Journal
SCIENCE CHINA-CHEMISTRY
Volume 55, Issue 4, Pages 484-493Publisher
SCIENCE PRESS
DOI: 10.1007/s11426-012-4541-x
Keywords
microfluidic; Caenorhabditis elegans; behavior; neurobiology; aging
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Funding
- Chinese Academy of Sciences [KJCX2-YW-H18, YZ200908]
- National Natural Science foundation of China [11161160552]
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Caenorhabditis elegans (C. elegans) is widely adopted as a model organism for a variety of biological studies including development, genetics and neurobiology. Micro-scale microfluidic technology is capable of handling single or populations of C. elegans in high throughput format and allows for the precise spatial and temporal control of their environment, which is well suited for the study of worms in different aspects. in this review, we highlight the recent advances in microfluidic technology for the analysis of worms ranging from behavioral studies to neurobiology. We believe that microfluidic device can further be applied to study the different aspects of worms, extending from fundamental investigation of behavioral dynamics to more complicated biological processes including neurochemistry and learning behaviors.
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