Article
Computer Science, Artificial Intelligence
Binh Thai Pham, Chinh Luu, Dong Van Dao, Tran Van Phong, Huu Duy Nguyen, Hiep Van Le, Jason von Meding, Indra Prakash
Summary: This study proposed a novel approach for flood risk assessment by combining deep learning algorithm and Multi-Criteria Decision Analysis (MCDA). The study focused on hazard, exposure, and vulnerability assessment in a flood-prone area in Quang Nam province, Vietnam, utilizing various algorithms for performance comparison and evaluation. Results indicated that integrating DNNs and MCDA models is a promising approach for accurate flood risk assessment map development and better flood hazard management.
KNOWLEDGE-BASED SYSTEMS
(2021)
Article
Environmental Sciences
Oluwafemi Soetan, Jing Nie, Huan Feng
Summary: This preliminary study aimed to investigate the short- and long-term effects of remedial dredging on metal contamination, dredging efficacy and ecological status of the Lower Passaic River. The short-term results showed effective reduction of heavy metal concentrations, although they increased in the water column, increasing the risk of bioaccumulation in aquatic biota. On the long-term, metal concentrations increased in surface sediments.
MARINE POLLUTION BULLETIN
(2022)
Article
Health Care Sciences & Services
Tom Menzies, Gaelle Saint-Hilary, Pavel Mozgunov
Summary: Multi-criteria decision analysis is a quantitative method used for drug benefit-risk assessment, which allows for consistent comparisons by summarizing various components into a single score. Different approaches to score construction may lead to different decision outcomes, with the product and Scale Loss Score models often providing more intuitive treatment recommendations compared to the linear and multi-linear models in many scenarios.
STATISTICAL METHODS IN MEDICAL RESEARCH
(2022)
Article
Immunology
Kyung-Hwa Son, Sun-Hong Kwon, Hye-Jung Na, Youngsuk Baek, Inok Kim, Eui-Kyung Lee
Summary: In this study, a quantitative benefit-risk assessment was conducted for four COVID-19 vaccines using multi-criteria decision analysis. The mRNA vaccine was found to have a good balance between preventing COVID-19 infection and adverse events. This assessment method can be updated with cumulated data and provide evidence for decision making by policy makers and health professionals.
Article
Engineering, Civil
Binh Thai Pham, Chinh Luu, Tran Van Phong, Huu Duy Nguyen, Hiep Van Le, Thai Quoc Tran, Huong Thu Ta, Indra Prakash
Summary: This study proposed a flood risk assessment framework combining flood susceptibility assessment and flood consequences using Multi-Criteria Decision Analysis (MCDA) method. Two hybrid AI models, ABMDT and BDT, were developed with Decision Table (DT) as a base classifier to create a flood susceptibility map. The BDT model performed the best with an AUC of 0.96, and the proposed framework and models can be applied to other flood-prone areas for better flood hazard management.
JOURNAL OF HYDROLOGY
(2021)
Article
Environmental Sciences
Yiqing Chen, Deyun Wang, Ludan Zhang, Haixiang Guo, Junwei Ma, Wei Gao
Summary: Floods are a frequent natural hazard that causes significant human and economic losses globally. Evaluating and mapping flood hazard levels is crucial in mitigating future flood disasters. This study developed a methodology, COS-AHP-EW, that combines subjective and objective information to assess flood risk. The method was validated in Wuhan, China and proved to accurately predict the risk in flood-prone areas. The flood risk maps generated using COS-AHP-EW can improve flood risk assessments and be applied in other study areas to provide reliable flood management information.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Virginia Namiotko, Aiste Galnaityte, Irena Krisciukaitiene, Tomas Balezentis
Summary: In recent years, humanity has been facing economic and environmental crises, with deteriorating agri-environmental situation being a crucial factor. The study evaluated the agri-environmental situation of selected EU countries and found Finland, Ireland, and Sweden to have the best situation, while the worst situation was in the Netherlands, Denmark, and Germany. Lithuania showed a decline, while Austria and Poland showed improvement. This research is important for the development of agri-environment and climate schemes for the EU Common Agricultural Policy post-2020.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Green & Sustainable Science & Technology
Amanda Vinhoza, Roberto Schaeffer
Summary: This study evaluates Brazil's offshore wind potential through a novel approach, finding a total potential of 1688 GW, technical potential of 1064 GW, and environmental and social potential of 330 GW. The Northeast region of Brazil is the most economically attractive area for offshore wind development, while the Southeast region is less attractive. The results show that Brazil has significant offshore wind potential that can be sustainably developed.
RENEWABLE & SUSTAINABLE ENERGY REVIEWS
(2021)
Article
Veterinary Sciences
Wang Haoran, Xiao Jianhua, Ouyang Maolin, Gao Hongyan, Bie Jia, Gao Li, Gao Xiang, Wang Hongbin
Summary: This study used spatial multi-criteria decision analysis (MCDA) to assess foot-and-mouth disease (FMD) risk areas in mainland China, identifying four major risk areas and highlighting spring as the main season for FMD outbreaks. The results can be used by veterinary services to adopt targeted preventive measures and control strategies.
BMC VETERINARY RESEARCH
(2021)
Article
Green & Sustainable Science & Technology
Lisa Kraus, Dirk Wittowsky, Heike Proff
Summary: To comply with the European Green Deal, decarbonizing transportation is crucial, with a focus on shifting towards more sustainable transportation services. This paper presents a methodology for assessing the sustainability of urban transportation services through identifying and weighting interrelated criteria, as well as using the PROMETHEE method for evaluation. Applying this methodology to the Ruhr region, public transportation has been proven to be the most sustainable alternative.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Environmental Sciences
Xinyu Liu, Mengchen Tu, Shuping Wang, Yizhe Wang, Jing Wang, Yin Hou, Xin Zheng, Zhenguang Yan
Summary: This study aims to derive water quality criteria (WQC) and sediment quality criteria (SQC) for protecting Chinese aquatic organisms from triclosan (TCS) and perform ecological risk assessment. WQC of TCS was derived based on acute and chronic toxicity data using species sensitivity distribution (SSD) models, and SQC was derived through phase-equilibrium partitioning method. The results suggest the existence of certain ecological risks of TCS in Chinese rivers and sediments.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Integrative & Complementary Medicine
Rong-rong Zhang, Ming-yi Shao, Yu Fu, Rui-xia Zhao, Jing-wen Wnag, Yu-xuan Fang
Summary: This study evaluated the benefit-risk of three commonly used Chinese medicine injections (Aidi Injection, Cinobufagin Injection, and Compound Kushen Injection) in the treatment of primary liver cancer and provided reference for clinical decision-making. The results showed that Aidi Injection combined with transcatheter arterial chemoembolization (TACE) had the best treatment effect, Cinobufagin Injection had the highest risk, and considering efficacy and safety, the possible priority order of the three Chinese medicine injections combined with TACE in the treatment of primary liver cancer is Aidi Injection, Compound Kushen Injection, and Cinobufagin Injection.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2023)
Article
Green & Sustainable Science & Technology
Saman Nadizadeh Shorabeh, Meysam Argany, Javad Rabiei, Hamzeh Karimi Firozjaei, Omid Nematollahi
Summary: This study assessed the potential for establishing multi-renewable energy farms in eastern Iran by using ANP and Fuzzy logic to determine weights, obtaining suitability maps through the WLC method. The results showed large areas suitable for renewable energy farms and highlighted the importance of weight distribution in decision-making processes for developing renewable energy sources.
JOURNAL OF CLEANER PRODUCTION
(2021)
Article
Environmental Sciences
Chi-Wei Huang, Wen-Yen Huang, Chitsan Lin, Yi-Lin Li, Tsung-Po Huang, Xuan-Thanh Bui, Huu Hao Ngo
Summary: In this study, an environmental risk assessment was conducted on a brine water storage pond with high PCDD/F pollution potential. Accumulation of PCDD/F was found in the fish and crab from the pond, and the concentrations in biota exceeded Taiwan's food safety standard. Before corrective actions, the sediment in the pond was highly polluted, but after corrective actions, pollution and ecological risk were reduced to some extent.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Energy & Fuels
Pawel Ziemba
Summary: In the contemporary literature on sustainability, there is a growing trend of using Multi-Criteria Decision Analysis (MCDA) methods instead of traditional sustainability indices. This article aims to scientifically analyze the applicability of various MCDA methods in decision-making problems related to sustainability. Based on a literature analysis, the article presents a set of features that determine the possibility of using individual MCDA methods in sustainability problems. The study found that MCDA methods, especially those based on arithmetic aggregation of criteria and fuzzy modifications of classical methods, are more commonly used in sustainability problems than classic sustainability indices. The use of MCDA methods provides more flexibility and functionality in sustainability assessment.
Review
Computer Science, Interdisciplinary Applications
Maureen S. Golan, Benjamin D. Trump, Jeffrey C. Cegan, Igor Linkov
Summary: This review identified gaps in modeling supply chain resilience, especially for vaccines, and proposed the application of resilience analytics and emerging network science tools to improve the critical function of vaccine supply chains. Pharmaceutical corporations prioritize efficiency over resilience in their vaccine supply chains, but leveraging resilience analytics and tools like artificial intelligence can help managers quantify efficiency/resilience tradeoffs and optimize system performance post disruption.
INDUSTRIAL MANAGEMENT & DATA SYSTEMS
(2021)
Article
Public, Environmental & Occupational Health
Marta Bonato, Beatrice Sambo, Anna Sperotto, James H. Lambert, Igor Linkov, Andrea Critto, Silvia Torresan, Antonio Marcomini
Summary: The increasing magnitude and frequency of climate and disruptive factors are stressing coastal systems, exacerbated by various factors like land use transformations and urbanization. By applying a multi-criteria decision analysis (MCDA), integrating qualitative and quantitative information, system resilience in facing climate-related threats can be enhanced. Different policy initiatives were considered to support critical functions identified by local stakeholders, with cognitive and informative initiatives proving to enhance resilience across most scenarios.
Article
Environmental Sciences
Sergey Vecherin, Derek Chang, Emily Wells, Benjamin Trump, Aaron Meyer, Jacob Desmond, Kyle Dunn, Maxim Kitsak, Igor Linkov
Summary: This paper presents a novel model for COVID-19 infection risks and policy evaluations, which combines the best principles of different approaches. It allows for effective risk assessment and policy evaluation, particularly suitable for COVID-19 risk assessments.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2022)
Editorial Material
Immunology
Benjamin D. Trump, Maureen S. Golan, Jeffrey M. Keisler, Jeffrey C. Cegan, Igor Linkov
Article
Health Care Sciences & Services
David G. Angeler, Harris A. Eyre, Michael Berk, Craig R. Allen, William Hynes, Igor Linkov
Summary: Adaptive capacity is crucial for building resilience in healthcare, but shocks like the Covid-19 pandemic can lead to system collapse. Both adaptive and transformative changes are necessary for effective management of healthcare systems during crises. Integration of mental health and other interdisciplinary paradigms can facilitate resilience planning and management.
INTERNATIONAL JOURNAL OF HEALTH POLICY AND MANAGEMENT
(2022)
Editorial Material
Environmental Sciences
Stephanie Galaitsi, Margaret Kurth, Igor Linkov
Summary: This commentary expands on the distinctions related to resilience discussed by Urquiza et al. (2021) and uses examples from the 2020-2021 coronavirus pandemic to illustrate the concepts. Understanding these differences can help planners choose strategies that best support their system goals.
Letter
Multidisciplinary Sciences
Igor Linkov
Article
Physics, Multidisciplinary
William Hynes, Benjamin D. Trump, Alan Kirman, Andrew Haldane, Igor Linkov
Summary: This article introduces a framework for understanding economic resilience factors and implementing strategies, with a focus on increasing resilience through design and intervention. The authors suggest that a deeper understanding of the underlying structure of the economic system could lead to more enlightened policy decisions and better long-term outcomes.
Editorial Material
Multidisciplinary Sciences
Emerson Mahoney, Maureen Golan, Margaret Kurth, Benjamin D. Trump, Igor Linkov
Summary: The fragility of food security and supply chains for remote and Indigenous communities has been revealed by the COVID-19 pandemic. In this article, we emphasize the challenges faced by the Tribal Population of Noepe (Martha's Vineyard) and advocate for the incorporation of Resilience-by-Design and Resilience-by-Intervention in supply chain management.
NATURE COMMUNICATIONS
(2022)
Article
Management
Robert Horton, Gregory A. Kiker, Benjamin D. Trump, Igor Linkov
Summary: The Dallas-Fort Worth International Airport serves as an example highlighting the drawbacks of traditional approaches in protecting isolated components of critical infrastructure. These approaches fail to address the risks of cascading failures, which can result in significant costs and unacceptable levels of vulnerability. To optimize the airport supply chain, an interdisciplinary approach is needed, taking into account the complex relationships between various components. Resilience-focused strategies that encompass the entire disruption life cycle, including planning, absorption, recovery, and adaptation, can offer a higher return on investment.
JOURNAL OF CONTINGENCIES AND CRISIS MANAGEMENT
(2022)
Article
Geosciences, Multidisciplinary
Igor Linkov, Benjamin D. Trump, Joshua Trump, Gianluca Pescaroli, William Hynes, Aleksandrina Mavrodieva, Abhilash Panda
Summary: This paper discusses the vulnerabilities of critical infrastructure to various stressors and proposes stress testing as a method for identifying risks and selecting mitigation and recovery strategies. The existing risk-based stress testing approaches may have limitations and the inclusion of systems thinking and interconnectedness is crucial.
INTERNATIONAL JOURNAL OF DISASTER RISK REDUCTION
(2022)
Article
Engineering, Civil
Ayodeji Oseni, Nour Moustafa, Gideon Creech, Nasrin Sohrabi, Andrew Strelzoff, Zahir Tari, Igor Linkov
Summary: The paper proposes an explainable deep learning-based intrusion detection framework to improve transparency and resiliency of DL-based IDS in IoT networks. The framework employs SHapley Additive exPlanations (SHAP) mechanism to interpret decisions made by deep learning-based IDS and help cybersecurity experts validate the system's effectiveness and develop more cyber-resilient systems. Experimental results show that the proposed framework performs highly in protecting IoV networks against sophisticated cyber-attacks.
IEEE TRANSACTIONS ON INTELLIGENT TRANSPORTATION SYSTEMS
(2023)
Article
Multidisciplinary Sciences
Maksim Kitsak, Alexander Ganin, Ahmed Elmokashfi, Hongzhu Cui, Daniel A. Eisenberg, David L. Alderson, Dmitry Korkin, Igor Linkov
Summary: Obtaining shortest paths between nodes in complex networks is difficult when there is incomplete information on the network structure. However, the authors have discovered that these paths can be geometrically localized in hyperbolic representations of the networks, allowing them to be detected even in the presence of missing network links. The authors demonstrate the usefulness of this geometric pathfinding in Internet routing and reconstructing cellular pathways.
NATURE COMMUNICATIONS
(2023)
Proceedings Paper
Computer Science, Information Systems
Emanuele Bellini, Franco Bagnoli, Mauro Caporuscio, Ernesto Damiani, Francesco Flammini, Igor Linkov, Pietro Lio, Stefano Marrone
Summary: Critical infrastructures in modern society, known as Human-Cyber-Physical-Systems (HPCS), face various systemic threats that require a paradigm shift in management methods towards intelligent, data-driven and run-time approaches for evaluation. Digital Twins can be leveraged to support decision-making and enhance system resilience under systemic stress.
PROCEEDINGS OF THE 2021 IEEE INTERNATIONAL CONFERENCE ON CYBER SECURITY AND RESILIENCE (IEEE CSR)
(2021)
Review
Computer Science, Interdisciplinary Applications
Alexandre K. Ligo, Krista Rand, Jason Bassett, S. E. Galaitsi, Benjamin D. Trump, Bamini Jayabalasingham, Thomas Collins, Igor Linkov
Summary: The study points out that there is more research combining technical and social science explorations in current AI studies, but less research solely focusing on social sciences, and both are far behind technical research. The future of AI research will benefit from both technical and social science examinations of the discipline's risk assessment, governance, and public engagement needs.
FRONTIERS IN COMPUTER SCIENCE
(2021)
Article
Environmental Sciences
Toshimi Nakajima, Mao Kuragano, Makoto Yamada, Ryo Sugimoto
Summary: This study compared the contribution of submarine groundwater discharge (SGD) to river nutrient budgets at nearshore and embayment scales, and found that SGD-derived nutrients become more important at larger spatial scales.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Fan Liu, Lei Zhang, Chongyang Zhang, Ziguang Chen, Jingguang Li
Summary: NO2 emissions from wall-mounted gas stoves used for household heating have become a significant source of indoor pollution in Chinese urban areas. The high indoor concentration of NO2 poses potential health risks to residents. It is urgently necessary to establish relevant regulations and implement emission reduction technologies to reduce NO2 emissions from wall-mounted gas stoves.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Letter
Environmental Sciences
Hans Peter H. Arp, Raoul Wolf, Sarah E. Hale, Sivani Baskaran, Juliane Gluege, Martin Scheringer, Xenia Trier, Ian T. Cousins, Harrie Timmer, Roberta Hofman-Caris, Anna Lennquist, Andre D. Bannink, Gerard J. Stroomberg, Rosa M. A. Sjerps, Rosa Montes, Rosario Rodil, Jose Benito Quintana, Daniel Zahn, Herve Gallard, Tobias Mohr, Ivo Schliebner, Michael Neumann
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Philomina Onyedikachi Peter, Binessi Edouard Ifon, Francois Nkinahamira, Kayode Hassan Lasisi, Jiangwei Li, Anyi Hu, Chang-Ping Yu
Summary: This study investigates the relationship between dissolved organic matter (DOM) and Rare Earth Elements (REEs) in sediments from Yundang Lagoon, China. The results show four distinct fluorescent components, with protein-like substances being the most prevalent. Additionally, the total fluorescence intensity and LREE concentrations exhibit a synchronized increase from Outer to Inner to Songbai Lake core sediments. The findings demonstrate a strong correlation between DOM content and pollution levels.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Surya Gupta, Pasquale Borrelli, Panos Panagos, Christine Alewell
Summary: The objective of this study is to incorporate soil hydraulic properties into the erodibility factor (K) of USLE-type models. By modifying and improving the existing equations for soil texture and permeability, the study successfully included information on saturated hydraulic conductivity (Ksat) into the calculation of K factor. Using the Random Forest machine learning algorithm, two independent K factor maps with different spatial resolutions were generated. The results show that the decrease in K factor values has a positive impact on the modeling of soil erosion rates.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jesmin Akter, Wendy J. M. Smith, Yawen Liu, Ilho Kim, Stuart L. Simpson, Phong Thai, Asja Korajkic, Warish Ahmed
Summary: The choice of workflow in wastewater surveillance has a significant impact on SARS-CoV-2 concentrations, while having minimal effects on HF183 and no effect on HAdV 40/41 concentrations. Certain components in the workflow can be interchangeable, but factors such as buffer type, chloroform, and homogenization speed can affect the recovery of viruses and bacteria.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yu Luo, Xueting Yang, Diwei Wang, Hongmei Xu, Hongai Zhang, Shasha Huang, Qiyuan Wang, Ningning Zhang, Junji Cao, Zhenxing Shen
Summary: Atmospheric PM2.5, which can generate reactive oxygen species (ROS), is associated with cardiorespiratory morbidity and mortality. The study found that both the mass concentration of PM2.5 and the DTT activity were higher during the heating season than during the nonheating season. Combustion sources were the primary contributors to DTT activity during the heating season, while secondary formation dominated during the nonheating season. The study also revealed that biomass burning had the highest inherent oxidation potential among all sources investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Erin L. Murphy, Leah R. Gerber, Chelsea M. Rochman, Beth Polidoro
Summary: Plastic pollution has devastating consequences for marine organisms. This study uses a trait-based framework to develop a vulnerability index for marine mammals, seabirds, and sea turtles in Hawai'i. The index ranks 63 study species based on their vulnerability to macroplastic pollution, providing valuable information for species monitoring and management priorities.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Kenji Maurice, Amelia Bourceret, Sami Youssef, Stephane Boivin, Liam Laurent-Webb, Coraline Damasio, Hassan Boukcim, Marc-Andre Selosse, Marc Ducousso
Summary: Growing pressure from climate change and agricultural land use is destabilizing soil microbial community interactions. Little is known about microbial community resistance and adaptation to disturbances, hindering our understanding of recovery latency and implications for ecosystem functioning. This study found that anthropic disturbance and natural disturbance have different effects on the topology and stability of soil microbial networks.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yunhao Li, Yali Feng, Haoran Li, Yisong Yao, Chenglong Xu, Jinrong Ju, Ruiyu Ma, Haoyu Wang, Shiwei Jiang
Summary: Deep-sea mining poses a serious threat to marine ecosystems and human health by disturbing sediment and transmitting metal ions through the food chain. This study developed a new regenerative adsorption material, OMN@SA, which effectively removes metal ions. The adsorption mechanism and performance of the material for metal ion fixation were investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Antonio Medici, Margherita Lavorgna, Marina Isidori, Chiara Russo, Elena Orlo, Giovanni Luongo, Giovanni Di Fabio, Armando Zarrelli
Summary: Valsartan, a widely used antihypertensive drug, has been detected in high concentrations in surface waters due to its unchanged excretion and incomplete degradation in wastewater treatment plants. This study investigated the degradation of valsartan and identified 14 degradation byproducts. The acute and chronic toxicity of these byproducts were evaluated in key organisms in the freshwater trophic chain.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jiang Lin, Lianbao Chi, Qing Yuan, Busu Li, Mingbao Feng
Summary: This study investigated the photodegradation behavior and product formation of two representative pharmaceuticals in simulated estuary water. The study found that the formed transformation products of these pharmaceuticals have potential toxicity on marine organisms, including oxidative stress and damage to cellular components.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Hua Fang, Dongdong Jiang, Ye He, Siyi Wu, Yuehong Li, Ziqi Zhang, Haoting Chen, Zixin Zheng, Yan Sun, Wenxiang Wang
Summary: This study revealed that exposure to lower levels of air pollutants led to decreased pregnancy rates, with PM10, NO2, SO2, and CO emerging as the four most prominent pollutants. Individuals aged 35 and above exhibited heightened susceptibility to pollutants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Ali Shaan Manzoor Ghumman, Rashid Shamsuddin, Amin Abbasi, Mohaira Ahmad, Yoshiaki Yoshida, Abdul Sami, Hamad Almohamadi
Summary: In this study, inverse vulcanized polysulfides (IVP) were synthesized by reacting molten sulfur with 4-vinyl benzyl chloride, and then functionalized using N-methyl D-glucamine (NMDG). The functionalized IVP showed a high mercury adsorption capacity and a machine learning model was developed to predict the amount of mercury removed. Furthermore, the functionalized IVP can be regenerated and reused, providing a sustainable and cost-effective adsorbent.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Rita Bonfiglio, Renata Sisto, Stefano Casciardi, Valeria Palumbo, Maria Paola Scioli, Erica Giacobbi, Francesca Servadei, Gerry Melino, Alessandro Mauriello, Manuel Scimeca
Summary: This study investigated the presence of aluminum in human colon cancer samples and its potential association with biological processes involved in cancer progression. Aluminum was found in tumor areas of 24% of patients and was associated with epithelial to mesenchymal transition (EMT) and cell death. Additional analyses revealed higher tumor mutational burden and mutations in genes related to EMT and apoptosis in aluminum-positive colon cancers. Understanding the molecular mechanisms of aluminum toxicity may improve strategies for the management of colon cancer patients.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
