in combination with other lipid-lowering medications, is recommended for individuals with mild to moderate HTG at risk of ASCVD. Novel therapies targeting apoC-III and ANGPTL3 have shown promise in reducing TG levels. Public health strategies are needed to improve access to effective pharmacotherapies, affordable and nutritious food options, and timely healthcare services.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Laura D'Erasmo, Michele Di Martino, Thomas Neufeld, Tyler J. Fraum, Chul Joo Kang, Kendall H. Burks, Alessia Di Costanzo, Ilenia Minicocci, Simone Bini, Marianna Maranghi, Giovanni Pigna, Giancarlo Labbadia, Jie Zheng, Davide Fierro, Anna Montali, Fabrizio Ceci, Carlo Catalano, Nicholas O. Davidson, Giuseppe Lucisano, Antonio Nicolucci, Marcello Arca, Nathan O. Stitziel
Summary: The study recruited participants with ANGPTL3 deficiency related to gene mutations as well as those with genetically determined reduction in plasma ANGPTL3 levels, showing that these conditions are not associated with increased risk of hepatic steatosis.
Article
Engineering, Environmental
Harsh B. Jadhav, Parag Gogate, Uday Annapure
Summary: This study focused on the intensified production of designer lipids using ultrasound assisted enzymatic acidolysis reaction, achieving a high yield and lower reaction time compared to conventional synthesis methods. Key design information for optimal operating conditions was elucidated, showcasing the efficacy of the ultrasound intensified approach for synthesis of designer lipids.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Arjun Majithia, Deepak L. Bhatt, Allon N. Friedman, Michael Miller, Ph Gabriel Steg, Eliot A. Brinton, Terry A. Jacobson, Steven B. Ketchum, Rebecca A. Juliano, Lixia Jiao, Ralph T. Doyle, Craig Granowitz, Matthew Budoff, R. Preston Mason, Jean-Claude Tardif, William E. Boden, Christie M. Ballantyne
Summary: In the REDUCE-IT trial, icosapent ethyl reduced fatal and nonfatal ischemic events across a broad range of baseline eGFR categories.
Article
Biology
Michael A. McCartney
Summary: The byssus is a unique structure in bivalves that plays a crucial role in settlement and metamorphosis in larvae. In adults, the byssus is scattered throughout bivalves, impacting morphological evolution and adaptive radiations of epifaunal species. Comparative studies of byssus structure and proteins in different bivalve species reveal divergence and rapid evolution, offering opportunities for further proteomic and genomic research to enhance understanding of this marine natural material.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Maria Breygina, Alexander Voronkov, Tatiana Ivanova, Ksenia Babushkina
Summary: Pollen grains are unique haploid organisms with special composition and structure. Angiosperms and gymnosperms share similar mechanisms for pollen germination but gymnosperms exhibit slower growth rates and reduced reliance on female tissues. The properties of pollen lipids, especially very-long-chain FAs, contribute to these features. By analyzing the absolute content and FA composition of pollen lipids, significant differences were found between species, with spruce pollen exhibiting a higher proportion of saturated and monoene FAs. Lily and tobacco also showed variations in the FA composition between pollen coat and gametophyte cells, with a lower unsaturation index in the coat. Moreover, the absolute content of lipids was highest in lily pollen. This study provides new insights into the FA changes during pollen germination in gymnosperms and angiosperms, and highlights the impact of H2O2 on spruce pollen germination.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Fisheries
Heloise Gendre, Yosra Ben Cheikh, Frank Le Foll, Alain Geffard, Melissa Palos Ladeiro
Summary: This study compared the sensitivity of cellular immunomarkers to chemical stressors combined with bacterial challenge in two mussel species from different environments. The results showed that the two mussel species had different basal levels and responded differently to chemical exposure and bacterial challenge. This work highlights the species-specific sensitivity of mussel immunomarkers to contaminants and the necessity of considering the presence of non-pathogenic microorganisms in future in situ applications.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Marine & Freshwater Biology
Fanny Louis, Damien Rioult, Beatrice Rocher, Veronique Gaillet, Laurence Delahaut, Severine Paris-Palacios, Elise David
Summary: Dreissena polymorpha is a freshwater mussel that plays a crucial role in nutrient recycling and filtration of suspended matter. This study investigated the responses of D. polymorpha to thermal stress (+15 degrees C) and hypoxic stress (30% of dissolved oxygen saturation) over a period of 7 days. The findings suggested a potential metabolic rate depression under hypoxia, while a contrasting pattern of response was observed in thermal-stressed mussels. The study highlighted the importance of considering the duration of exposure to environmental variations in understanding the tolerance of organisms in a changing environment.
AQUATIC TOXICOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Celian Roman-Figueroa, Mara Cea, Manuel Paneque
Summary: Industrial crops in Chile have limited production data and require further research and market development. Sunflower and rapeseed have been poorly studied, while native oilseed plants have potential for development.
BIOFUELS BIOPRODUCTS & BIOREFINING-BIOFPR
(2023)
Article
Chemistry, Applied
Purnima Gunness, Honglei Zhai, Barbara A. Williams, Dagong Zhang, Michael J. Gidley
Summary: The study found that pectin can reduce plasma cholesterol and triglyceride levels, increase total bile acid levels, and have different effects on intestinal cholesterol compared to mango; pectin has prebiotic properties and promotes the increase of therapeutic bile acid ursodesoxycholic acid (UDCA).
FOOD HYDROCOLLOIDS
(2021)
Article
Environmental Sciences
Audrey Catteau, Antoine Le Guernic, Melissa Palos Ladeiroa, Odile Dedourge-Geffard, Marc Bonnard, Isabelle Bonnard, Laurence Delahaut, Anne Bado-Nilles, Jean -Marc Porcher, Christelle Lopes, Olivier Geffard, Alain Geffard
Summary: The Integrated Biomarker Response (IBR) is commonly used in biomonitoring, but it has limitations for routine and large-scale use. To overcome these limitations, a new index called IBR-T was proposed, which considers the threshold values of biomarkers and calculates the IBR value only for significantly modulated biomarkers. The comparison between IBR-T and IBRv2 showed that IBR-T has a better correlation with the percentage of significantly modulated biomarkers and provides a more ecologically relevant ranking of sites. IBR-T is important for biomonitoring as it simplifies data interpretation, directly indicates the contamination status of a site, aids in decision-making, and facilitates communication of results to the general public.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Environmental Sciences
Alejandra Gilabert, Perrine Geraudie, Joaquim Jaumot, Cinta Porte
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2020)
Article
Marine & Freshwater Biology
Karina Dale, Fekadu Yadetie, Mette Bjorge Muller, Daniela M. Pampanin, Alejandra Gilabert, Xiaokang Zhang, Zhanna Tairova, Ane Haarr, Roger Lille-Langoy, Jan Ludvig Lyche, Cinta Porte, Odd Andre Karlsen, Anders Goksoyr
AQUATIC TOXICOLOGY
(2020)
Article
Environmental Sciences
Elisabet Perez-Albaladejo, Alejandra Solis, Ilaria Bani, Cinta Porte
Summary: This study investigated the effects of different plastic additives on fish lipid homeostasis using PLHC-1 cells as a model, revealing distinct modes of action and higher lipotoxicity of BADGE·2HCl and BPF compared to BPA. Bioconcentration of BADGE·2HCl, DBP, and DEHP was highest, leading to alterations in lipidome of the cells. Exposure to BPF resulted in the generation of reactive oxygen species and significant depletion of certain lipid species in the cells.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Marine & Freshwater Biology
Anna Marqueno, Cintia Flores, Marta Casado, Cinta Porte
Summary: The study found that exposure to endocrine disruptors can affect lipid homeostasis in vertebrates, including fish, and fish liver cells are a potential tool for screening metabolic and lipid disruptors in aquatic environments. The results suggest that fish liver cells show sensitivity and responses to certain compounds comparable to mammalian cells, supporting their use as alternative models for detecting lipid disruptors in water environments.
AQUATIC TOXICOLOGY
(2021)
Article
Environmental Sciences
Anna Marqueno, Elisabet Perez-Albaladejo, Nancy D. Denslow, John A. Bowden, Cinta Porte
Summary: This study used the zebrafish liver cell line as a model to investigate the toxic effects of BPA, BPF, and BADGE.2HCl on fish lipid metabolism. The results showed that these compounds target lipid homeostasis in fish cells through different mechanisms, with BADGE.2HCl exhibiting higher lipotoxicity compared to BPA and BPF.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemical Research Methods
Julia Mestres, Elisabet Perez-Albaladejo, Cinta Porte, Cristina Postigo
Summary: This study presents a greener and safer analytical method for evaluating the interference of contaminants with estrogen synthesis during pregnancy. The method measures trace amounts of steroids in the culture medium. The results show that iodoacetic acid has an estrogenic effect on JEG-3 cells.
JOURNAL OF CHROMATOGRAPHY A
(2022)
Editorial Material
Environmental Sciences
Melissa Faria, Carlos Barata, Demetrio Raldua
Article
Environmental Sciences
M. Lopez, C. Reche, E. Perez-Albaladejo, C. Porte, A. Balasch, E. Monfort, E. Eljarrat, M. Viana
Summary: Electronic waste is one of the fastest growing waste streams in the world, and the fine and ultrafine particles generated during its processing may have potential impacts on human health and the environment.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Nathalie Leroux, Mahboubeh Hosseinzadeh, Alberto Katsumiti, Cinta Porte, Miren P. Cajaraville
Summary: The production and usage of plastics have significantly increased in the past decades, leading to insufficient waste management and the accumulation of plastic particles in the environment. This study focuses on the impact of polystyrene nanoparticles on the lipid composition of mussel hemocytes, showing that exposure to these particles leads to membrane reorganization and oxidation of highly unsaturated lipids. The findings suggest potential effects on the immune function of hemocytes, although further investigation is needed.
ENVIRONMENTAL RESEARCH
(2022)
Article
Toxicology
Mahaboubeh Hosseinzadeh, Alejandra Gilabert, Cinta Porte
Summary: This study investigates the effects of the antimicrobial triclosan (TCS) on the digestive gland of mussels using precision-cut tissue slices (PCTS). The results demonstrate that TCS disrupts the expression of genes related to energy, phenylalanine, and lipid metabolism, and alters lipid dynamics in mussels.
TOXICOLOGY IN VITRO
(2022)
Review
Environmental Sciences
Ilias Vouitsis, Jose Portugal, Anastasios Kontses, Hanna L. Karlsson, Melissa Faria, Karine Elihn, Ana Teresa Juarez-Facio, Fulvio Amato, Benjamin Pina, Zisis Samaras
Summary: Nanoparticle emissions from transport are a major concern due to their high concentration and potential health risks. This paper reviews the different aerosol modes produced by various transport sources, such as road, shipping, aviation, and rail, and investigates their toxicity effects. It concludes that transport sources emit a large number of nanoparticles that can damage the respiratory tract, lungs, and other organs, leading to systemic toxicity.
ATMOSPHERIC ENVIRONMENT
(2023)
Article
Environmental Sciences
Elisabet Perez-Albaladejo, Raquel Pinteno, Maria del Carmen Aznar-Luque, Marta Casado, Cristina Postigo, Cinta Porte
Summary: This study explored the toxicity potential of several haloacetic acids (HAAs) in water, with a focus on their effects on human cells. The results showed that iodoacetic acid (IAA) had the highest cytotoxicity and ability to generate reactive oxygen species (ROS). These substances also caused damage to the endocrine system and genotoxicity. The findings suggest that low concentrations of these substances may have teratogenic and endocrine disruption effects on human health.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Physiology
Marta Eide, Anders Goksoyr, Fekadu Yadetie, Alejandra Gilabert, Zdenka Bartosova, Havard G. Froysa, Shirin Fallahi, Xiaokang Zhang, Nello Blaser, Inge Jonassen, Per Bruheim, Guttorm Alendal, Morten Brun, Cinta Porte, Odd Andre Karlsen
Summary: The involvement of Ppar a and b subtypes in lipid metabolism regulation in Atlantic cod was studied using two model agonists. WY-14,643 and GW501516 were found to activate Ppar a and b, affecting genes in lipid metabolism pathways and inducing changes in lipid composition.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Environmental Sciences
Maria Lopez, Ana Lopez-Lilao, Fernando Romero, Elisabet Perez-Albaladejo, Raquel Pinteno, Cinta Porte, Aleix Balasch, Ethel Eljarrat, Mar Viana, Eliseo Monfort
Summary: Ship refit and repair operations in shipyards generate aerosol emissions with high potential for environmental impacts. This study aimed to characterize the chemical composition, organophosphate ester content, and cytotoxic and genotoxic potential of aerosol particles. The results showed that nanoparticle emissions occurred during mechanical abrading and spray-painting processes, with key components being V and Cu. Toxicity assessments revealed hazardous potential for various endpoints, including reduced cell viability, generation of reactive oxygen species, and increased genotoxicity. Although personal protective equipment and filtration systems can prevent direct human exposures, the impacts on ambient air and the aquatic environment cannot be fully prevented. Therefore, the use of good practices is encouraged to reduce inhalation exposures and mitigate the health and environmental impacts of ship refit operations.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Toxicology
Elisabet Perez-Albaladejo, Montserrat Sole, Cinta Porte
CURRENT OPINION IN TOXICOLOGY
(2020)
Article
Environmental Sciences
Toshimi Nakajima, Mao Kuragano, Makoto Yamada, Ryo Sugimoto
Summary: This study compared the contribution of submarine groundwater discharge (SGD) to river nutrient budgets at nearshore and embayment scales, and found that SGD-derived nutrients become more important at larger spatial scales.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Fan Liu, Lei Zhang, Chongyang Zhang, Ziguang Chen, Jingguang Li
Summary: NO2 emissions from wall-mounted gas stoves used for household heating have become a significant source of indoor pollution in Chinese urban areas. The high indoor concentration of NO2 poses potential health risks to residents. It is urgently necessary to establish relevant regulations and implement emission reduction technologies to reduce NO2 emissions from wall-mounted gas stoves.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Letter
Environmental Sciences
Hans Peter H. Arp, Raoul Wolf, Sarah E. Hale, Sivani Baskaran, Juliane Gluege, Martin Scheringer, Xenia Trier, Ian T. Cousins, Harrie Timmer, Roberta Hofman-Caris, Anna Lennquist, Andre D. Bannink, Gerard J. Stroomberg, Rosa M. A. Sjerps, Rosa Montes, Rosario Rodil, Jose Benito Quintana, Daniel Zahn, Herve Gallard, Tobias Mohr, Ivo Schliebner, Michael Neumann
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Philomina Onyedikachi Peter, Binessi Edouard Ifon, Francois Nkinahamira, Kayode Hassan Lasisi, Jiangwei Li, Anyi Hu, Chang-Ping Yu
Summary: This study investigates the relationship between dissolved organic matter (DOM) and Rare Earth Elements (REEs) in sediments from Yundang Lagoon, China. The results show four distinct fluorescent components, with protein-like substances being the most prevalent. Additionally, the total fluorescence intensity and LREE concentrations exhibit a synchronized increase from Outer to Inner to Songbai Lake core sediments. The findings demonstrate a strong correlation between DOM content and pollution levels.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Surya Gupta, Pasquale Borrelli, Panos Panagos, Christine Alewell
Summary: The objective of this study is to incorporate soil hydraulic properties into the erodibility factor (K) of USLE-type models. By modifying and improving the existing equations for soil texture and permeability, the study successfully included information on saturated hydraulic conductivity (Ksat) into the calculation of K factor. Using the Random Forest machine learning algorithm, two independent K factor maps with different spatial resolutions were generated. The results show that the decrease in K factor values has a positive impact on the modeling of soil erosion rates.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jesmin Akter, Wendy J. M. Smith, Yawen Liu, Ilho Kim, Stuart L. Simpson, Phong Thai, Asja Korajkic, Warish Ahmed
Summary: The choice of workflow in wastewater surveillance has a significant impact on SARS-CoV-2 concentrations, while having minimal effects on HF183 and no effect on HAdV 40/41 concentrations. Certain components in the workflow can be interchangeable, but factors such as buffer type, chloroform, and homogenization speed can affect the recovery of viruses and bacteria.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yu Luo, Xueting Yang, Diwei Wang, Hongmei Xu, Hongai Zhang, Shasha Huang, Qiyuan Wang, Ningning Zhang, Junji Cao, Zhenxing Shen
Summary: Atmospheric PM2.5, which can generate reactive oxygen species (ROS), is associated with cardiorespiratory morbidity and mortality. The study found that both the mass concentration of PM2.5 and the DTT activity were higher during the heating season than during the nonheating season. Combustion sources were the primary contributors to DTT activity during the heating season, while secondary formation dominated during the nonheating season. The study also revealed that biomass burning had the highest inherent oxidation potential among all sources investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Erin L. Murphy, Leah R. Gerber, Chelsea M. Rochman, Beth Polidoro
Summary: Plastic pollution has devastating consequences for marine organisms. This study uses a trait-based framework to develop a vulnerability index for marine mammals, seabirds, and sea turtles in Hawai'i. The index ranks 63 study species based on their vulnerability to macroplastic pollution, providing valuable information for species monitoring and management priorities.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Kenji Maurice, Amelia Bourceret, Sami Youssef, Stephane Boivin, Liam Laurent-Webb, Coraline Damasio, Hassan Boukcim, Marc-Andre Selosse, Marc Ducousso
Summary: Growing pressure from climate change and agricultural land use is destabilizing soil microbial community interactions. Little is known about microbial community resistance and adaptation to disturbances, hindering our understanding of recovery latency and implications for ecosystem functioning. This study found that anthropic disturbance and natural disturbance have different effects on the topology and stability of soil microbial networks.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yunhao Li, Yali Feng, Haoran Li, Yisong Yao, Chenglong Xu, Jinrong Ju, Ruiyu Ma, Haoyu Wang, Shiwei Jiang
Summary: Deep-sea mining poses a serious threat to marine ecosystems and human health by disturbing sediment and transmitting metal ions through the food chain. This study developed a new regenerative adsorption material, OMN@SA, which effectively removes metal ions. The adsorption mechanism and performance of the material for metal ion fixation were investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Antonio Medici, Margherita Lavorgna, Marina Isidori, Chiara Russo, Elena Orlo, Giovanni Luongo, Giovanni Di Fabio, Armando Zarrelli
Summary: Valsartan, a widely used antihypertensive drug, has been detected in high concentrations in surface waters due to its unchanged excretion and incomplete degradation in wastewater treatment plants. This study investigated the degradation of valsartan and identified 14 degradation byproducts. The acute and chronic toxicity of these byproducts were evaluated in key organisms in the freshwater trophic chain.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jiang Lin, Lianbao Chi, Qing Yuan, Busu Li, Mingbao Feng
Summary: This study investigated the photodegradation behavior and product formation of two representative pharmaceuticals in simulated estuary water. The study found that the formed transformation products of these pharmaceuticals have potential toxicity on marine organisms, including oxidative stress and damage to cellular components.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Hua Fang, Dongdong Jiang, Ye He, Siyi Wu, Yuehong Li, Ziqi Zhang, Haoting Chen, Zixin Zheng, Yan Sun, Wenxiang Wang
Summary: This study revealed that exposure to lower levels of air pollutants led to decreased pregnancy rates, with PM10, NO2, SO2, and CO emerging as the four most prominent pollutants. Individuals aged 35 and above exhibited heightened susceptibility to pollutants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Ali Shaan Manzoor Ghumman, Rashid Shamsuddin, Amin Abbasi, Mohaira Ahmad, Yoshiaki Yoshida, Abdul Sami, Hamad Almohamadi
Summary: In this study, inverse vulcanized polysulfides (IVP) were synthesized by reacting molten sulfur with 4-vinyl benzyl chloride, and then functionalized using N-methyl D-glucamine (NMDG). The functionalized IVP showed a high mercury adsorption capacity and a machine learning model was developed to predict the amount of mercury removed. Furthermore, the functionalized IVP can be regenerated and reused, providing a sustainable and cost-effective adsorbent.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Rita Bonfiglio, Renata Sisto, Stefano Casciardi, Valeria Palumbo, Maria Paola Scioli, Erica Giacobbi, Francesca Servadei, Gerry Melino, Alessandro Mauriello, Manuel Scimeca
Summary: This study investigated the presence of aluminum in human colon cancer samples and its potential association with biological processes involved in cancer progression. Aluminum was found in tumor areas of 24% of patients and was associated with epithelial to mesenchymal transition (EMT) and cell death. Additional analyses revealed higher tumor mutational burden and mutations in genes related to EMT and apoptosis in aluminum-positive colon cancers. Understanding the molecular mechanisms of aluminum toxicity may improve strategies for the management of colon cancer patients.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
