Journal
SCIENCE CHINA-LIFE SCIENCES
Volume 57, Issue 8, Pages 845-851Publisher
SCIENCE PRESS
DOI: 10.1007/s11427-014-4710-6
Keywords
diabetic vascular complications; metabolic memory; oxidative stress; inflammation; epigenetic modifications
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Funding
- National Natural Science Foundation of China [91339103]
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In the past decades, a persistent progression of diabetic vascular complications despite reversal of hyperglycemia has been observed in both experimental and clinical studies. This durable effect of prior hyperglycemia on the initiation and progression of diabetic vasculopathies was defined as metabolic memory. Subsequently, enhanced glycation of cellular proteins and lipids, sustained oxidative stress, and prolonged inflammation were demonstrated to mediate this phenomenon. Recently, emerging evidence strongly suggests that epigenetic modifications may account for the molecular and phenotypic changes associated with hyperglycemic memory. In this review, we presented an overview on the discovery of metabolic memory, the recent progress in its molecular mechanisms, and the future implications related to its fundamental research and clinical application.
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