Journal
SCIENCE
Volume 362, Issue 6412, Pages 319-+Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aao6750
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Funding
- NIH [DA045550, CA199849, GM104960]
- NSF [CCF1518715, 1509794, CMMI-1636136]
- CalBrain
- NantWorks
- Hewlett Packard
- Merkin Family Foundation
- China Scholarship Council
- Directorate For Engineering [1509794] Funding Source: National Science Foundation
- Div Of Electrical, Commun & Cyber Sys [1509794] Funding Source: National Science Foundation
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Detection of analytes by means of field-effect transistors bearing ligand-specific receptors is fundamentally limited by the shielding created by the electrical double layer (the Debye length limitation). We detected small molecules under physiological high-ionic strength conditions by modifying printed ultrathin metal-oxide field-effect transistor arrays with deoxyribonucleotide aptamers selected to bind their targets adaptively. Target-induced conformational changes of negatively charged aptamer phosphodiester backbones in close proximity to semiconductor channels gated conductance in physiological buffers, resulting in highly sensitive detection. Sensing of charged and electroneutral targets (serotonin, dopamine, glucose, and sphingosine-1-phosphate) was enabled by specifically isolated aptameric stem-loop receptors.
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