Review
Medical Laboratory Technology
Giuseppe Lippi, Francois Mullier, Emmanuel J. Favaloro
Summary: D-dimer measurement is important in the diagnosis, exclusion, and prognostication of venous thromboembolism and disseminated intravascular coagulation. Its clinical applications are expanding to include other diseases such as acute aortic dissection, acute intestinal ischemia, and cerebral venous thrombosis, as well as the management of COVID-19.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Endocrinology & Metabolism
Samuel M. Lockhart, Stephen O'Rahilly
Summary: Colchicine, an anti-inflammatory agent commonly used to treat gout, exerts its effects in mice by inducing the hormone GDF-15 in the liver, as demonstrated by Weng et al. in the latest issue of Nature Metabolism.
Editorial Material
Biology
Alexandre Faille, Alan J. Warren
Summary: Understanding how streptomycin binds to the small subunit of the mitoribosome may aid in the development of less toxic derivatives of this antibiotic.
Editorial Material
Biochemistry & Molecular Biology
Simon W. Townsend, Alexis Hervais-Adelman
Summary: The study found that dogs and humans may segment speech in similar ways when listening to it.
Article
Business
Yi-Hou Huang, Woan-lih Liang, Quang-Thai Truong, Yanzhi Wang
Summary: This study found that U.S. listed firms with a higher percentage of old directors are more likely to engage in innovation activities, especially in companies with less experienced board members, low meeting frequency of boards, lower institutional ownership, CEO duality, and/or a less competitive product market.
TECHNOLOGICAL FORECASTING AND SOCIAL CHANGE
(2022)
Editorial Material
Chemistry, Organic
Kevin Lam, Shelley D. Minteer, Darren L. Poole
Summary: Guest editors Kevin Lam, Shelley D. Minteer, and Darren L. Poole introduce the themed issue on synthetic electrochemistry in Organic & Biomolecular Chemistry.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Editorial Material
Pharmacology & Pharmacy
Vega Miguel-Ruano, Juan A. Hermoso
Summary: A recent study by Martelli and colleagues unveiled a new class of antimycobacterials based on N-thio-beta-lactams, with an inhibitory mechanism that provides an unexpected route to combat drug-resistant strains of Mycobacterium tuberculosis. This discovery sheds light on potential alternative approaches to tackle drug resistance in tuberculosis.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Adel B. Alharbi, Ulf Schmitz, Charles G. Bailey, John E. J. Rasko
Summary: Decades of research have identified CTCF as a ubiquitous chromatin organizing factor and master regulator of gene expression, with a newly discovered role in regulating alternative splicing. CTCF's regulation of AS involves mechanisms such as transcriptional elongation, DNA methylation, histone modifications, and splicing factor expression, contributing to the complexity of the transcriptome. Further exploration of CTCF's role in splicing regulation may reveal it as a 'conductor of the splicing orchestra' due to its multiple connections.
NUCLEIC ACIDS RESEARCH
(2021)
Review
Virology
Ruikun Du, Qinghua Cui, Lijun Rong
Summary: Conventional influenza vaccines are limited in effectiveness as the antigenicity of vaccine strains may not always match circulating viruses. Developing universal influenza vaccines targeting highly conserved immunogens provides a promising approach for broader protection.
Review
Pharmacology & Pharmacy
Elliot Medina, David H. Perez, Daniel Antfolk, Vincent C. Luca
Summary: The Notch pathway plays a crucial role in regulating cell fate decisions and has potential applications in cancer therapy and regenerative medicine. Recent advances in understanding the Notch structure and signaling have led to the development of innovative biotechnologies, including inhibitors, activators, and synthetic receptors. However, challenges and opportunities still exist in the clinical development of Notch-based compounds, biologics, and cell therapies.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2023)
Article
Plant Sciences
Min-Rui Wang, Wen-Lu Bi, Li Ren, A-Ling Zhang, Xiao-Yan Ma, Dong Zhang, Gayle M. Volk, Qiao-Chun Wang
Summary: Micrografting is a versatile research method that can be used for studying virus transmission, signaling, and disease resistance screening.
Editorial Material
Oncology
Mario Sznol, Naiyer Rizvi
Summary: Various approaches are being explored to address the unmet medical need in advanced cancer patients who don't respond to immune checkpoint inhibitors. Interleukin-2 (IL-2) has gained attention due to its clinical activity and the ability to engineer variant proteins. Bempegaldesleukin, a modified form of IL-2, didn't improve outcomes in patients with metastatic melanoma and renal carcinoma, raising questions about the efficacy of other IL-2 variants.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Editorial Material
Microbiology
James E. Crowe, Robert H. Carnahan
Summary: The paper provides a comprehensive investigation into the molecular and functional basis of 17D vaccine responses, as well as the differences in antibody neutralization between the 17D and related African lineage strains and contemporary Central/South American strains.
CELL HOST & MICROBE
(2022)
Review
Gastroenterology & Hepatology
Paul N. Brennan, John F. Dillon, Elliot B. Tapper
Summary: Gamma-Glutamyl Transferase plays important roles in antioxidant defense, xenobiotic metabolism, and prediction of mortality across various diseases. It is sensitive for diagnosing liver injury but lacks specificity, and has been widely used for monitoring and research purposes.
LIVER INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Andrea M. Schmidt, Mario J. F. Calvete
Summary: Phthalocyanines, as exquisite compounds with favorable properties, have seen steady growth in applications, particularly in cutting-edge technologies relying on their great photophysical properties. The spotlight remains on phthalocyanines, with many researchers providing vivid reports on their innovative use in photo-applications.