Article
Nutrition & Dietetics
Annie Lauer, Markus Burkard, Heike Niessner, Christian Leischner, Olga Renner, Claudia Vollbracht, Holger Michels, Christian Busch, Tobias Sinnberg, Sascha Venturelli
Summary: Sepsis is a complex clinical syndrome with an excessive inflammatory response, where vitamin C deficiency plays a crucial role. Research shows that high-dose vitamin C, either alone or in combination with other drugs, can effectively reduce cytokine response and potentially improve the condition of sepsis patients.
Article
Chemistry, Applied
Fabio Mastrogiovanni, Annalisa Romani, Luca Santi, Nicola Lacetera, Roberta Bernini
Summary: The study demonstrated that pomegranate peel extracts have a protective effect on bovine peripheral blood mononuclear cells and are not cytotoxic at certain concentrations. Additionally, the extracts show significant anti-proliferative activity.
NATURAL PRODUCT RESEARCH
(2021)
Article
Endocrinology & Metabolism
Heri Wibowo, Dante S. Harbuwono, Dicky L. Tahapary, Rona Kartika, Saraswati Pradipta, Rahma A. Larasati
Summary: Type 2 diabetes mellitus is associated with chronic low-grade inflammation, and butyrate, as an immunoregulatory agent, may play a role in reducing inflammation. This study aimed to measure plasma butyrate levels in poorly controlled T2DM and normoglycemic participants, as well as to compare the response of PBMCs to sodium butyrate treatment. The results suggest that butyrate may modulate inflammatory cytokine production in human PBMCs.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lidiane Cristina Pinho Nascimento Portela, Thiago Barbosa Cahu, Thais Santos Bezerra, Dayane Kelly Dias do Nascimento Santos, Georon Ferreira Sousa, Rogerio William Santos Portela, Cristiane Moutinho Lagos Melo, Ranilson de Souza Bezerra
Summary: This study investigated the immunostimulatory effects of collagen and chitosan preparations extracted from fishery discards on human peripheral blood mononuclear cells (PBMCs). The results showed that these preparations did not exhibit cytotoxic effects, but they promoted the release of cytokines and increased the production of cellular ROS. They also led to the activation of T CD8(+) and CD4(+) lymphocytes, as well as an increase in cytosolic calcium concentration and mitochondrial membrane potential.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Immunology
Yaqing Shu, Fuhua Peng, Bingchu Zhao, Chunxin Liu, Qihui Li, Huilu Li, Yuge Wang, Yanjun Jiang, Tingting Lu, Qin Wang, Jian Sun, Huiyu Feng, Zhengqi Lu, Xiaodong Liu, Jie Wang, Wei Qiu
Summary: In this study, a novel humanized mouse model of anti-NMDAR encephalitis was established by injecting patients' peripheral blood mononuclear cells into mice. The engraftment of patients' cells produced potent anti-GluN1 autoantibodies and disrupted the blood-brain barrier, leading to behavioral and cognitive changes in the mice. Il-1 ss was identified as a key gene involved in these pathological changes.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Multidisciplinary Sciences
Olivier Dionne, Audrey Lortie, Florence Gagnon, Francois Corbin
Summary: This study revealed a decrease in the rate of protein synthesis in peripheral blood mononuclear cells (PBMCs) of fragile X individuals compared to controls. The method used was highly reproducible, suggesting potential for broader application in cases of intellectual disability to assess abnormal protein synthesis as a common mechanism for impairment in synaptic plasticity and intellectual disability.
Article
Immunology
Atefe Ghamar Talepoor, Banafsheh Rastegari, Mehdi Kalani, Mehrnoosh Doroudchi
Summary: The study found that Eritoran has an inhibitory effect on the production of cytokines induced by LPS, with a more significant effect on the inflammatory responses of PBMCs from patients with atherosclerosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Environmental Sciences
Tiina Santonen, Simo P. Porras, Beatrice Bocca, Radia Bousoumah, Radu Corneliu Duca, Karen S. Galea, Lode Godderis, Thomas Goen, Emilie Hardy, Ivo Iavicoli, Beata Janasik, Kate Jones, Elizabeth Leese, Veruscka Leso, Henriqueta Louro, Nicole Majery, Sophie Ndaw, Herminia Pinhal, Flavia Ruggieri, Maria J. Silva, An van Nieuwenhuyse, Jelle Verdonck, Susana Viegas, Wojciech Wasowicz, Ovnair Sepai, Paul T. J. Scheepers
Summary: This study aimed to provide EU relevant data on occupational Cr(VI) exposure and evaluated the validity of different biomarkers for assessing Cr(VI) exposure, involving 399 workers from nine European countries. The use of chromium in urine was found to be an effective biomonitoring method. The study also highlighted the importance of multinational collaboration in occupational biomonitoring studies to support policy actions aiming to reduce chemical exposure.
ENVIRONMENTAL RESEARCH
(2022)
Article
Genetics & Heredity
M. M. De Souza, D. A. Koltes, H. Beiki, M. A. Sales, T. Tsai, C. V. Maxwell, J. Zhao, J. E. Koltes
Summary: Exposure to less hygienic conditions during early childhood has been linked to immune system development. This study investigated the impact of early-life topsoil exposure on RNA expression in piglets' blood cells and identified changes in genes related to T-cell activation and antigen-presenting cells.
FRONTIERS IN GENETICS
(2022)
Article
Medicine, Legal
Shalenie P. den Braver-Sewradj, Jan van Benthem, Yvonne C. M. Staal, Janine Ezendam, Aldert H. Piersma, Ellen V. S. Hessel
Summary: This study summarized the irreversible adverse health effects caused by occupational exposure to hexavalent chromium (Cr(VI)), and found that such exposure may lead to lung cancer, nose and nasal sinus cancer in humans.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Byeongyeon Kim, In-Ho Seo, Gwang Myeong Seo, Woo-Joong Kim, Eui-Cheol Shin, Sungyoung Choi
Summary: The study introduces a blood divider (B-DV) as a centrifuge tube insert to prevent RBC contamination during PBMC harvest, simplifying the separation process and enabling rapid, easy PBMC isolation.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Article
Veterinary Sciences
Seo-Young Hwang, Ju-Hyun An, Kyung-Bo Kim, Jeong-Hwa Lee, Su-Min Park, Ye-In Oh, Hyung Kyu Chae, Hwa-Young Youn
Summary: This study evaluated the role of PBMCs in obesity-related chronic inflammation and found that the gene expression levels of inflammation-related adipokines and pro-inflammatory cytokines were altered in PBMCs, potentially contributing to the low-grade chronic inflammation observed in obesity.
VETERINARY MEDICINE AND SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Vera Vorstandlechner, Dragan Copic, Katharina Klas, Martin Direder, Bahar Golabi, Christine Radtke, Hendrik J. Ankersmit, Michael Mildner
Summary: This study demonstrates the anti-fibrotic effect of PBMCsec on cutaneous scars in both mouse and human experimental settings. PBMCsec regulates the expression of fibrosis-related genes, attenuates myofibroblast differentiation, and inhibits the breakdown of elastic fibers. These findings suggest that PBMCsec could be a novel therapeutic option for treating skin scarring.
Article
Multidisciplinary Sciences
Olivier Dionne, Francois Corbin
Summary: Fragile X syndrome is the most common inherited cause of intellectual disabilities and autism spectrum disorders, characterized by a wide range of behavioral, cognitive, and metabolic impairments with significant phenotypic heterogeneity among patients. Current tools for patient prognosis are lacking, leading researchers to identify potential proteomic biomarkers through analyzing the nascent proteome. This study suggests that the nascent proteome of PBMCs is a promising avenue for discovering biomarkers of FXS.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
V Lavanya, Anil Kumar Bommanabonia, Neesar Ahmed, Shazia Jamal
Summary: The tumor microenvironment plays a key role in regulating tumor growth and invasion. Jacalin, as a mitogen for PBMCs, may modulate immune responses by altering cytokine secretion, thereby influencing tumor growth and its surrounding environment.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2022)
Article
Green & Sustainable Science & Technology
Ranjeev K. Sahu, Shashwat Katiyar, Awadhesh K. Yadav, Narendra Kumar, Jatin Srivastava
CLEAN-SOIL AIR WATER
(2008)
Article
Environmental Sciences
Pramod W. Ramteke, S. Awasthi, T. Srinath, Babu Joseph
ENVIRONMENTAL MONITORING AND ASSESSMENT
(2010)
Article
Environmental Sciences
Shashwat Katiyar, S. K. Awasthi, Ranjeev K. Sahu
SCIENCE OF THE TOTAL ENVIRONMENT
(2008)
Article
Infectious Diseases
Babban Jee, Pawan Sharma, Kiran Katoch, Beenu Joshi, Sudhir Kumar Awasthi
BRAZILIAN JOURNAL OF INFECTIOUS DISEASES
(2017)
Article
Environmental Sciences
Shashwat Katiyar, Dharam Singh
JOURNAL OF ENVIRONMENTAL BIOLOGY
(2014)
Article
Environmental Sciences
R. K. Sahu, S. Katiyar, Jaya Tiwari, G. C. Kisku
JOURNAL OF ENVIRONMENTAL BIOLOGY
(2007)
Article
Biochemistry & Molecular Biology
Renu Yadav, Babban Jee, Sudhir Kumar Awasthi
INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY
(2015)
Review
Immunology
VK Singh, KP Mishra, R Rani, VS Yadav, SK Awasthi, SK Garg
IMMUNOLOGIC RESEARCH
(2003)
Article
Environmental Sciences
Toshimi Nakajima, Mao Kuragano, Makoto Yamada, Ryo Sugimoto
Summary: This study compared the contribution of submarine groundwater discharge (SGD) to river nutrient budgets at nearshore and embayment scales, and found that SGD-derived nutrients become more important at larger spatial scales.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Fan Liu, Lei Zhang, Chongyang Zhang, Ziguang Chen, Jingguang Li
Summary: NO2 emissions from wall-mounted gas stoves used for household heating have become a significant source of indoor pollution in Chinese urban areas. The high indoor concentration of NO2 poses potential health risks to residents. It is urgently necessary to establish relevant regulations and implement emission reduction technologies to reduce NO2 emissions from wall-mounted gas stoves.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Letter
Environmental Sciences
Hans Peter H. Arp, Raoul Wolf, Sarah E. Hale, Sivani Baskaran, Juliane Gluege, Martin Scheringer, Xenia Trier, Ian T. Cousins, Harrie Timmer, Roberta Hofman-Caris, Anna Lennquist, Andre D. Bannink, Gerard J. Stroomberg, Rosa M. A. Sjerps, Rosa Montes, Rosario Rodil, Jose Benito Quintana, Daniel Zahn, Herve Gallard, Tobias Mohr, Ivo Schliebner, Michael Neumann
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Philomina Onyedikachi Peter, Binessi Edouard Ifon, Francois Nkinahamira, Kayode Hassan Lasisi, Jiangwei Li, Anyi Hu, Chang-Ping Yu
Summary: This study investigates the relationship between dissolved organic matter (DOM) and Rare Earth Elements (REEs) in sediments from Yundang Lagoon, China. The results show four distinct fluorescent components, with protein-like substances being the most prevalent. Additionally, the total fluorescence intensity and LREE concentrations exhibit a synchronized increase from Outer to Inner to Songbai Lake core sediments. The findings demonstrate a strong correlation between DOM content and pollution levels.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Surya Gupta, Pasquale Borrelli, Panos Panagos, Christine Alewell
Summary: The objective of this study is to incorporate soil hydraulic properties into the erodibility factor (K) of USLE-type models. By modifying and improving the existing equations for soil texture and permeability, the study successfully included information on saturated hydraulic conductivity (Ksat) into the calculation of K factor. Using the Random Forest machine learning algorithm, two independent K factor maps with different spatial resolutions were generated. The results show that the decrease in K factor values has a positive impact on the modeling of soil erosion rates.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jesmin Akter, Wendy J. M. Smith, Yawen Liu, Ilho Kim, Stuart L. Simpson, Phong Thai, Asja Korajkic, Warish Ahmed
Summary: The choice of workflow in wastewater surveillance has a significant impact on SARS-CoV-2 concentrations, while having minimal effects on HF183 and no effect on HAdV 40/41 concentrations. Certain components in the workflow can be interchangeable, but factors such as buffer type, chloroform, and homogenization speed can affect the recovery of viruses and bacteria.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yu Luo, Xueting Yang, Diwei Wang, Hongmei Xu, Hongai Zhang, Shasha Huang, Qiyuan Wang, Ningning Zhang, Junji Cao, Zhenxing Shen
Summary: Atmospheric PM2.5, which can generate reactive oxygen species (ROS), is associated with cardiorespiratory morbidity and mortality. The study found that both the mass concentration of PM2.5 and the DTT activity were higher during the heating season than during the nonheating season. Combustion sources were the primary contributors to DTT activity during the heating season, while secondary formation dominated during the nonheating season. The study also revealed that biomass burning had the highest inherent oxidation potential among all sources investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Erin L. Murphy, Leah R. Gerber, Chelsea M. Rochman, Beth Polidoro
Summary: Plastic pollution has devastating consequences for marine organisms. This study uses a trait-based framework to develop a vulnerability index for marine mammals, seabirds, and sea turtles in Hawai'i. The index ranks 63 study species based on their vulnerability to macroplastic pollution, providing valuable information for species monitoring and management priorities.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Kenji Maurice, Amelia Bourceret, Sami Youssef, Stephane Boivin, Liam Laurent-Webb, Coraline Damasio, Hassan Boukcim, Marc-Andre Selosse, Marc Ducousso
Summary: Growing pressure from climate change and agricultural land use is destabilizing soil microbial community interactions. Little is known about microbial community resistance and adaptation to disturbances, hindering our understanding of recovery latency and implications for ecosystem functioning. This study found that anthropic disturbance and natural disturbance have different effects on the topology and stability of soil microbial networks.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yunhao Li, Yali Feng, Haoran Li, Yisong Yao, Chenglong Xu, Jinrong Ju, Ruiyu Ma, Haoyu Wang, Shiwei Jiang
Summary: Deep-sea mining poses a serious threat to marine ecosystems and human health by disturbing sediment and transmitting metal ions through the food chain. This study developed a new regenerative adsorption material, OMN@SA, which effectively removes metal ions. The adsorption mechanism and performance of the material for metal ion fixation were investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Antonio Medici, Margherita Lavorgna, Marina Isidori, Chiara Russo, Elena Orlo, Giovanni Luongo, Giovanni Di Fabio, Armando Zarrelli
Summary: Valsartan, a widely used antihypertensive drug, has been detected in high concentrations in surface waters due to its unchanged excretion and incomplete degradation in wastewater treatment plants. This study investigated the degradation of valsartan and identified 14 degradation byproducts. The acute and chronic toxicity of these byproducts were evaluated in key organisms in the freshwater trophic chain.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jiang Lin, Lianbao Chi, Qing Yuan, Busu Li, Mingbao Feng
Summary: This study investigated the photodegradation behavior and product formation of two representative pharmaceuticals in simulated estuary water. The study found that the formed transformation products of these pharmaceuticals have potential toxicity on marine organisms, including oxidative stress and damage to cellular components.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Hua Fang, Dongdong Jiang, Ye He, Siyi Wu, Yuehong Li, Ziqi Zhang, Haoting Chen, Zixin Zheng, Yan Sun, Wenxiang Wang
Summary: This study revealed that exposure to lower levels of air pollutants led to decreased pregnancy rates, with PM10, NO2, SO2, and CO emerging as the four most prominent pollutants. Individuals aged 35 and above exhibited heightened susceptibility to pollutants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Ali Shaan Manzoor Ghumman, Rashid Shamsuddin, Amin Abbasi, Mohaira Ahmad, Yoshiaki Yoshida, Abdul Sami, Hamad Almohamadi
Summary: In this study, inverse vulcanized polysulfides (IVP) were synthesized by reacting molten sulfur with 4-vinyl benzyl chloride, and then functionalized using N-methyl D-glucamine (NMDG). The functionalized IVP showed a high mercury adsorption capacity and a machine learning model was developed to predict the amount of mercury removed. Furthermore, the functionalized IVP can be regenerated and reused, providing a sustainable and cost-effective adsorbent.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Rita Bonfiglio, Renata Sisto, Stefano Casciardi, Valeria Palumbo, Maria Paola Scioli, Erica Giacobbi, Francesca Servadei, Gerry Melino, Alessandro Mauriello, Manuel Scimeca
Summary: This study investigated the presence of aluminum in human colon cancer samples and its potential association with biological processes involved in cancer progression. Aluminum was found in tumor areas of 24% of patients and was associated with epithelial to mesenchymal transition (EMT) and cell death. Additional analyses revealed higher tumor mutational burden and mutations in genes related to EMT and apoptosis in aluminum-positive colon cancers. Understanding the molecular mechanisms of aluminum toxicity may improve strategies for the management of colon cancer patients.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)