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Multidisciplinary Sciences
Oguzhan Baltaci, Mikael Egebjerg Pedersen, Tessa Sherry, Ava Handley, Goda Snieckute, Wei Cao, Matilda Haas, Stuart Archer, Roger Pocock
Summary: Coordinated expression of cell adhesion and signaling molecules is crucial for brain development. This study found that SMA-6 acts independently of DAF-4 to control neuronal guidance by limiting the expression of NLR-1.
Review
Cell Biology
Junichi Yuasa-Kawada, Mariko Kinoshita-Kawada, Yoshio Tsuboi, Jane Y. Wu
Summary: Neurons migrate and extend axons to their synaptic targets by sensing extracellular cues. Guidance genes play critical roles in neural development and also regulate cell migration and communication outside the nervous system. Understanding the signaling mechanisms of guidance genes and their involvement in human diseases is important for therapeutic potentials in neural repair.
Review
Cell Biology
Eloisa Herrera, Augusto Escalante
Summary: The development of the nervous system involves neurogenesis, neuronal specification, axonal navigation, and circuits assembly. The growth cone located at the tip of the axon plays a crucial role in guiding axons towards their final targets. The transcriptional control and epigenetic regulation of axon guidance molecules are important for determining specific axonal behaviors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Greta Limoni
Summary: The establishment and maintenance of neuronal circuits involve genetic regulations and environmental factors, maintaining a homeostatic balance throughout the lifespan. These processes include dendritic arborization, synaptic contact formation, and refinement.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Juan Antonio Moreno Bravo, Quentin Rappeneau, Sergi Roig-Puiggros, Constantino Sotelo, Alain Chedotal
Summary: Inferior olivary neurons in the dorsal hindbrain migrate toward the ventral midline and project into the contralateral cerebellum. The absence of the axon guidance receptor Robo3 results in migration delay and opposite direction of migration in the absence of axon guidance.
JOURNAL OF COMPARATIVE NEUROLOGY
(2022)
Article
Neurosciences
Emilia Asante, Devynn Hummel, Suman Gurung, Yasmin M. Kassim, Noor Al-Shakarji, Kannappan Palaniappan, Vinoth Sittaramane, Anand Chandrasekhar
Summary: Precise positioning of neurons during development is crucial for normal brain function, while disrupted neuronal migration can lead to neurological disorders. A study on zebrafish mutants with defective neuronal positioning revealed subtle defects in fasciculation and neuronal activity, potentially resulting in defective functional outputs.
FRONTIERS IN NEURAL CIRCUITS
(2021)
Article
Biochemistry & Molecular Biology
Silvia Vicenzi, Lisa Foa, Robert J. Gasperini
Summary: The neurotransmitter serotonin can act as both an attractive and repulsive guidance cue for rodent sensory neurons in vitro, with extracellular gradients of 50 mu M serotonin inducing attraction mediated by the serotonin 5-HT2a receptor and 100 mu M serotonin inducing repulsion mediated by the 5-HT1b receptor. High resolution imaging of growth cones showed that these receptors signal through their canonical pathways to shape neuronal circuit formation during development.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Giorgia Scapin, Matteo Gasparotto, Daniele Peterle, Simone Tescari, Elena Porcellato, Alberto Piovesan, Irene Righetto, Laura Acquasaliente, Vincenzo De Filippis, Francesco Filippini
Summary: The discovery of conserved protein motifs can reveal important regulatory signals, and synthetic peptides derived from such motifs can be used as biomimetics for biotechnological and therapeutic purposes. Specific Ig-like repeats from neuronal Cell Adhesion Molecules share a highly conserved Neurite Outgrowth and Guidance (NOG) motif, which can boost neurite formation.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Article
Anatomy & Morphology
Isabel M. Garcia-Guillen, Antonia Alonso, Luis Puelles, Faustino Marin, Pilar Aroca
Summary: The interpeduncular nucleus (IPN) is a highly conserved limbic structure in the vertebrate brain, composed of different populations that play roles in neuron development, cell morphogenesis, and axon guidance. Genes expressed within the IPN were found to be associated with specific functions, including overrepresented gene families related to neuron development, cell morphogenesis, and axon guidance. Interactome analysis revealed networks involving ephrin/Eph and Cadherin family members, transcription factors, and molecules related to synaptic neurotransmission within each IPN domain.
FRONTIERS IN NEUROANATOMY
(2021)
Article
Cell Biology
Manuela D. Mitsogiannis, Anna Pancho, Tania Aerts, Sonja M. Sachse, Ria Vanlaer, Lut Noterdaeme, Dietmar Schmucker, Eve Seuntjens
Summary: DSCAMs are involved in various neurodevelopmental processes, and their malfunction can lead to disorders such as Fragile X syndrome, intellectual disability, autism, and bipolar disorder. While Dscam and Dscaml1 knockout did not significantly affect developmental events in mice, gain of function experiments showed negative impacts on neural migration processes important for cortical development. This highlights the importance of genes encoding adhesive cues in neuronal migration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Neurosciences
Bekir Altas, Andrea J. Romanowski, Garrett W. Bunce, Alexandros Poulopoulos
Summary: The subcellular localization of mTOR in neurons has significant implications for nervous system development, function, and disease. The model of mTOR outposts suggests that localized signaling is selected and amplified through these structures.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Hui-Lin Liu, Xiu-Min Lu, Hai-Yan Wang, Kai-Bin Hu, Qing-Yun Wu, Ping Liao, Sen Li, Zai-Yun Long, Yong-Tang Wang
Summary: Alternative pre-mRNA splicing, regulated by specific RNA-binding proteins, produces mRNA isoforms with distinct structures and functions from a single gene, and abnormal splicing mis-regulation is associated with various neurological diseases. Polypyrimidine tract binding protein 1 (PTBP1) is a well-known splicing regulator that affects neuronal development through its involvement in axon formation, synaptogenesis, and neuronal apoptosis. This study summarizes the mechanism of alternative splicing, structure and function of PTBP1, and the role of PTBP1-regulated alternative splicing events in axon formation, synaptogenesis, and neuronal apoptosis, aiming to reveal the mechanism of PTBP1-regulated changes in neuronal development process.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2023)
Review
Anatomy & Morphology
Jennifer N. Jahncke, Kevin M. Wright
Summary: Glycoprotein dystroglycan plays a crucial role in connecting the extracellular matrix to the actin cytoskeleton in muscles, and also plays an important role in proper nervous system development. Animal models of dystroglycanopathy have been instrumental in uncovering the various roles of dystroglycan in neural circuit development.
DEVELOPMENTAL DYNAMICS
(2023)
Review
Biochemistry & Molecular Biology
Rosa Manzoli, Lorenzo Badenetti, Michela Rubin, Enrico Moro
Summary: This review discusses the crucial role of lysosomes in the regulation of axonal guidance cue delivery, localization, and function, providing evidence to understand the relationship between lysosomal storage disorders and neurodegenerative diseases.
Article
Biochemistry & Molecular Biology
Shutaro Katsurabayashi, Kohei Oyabu, Kaori Kubota, Takuya Watanabe, Tomohisa Nagamatsu, Norio Akaike, Katsunori Iwasaki
Summary: The study found that TND1128 can promote morphological growth of mouse hippocampal neurons, increase the number of excitatory synapses, and provide a new drug treatment approach for improving brain function.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Neurosciences
Ping-ping Zhao, Mao-jin Yao, Si-yuan Chang, Lan-tao Gou, Mo-fang Liu, Zi-long Qiu, Xiao-bing Yuan
Article
Cell Biology
Anand N. Rao, Aditi Falnikar, Eileen T. O'Toole, Mary K. Morphew, Andreas Hoenger, Michael W. Davidson, Xiaobing Yuan, Peter W. Baas
JOURNAL OF CELL BIOLOGY
(2016)
Editorial Material
Cell Biology
Xiao-bing Yuan, Christopher Haas, Itzhak Fischer
NEURAL REGENERATION RESEARCH
(2016)
Article
Multidisciplinary Sciences
Xiao-bing Yuan, Ying Jin, Christopher Haas, Lihua Yao, Kazuo Hayakawa, Yue Wang, Chunlei Wang, Itzhak Fischer
SCIENTIFIC REPORTS
(2016)
Article
Cell Biology
Wenlong Zhao, Zhengzheng Li, Ping Ping, Guishuan Wang, Xiaobing Yuan, Fei Sun
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2018)
Article
Physiology
Huiping Li, Xiaobing Yuan, Jun Tang, Yongjun Zhang
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2012)
Article
Biotechnology & Applied Microbiology
Mao-jin Yao, Gang Chen, Ping-ping Zhao, Ming-hua Lu, Jiang Jian, Mo-fang Liu, Xiao-bing Yuan
Article
Neurosciences
Wang Zheng, An-qi Geng, Peng-Fei Li, Yi Wang, Xiao-bing Yuan
Article
Developmental Biology
Chen-yan Ma, Mao-jin Yao, Qi-wei Zhai, Jian-wei Jiao, Xiao-bing Yuan, Mu-ming Poo
Article
Developmental Biology
Patricia Guijarro, Yi Wang, Yanting Ying, Yini Yao, Xiong Jieyi, Xiaobing Yuan
DEVELOPMENTAL NEUROBIOLOGY
(2013)
Article
Immunology
Lei Ma, Xiao-wei Li, Shi-jun Zhang, Feng Yang, Ge-min Zhu, Xiao-bing Yuan, Wen Jiang
JOURNAL OF NEUROINFLAMMATION
(2014)
Article
Multidisciplinary Sciences
Dong Wang, Liang She, Ya-nan Sui, Xiao-bing Yuan, Yunqing Wen, Mu-ming Poo
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2012)
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Pharmacology & Pharmacy
Bao-Qiang Guo, Chong-Huai Yan, Shi-Zhong Cai, Xiao-Bing Yuan, Xiao-Ming Shen
Article
Neurosciences
Chunlei Wang, Yi-Hsuan Pan, Yue Wang, Gene Blatt, Xiao-Bing Yuan
Review
Cell Biology
Yi-Hsuan Pan, Nan Wu, Xiao-Bing Yuan
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2019)
