Review
Medicine, Research & Experimental
Yan Yang, Yingying Huang, Wu Lin, Jin Liu, Xiangliu Chen, Chuanzhi Chen, Xiongfei Yu, Lisong Teng
Summary: Gastric cancer has a significant impact on the quality of life and survival of patients. The correlation between the microbiota and gastric cancer has been widely studied, but the specific mechanism of its impact remains unclear. Recent studies have shown that the microbiota can affect the occurrence and development of gastric cancer by influencing the expression of miRNAs. This paper presents all available data on miRNAs, microbiota, and gastric cancer, and provides a preliminary description of their relationship.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Yanxuan Xiao, Hangfan Zhou, Lu Jiang, Rui Liu, Qianming Chen
Summary: Taste is mediated by specialized neuroepithelial cells called taste receptor cells located at tongue papillae. Ion channels play a crucial role in various cell physiological activities, while epigenetic modifications regulate gene expression without altering DNA sequence.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Immunology
Guillaume St-Cyr, Daphne Penarroya, Lauren Daniel, Hugo Giguere, Almohanad A. A. Alkayyal, Lee-Hwa Tai
Summary: MiRNAs play important roles in the tumor microenvironment by silencing gene expression. They are dysregulated in cancer and have become attractive therapeutic targets. MiRNAs can improve oncolytic viruses by enhancing viral oncolysis, tumor suppression, and immune modulation. On the other hand, oncolytic viruses can overcome the limitations of miRNA-based therapies by delivering therapeutic payloads directly into the tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Teresa Gagliano, Claudio Brancolini
Summary: This review article delves into the communication between cancer cells and non-cancerous cells, focusing on the role of epigenetics in cell-cell interactions. Studies suggest that epigenetic regulations are closely linked to tumor-stroma interactions, which could be crucial for future cancer therapy design.
Review
Oncology
Faheem Hyder Pottoo, Ashif Iqubal, Mohammad Kashif Iqubal, Mohammed Salahuddin, Jawad Ur Rahman, Noora AlHajri, Mustafa Shehadeh
Summary: miRNAs can modulate multiple signaling pathways of the immune system, aiding in cancer diagnosis and treatment to reduce immune escape. Although immunotherapy holds promise for cancer treatment, it faces challenges like high treatment costs, unpredictable toxicity, and uncertain clinical outcomes.
Article
Medical Laboratory Technology
Xinlei Zou, Ziyue Huang, Canghai Guan, Wujiang Shi, Jianjun Gao, Jiangang Wang, Yunfu Cui, Mei Wang, Yi Xu, Xiangyu Zhong
Summary: Pancreatic cancer (PC) is highly aggressive with a poor prognosis. The tumor microenvironment (TME) of PC is complex and diverse. Various cellular components in the microenvironment secrete different substances that promote tumor development. These substances can be released via exosomes, which are abundant extracellular vesicles (EVs) capable of carrying factors and enabling intercellular communication. MiRNAs are involved in regulating pathological and physiological processes and can be transported by exosomes to regulate the TME. Exosomal miRNAs hold promise as future targets for PC diagnosis and prognosis, offering potential new treatment strategies.
CLINICA CHIMICA ACTA
(2023)
Review
Oncology
Yirizhati Aili, Nuersimanguli Maimaitiming, Yusufu Mahemuti, Hu Qin, Yongxin Wang, Zengliang Wang
Summary: Gliomas are central nervous system tumors with poor prognosis, where exosomal miRNA plays a significant role in their occurrence, development, invasion, metastasis, and treatment resistance. Further systematic research on the association of exosomal miRNA in gliomas is needed for innovative diagnosis and treatment approaches.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Asmita Parab, Lokesh Kumar Bhatt, Abdelwahab Omri
Summary: Immunotherapy shows promise in cancer treatment, but challenges remain such as partial response, resistance, and toxicities. Combining immunotherapy with other therapeutic approaches is a potential solution. Aberrant epigenetic modifications play a role in carcinogenesis, immune cell functioning, and targeting these mechanisms could enhance the antitumor effect. Recent advancements in potent epigenetic drugs and immunomodulators offer hope for this combination therapy.
Review
Immunology
Gabriela M. Wiedemann
Summary: This review focuses on the epigenetic regulation of NK cell functionality and plasticity in different tissue and tumor microenvironments, which is crucial for the development of NK cell-based cancer therapies.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Ken Maes, Anna Mondino, Juan Jose Lasarte, Xabier Agirre, Karin Vanderkerken, Felipe Prosper, Karine Breckpot
Summary: Cancer cells can evade the immune system through epigenetic alterations, but epigenetic modulating agents have the potential to restore immunological fitness and overcome peripheral tolerance to transformed cells. By acting on both cancer cells and immune cells, EMAs represent interesting strategies for combinatorial therapies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Bianca Vezzani, Marianna Carinci, Maurizio Previati, Stefania Giacovazzi, Mario Della Sala, Roberta Gafa, Giovanni Lanza, Mariusz R. Wieckowski, Paolo Pinton, Carlotta Giorgi
Summary: Epigenetics refers to a group of dynamic, reversible, and heritable modifications within cells that are not caused by gene mutations. These modifications are highly influenced by the surrounding environment and the internal microenvironments of tissues and cells. Understanding the interaction between the tumor microenvironment and cancer cells in terms of epigenetic networks may reveal new targetable mechanisms to prevent tumor progression.
Review
Oncology
Madhumathy G. Nair, Vidya M. Somashekaraiah, Vishakha Ramamurthy, Jyothi S. Prabhu, T. S. Sridhar
Summary: MicroRNA plays a crucial role in regulating the complex process of breast cancer metastasis through altering tumor cells' phenotype and tumor microenvironment, influencing the multi-step progression from carcinogenesis to organotropism. This review focuses on the compelling role of miRNAs in breast cancer metastasis.
EXPERIMENTAL CELL RESEARCH
(2021)
Review
Oncology
Jiayu Zhao, Mei Li, Jiao Xu, Wei Cheng
Summary: Ion channels play a crucial role in regulating ion balance, generating electrical and chemical signals, and their dysfunction is associated with cancer and cancer chemo-resistance.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Jiehan Li, Haolin Bao, Ziyue Huang, Zixin Liang, Mei Wang, Ning Lin, Chunjie Ni, Yi Xu
Summary: Hepatocellular carcinoma (HCC) is a highly lethal and aggressive cancer with increasing incidence. Understanding the pathogenesis of HCC and identifying reliable therapeutic targets are essential for improving patient survival. MiRNAs, non-coding RNAs involved in gene regulation, have been extensively studied in HCC and are involved in various HCC-related processes. The expression status of miRNAs also plays a role in drug resistance mechanisms in HCC, with important implications for systemic treatment.
FRONTIERS IN ONCOLOGY
(2023)
Review
Cell Biology
Hera Hasan, Mohammad Afzal, Javier S. Castresana, Mehdi H. Shahi
Summary: Glioblastoma, a highly aggressive brain tumor originating from glial cells, has a maximum life expectancy of 14.6 months. Despite multiple promising therapies, clinical outcomes for glioblastoma patients are poor due to drug resistance. Epigenetic modification, particularly DNA methylation, and miRNAs have been identified as major factors in glioblastoma progression and drug resistance. This review aims to explore the role of known miRNAs in glioblastoma, how epigenetic modification affects their expression, and their potential as predictors of treatment response.
Article
Environmental Sciences
Yu Yan, Guang Wang, Ju Huang, Yan Zhang, Xin Cheng, Manli Chuai, Beate Brand-Saberi, Guobing Chen, Xiaohua Jiang, Xuesong Yang
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2020)
Article
Cell Biology
Minyue Zhao, Jieting Zhang, Wenqing Huang, Jianda Dong, Jinghui Guo, Kin U. Pong, ZhiHui Weng, Si Liu, Hsiao Chang Chan, Hua Feng, Xiaohua Jiang
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2020)
Article
Cell & Tissue Engineering
Hailong Liu, Biao Huang, Shaolong Xue, Kin U. Pong, Lai Ling Tsang, Xiaohu Zhang, Gang Li, Xiaohua Jiang
STEM CELL RESEARCH & THERAPY
(2020)
Article
Orthopedics
Yonghui Hou, Weiping Lin, Ying Li, Yuxin Sun, Yamei Liu, Chen Chen, Xiaohua Jiang, Gang Li, Liangliang Xu
Summary: The study showed that mir-92b could promote osteogenesis of MSCs and accelerate fracture healing. In vivo experiments confirmed the potential of De-Os-MSCs in bone regeneration.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2021)
Article
Pharmacology & Pharmacy
Denglu Long, Meng Liu, Haiyang Li, Jinhuan Song, Xiaohua Jiang, Guang Wang, Xuesong Yang
Summary: The study identified that the suppression of neurogenesis induced by dysbacteriosis-derived LPS could be significantly reversed through fecal microbiota transplantation. This suggests that gut dysbacteriosis impairs embryonic neurogenesis. The NF-kappa B/IL-6 pathway may be one of the main factors triggering the downstream signaling cascade.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Boning Niu, Jie Liu, Ben Lv, Jiacheng Lin, Xin Li, Chunxiao Wu, Xiaohua Jiang, Zhiping Zeng, Xiao-kun Zhang, Hu Zhou
Summary: The study unveils the intricate interplay between nuclear receptor Nur77 and Transforming Growth Factor-beta (TGF β) in regulating ID1 expression at both transcriptional and post-translational levels, which is relevant to colon cancer stemness, metastasis, and resistance to oxaliplatin. ID1 serves as an oncogene for colorectal cancer, and the findings shed light on the paradoxical roles of TGF β and Nur77 in colon cancer progression.
NATURE COMMUNICATIONS
(2021)
Review
Cell Biology
Weiping Lin, Shuxun Chen, Yan Wang, Ming Wang, Wayne Yuk-Wai Lee, Xiaohua Jiang, Gang Li
Summary: Cellular therapy shows potential for curing various diseases. Adult stem cells in dynamic niches play a crucial role in tissue homeostasis, with mitochondrial-mediated mechanisms responsible for their diversity and tissue repair abilities. Understanding mitochondrial dynamics in stem cells could lead to novel strategies for anti-aging interventions and healthy aging.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Zhihui Weng, Jiacheng Lin, Jiaozi He, Lin Gao, Sien Lin, Lai Ling Tsang, Hang Zhang, Xiaoyan He, Guang Wang, Xuesong Yang, Hu Zhou, Hui Zhao, Gang Li, Lin Zou, Xiaohua Jiang
Summary: The study found that MYCN regulates the expression of CD55 gene, and high expression of CD55 is associated with poor prognosis in MYCN-amplified neuroblastoma. CD55 promotes tumor growth and cancer stemness through the regulation of the JNK pathway. Targeting CD55 with neutralizing antibodies effectively inhibits tumor growth and improves survival.
Article
Clinical Neurology
Shanshan Bai, Xuan Lu, Qi Pan, Bin Wang, Kin U. Pong, Yongkang Yang, Haixing Wang, Sien Lin, Lu Feng, Yan Wang, Yucong Li, Weiping Lin, Yujia Wang, Xiaoting Zhang, Yuan Li, Linlong Li, Zhengmeng Yang, Ming Wang, Wayne Yuk-Wai Lee, Xiaohua Jiang, Gang Li
Summary: This study investigates the role of cranial bone transport (CBT) in the recovery of ischemic stroke using an MCAO rat model. The results show that CBT treatment reduces ischemic lesion areas, improves neurological deficits, promotes angiogenesis and neurogenesis, and improves meningeal lymphatic drainage function. These findings provide evidence for the mechanisms of how CBT attenuates ischemic stroke injury and facilitates rapid neuronal function recovery.
Article
Medicine, Research & Experimental
Jiawei Huang, Kin U. Pong, Fuyuan Yang, Zeyuan Ji, Jiacheng Lin, Zhihui Weng, Lai Ling Tsang, Tobias D. Merson, Ye Chun Ruan, Chao Wan, Gang Li, Xiaohua Jiang
Summary: The use of hPSC-EMSCs shows potential as a treatment avenue for HIE, as they exhibit higher neuroprotective effects compared to hUC-MSCs. These stem cells promote endogenous neurogenesis, alleviate astrogliosis and microgliosis, and enhance brain functional recovery in rats with HIE.
Article
Biochemistry & Molecular Biology
Aaron Mendez-Bermudez, Liudmyla Lototska, Melanie Pousse, Florent Tessier, Oliver Croce, Chrysa M. Latrick, Veronica Cherdyntseva, Joe Nassour, Jiang Xiaohua, Yiming Lu, Corinne Abbadie, Sarantis Gagos, Jing Ye, Eric Gilson
Summary: Cellular senescence triggers various types of heterochromatin remodeling, including decondensation, DNA damage, and illegitimate recombination. In this study, it was discovered that at the onset of senescence, pericentromeric heterochromatin is specifically dismantled due to telomere shortening or genotoxic stress. This process is initiated by the TP53-TRF2 axis and involves the downregulation of TRF2, resulting in heterochromatin decondensation and DNA breaks.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Multidisciplinary Sciences
Philip Chiu-Tsun Tang, Jeff Yat-Fai Chung, Jinyue Liao, Max Kam-Kwan Chan, Alex Siu-Wing Chan, Guangyao Cheng, Chunjie Li, Xiao-Ru Huang, Calvin Sze -Hang Ng, Eric W. -F Lam, Dongmei Zhang, Yi-Ping Ho, Ka-Fai To, Kam -Tong Leung, Xiaohua Jiang, Ho Ko, Tin -Lap Lee, Hui-Yao Lan, Patrick Ming-Kuen Tang
Summary: This study discovered a direct mechanism of tumor-associated macrophage (TAM) for promoting de novo neurogenesis, which contributes to a better understanding of tumor innervation. The study also identified a phenomenon of macrophage to neuron-like cell transition (MNT) and identified a crucial regulator for MNT. This finding has potential clinical significance for the treatment of cancer pain.
Review
Cell Biology
Zoey Zeyuan Ji, Max Kam-Kwan Chan, Alex Siu-Wing Chan, Kam-Tong Leung, Xiaohua Jiang, Ka-Fai To, Yi Wu, Patrick Ming-Kuen Tang
Summary: Tumour-Associated Macrophages (TAMs) are a key component of the tumour microenvironment, with complex roles in cancer immunity. TAMs can exhibit both pro-tumour and anti-cancer activities. Advanced single-cell technology has revealed novel dedifferentiation phenomena of TAMs. Additionally, TAMs show potential in cancer immunotherapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Oncology
Guang Wang, Jia-Qi Lu, Yong Ding, Tonghua Zhang, Jin-Huan Song, Denglu Long, Jianxin Liang, Xin Cheng, Zhenpeng Si, Guolong Qi, Xiaohua Jiang, Xuesong Yang
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2020)
Article
Multidisciplinary Sciences
Biao Huang, Bin Wang, Wayne Yuk-Wai Lee, Kin U. Pong, Kam Tong Leung, Xican Li, Zhenqing Liu, Rui Chen, Jia Cheng Lin, Lai Ling Tsang, Baohua Liu, Ye Chun Ruan, Hsiao Chang Chan, Gang Li, Xiaohua Jiang