Article
Oncology
Heba Alshaker, Ewan Hunter, Matthew Salter, Aroul Ramadass, Willem Westra, Mathias Winkler, Jayne Green, Alexandre Akoulitchev, Dmitri Pchejetski
Summary: Three-dimensional chromosome loop conformations play a significant role in gene expression regulation. In this study, specific chromosome conformations were detected in circulating cells of prostate cancer patients, showing a potential horizontal transfer of chromosome conformations.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Norma B. Bulamu, Christine Mpundu-Kaambwa, Michael O'Callaghan, Billingsley Kaambwa
Summary: The purpose of this study was to assess the construct validity and responsiveness of EPIC-26 relative to SF-6D and AQoL-6D in prostate cancer patients. The findings showed moderate convergent validity between EPIC-26 and both AQoL-6D and SF-6D at both timepoints, and EPIC-26 was more responsive compared to AQoL-6D and SF-6D. Therefore, EPIC-26 can be used in cost-effectiveness analyses.
Review
Biochemistry & Molecular Biology
Belen Congregado, Ines Rivero, Ignacio Osman, Carmen Saez, Rafael Medina Lopez
Summary: The introduction of PARP inhibitors in prostate cancer treatment is a significant milestone, as it represents the first approval of drugs based on the concept of synthetic lethality for this disease. It also marks the inclusion of genetic mutation tests in the therapeutic algorithm, advancing the precision and personalized treatment of prostate cancer. This review aims to provide comprehensive insights into the mechanism of action, patient selection, pivotal studies, and ongoing trials of PARP inhibitors.
Article
Oncology
Jean A. Shapiro, Ashwini Soman, Zahava Berkowitz, Stacey A. Fedewa, Susan A. Sabatino, Janet S. de Moor, Tainya C. Clarke, V. Paul Doria-Rose, Erica S. Breslau, Ahmedin Jemal, Marion R. Nadel
Summary: In 2018, an estimated 66.9% of U.S. adults aged 50-75 had colorectal cancer screening, with colonoscopy, FOBT/FIT, and FIT-DNA being the most commonly used screening types within recommended intervals. Despite some progress, colorectal cancer testing remains low in certain population subgroups, indicating efforts are needed to reach screening goals.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Rehabilitation
Robert S. Gailey, Ignacio Gaunaurd, Sara J. Morgan, Anat Kristal, Geoffrey S. Balkman, Eavey M. Newton, Jose J. Palomo, Kevin M. Shay, Rana Salem, Brian J. Hafner
Summary: The study aimed to determine if the two-minute walk test could serve as an alternative measure of high-level mobility in lower limb prosthesis users when the Comprehensive High-level Activity Mobility Predictor cannot be administered. The results showed a strong positive relationship between the 2MWT and CHAMP, suggesting that the former can be used as an alternative measure for assessing high-level mobility capabilities in this population.
CLINICAL REHABILITATION
(2022)
Article
Oncology
Natalia Araujo, Adriana Costa, Catarina Lopes, Luisa Lopes-Conceicao, Augusto Ferreira, Filipa Carneiro, Jorge Oliveira, Samantha Morais, Luis Pacheco-Figueiredo, Luis Ruano, Vitor Tedim Cruz, Susana Pereira, Nuno Lunet
Summary: The impact of prostate cancer on cognitive performance may be negligible in the short term, unlike other types of cancer.
Review
Plant Sciences
Toyosi T. George, Anthony O. Obilana, Ayodeji B. Oyenihi, Anthony B. Obilana, Damilola O. Akamo, Joseph M. Awika
Summary: This article presents a bibliometric analysis of research on sorghum, showing a significant increase in publications in recent years. The research identifies the potential opportunities and challenges for sorghum as a climate-resilient crop. Sorghum demonstrates stability and nutritional advantages compared to other major cereal crops, and it is recognized as a potential food and energy security crop. Gene editing technology offers promise for designing sorghums with high-value food traits.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Ophthalmology
Sylvie Denkinger, Maria-Paraskevi Antoniou, Demetrio Tarello, Dennis M. Levi, Benjamin T. Backus, Daphne Bavelier, Adrien Chopin
Summary: This study introduces two new stereoacuity tests: the eRDS v6 stereotest and the Vivid Vision Stereo Test version 2 (VV). The tests' reliability, validity, and learning effects were evaluated. The eRDS v6 test was found to be precise and reliable with learning effects, while the VV test was less precise but easy to use and showed no learning effects.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2023)
Article
Geriatrics & Gerontology
Li Huang, Yadong Liu, Taiping Lin, Lisha Hou, Quhong Song, Ning Ge, Jirong Yue
Summary: This study evaluated the reliability and validity of the CAMRY dynamometer compared with the Jamar dynamometer and found that the CAMRY EH101 dynamometer provides excellent reliability and validity. A linear regression equation was derived to establish the relationship between the two devices.
Article
Chemistry, Medicinal
Veronica Di Sarno, Pia Giovannelli, Alicia Medina-Peris, Tania Ciaglia, Marzia Di Donato, Simona Musella, Gianluigi Lauro, Vincenzo Vestuto, Gerardina Smaldone, Francesca Di Matteo, Giuseppe Bifulco, Gabriella Castoria, Antimo Migliaccio, Asia Fernandez-Carvajal, Pietro Campiglia, Isabel Gomez-Monterrey, Carmine Ostacolo, Alessia Bertamino
Summary: This study describes the design and synthesis of a new series of TRPM8 antagonists, which were preliminarily characterized for potency and selectivity in vitro, showing remarkable efficacy in inhibiting the growth of prostate cancer cells.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Genetics & Heredity
Yishuo Wu, Xiaohao Ruan, Peng Gao, Huang Da, Zujun Fang, Danfeng Xu, Haowen Jiang, Qiang Ding, Xiaoling Lin, Daru Lu, Rong Na
Summary: The aim of this study was to assess the validity of polygenic risk score (PRS) for prostate cancer (PCa) in a Chinese prostate biopsy cohort. Germline DNA samples were genotyped and PRS was calculated for each subject using PCa risk-associated genetic variants. The results showed that PRS values were significantly higher in PCa cases compared to negative biopsy results, and there were dose-response associations between PRS values and odds ratios for PCa. However, the calibration results were inaccurate when performed between different study populations.
Article
Multidisciplinary Sciences
Agnieszka Danuta Jastrzebska
Summary: This study aimed to investigate the usefulness of the Running-based Anaerobic Sprint Test (RAST) in estimating anaerobic performance in trained and untrained U12 girls, and the effect of an 8-week training period on anaerobic performance in female U12 soccer players. The results showed a significant increase in anaerobic performance in the trained group, and a strong correlation between the traditional Wingate test (WAnT) and the RAST in assessing anaerobic capacity. The simplicity of the RAST encourages its use in monitoring anaerobic capacity in both trained and untrained girls.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, Research & Experimental
Heba Alshaker, Robert Mills, Ewan Hunter, Matthew Salter, Aroul Ramadass, Benjamin Matthew Skinner, Willem Westra, Jayne Green, Alexandre Akoulitchev, Mathias Winkler, Dmitri Pchejetski
Summary: Specific chromosome conformation changes in the blood of prostate cancer (PCa) patients have been identified with 80% sensitivity and specificity for PCa detection. Prognostic validation sets consisting of specific genes have been found to stratify high-risk and low-risk PCa patients with high sensitivity and specificity, indicating the potential for PCa diagnosis and risk stratification using genome architecture and chromosome structures.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Jeannette M. Schenk, Cathee Till, Marian L. Neuhouser, Phyllis J. Goodman, M. Scott Lucia, Ian M. Thompson, Catherine M. Tangen
Summary: This study used data from the SELECT trial and found that there were differences in the association between MVI use and prostate cancer risk. Analyzing the observed biopsy data, it was found that current and long-term MVI use was associated with a higher risk of high-grade prostate cancer. However, after accounting for differential acceptance of biopsy, the association between MVI use and prostate cancer was no longer significant.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Medical Laboratory Technology
Robert M. West
Summary: This article discusses the importance of using the Welch t-test instead of the Student's t-test in clinical biochemistry research, as it provides better validity in a broader range of settings. It emphasizes the subtle but important differences between the two tests and advises practitioners to opt for the Welch t-test for accurate comparisons between two groups of measurements.
ANNALS OF CLINICAL BIOCHEMISTRY
(2021)
