Article
Neurosciences
Carlos Puentes-Mestril, James Delorme, Lijing Wang, Marcus Donnelly, Donald Popke, Sha Jiang, Sara J. Aton
Summary: Sleep and sleep deprivation have differential effects on gene transcription and protein translation in the mammalian forebrain, with stronger impacts observed in the neocortex compared to the hippocampus. These effects are cell type-specific and brain region-specific, indicating heterogeneous alterations in synapse strength, excitatory-inhibitory balance, and cellular timekeeping.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Andrew P. Patton, Emma L. Morris, David McManus, Huan Wang, Yulong Li, Jason W. Chin, Michael H. Hastings
Summary: The hypothalamic suprachiasmatic nucleus (SCN) is the master mammalian circadian clock. GABA plays a role in circuit-level timekeeping of SCN neurons, despite the inhibitory effect of increased neuronal firing. The astrocytic clocks in SCN maintain the circadian clockwork by controlling GABAergic inhibition.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Min Tang, Li-Hui Cao, Tian Yang, Si-Xing Ma, Bi-Yang Jing, Na Xiao, Shuang Xu, Kang-Rui Leng, Dong Yang, Meng-Tong Li, Dong-Gen Luo
Summary: Researchers have found a set of ultradian oscillators in the Drosophila brain that support free-running timekeeping, despite lacking clock gene expression and being located outside the master clock circuit. Silencing these extra-clock electrical oscillators disrupts daily electrical rhythms in clock neurons, impairing neuropeptide cycling and leading to the loss of free-running locomotor rhythms.
Review
Behavioral Sciences
Robert Lee, Amaris Tapia, Sevag Kaladchibachi, Michael A. Grandner, Fabian-Xose Fernandez
Summary: A meta-analysis of papers on the phase-shifting effects of timed light exposure on rodent locomotor rhythms published in the past half-century revealed biases in study design with respect to important biological variables, potentially limiting the translation of relevant data to phototherapy for women and older individuals.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Multidisciplinary Sciences
Paul Petrus, Jacob G. Smith, Kevin B. Koronowski, Siwei Chen, Tomoki Sato, Carolina M. Greco, Thomas Mortimer, Patrick-Simon Welz, Valentina M. Zinna, Kohei Shimaji, Marlene Cervantes, Daniela Punzo, Pierre Baldi, Pura Munoz-Canoves, Paolo Sassone-Corsi, Salvador Aznar Benitah
Summary: Life on Earth relies on molecular clocks and intertissue communication to regulate circadian and metabolic rhythms, with the central clock playing a crucial role in governing metabolic rhythms.
Article
Multidisciplinary Sciences
Alessandra Stangherlin, Joseph L. Watson, David C. S. Wong, Silvia Barbiero, Aiwei Zeng, Estere Seinkmane, Sew Peak Chew, Andrew D. Beale, Edward A. Hayter, Alina Guna, Alison J. Inglis, Marrit Putker, Eline Bartolami, Stefan Matile, Nicolas Lequeux, Thomas Pons, Jason Day, Gerben van Ooijen, Rebecca M. Voorhees, David A. Bechtold, Emmanuel Derivery, Rachel S. Edgar, Peter Newham, John S. O'Neill
Summary: This study reveals that circadian control of the proteome impacts ion homeostasis in cells, especially cardiomyocytes, through mechanisms involving osmotic compensation via electroneutral ion transport. Changes in ion content due to perturbation of soluble protein abundance drive daily rhythms in cardiomyocyte electrical activity, with substantial consequences for cell physiology.
NATURE COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Noboru Imai
Summary: Migraine, a type of primary headache, exhibits circadian and circannual rhythms in attack onset, which involve the hypothalamus and melatonin. The prophylactic effect of melatonin in migraines is still controversial. Meanwhile, calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-activating peptide (PACAP) play important roles in the pathophysiology and treatment of migraines by regulating circadian entrainment to light and could be potential therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Natthapong Sueviriyapan, Daniel Granados-Fuentes, Tatiana Simon, Erik D. Herzog, Michael A. Henson
Summary: In the SCN, different types of GABA(A) receptors have been found to regulate circadian rhythms, with blocking GABA signaling modestly increasing synchrony and increasing the relative density of gamma over delta subunits significantly increasing synchrony.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2021)
Article
Food Science & Technology
Kazuaki Mawatari, Nobuya Koike, Kazunari Nohara, Marvin Wirianto, Takashi Uebanso, Takaaki Shimohata, Yasuhiro Shikishima, Hiroyuki Miura, Yoshitaka Nii, Mark J. Burish, Kazuhiro Yagita, Akira Takahashi, Seung-Hee Yoo, Zheng Chen
Summary: A study found that Sudachitin, a compound found in Citrus sudachi, can modulate the circadian clock and improve metabolic disorders and liver function. The results showed that Sudachitin can alter the expression of core clock genes and improve metabolic levels and liver physiology, maintaining a good day-night rhythm. This study demonstrates the importance of the circadian clock as a mechanism to protect physiological well-being.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Review
Cardiac & Cardiovascular Systems
Joshua M. Cherubini, Jem L. Cheng, Jennifer S. Williams, Maureen J. MacDonald
Summary: Sleep is crucial for maintaining physiological homeostasis, and inadequate sleep can lead to various pathologies, especially increasing the risk of cardiovascular diseases and atherosclerosis. Short sleep durations are found to decrease endothelial function, possibly disrupting autonomic balance and circadian rhythmicity of vascular clock components.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Anna Wirz-Justice, Debra J. Skene, Mirjam Munch
Summary: Daylight plays a crucial role in mammalian vision and non-visual functions, influencing mood, cognition, and sleep, as well as contributing to disease prevention and overall health.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Physiology
Yaarit Adamovich, Vaishnavi Dandavate, Gad Asher
Summary: This article reviews the interaction between the circadian clock and the oxygen-signalling pathway in mammals under normal and pathological conditions. Evidence suggests that the circadian clock can sense and regulate changes in oxygen levels through the HIF-1 signalling pathway, further influencing the rhythmicity of the clock itself.
Article
Multidisciplinary Sciences
Makoto Takeo, Koh-ei Toyoshima, Riho Fujimoto, Tomoyo Iga, Miki Takase, Miho Ogawa, Takashi Tsuji
Summary: Biological rhythms play a role in various biological processes, including morphogenesis. By studying mouse zigzag hair, it was discovered that hair progenitors and their micro-niche undergo changes every three days, resulting in bend formation. The genes Ptn and Aff3 regulate the rhythm of bend formation, and their dysfunction leads to defects in micro-niche movement and bend formation.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Marrit Putker, David C. S. Wong, Estere Seinkmane, Nina M. Rzechorzek, Aiwei Zeng, Nathaniel P. Hoyle, Johanna E. Chesham, Mathew D. Edwards, Kevin A. Feeney, Robin Fischer, Nicolai Peschel, Ko-Fan Chen, Michael Vanden Oever, Rachel S. Edgar, Christopher P. Selby, Aziz Sancar, John S. O'Neill
Summary: CRY proteins are considered essential components of the cellular clock mechanism, but studies show that circadian rhythms can still exist in the absence of CRY, albeit with variable expression and shorter periods. The classic circadian hallmarks like temperature compensation and period determination by specific activities are maintained even without CRY-mediated feedback repression. The sustained PER2 protein rhythms and circadian variation in protein stability suggest a post-translational core mechanism for biological clocks.
Article
Multidisciplinary Sciences
Seok Joo Chae, Dae Wook Kim, Seunggyu Lee, Jae Kyoung Kim
Summary: In this study, a mathematical model was developed to understand the precise nuclear entry of PER protein in the circadian clock. It was found that the spatially coordinated bistable phosphoswitch of PER plays a crucial role in synchronizing and accurately timing the nuclear entry of PER. This reveals the mechanism of how the circadian clock compensates for spatiotemporal noise.