Journal
SCIENCE CHINA-LIFE SCIENCES
Volume 57, Issue 2, Pages 248-255Publisher
SCIENCE PRESS
DOI: 10.1007/s11427-013-4603-0
Keywords
esophagus; re-epithelialization; re-vascularization; muscle regeneration; copper; small intestinal submucosa
Categories
Funding
- National Natural Science Foundation of China [31271058, 81100327]
- National High Technology Research and Development Program of China [2012AA020503]
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Acellular porcine small intestinal submucosa (SIS) has been used for esophagoplasty with success in a canine model. However, it did not lead to complete epithelialization. For better reconstruction, a cellular component is required. Moreover, promotion of angiogenesis with copper has been widely recognized by basic research as well as clinical studies. In this study, we have evaluated the feasibility and effectiveness of combined Cu and SIS (SIS-Cu patch) for the esophageal repair using a canine model. Eighteen male beagle dogs were subjected to surgical resection to produce cervical esophageal defects (5 cm in length, 180A degrees in range). SIS with Cu (5 or 25 mu mol L-1 copper) or without Cu was patched on the esophageal defects. Barium esophagram and histology exam were carried out to evaluate the effectiveness of the therapy. As shown, the SIS-Cu graft promoted re-epithelialization, re-vascularization and muscular regeneration. SIS-Cu patch is more effective than SIS alone for esophageal repair, and the SIS+25 mu mol L-1 Cu group demonstrated additional advantages over the SIS+5 mu mol L-1 Cu.
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