Sumoylation of hypoxia inducible factor-1α and its significance in cancer

Cbx4 Governs HIF-1α to Potentiate Angiogenesis of Hepatocellular Carcinoma by Its SUMO E3 Ligase Activity

(2014) Jie Li et al.   CANCER CELL

Polycomb chromobox 4 enhances migration and pulmonary metastasis of hepatocellular carcinoma cell line MHCC97L

(2014) Zhu Mei et al.   Science China-Life Sciences

Chromobox Homolog 4 Is Correlated with Prognosis and Tumor Cell Growth in Hepatocellular Carcinoma

(2013) Boqing Wang et al.   ANNALS OF SURGICAL ONCOLOGY

HIF1A Employs CDK8-Mediator to Stimulate RNAPII Elongation in Response to Hypoxia

(2013) Matthew D. Galbraith et al.   CELL

What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer

(2013) J.-A. Losman et al.   GENES & DEVELOPMENT

Hypoxic retinal Müller cells promote vascular permeability by HIF-1–dependent up-regulation of angiopoietin-like 4

(2013) Xiaoban Xin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

(R)-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible

(2013) J.-A. Losman et al.   SCIENCE

Metabolic alteration in tumorigenesis

(2013) Hui Yang et al.   Science China-Life Sciences

Down-regulation of SENP1 Expression Increases Apoptosis of Burkitt Lymphoma Cells

(2012) Bin-Bin Huang et al.   Asian Pacific Journal of Cancer Prevention

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

HIF-1α downregulates miR-17/20a directly targeting p21 and STAT3: a role in myeloid leukemic cell differentiation

(2012) M He et al.   CELL DEATH AND DIFFERENTIATION

SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors

(2012) Marco Montagner et al.   NATURE

SUMO-specific protease 1 promotes prostate cancer progression and metastasis

(2012) Q Wang et al.   ONCOGENE

Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression

(2012) W. Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Passing the baton: the HIF switch

(2012) Mei Yee Koh et al.   TRENDS IN BIOCHEMICAL SCIENCES

Hallmarks of cancer: of all cancer cells, all the time?

(2012) Sébastien L. Floor et al.   TRENDS IN MOLECULAR MEDICINE

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

(2011) Eric V. Dang et al.   CELL

Synergistic Induction of Galectin-1 by CCAAT/Enhancer Binding Protein α and Hypoxia-inducible Factor 1α and Its Role in Differentiation of Acute Myeloid Leukemic Cells

(2011) Xu-Yun Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia inducible factor-1 mediates expression of galectin-1: the potential role in migration/invasion of colorectal cancer cells

(2010) Xu-Yun Zhao et al.   CARCINOGENESIS

SENP1 Induces Prostatic Intraepithelial Neoplasia through Multiple Mechanisms

(2010) Tasneem Bawa-Khalfe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overexpression of SUMO-1 in hepatocellular carcinoma: a latent target for diagnosis and therapy of hepatoma

(2010) Wu-hua Guo et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

The SUMO E3 Ligase Activity of Pc2 Is Coordinated through a SUMO Interaction Motif

(2010) S. h. Yang et al.   MOLECULAR AND CELLULAR BIOLOGY

Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α

(2010) Ji-Hong Lim et al.   MOLECULAR CELL

HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase

(2010) Ataman Sendoel et al.   NATURE

PIASy stimulates HIF1α SUMOylation and negatively regulates HIF1α activity in response to hypoxia

(2010) X Kang et al.   ONCOGENE

A Role for Non-Covalent SUMO Interaction Motifs in Pc2/CBX4 E3 Activity

(2010) Jacqueline C. Merrill et al.   PLoS One

SUMO-dependent regulation of centrin-2

(2009) U. R. Klein et al.   JOURNAL OF CELL SCIENCE

Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

(2009) G. Bellot et al.   MOLECULAR AND CELLULAR BIOLOGY

Direct Binding of CoREST1 to SUMO-2/3 Contributes to Gene-Specific Repression by the LSD1/CoREST1/HDAC Complex

(2009) Jian Ouyang et al.   MOLECULAR CELL

Proteomics-based identification of two novel direct targets of hypoxia-inducible factor-1 and their potential roles in migration/invasion of cancer cells

(2009) Shi-Hua Liao et al.   PROTEOMICS

Accumulation of hypoxia-inducible factor-1  protein and its role in the differentiation of myeloid leukemic cells induced by all-trans retinoic acid

(2008) J. Zhang et al.   HAEMATOLOGICA

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL