Article
Cell Biology
Juyeun Lee, Michael Nicosia, Justin D. Lathia
Summary: A study demonstrated that combining an antibody-cytokine fusion molecule with chemotherapy can enhance anti-tumor immunity and lead to tumor regression in patients with recurrent glioblastoma and mice.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Review
Engineering, Biomedical
Argus M. Sun, Tyler Hoffman, Bao Q. Luu, Nureddin Ashammakhi, Song Li
Summary: Efforts are focused on refining and adapting in vitro human microphysiological systems for mechanistic studies and drug screening during the COVID-19 pandemic, with emphasis on modeling pathological processes and addressing practical design and fabrication issues in MPS. The role of lung MPS in multi-organ models is discussed, along with the integration of high-throughput screening and artificial intelligence to accelerate drug development for COVID-19 and other infectious diseases.
BIO-DESIGN AND MANUFACTURING
(2021)
News Item
Microbiology
Martin T. Jahn, Ravinash Krishna Kumar
Summary: This article introduces a new method for imaging anaerobic gut bacteria using nanoerobic growth conditions.
NATURE REVIEWS MICROBIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Jingyu Fu, Hailong Qiu, Cherie S. Tan
Summary: Drug discovery is a costly and complex process, and efficient methods are needed to screen potential compounds and remove toxic substances. The liver plays a crucial role in determining drug efficacy and potential side effects. The liver-on-a-chip platform based on microfluidic technology has gained attention for its ability to predict drug metabolism and hepatotoxicity, as well as study pharmacokinetics and pharmacodynamics when combined with other organ-on-chip systems.
Article
Biology
Brad A. Seibel, Alyssa Andres, Matthew A. Birk, Alexandra L. Burns, C. Tracy Shaw, Alexander W. Timpe, Christina J. Welsh
Summary: P-crit is the critical oxygen partial pressure below which an animal's metabolic rate is unsustainable, while alpha reflects the oxygen supply capacity. The relationship between alpha values and metabolic rate is stronger than that between alpha and P-crit, indicating that P-crit is more of a reflection of oxygen supply capacity than hypoxia tolerance.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Zhun Lin, Zhengyu Zou, Zhe Pu, Minhao Wu, Yuanqing Zhang
Summary: The COVID-19 pandemic has accelerated antiviral research, with microfluidic technologies playing a crucial role in SARS-CoV-2 diagnosis and drug development. This review highlights the structure of SARS-CoV-2 and the basics of microfluidic design. It discusses the application of microfluidic devices in SARS-CoV-2 diagnosis, emphasizing their contribution to the manufacturing of accurate, sensitive, low-cost, and user-friendly virus-detection devices. Additionally, it explores the use of organ-on-a-chip and lipid nanoparticles (LNPs) synthesizing chips in antiviral drug screening and mRNA vaccine preparation, showcasing the potential of microfluidic technologies in ongoing research efforts and future viral outbreaks.
ACTA PHARMACEUTICA SINICA B
(2023)
Review
Biotechnology & Applied Microbiology
Xiao Zeng, Qiong Ma, Xue-Ke Li, Li-Ting You, Jia Li, Xi Fu, Feng-Ming You, Yi-Feng Ren
Summary: Lung cancer is a common malignant tumor with high morbidity and mortality. Personalized treatment is necessary for improving survival, and patient-derived organoids (PDOs) have great potential in biomedical applications and personalized treatment. However, the limitations of traditional PDOs, such as poor stability and low throughput, hinder their clinical transformation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Biology
Sung-Min Kang, Do-Hee Kim
Summary: Autophagy, a lysosome-dependent intracellular degradation machinery, is crucial in regulating cellular homeostasis and is associated with various diseases. Recent structural studies and discovery of modulators have identified targeting autophagy as a promising strategy for novel drug development.
Article
Chemistry, Analytical
Jianfeng Tan, Xindi Sun, Jianhua Zhang, Huili Li, Jun Kuang, Lulu Xu, Xinghua Gao, Chengbin Zhou
Summary: In this study, a 3D printed lung chip was successfully constructed to simulate the microenvironment of lung tissue and facilitate coculture of different cells. Compared to 2D well plates, the 3D lung chip showed superior performance in evaluating the effects of EGFR-targeting drugs on tumor cells and provided more accurate predictions of clinical data. The study of primary tumor cells is particularly important as the 3D lung chip can simulate conditions that are closer to the physiological cell microenvironment.
Review
Biochemistry & Molecular Biology
Bellinda Benhamu, Mar Martin-Fontecha, Henar Vazquez-Villa, Maria L. Lopez-Rodriguez, Silvia Ortega-Gutierrez
Summary: Aging, considered a major risk factor for chronic diseases, is being questioned by recent research that suggests removing senescent cells can ameliorate aging phenotype and associated diseases. This opens the door to tailored therapeutic interventions for extending healthspan and treating aging as a chronic disease.
Article
Biophysics
Jiasheng Yan, Ziwei Li, Jiuchuan Guo, Shan Liu, Jinhong Guo
Summary: Organ-on-a-chip (OOC) technology is a powerful tool that can simulate the human microenvironment and synthesize functional units in a fluidic chip. It has great potential in drug development and screening, overcoming the limitations of 2D cell cultures and animal trials. These advancements in technology can reduce the failure rate in clinical trials, lower the cost of drug development, and accelerate the introduction of effective drugs.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Engineering, Environmental
Sheng Yang, Tianyi Zhang, Yiling Ge, Yanping Cheng, Lihong Yin, Yuepu Pu, Zaozao Chen, Geyu Liang
Summary: Nanoplastics in the air pose a threat to respiratory health, especially chronic obstructive pulmonary disease (COPD), but there have been few studies on the impact of nanoplastics on lung injury. Existing models cannot fully understand pollutant-induced COPD. In this study, a lung-on-a-chip model was built to accurately mimic the alveolar-blood barrier and include immune cells. The model demonstrated that polystyrene nanoplastics (PS-NPs) can harm the barrier, induce oxidative damage and inflammation, and increase the risk of COPD.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Review
Materials Science, Biomaterials
Yashi Sisodia, Komal Shah, Adil Ali Sayyed, Meenakshi Jain, Syed Ansar Ali, Piyush Gondaliya, Kiran Kalia, Rakesh Kumar Tekade
Summary: Respiratory diseases have high mortality rates due to a lack of personalized or sufficient therapeutic interventions. The lung-on-chip microfluidic simulator, which mimics the complexities of the human body, holds great potential for managing pulmonary threats. This review discusses the emerging roles of these devices in translational pulmonary drug discovery and personalized medicine, as well as how they emulate the breathing patterns, elasticity, and vascularization of lungs in a 3D pulmonary microenvironment.
BIOMATERIALS SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Simona Musella, Giulio Verna, Alessio Fasano, Simone Di Micco
Summary: Artificial intelligence methods, particularly machine learning, play a crucial role in drug development from structural design to clinical trials. These methods utilize large data sets and new ways of interpreting information to identify patterns for study scope.
CURRENT MEDICINAL CHEMISTRY
(2021)
Review
Biotechnology & Applied Microbiology
Leqing Zhu, Jianhua Zhang, Quanwei Guo, Jun Kuang, Dongfang Li, Mengxi Wu, Yijun Mo, Tao Zhang, Xinghua Gao, Jianfeng Tan
Summary: Lung cancer has high recurrence rate, easy metastasis, and drug resistance, requiring personalized diagnostic and treatment strategies. Innovative three-dimensional culture systems such as organoids and organ-on-a-chip models offer new opportunities for lung cancer research. These systems can mimic the pathological and physiological microenvironment of the lung, holding important implications for lung cancer research and drug evaluation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
