Journal
SCIENCE CHINA-CHEMISTRY
Volume 57, Issue 7, Pages 926-929Publisher
SCIENCE PRESS
DOI: 10.1007/s11426-014-5144-5
Keywords
intermolecular Diels-Alder reaction; bio-inspired synthesis; dimerization; terpenoid
Categories
Funding
- Ministry of Science Technology [2013CB836900]
- National Natural Science Foundation of China [21290180, 21172235, 21222202]
- Chinese Academy of Sciences
Ask authors/readers for more resources
The Diels-Alder (D-A) reaction is one of the most powerful reactions in organic synthesis. The intermolecular D-A reaction attracts much less attentions than its intramolecular counterpart in natural product synthesis, possibly due to the issues of reactivity and selectivity. In the past decade, the intermolecular D-A reaction has been increasingly utilized in the total synthesis of structurally complex natural products. In this article, we present a few examples for the elegant applications of the intermolecular D-A reaction that are inspired by biosynthetic hypotheses of the target natural products. These examples demonstrate that D-A reaction is not only useful for preparing building blocks but also powerful for coupling structurally complicated and sterically demanding segments in a highly chemo- and stereo-controlled fashion, which may inspire further developments of intermolecular D-A reaction from both strategy and methodology perspectives.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available