Article
Psychiatry
Natalie Martos, William Hall, Alicia Marhefka, Thomas W. Sedlak, Frederick C. Nucifora
Summary: Neutropenia is a potential adverse effect of antipsychotic medications, with clozapine receiving most of the attention. However, paliperidone can also cause neutropenia, as demonstrated in a case report of a 23-year-old African American male. Clinicians should be aware of the risk of neutropenia when initiating paliperidone and consider comparative risks across antipsychotics for treatment decisions.
Article
Psychiatry
J. Mayoral-van Son, Marcos Gomez-Revuelta, Rosa Ayesa-Arriola, Javier Vazquez-Bourgon, Victor Ortiz-Garcia De La Foz, Miguel Ruiz-Veguilla, Nathalia Garrido, Diana Tordesillas-Gutierrez, Esther Setien-Suero, Benedicto Crespo-Facorro
Summary: The PAFIP 3 clinical trial aims to provide valuable information on clinical guidelines for treating patients with a first episode of non-affective psychosis and the benefits and risks of early use of clozapine in treatment-resistant patients.
REVISTA DE PSIQUIATRIA Y SALUD MENTAL
(2021)
Article
Clinical Neurology
Marcos Gomez-Revuelta, Jose Maria Pelayo-Teran, Javier Vazquez-Bourgon, Victor Ortiz-Garcia de la Foz, Jacqueline Mayoral-van Son, Rosa Ayesa-Arriola, Benedicto Crespo-Facorro
Summary: This study compared the effectiveness of aripiprazole and risperidone in the acute-phase treatment of FEP and found no differences in treatment discontinuation rates and mean time until discontinuation between the two drugs. However, risperidone showed better performance in terms of clinical efficacy, but patients on risperidone were more likely to experience sex-related adverse events.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2021)
Review
Psychiatry
Laura Lockwood, Brian Miller, Nagy A. Youssef
Summary: This systematic review examined 17 studies related to epigenetic changes in first-episode psychosis, finding evidence of epigenetic alterations in certain portions of the genome in early psychosis patients. Further research in this area is warranted for more definitive epigenetic correlations.
PSYCHIATRY RESEARCH
(2022)
Article
Psychiatry
Olesya Ajnakina, Tushar Das, John Lally, Marta Di Forti, Carmine M. Pariante, Tiago Reis Marques, Valeria Mondelli, Anthony S. David, Robin M. Murray, Lena Palaniyappan, Paola Dazzan
Summary: The study suggests that treatment resistance in patients with first-episode psychosis may be related to disruptions in cortical folding principles. Patients with treatment resistance showed significantly reduced small-worldness and clustering coefficient, with increased length, indicating disturbances in the organizing principles of cortical folding.
SCHIZOPHRENIA BULLETIN
(2021)
Article
Psychology, Clinical
Brian O'Donoghue, John Lyne, Eric Roche, Nathan Mifsud, Laoise Renwick, Caragh Behan, Mary Clarke
Summary: This study found that migrants from Africa have a nearly twofold increased risk of developing a psychotic disorder compared to those born in the Republic of Ireland, while migrants from certain Asian countries have a reduced risk. Further research into the factors behind this increased risk in specific migrant groups could provide insights into the cause of psychotic disorders.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Clinical Neurology
Lucia Garrido-Sanchez, Marcos Gomez-Revuelta, Victor Ortiz-Garcia De la Foz, Jose Maria Pelayo-Teran, Maria Juncal-Ruiz, Miguel Ruiz-Veguilla, Jacqueline Mayoral-Van Son, Rosa Ayesa-Arriola, Javier Vazquez-Bourgon, Benedicto Crespo-Facorro
Summary: This study compared the short-term effectiveness of aripiprazole and risperidone in patients with first episode psychosis (FEP). The results showed no statistically significant differences in treatment discontinuation rates and time to discontinuation between the two drugs. However, aripiprazole required higher dosage and extended time to achieve clinical response.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Psychiatry
Franck Schurhoff, Cecile Corfdir, Baptiste Pignon, Mohamed Lajnef, Jean-Romain Richard, Elisabeth Marcos, Antoine Pelissolo, Marion Leboyer, Serge Adnot, Stephane Jamain, Andrei Szoke
Summary: This study compared telomere length between first-episode schizophrenia patients and controls, finding no significant association after adjusting for confounders. The results suggest that psycho-social stress may impact telomere length in individuals with schizophrenia, rather than telomere erosion contributing to the development of the disorder.
PSYCHIATRY RESEARCH
(2021)
Article
Psychiatry
Miquel Bioque, Ana Catarina Matias-Martins, Vicent Llorca-Bofi, Gisela Mezquida, Manuel J. Cuesta, Eduard Vieta, Silvia Amoretti, Antonio Lobo, Ana Gonzalez-Pinto, Carmen Moreno, Alexandra Roldan, Anabel Martinez-Aran, Immaculada Baeza, Daniel Berge, Clemente Garcia-Rizo, Sergi Mas Herrero, Miquel Bernardo
Summary: This study evaluated the neutrophil-lymphocyte ratio (NLR) in patients with a first episode of psychosis (FEP) and found that FEP patients had a significantly higher NLR compared to healthy controls, and this difference increased over time. Within the FEP group, NLR did not change significantly over the follow-up period, and there were no differences based on gender or diagnosis. The group of patients who did not reach remission criteria showed a higher NLR compared to those who remitted. There was a significant correlation between antipsychotic doses and NLR at the two-year follow-up.
SCHIZOPHRENIA BULLETIN
(2022)
Article
Psychiatry
Yi Yin, Shuangshuang Li, Jinghui Tong, Junchao Huang, Baopeng Tian, Song Chen, Yimin Cui, Shuping Tan, Zhiren Wang, Fude Yang, Yongsheng Tong, L. Elliot Hong, Yunlong Tan
Summary: In schizophrenia, the age at illness onset may reflect genetic loading and predict prognosis. We aimed to compare the pre-treatment symptom profiles and clinical symptom responses to antipsychotic treatment of individuals with late-onset schizophrenia (LOS; onset age: 40-59 years) with individuals with early-onset schizophrenia (EOS; onset age < 18 years) or typical-onset schizophrenia (TOS; onset age: 18-39 years). Our study found that individuals with late-onset schizophrenia showed better improvement in positive symptoms compared to those with early-onset schizophrenia.
SCHIZOPHRENIA RESEARCH
(2023)
Article
Psychiatry
Freda Scheffler, Lebogang Phahladira, Hilmar Luckhoff, Stefan du Plessis, Laila Asmal, Sanja Kilian, Marta Di Forti, Robin Murray, Robin Emsley
Summary: The study found that there were no significant differences in baseline symptom severity and treatment outcomes between cannabis users and non-users in first-episode schizophrenia spectrum disorders. However, as the frequency of cannabis use increased during treatment, the risk of relapse also increased.
PSYCHIATRY RESEARCH
(2021)
Article
Psychiatry
Yuta Kawakita, Masahiro Takeshima, Tomonari Komatsu, Aya Imanishi, Dai Fujiwara, Yu Itoh, Kazuo Mishima
Summary: This study retrospectively compared the incidence of appendicitis in patients with schizophrenia with and without a history of clozapine exposure, finding a relationship between clozapine exposure and appendicitis onset.
Article
Psychiatry
Alba Toll, Emilio Pechuan, Daniel Berge, Teresa Legido, Laura Martinez-Sadurni, Khadija El-Abidi, Victor Perez-Sola, Anna Mane
Summary: The risk of suicide is high in individuals experiencing first-episode psychosis (FEP), but the factors associated with this risk are not well-understood. This study aimed to identify the sociodemographic and clinical factors that contribute to suicide attempts in FEP patients over a two-year period. The findings revealed that prior suicide attempts, low functionality, depression, and feelings of guilt were significantly associated with suicide attempts. These findings highlight the importance of targeted interventions, particularly during the prodromal stage, in identifying and treating FEP patients with a high suicide risk.
PSYCHIATRY RESEARCH
(2023)
Article
Clinical Neurology
Mengqing Xia, Yingchan Wang, Wenjun Su, Yingying Tang, Tianhong Zhang, Huiru Cui, Yanyan Wei, Xiaochen Tang, Lihua Xu, Hao Hu, Qian Guo, Zhenying Qian, Xuming Wu, Chunbo Li, Jijun Wang
Summary: This study explores the interaction between age and antipsychotic-induced volumetric changes in the hippocampus and amygdala of first-episode schizophrenia patients undergoing medication treatment. It was found that older patients had smaller baseline hippocampal volumes compared to healthy controls. Additionally, younger patients exhibited greater hippocampal volumetric decreases following treatment.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Psychology, Clinical
Toby Pillinger, Robert A. McCutcheon, Oliver D. Howes
Summary: Patients with first-episode psychosis (FEP) show greater variability in metabolic parameters compared to controls, indicating potential subgroups of patients with more susceptibility to metabolic dysregulation. Female sex and higher symptom severity are associated with poorer metabolic outcomes.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Clinical Neurology
Kristina Sabaroedin, Adeel Razi, Sidhant Chopra, Nancy Tran, Andrii Pozaruk, Zhaolin Chen, Amy Finlay, Barnaby Nelson, Kelly Allott, Mario Alvarez-Jimenez, Jessica Graham, Hok P. Yuen, Susy Harrigan, Vanessa Cropley, Sujit Sharma, Bharat Saluja, Rob Williams, Christos Pantelis, Stephen J. Wood, Brian O'Donoghue, Shona Francey, Patrick McGorry, Kevin Aquino, Alex Fornito
Summary: This study found that subcortical dysconnectivity is evident in the early stages of psychosis, while cortical dysfunction may emerge later in the illness. Nigrostriatal and striatothalamic signalling are closely related to striatal dopamine synthesis capacity, which is a robust marker for psychosis.
Article
Psychiatry
Ellie Brown, Emily Castagnini, Alison Langstone, Nathan Mifsud, Caroline Gao, Patrick McGorry, Eoin Killackey, Brian O'Donoghue
Summary: This study explored the high-risk sexual behaviors and sexual well-being indicators of young people experiencing a first episode of psychosis (FEP). The results showed that a high proportion of young people had engaged in high-risk sexual behaviors, highlighting the need to promote sexual well-being and communication skills to mitigate high-risk sexual health outcomes.
EARLY INTERVENTION IN PSYCHIATRY
(2023)
Article
Psychiatry
Danielle Moore, Scott Eaton, Andrea Polari, Patrick McGorry, Barnaby Nelson, Brian O'Donoghue
Summary: This study found an association between neighborhood-level social deprivation and the rate of identification of individuals at Ultra-High Risk for psychosis (UHR), as well as the risk of transition to psychosis in UHR individuals. People living in the most deprived neighborhoods had a higher rate of identification as UHR individuals, and residing in a neighborhood of above average deprivation was associated with a higher risk of transition to psychosis.
INTERNATIONAL JOURNAL OF SOCIAL PSYCHIATRY
(2023)
Article
Psychiatry
Aurelie Schandrin, Shona Francey, Lucia Nguyen, Dean Whitty, Patrick McGorry, Andrew M. Chanen, Brian O'Donoghue
Summary: This study aimed to determine the prevalence of borderline personality pathology (BPP) in individuals diagnosed with first episode of psychosis (FEP), as well as its associated demographic and clinical factors, and symptomatic and functional outcomes. The study found that 18.4% of young people with FEP also had BPP. These individuals were more likely to be female, younger, and Australian-born. They were also more likely to be diagnosed with Psychosis NOS, experience more severe hallucinations, and have alcohol abuse. They had more relationship difficulties, suffered from depression, and engaged in self-harm throughout the follow-up.
EARLY INTERVENTION IN PSYCHIATRY
(2023)
Article
Psychiatry
Brian O'Donoghue, Kelly Allott, Susy Harrigan, Franco Scalzo, Janine Ward, Sumudu Mallawaarachchi, Sarah Whitson, Lara Baldwin, Jessica Graham, Edward Mullen, Craig MacNeil, Dylan Alexander, Stephen J. Wood, Michael Berk, Mario Alvarez-Jimenez, Andrew Thompson, Alex Fornito, Hok Pan Yuen, Barnaby Nelson, Shona M. Francey, Patrick McGorry
Summary: This study aimed to analyze the effects of medication and non-medication factors on the physical health of individuals with a first episode of psychosis. The findings suggest that some of the metabolic complications observed in psychotic disorders may not be solely attributed to medication. This highlights the importance of providing early physical health interventions in the course of first episode psychosis.
EARLY INTERVENTION IN PSYCHIATRY
(2023)
Article
Psychiatry
Andrew Thompson, Joanna Fitzsimons, Eoin Killackey, Susannah Ahern, Paul Amminger, Mario Alvarez-Jimenez, Michael Berk, Sue Cotton, John McNeil, Patrick McGorry, Barnaby Nelson, Brian O'Donoghue, Aswin Ratheesh, Debra Rickwood, Alison Yung, Stephen Wood
Summary: The field of early psychosis has expanded rapidly over the past few decades with a strong evidence base. However, there is a need for early psychosis services to consistently provide higher quality care. The establishment of the Australian Early Psychosis Collaborative Consortium (AEPCC) aims to address this through the implementation of a clinical research infrastructure.
AUSTRALASIAN PSYCHIATRY
(2023)
Article
Psychiatry
Brian O'Donoghue, Chantal Michel, Katherine N. Thompson, Marialuisa Cavelti, Scott Eaton, Jennifer K. Betts, Claire Fowler, Stefan Luebbers, Michael Kaess, Andrew M. Chanen
Summary: This study aimed to determine the association between the treated incidence rate of borderline personality pathology and specific neighbourhood characteristics. The results showed a significant increase in the treated incidence rate of borderline personality pathology in neighbourhoods with higher levels of social deprivation and fragmentation. These findings have implications for the provision of clinical services and allocation of resources for young people with borderline personality pathology.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Brian O'Donoghue, Andrew Thompson, Patrick McGorry, Ellie Brown
Summary: Early intervention for psychosis services have superior outcomes compared to standard services, but the optimal duration of care is unknown. This study determined the discharge destinations from these services and factors associated with discharge to secondary care. The findings indicate a significant minority who may benefit from longer care with early intervention for psychosis services.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Review
Psychiatry
Matteo Cella, Safina Roberts, Matthias Pillny, Marcel Riehle, Brian O'Donoghue, John Lyne, Paul Tomlin, Lucia Valmaggia, Antonio Preti
Summary: Currently, there is no recommended first-line treatment for the negative symptoms of schizophrenia. Psychosocial and behavioural interventions are commonly used to reduce the burden of these symptoms. Meta-analytic studies have summarized the evidence for specific interventions but have not compared the quality of evidence and the level of benefit.
BRITISH JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Brian O'Donoghue, Eric Roche, John Lyne, Laoise Renwick, Mary Clarke
Summary: Migration is a strong risk factor for developing a psychotic disorder, but there is limited research on the outcomes of migrants with a psychotic disorder. This study aimed to evaluate various outcomes for migrants with first episode psychosis (FEP) in Ireland. The results showed that migrants had similar outcomes to the native-born populations, highlighting the need to improve outcomes for all individuals affected by psychotic disorders.
INTERNATIONAL JOURNAL OF SOCIAL PSYCHIATRY
(2023)
Letter
Psychiatry
Brian O'Donoghue, Andrew Thompson, Patrick Mcgorry, Ellie Brown
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Jonathan Tsiglopoulos, Nicholas Pearson, Nathan Mifsud, Emily Castagnini, Kelly Allott, Andrew Thompson, Eoin Killackey, Patrick Mcgorry, Brian O'Donoghue
Summary: This study aimed to determine the prevalence of vitamin D deficiency in people with first-episode psychosis (FEP) and identify the factors associated with vitamin D status. Results showed that 24% of participants were vitamin D deficient, and a further 30% were vitamin D insufficient. The study also found that vitamin D levels were associated with season of sampling. Therefore, it is necessary to ensure that this clinical population receives necessary vitamin D supplementation.
EARLY INTERVENTION IN PSYCHIATRY
(2023)
Article
Psychiatry
Eliza Fordham, Caroline X. Gao, Kate Filia, Brian O'Donoghue, Catherine Smith, Shona Francey, Debra Rickwood, Nic Telford, Andrew Thompson, Ellie Brown
Summary: The incidence of psychosis is influenced by geographical factors such as social disadvantage. This study analyzed data from young people accessing early psychosis services in Australia and found that social disadvantage was associated with variations in clinical presentation and engagement.
PSYCHIATRY RESEARCH
(2023)
Letter
Psychiatry
Louisa Gannon, Nicholas Pearson, Jonathan Tsiglopoulos, Nathan Mifsud, Emily Castagnini, Andrew Thompson, Alison Langstone, Eoin Killackey, Patrick McGorry, Brian O' Donoghue
SCHIZOPHRENIA RESEARCH
(2023)
Article
Psychiatry
Louisa Gannon, Eddie Mullen, Patrick Mcgorry, Brian O'Donoghue
Summary: This study aimed to determine the proportion of individuals with first episode psychosis (FEP) who were admitted at the time of presentation and to identify associated demographic and clinical factors. The study found that being a migrant, aggression, and more severe psychotic symptoms were predictors of admission. The high admission rate for FEP patients highlights the need for interventions to reduce admissions.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2023)
