The complexity of G-protein coupled receptor-ligand interactions

Structure-Function of the G Protein–Coupled Receptor Superfamily

(2012) Vsevolod Katritch et al.   Annual Review of Pharmacology and Toxicology

The GPCR Network: a large-scale collaboration to determine human GPCR structure and function

(2012) Raymond C. Stevens et al.   NATURE REVIEWS DRUG DISCOVERY

Orphan GPCRs and Neuromodulation

(2012) Olivier Civelli   NEURON

Biased Signaling Pathways in  2-Adrenergic Receptor Characterized by 19F-NMR

(2012) J. J. Liu et al.   SCIENCE

Structure of a nanobody-stabilized active state of the β2 adrenoceptor

(2011) Søren G. F. Rasmussen et al.   NATURE

Structure and function of an irreversible agonist-β2 adrenoceptor complex

(2011) Daniel M. Rosenbaum et al.   NATURE

Structure of an Agonist-Bound Human A2A Adenosine Receptor

(2011) F. Xu et al.   SCIENCE

Retinal release from opsin in molecular dynamics simulations

(2010) Ting Wang et al.   JOURNAL OF MOLECULAR RECOGNITION

Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor

(2010) Michael P. Bokoch et al.   NATURE

Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

(2010) E. Y. T. Chien et al.   SCIENCE

X-ray structure breakthroughs in the GPCR transmembrane region

(2009) Sid Topiol et al.   BIOCHEMICAL PHARMACOLOGY

Ligand Entry and Exit Pathways in the β2-Adrenergic Receptor

(2009) Ting Wang et al.   JOURNAL OF MOLECULAR BIOLOGY

The structure and function of G-protein-coupled receptors

(2009) Daniel M. Rosenbaum et al.   NATURE

Discovery of New GPCR Biology: One Receptor Structure at a Time

(2009) Michael A. Hanson et al.   STRUCTURE

Ligand-Specific Changes in M3Muscarinic Acetylcholine Receptor Structure Detected by a Disulfide Scanning Strategy†

(2008) Jian Hua Li et al.   BIOCHEMISTRY

Virtual screening of GPCRs: An in silico chemogenomics approach

(2008) Laurent Jacob et al.   BMC BIOINFORMATICS

Dualsteric GPCR targeting: a novel route to binding and signaling pathway selectivity

(2008) Johannes Antony et al.   FASEB JOURNAL

Binding modes of CCR5-targetting HIV entry inhibitors: Partial and full antagonists

(2008) Ting Wang et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

G Protein Coupling and Signaling Pathway Activation by M1 Muscarinic Acetylcholine Receptor Orthosteric and Allosteric Agonists

(2008) R. L. Thomas et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Structure of a β1-adrenergic G-protein-coupled receptor

(2008) Tony Warne et al.   NATURE

Insights into signaling from the β2-adrenergic receptor structure

(2008) Martin Audet et al.   Nature Chemical Biology

Structural diversity of G protein-coupled receptors and significance for drug discovery

(2008) Malin C. Lagerström et al.   NATURE REVIEWS DRUG DISCOVERY

A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic Receptor

(2008) Michael A. Hanson et al.   STRUCTURE

Conformational changes in G-protein-coupled receptors-the quest for functionally selective conformations is open

(2007) C Hoffmann et al.   BRITISH JOURNAL OF PHARMACOLOGY

Orphan GPCR research

(2007) S Chung et al.   BRITISH JOURNAL OF PHARMACOLOGY

Alternative drug discovery approaches for orphan GPCRs

(2007) A LEVOYE   DRUG DISCOVERY TODAY

G-protein-coupled receptors: past, present and future

(2006) Stephen J Hill   BRITISH JOURNAL OF PHARMACOLOGY