Article
Chemistry, Multidisciplinary
Jing Zhang, Luoxing Yang, Jie Pei, Yanzhang Tian, Jiyang Liu
Summary: A convenient and sensitive reagentless electrochemical immunosensor for the detection of tumor marker CEA has been successfully fabricated. The immunosensor showed high sensitivity and excellent regenerability, making it suitable for early diagnosis of cancer.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Analytical
Dandan Song, Jing Zheng, Nosang Myung, Jingli Xu, Min Zhang
Summary: A sandwich-type electrochemical immunosensor was developed for the detection of CEA, with excellent sensing performance and low detection limit. The magnetic assembly of nanocomposites simplifies further modification process, improving the reliability and reproducibility of the sensor.
Article
Chemistry, Analytical
Angelica Dominguez-Aragon, Erasto Armando Zaragoza-Contreras, Gabriela Figueroa-Miranda, Andreas Offenhausser, Dirk Mayer
Summary: A novel sandwich-type electrochemical immunosensor was developed for the quantitative detection of carcinoembryonic antigen, a significant tumor marker. The immobilization of antibodies was achieved through Au-S bonds using a novel photochemical technique, allowing control over antibody orientation. The SWCNH/Thi/AuNPs nanocomposite acted as a signal tag for detection and signal amplification. The immunoassay demonstrated a linear detection range from 0.001-200 ng/mL with a low detection limit of 0.1385 pg/mL. Carbon nanohorns hold promise as a conductive and binding matrix for signal amplification in clinical diagnostics.
Article
Chemistry, Analytical
Hayati Filik, Asiye Aslihan Avan, Nilay Altas Puntar, Mustafa Ozyurek, Zeynep Banu Gungor, Mine Kucur, Handan Kamis, Diclehan Ali Dicle
Summary: A sensitive sandwich-model immunoassay was designed for simultaneous electrochemical measurement of alphafetoprotein and carcinoembryonic antigen using multiple-label strategy. The immunoassay showed good linear relationship and low detection limits for both analytes. The sandwich-type immunosensor was successfully applied to real serum sample analysis.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Zhe Zhao, Ping Wang, Feng Tang, Yao Wang, Shujun Wang, Qing Liu, Yueyun Li
Summary: Here, an innovative sandwich-type electrochemical immunosensor based on multi-order Rubik's cube-type platinum nickel nanocubes and Au NPs/cPDA NTs was developed for ultrasensitive detection of CEA. The immunosensor exhibited a broad linear range, low detection limit, and excellent selectivity, reproducibility, and stability.
BIOELECTROCHEMISTRY
(2023)
Article
Environmental Sciences
Peng Huang, Lingzhang Meng, Jun Pang, Haiting Huang, Jing Ma, Linlin He, Parnian Amani
Summary: This study successfully developed a label-free electrochemical immunosensor based on a metal-organic framework (MOF)-graphene oxide nanocomposite for the detection of carcinoembryonic antigen (CEA), a tumor marker in lung cancer for early cancer diagnosis. The immunosensor showed improved sensitivity, stability, and selectivity, and demonstrated satisfactory accuracy in detecting CEA in human serum samples. These findings suggest that the prepared CEA immunosensor has potential for clinical applications and analysis of human fluids.
ENVIRONMENTAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Priyanka Singh, Pranav K. Katkar, Umakant M. Patil, Raghvendra A. Bohara
Summary: This study successfully developed an immunosensor for detecting carcinoembryonic antigen by coating silver nanoparticles with silica, improving sensitivity and stability of the reaction with a detection limit of 0.01 ng/mL.
Article
Biochemical Research Methods
Maryam Jozghorbani, Mojtaba Fathi, Sayed Habib Kazemi, Navid Alinejadian
Summary: A label-free electrochemical immunosensor for detecting CEA was developed, which showed promising results for clinical screening through studying the electrochemical behavior of antibody-antigen immune complexes.
ANALYTICAL BIOCHEMISTRY
(2021)
Article
Environmental Sciences
Hongli Yang, Zaihua Zhang, Xiaohong Zhou, Norhefozge Binbr Abe Menen, Omid Rouhi
Summary: In this study, electrochemical immunosensing for monitoring carcinoembryonic antigen (CEA) was successfully achieved by immobilizing the antibody on a thionine, chitosan, or graphene oxide nanocomposite modified electrode. The resulting immunosensor showed exceptional sensitivity and selectivity towards CEA compounds, with a low detection limit of 0.8 pg/mL. The application of the immunosensor in detecting CEA in human serum samples demonstrated high accuracy and consistency with ELISA results.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Linlin Cao, Wen Zhang, Sumei Lu, Chengjie Guo, Peijun Wang, Dantong Zhang, Wanshan Ma
Summary: In this study, a snowflake Cu2S/Pd/CuO nanocomposite was developed to construct an original label-free electrochemical immunosensor for ultrasensitive detection of CEA levels. The immunosensor showed excellent detection performance and potential value for clinical application in detecting human serum samples.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Analytical
Xinmei Song, Huahui Gao, Ruo Yuan, Yun Xiang
Summary: This study developed a label-free and aptamer-based sensitive carcinoembryonic antigen (CEA) detection method, which achieved high sensitivity through cyclic cleavage and catalytic reduction.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Nanoscience & Nanotechnology
Jingxian Li, Hongfen Yang, Ren Cai, Weihong Tan
Summary: A novel sandwich-type immunosensor was developed using Pt@ SnS2 as a matrix and N,B-Eu MOFs as a signal amplifier. The immunosensor showed high sensitivity and selectivity for the detection of CEA. It exhibited excellent ECL performance and stability, making it suitable for real human serum.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Chemistry, Multidisciplinary
Charuksha Walgama, Nikhil Raj
Summary: Nanoparticle-based electrochemical immunosensors show high sensitivity and amplification ability due to their large surface area. Silver nanoparticles (AgNPs) have been widely used in electrochemical sensors for their unique properties. This article describes six approaches for incorporating AgNPs in electrochemical platforms, focusing on the silver-gold galvanic exchange-based detection strategy. These methods utilize AgNP oxidation into Ag+ ions and subsequent electrodeposition of Ag+ ions onto the working electrode. The article also discusses the impact of AgNP size and shape on detection limits and sensitivity, as well as recent developments in lab-on-a-chip immunosensors for Ag-based metalloimmunoassay detection.
CHEMICAL COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Mengmeng Zhang, Lisha Mei, Li Zhang, Xiao Wang, Xiaochen Liao, Xiuwen Qiao, Chenglin Hong
Summary: In this study, Ti3C2 MXene anchored CuAu-LDH two-dimensional hydroxide heterojunctions were fabricated for dual-mode electrochemical immunosensors, improving sensitivity for biomarker detection and demonstrating excellent electrocatalytic activity.
BIOELECTROCHEMISTRY
(2021)
Article
Nanoscience & Nanotechnology
Pushpesh Ranjan, Shalu Yadav, Mohd Abubakar Sadique, Raju Khan, Avanish Kumar Srivastava
Summary: In this study, an electrochemical immunosensor based on a ZrO2-rGO-IL nanocomposite was developed for the detection of CEA breast cancer biomarker. The sensor exhibited high sensitivity and selectivity, and was able to detect CEA in both a broad detection range and serum samples.
ACS APPLIED NANO MATERIALS
(2022)