Article
Pharmacology & Pharmacy
Huan Yang, Wanda van der Stel, Randy Lee, Caroline Bauch, Sam Bevan, Paul Walker, Bob van de Water, Erik H. J. Danen, Joost B. Beltman
Summary: Mitochondria are the main bioenergetic organelles of cells and exposure to chemicals targeting mitochondria generally results in toxicity. Different mitochondrial respiration inhibitors have varying effects on mitochondrial membrane potential, and mathematical modeling can help understand these dynamics. Additionally, incorporating pharmacokinetic decay into the model can improve the fit for certain compounds, showing a complex interplay between pharmacokinetics and MMP dynamics within mitochondria.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Valeriya Vays, Irina Vangeli, Chupalav Eldarov, Vasily Popkov, Susanne Holtze, Thomas Hildebrandt, Olga Averina, Dmitry Zorov, Lora Bakeeva
Summary: The exceptional longevity of the naked mole rat remains a mystery to researchers. A comparison of the hepatic mitochondria and endoplasmic reticulum (ER) of the naked mole rat and mice revealed structural and spatial differences that may contribute to its greater tolerance to hypoxia and toxins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Analytical
Jie Niu, Shuxian Yang, Minggang Tian, Xiaoqiang Yu
Summary: This study proposes a new strategy to alter the fluorescence lifetime of probes by changing their subcellular immigration and develops two viscosity-responsive isomeric probes (PQO and PQP) for monitoring changes in mitochondrial membrane potential (ΔΨm) under fluorescence lifetime imaging microscopy. The probes exhibit different fluorescence lifetime in cells with high and low levels of ΔΨm, enabling visualization of ΔΨm.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Biochemistry & Molecular Biology
Yi Li, Wen Chen, Danling Wang
Summary: PINK1 deficiency leads to the formation of a new type of mitochondrial membrane deformity called mitochondrial spherical compartmentation (MSC) in Drosophila. This structure can be inhibited through mitochondrial dynamics and the phosphagen energy-buffer system might regulate mitochondrial dynamics.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Stefania Di Mauro, Alessandra Scamporrino, Agnese Filippello, Maurizio Di Marco, Maria Teresa Di Martino, Francesca Scionti, Antonino Di Pino, Roberto Scicali, Roberta Malaguarnera, Francesco Purrello, Salvatore Piro
Summary: This study identified a specific molecular signature of diabetic kidney disease (DKD) by analyzing the transcriptome of serum samples from diabetic patients. Downregulation of certain transcripts, including mitochondrial RNAs, was found to be associated with DKD and correlated with markers of kidney function and other clinical parameters. These mitochondrial RNAs showed high diagnostic performance in distinguishing between different stages of DKD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Multidisciplinary
Rongxiu Zhai, Bin Fang, Yaqi Lai, Bo Peng, Hua Bai, Xiaowang Liu, Lin Li, Wei Huang
Summary: Mitochondria play an essential role in the development of diseases and cellular metabolism disorders. Super-resolution imaging is crucial for studying the ultrafine structures and functions of mitochondria. Small-molecule fluorogenic probes have unique properties that make them ideal for super-resolution imaging of mitochondria. This paper summarizes recent advances in small-molecule fluorogenic probes, focusing on their chemical and spectroscopic properties for mitochondrial imaging. Future challenges in this field, including the design principles of small-molecule fluorogenic probes and nanoscopic techniques, are also discussed.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Food Science & Technology
Amal S. Albedwawi, Reem Al Sakkaf, Tareq M. Osaili, Ahmed Yusuf, Amin Olaimat, Shao-Quan Liu, Giovanni Palmisano, Nagendra P. Shah, Mutamed M. Ayyash
Summary: This paper investigated the ability of lactic acid bacteria (LAB) and Bifidobacterium to remove acrylamide (AA) and examined the mechanism(s) of the AA removal using various microscopic techniques. The results showed that Bifidobacterium breve and Lactiplantibacillus plantarum exhibited higher acrylamide reduction rates. The study also found that both strains could tolerate low pH levels and remove acrylamide under in vitro gastrointestinal conditions.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Anatomy & Morphology
Zhitao Chen, Xiaohong Lin, Chuanbao Chen, Yuan Liao, Min Han, Xiaoshun He, Weiqiang Ju, Maogen Chen
Summary: This study aimed to observe ultrastructural changes in the donor liver by electron microscopy (EM) and analyze their relationship with prognosis. The results showed that patients with higher organelle injury scores had a worse early prognosis, but long-term survival was not affected.
MICROSCOPY RESEARCH AND TECHNIQUE
(2022)
Article
Neurosciences
Karlis A. Justs, Zhongmin Lu, Amit K. Chouhan, Jolanta A. Borycz, Zhiyuan Lu, Ian A. Meinertzhagen, Gregory T. Macleod
Summary: Neurons require stable energy supply and optimize mitochondrial volume and density according to presynaptic power demands.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Komal Tilwani, Abhishek Patel, Hirak Parikh, Janki Thakker, Gayatri Dave
Summary: This study explores the health benefits of Yarrow tea and evaluates its antiviral and anti-inflammatory properties. The results suggest that the constituent Luteolin in Yarrow tea may exhibit anti-inflammatory actions by inhibiting Cyclooxygenase II, and Yarrow exhibits virucidal activity against SARS-nCoV-2.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Cell Biology
Valeriya Vays, Irina Vangely, Chupalav Eldarov, Susanne Holtze, Thomas Hildebrandt, Lora Bakeeva, Vladimir Skulachev
Summary: The mitochondrial apparatus in the skeletal muscles of naked mole rats is not well-developed below 5 years of age, but becomes powerful starting from 5 years, with a unique structure by the age of 11. The increase in mitochondria is mainly driven by an increase in organelles, and there are no abnormal changes in mitochondrial ultrastructure observed during this growth.
Article
Biochemistry & Molecular Biology
Sarah M. Smith, Gabrielle Larocque, Katherine M. Wood, Kyle L. Morris, Alan M. Roseman, Richard B. Sessions, Stephen J. Royle, Corinne J. Smith
Summary: The interaction between Clathrin and the AP2 complex plays a crucial role in coated-pit assembly, with a beta 2 appendage able to bind in at least two positions in the clathrin cage. This multi-modal binding is shown to be a fundamental property of clathrin-AP2 interactions.
Article
Biochemical Research Methods
Matthew J. Fogarty, Sabhya Rana, Carlos B. Mantilla, Gary C. Sieck
Summary: The new method of using fluorescent imaging for assessing mitochondrial volume density in PhMNs demonstrated comparable results to the traditional EM method, although EM was able to distinguish finer mitochondrial morphology compared to MitoTracker fluorescence. The major advantages of using fluorescent imaging over EM methods include the assessment of a larger sample size and unambiguous identification of motor neurons belonging to a specific motor neuron pool.
JOURNAL OF NEUROSCIENCE METHODS
(2021)
Article
Gastroenterology & Hepatology
Masashi Miyao, Chihiro Kawai, Hirokazu Kotani, Hirozo Minami, Hitoshi Abiru, Hideki Hamayasu, Satoru Eguchi, Keiji Tamaki
Summary: This study investigates the role of mitochondrial fission in the progression of NAFLD. The findings suggest that excessive mitochondrial fission in hepatocytes could contribute to liver inflammation and fibrogenesis, providing a potential therapeutic target for NAFLD.
HEPATOLOGY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Siqi Liu, Shanshan Liu, Baiyu He, Lanlan Li, Lin Li, Jiawen Wang, Tao Cai, She Chen, Hui Jiang
Summary: The research reveals that yeast mutants deficient in certain oxidative phosphorylation complexes and mtDNA exhibit progressive reduction of mitochondrial membrane potential. These mutants activate adaptive responses, including remodeling of mitochondrial proteome and reshaping of cellular metabolism.
Article
Environmental Sciences
Toshimi Nakajima, Mao Kuragano, Makoto Yamada, Ryo Sugimoto
Summary: This study compared the contribution of submarine groundwater discharge (SGD) to river nutrient budgets at nearshore and embayment scales, and found that SGD-derived nutrients become more important at larger spatial scales.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Fan Liu, Lei Zhang, Chongyang Zhang, Ziguang Chen, Jingguang Li
Summary: NO2 emissions from wall-mounted gas stoves used for household heating have become a significant source of indoor pollution in Chinese urban areas. The high indoor concentration of NO2 poses potential health risks to residents. It is urgently necessary to establish relevant regulations and implement emission reduction technologies to reduce NO2 emissions from wall-mounted gas stoves.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Letter
Environmental Sciences
Hans Peter H. Arp, Raoul Wolf, Sarah E. Hale, Sivani Baskaran, Juliane Gluege, Martin Scheringer, Xenia Trier, Ian T. Cousins, Harrie Timmer, Roberta Hofman-Caris, Anna Lennquist, Andre D. Bannink, Gerard J. Stroomberg, Rosa M. A. Sjerps, Rosa Montes, Rosario Rodil, Jose Benito Quintana, Daniel Zahn, Herve Gallard, Tobias Mohr, Ivo Schliebner, Michael Neumann
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Philomina Onyedikachi Peter, Binessi Edouard Ifon, Francois Nkinahamira, Kayode Hassan Lasisi, Jiangwei Li, Anyi Hu, Chang-Ping Yu
Summary: This study investigates the relationship between dissolved organic matter (DOM) and Rare Earth Elements (REEs) in sediments from Yundang Lagoon, China. The results show four distinct fluorescent components, with protein-like substances being the most prevalent. Additionally, the total fluorescence intensity and LREE concentrations exhibit a synchronized increase from Outer to Inner to Songbai Lake core sediments. The findings demonstrate a strong correlation between DOM content and pollution levels.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Surya Gupta, Pasquale Borrelli, Panos Panagos, Christine Alewell
Summary: The objective of this study is to incorporate soil hydraulic properties into the erodibility factor (K) of USLE-type models. By modifying and improving the existing equations for soil texture and permeability, the study successfully included information on saturated hydraulic conductivity (Ksat) into the calculation of K factor. Using the Random Forest machine learning algorithm, two independent K factor maps with different spatial resolutions were generated. The results show that the decrease in K factor values has a positive impact on the modeling of soil erosion rates.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jesmin Akter, Wendy J. M. Smith, Yawen Liu, Ilho Kim, Stuart L. Simpson, Phong Thai, Asja Korajkic, Warish Ahmed
Summary: The choice of workflow in wastewater surveillance has a significant impact on SARS-CoV-2 concentrations, while having minimal effects on HF183 and no effect on HAdV 40/41 concentrations. Certain components in the workflow can be interchangeable, but factors such as buffer type, chloroform, and homogenization speed can affect the recovery of viruses and bacteria.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yu Luo, Xueting Yang, Diwei Wang, Hongmei Xu, Hongai Zhang, Shasha Huang, Qiyuan Wang, Ningning Zhang, Junji Cao, Zhenxing Shen
Summary: Atmospheric PM2.5, which can generate reactive oxygen species (ROS), is associated with cardiorespiratory morbidity and mortality. The study found that both the mass concentration of PM2.5 and the DTT activity were higher during the heating season than during the nonheating season. Combustion sources were the primary contributors to DTT activity during the heating season, while secondary formation dominated during the nonheating season. The study also revealed that biomass burning had the highest inherent oxidation potential among all sources investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Erin L. Murphy, Leah R. Gerber, Chelsea M. Rochman, Beth Polidoro
Summary: Plastic pollution has devastating consequences for marine organisms. This study uses a trait-based framework to develop a vulnerability index for marine mammals, seabirds, and sea turtles in Hawai'i. The index ranks 63 study species based on their vulnerability to macroplastic pollution, providing valuable information for species monitoring and management priorities.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Kenji Maurice, Amelia Bourceret, Sami Youssef, Stephane Boivin, Liam Laurent-Webb, Coraline Damasio, Hassan Boukcim, Marc-Andre Selosse, Marc Ducousso
Summary: Growing pressure from climate change and agricultural land use is destabilizing soil microbial community interactions. Little is known about microbial community resistance and adaptation to disturbances, hindering our understanding of recovery latency and implications for ecosystem functioning. This study found that anthropic disturbance and natural disturbance have different effects on the topology and stability of soil microbial networks.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yunhao Li, Yali Feng, Haoran Li, Yisong Yao, Chenglong Xu, Jinrong Ju, Ruiyu Ma, Haoyu Wang, Shiwei Jiang
Summary: Deep-sea mining poses a serious threat to marine ecosystems and human health by disturbing sediment and transmitting metal ions through the food chain. This study developed a new regenerative adsorption material, OMN@SA, which effectively removes metal ions. The adsorption mechanism and performance of the material for metal ion fixation were investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Antonio Medici, Margherita Lavorgna, Marina Isidori, Chiara Russo, Elena Orlo, Giovanni Luongo, Giovanni Di Fabio, Armando Zarrelli
Summary: Valsartan, a widely used antihypertensive drug, has been detected in high concentrations in surface waters due to its unchanged excretion and incomplete degradation in wastewater treatment plants. This study investigated the degradation of valsartan and identified 14 degradation byproducts. The acute and chronic toxicity of these byproducts were evaluated in key organisms in the freshwater trophic chain.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jiang Lin, Lianbao Chi, Qing Yuan, Busu Li, Mingbao Feng
Summary: This study investigated the photodegradation behavior and product formation of two representative pharmaceuticals in simulated estuary water. The study found that the formed transformation products of these pharmaceuticals have potential toxicity on marine organisms, including oxidative stress and damage to cellular components.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Hua Fang, Dongdong Jiang, Ye He, Siyi Wu, Yuehong Li, Ziqi Zhang, Haoting Chen, Zixin Zheng, Yan Sun, Wenxiang Wang
Summary: This study revealed that exposure to lower levels of air pollutants led to decreased pregnancy rates, with PM10, NO2, SO2, and CO emerging as the four most prominent pollutants. Individuals aged 35 and above exhibited heightened susceptibility to pollutants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Ali Shaan Manzoor Ghumman, Rashid Shamsuddin, Amin Abbasi, Mohaira Ahmad, Yoshiaki Yoshida, Abdul Sami, Hamad Almohamadi
Summary: In this study, inverse vulcanized polysulfides (IVP) were synthesized by reacting molten sulfur with 4-vinyl benzyl chloride, and then functionalized using N-methyl D-glucamine (NMDG). The functionalized IVP showed a high mercury adsorption capacity and a machine learning model was developed to predict the amount of mercury removed. Furthermore, the functionalized IVP can be regenerated and reused, providing a sustainable and cost-effective adsorbent.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Rita Bonfiglio, Renata Sisto, Stefano Casciardi, Valeria Palumbo, Maria Paola Scioli, Erica Giacobbi, Francesca Servadei, Gerry Melino, Alessandro Mauriello, Manuel Scimeca
Summary: This study investigated the presence of aluminum in human colon cancer samples and its potential association with biological processes involved in cancer progression. Aluminum was found in tumor areas of 24% of patients and was associated with epithelial to mesenchymal transition (EMT) and cell death. Additional analyses revealed higher tumor mutational burden and mutations in genes related to EMT and apoptosis in aluminum-positive colon cancers. Understanding the molecular mechanisms of aluminum toxicity may improve strategies for the management of colon cancer patients.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)