Article
Biochemistry & Molecular Biology
Keqiang Wang, Meihong Xiu, Xiuru Su, Fengchun Wu, Xiangyang Zhang
Summary: This study examined the effect of risperidone monotherapy on total antioxidant status (TAS) in antipsychotic-naive first-episode schizophrenia (ANFE) patients, and found that antioxidant protection may be associated with clinical improvement.
Article
Psychiatry
Ge Yang, Sen Zhang, Youqi Zhou, Yichen Song, Wenyan Hu, Yue Peng, Han Shi, Yan Zhang
Summary: The study found that drug-naive first-episode AOS patients demonstrate abnormalities in interhemispheric functional connectivity, which are not mitigated by short-term antipsychotic treatment.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Nina Vanessa Kraguljac, Thomas Anthony, Charity Johanna Morgan, Ripu Daman Jindal, Mark Steven Burger, Adrienne Carol Lahti
Summary: The study revealed that longer duration of untreated psychosis is associated with adverse clinical outcomes, and white matter integrity may mediate this relationship. This highlights the importance of early intervention efforts to improve treatment outcomes in psychosis spectrum disorders.
MOLECULAR PSYCHIATRY
(2021)
Article
Psychiatry
Qiaoling Sun, Linlin Zhao, Liwen Tan
Summary: This study found abnormal patterns of EEG microstates in drug-naive, first-episode schizophrenia patients, which may help distinguish individuals with schizophrenia in the early stage and develop early intervention strategies.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Du Lei, Xueling Suo, Kun Qin, Walter H. L. Pinaya, Yuan Ai, Wenbin Li, Weihong Kuang, Su Lui, Graham J. Kemp, John A. Sweeney, Qiyong Gong
Summary: This study aimed to explore the changes in brain magnetization transfer ratio (MTR) in antipsychotic-naive first-episode schizophrenia (FES) and their correlation with symptom severity. The results showed that individuals with FES had higher MTR values in certain brain regions, such as the left thalamus, precuneus, cuneus, and paracentral lobule, which were positively correlated with the severity of schizophrenia symptoms. A whole-brain MTR map was able to distinguish FES patients from healthy controls with a 75.5% accuracy using a support vector machine approach.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Medicine, General & Internal
Beisheng Yang, Wenjing Zhang, Rebekka Lencer, Bo Tao, Biqiu Tang, Jing Yang, Siyi Li, Jiaxin Zeng, Hengyi Cao, John A. Sweeney, Qiyong Gong, Su Lui
Summary: The study found abnormalities in the brain networks of untreated schizophrenia patients, mainly involving the central executive, default mode, and salience networks. Additionally, accelerated age-related declines and illness duration-related declines were observed in schizophrenia patients, primarily in terms of global assortativity and nodal metrics of the left superior temporal pole.
Article
Psychology, Clinical
Xiaojing Li, Wei Deng, Rui Xue, Qiang Wang, Hongyan Ren, Wei Wei, Yamin Zhang, Mingli Li, Liansheng Zhao, Xiangdong Du, Yajing Meng, Xiaohong Ma, Mei-Hua Hall, Tao Li
Summary: This study found deficits in event-related potential, including duration mismatch negativity and P3a, in drug naive patients with chronic schizophrenia and bipolar disorder. These deficits appeared to be related to levels of higher-order cognition and functioning.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Lei Chen, Wen-Hui Zheng, Yang Du, Xue-Song Li, Yun Yu, Hua Wang, Yong Cheng
Summary: Patients with first-episode drug-free schizophrenia exhibit unique immune profiles, and antipsychotic medications seem to suppress their immune function. G-CSF and IFN-gamma show good performance in differentiating between patients and healthy controls.
FRONTIERS IN MEDICINE
(2021)
Article
Neurosciences
Xin Gao, Li Yao, Fei Li, Chengmin Yang, Fei Zhu, Qiyong Gong, Su Lui
Summary: In first-episode antipsychotic-naive schizophrenia patients, widespread cortical local gyrification index (LGI) alterations were found, and specific risk genes associated with LGI deficits were identified. Lower LGI values were observed in frontotemporal and limbic regions. These findings may contribute to understanding the neurobiological basis of cortical impairments in early-stage schizophrenia.
Article
Psychology, Clinical
Miranda Bridgwater, Peter Bachman, Brenden Tervo-Clemmens, Gretchen Haas, Rebecca Hayes, Beatriz Luna, Dean F. Salisbury, Maria Jalbrzikowski
Summary: This study investigates the developmental influence on symptom expression in first-episode psychosis. The results show that perceptual symptoms attenuate while non-perceptual symptoms enhance as maturation proceeds. Findings highlight the variability of pathological brain-behavior relationships with development.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Psychiatry
Junyao Liu, Dongmei Wang, Huixia Zhou, Ning Olivia Zhao, Hanjing Emily Wu, Xiangyang Zhang
Summary: The prevalence of Deficit Syndrome (DS) in Chinese Han patients with first-episode drug naive (FEDN) schizophrenia was found to be 23.0%. Patients with DS were younger, had lower education levels, and were more likely to be single compared to those without DS. DS patients had lower scores of positive symptoms, general psychopathology, and depression, but more severe negative symptoms and cognitive impairment. Multiple regression analysis showed that poor cognitive functioning, lower levels of depression, and younger age at onset were predictors of DS.
ASIAN JOURNAL OF PSYCHIATRY
(2021)
Article
Clinical Neurology
Shen Li, Bin Yu, Dongmei Wang, Luyao Xia, Li Wang, Dachun Chen, Meihong Xiu, Xiang Yang Zhang
Summary: This study found that SG-P50 deficit may be an informational biomarker for depressive symptoms and neurocognitive impairments in FEAN-SCZ patients. For depressive FEAN-SCZ patients, the S2 amplitude of SG-P50 may serve as an independent predictor of MCCB-Mazes (NAB).
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Jinghan Hu, Yongjie Zhou, Ruoxi Wang, Ling Qi, Xin Zhou, Xiuli Song, Lingyun Zeng, Xiangyang Zhang
Summary: Adolescent-onset patients with first-episode drug-naive schizophrenia are more likely to have abnormal glucose metabolism and dyslipidemia compared to healthy controls. Abnormal glucose metabolism may be closely related to the psychopathological symptoms of schizophrenia in the early stage of the disease.
ASIAN JOURNAL OF PSYCHIATRY
(2021)
Article
Clinical Neurology
Mengqing Xia, Yingchan Wang, Wenjun Su, Yingying Tang, Tianhong Zhang, Huiru Cui, Yanyan Wei, Xiaochen Tang, Lihua Xu, Hao Hu, Qian Guo, Zhenying Qian, Xuming Wu, Chunbo Li, Jijun Wang
Summary: This study explores the interaction between age and antipsychotic-induced volumetric changes in the hippocampus and amygdala of first-episode schizophrenia patients undergoing medication treatment. It was found that older patients had smaller baseline hippocampal volumes compared to healthy controls. Additionally, younger patients exhibited greater hippocampal volumetric decreases following treatment.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Psychiatry
Hengyi Cao, Xia Wei, Wenjing Zhang, Yuan Xiao, Jiaxin Zeng, John A. Sweeney, Qiyong Gong, Su Lui
Summary: This study provides an in-depth characterization of cerebellar dysconnectivity in early schizophrenia, revealing a common bidirectional dysconnectivity pattern that may be related to genetic factors.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Psychiatry
Hengyi Cao, Xia Wei, Wenjing Zhang, Yuan Xiao, Jiaxin Zeng, John A. Sweeney, Qiyong Gong, Su Lui
Summary: This study provides an in-depth characterization of cerebellar dysconnectivity in early schizophrenia, revealing a common bidirectional dysconnectivity pattern that may be related to genetic factors.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Neurosciences
Xin Xu, Xue Li, Xu Qi, Xi Jiang, Haoyang Xing, Xiaoqi Huang, Qiyong Gong
Summary: Resting-state functional magnetic resonance imaging (RS-FMRI) was used to evaluate the effects of intermittent theta burst stimulation (iTBS) and continuous theta burst stimulation (cTBS) on intrinsic brain activity in the precuneus. The results showed that iTBS decreased functional connectivity in the bilateral precuneus, while cTBS decreased functional connectivity in the bilateral insula and increased it in the thalamus.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Xiaoyi Sun, Jinrong Sun, Xiaowen Lu, Qiangli Dong, Liang Zhang, Wenxu Wang, Jin Liu, Qing Ma, Xiaoqin Wang, Dongtao Wei, Yuan Chen, Bangshan Liu, Chu-Chung Huang, Yanting Zheng, Yankun Wu, Taolin Chen, Yuqi Cheng, Xiufeng Xu, Qiyong Gong, Tianmei Si, Shijun Qiu, Ching-Po Lin, Jingliang Cheng, Yanqing Tang, Fei Wang, Jiang Qiu, Peng Xie, Lingjiang Li, Yong He, Mingrui Xia
Summary: Major depressive disorder is a highly heterogeneous disorder with two reproducible neurophysiological subtypes identified in the study, showing severe and moderate deviation patterns in functional connectivity. These subtypes have predictive value for antidepressant treatment outcomes.
BIOLOGICAL PSYCHIATRY
(2023)
Review
Clinical Neurology
Xipeng Long, Lei Li, Xiuli Wang, Yuan Cao, Baolin Wu, Neil Roberts, Qiyong Gong, Graham J. Kemp, Zhiyun Jia
Summary: This study conducted a comprehensive meta-analysis of gray matter volume alterations in adolescents with major depressive disorder and bipolar disorder. The findings suggest that distinct patterns of GMV alterations in these two populations could aid in differentiation and provide potential diagnostic biomarkers.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Chemistry, Multidisciplinary
Yuxin Zhang, Jie Zhou, Xiaoting Chen, Zhiqian Li, Lei Gu, Dayi Pan, Xiuli Zheng, Qianfeng Zhang, Rongjun Chen, Hu Zhang, Qiyong Gong, Zhongwei Gu, Kui Luo
Summary: Interaction between carcinoma-associated fibroblasts (CAFs) and tumor cells promotes breast cancer invasion and metastasis. A redox-responsive chondroitin sulfate (CS)-based nanomedicine was developed, containing hydrophobic cabazitaxel (CTX) conjugated to CS backbone via glutathione (GSH)-sensitive dithio-maleimide (DTM) to form an amphipathic CS-DTM-CTX (CDC) conjugate. Dasatinib (DAS) was co-assembled with the CDC conjugate to obtain DAS@CDC. The nanomedicine could reverse CAFs to normal fibroblasts, block their crosstalk with tumor cells, inhibit tumor extracellular matrix protein synthesis, and effectively suppress tumor proliferation and metastasis, demonstrating a synergistic therapy effect against breast cancer.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Psychology, Clinical
Lekai Luo, Lizhou Chen, Yuxia Wang, Qian Li, Ning He, Yuanyuan Li, Wanfang You, Yaxuan Wang, Fenghua Long, Lanting Guo, Kui Luo, John A. Sweeney, Qiyong Gong, Fei Li
Summary: This study uses sparse canonical correlation analysis to identify four distinct patterns of dynamic functional brain activity associated with attention-deficit/hyperactivity disorder (ADHD). It also finds that cognitive deficits mediate the relationship between brain dynamics and ADHD-related behaviors. These findings provide important insights into the behavioral and cognitive features of ADHD.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Clinical Neurology
Huifang Xu, Tongtong Li, Qiyong Gong, Haizhen Xu, Yongbo Hu, Wenqi Lue, Xin Yang, Jin Li, Wenming Xu, Weihong Kuang
Summary: This study investigated the potential role of genetic mutations in the retrograde endocannabinoid (eCB) pathway in Han Chinese patients with major depressive disorder (MDD). Whole-exome sequencing was performed and 146 depression-related mutations were identified, with 37 of them enriched in the eCB pathway. Seven hub genes in the eCB pathway were found to be closely related to mitochondrial function. These results suggest that genetic mutations in the eCB pathway may contribute to the pathogenesis of MDD.
FRONTIERS IN NEUROLOGY
(2023)
Article
Engineering, Biomedical
Zaixiang Fang, Ling Lin, Zhiqian Li, Lei Gua, Dayi Pan, Yunkun Li, Jie Chen, Haitao Ding, Xiaohe Tian, Qiyong Gong, Kui Luo
Summary: This study utilized nanotechnology to co-deliver chemotherapeutic drugs and photosensitizers using heparin as a carrier for synergistic cancer therapy, enhancing the efficacy of combination therapy. The co-assembled HP-PP nanoparticles significantly increased the stability and photostability of the drugs, resulting in enhanced cytotoxicity and a remarkable synergistic antitumor effect.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Multidisciplinary
Yunkun Li, Yahui Wu, Zaixiang Fang, Yuxin Zhang, Haitao Ding, Long Ren, Lu Zhang, Qiyong Gong, Zhongwei Gu, Kui Luo
Summary: This study develops a target ligand-modified dendritic nanomedicine for tumor chemo-immunotherapy. The nanomedicine promotes cellular internalization, penetration, and drug release. It triggers immune response and remodels the tumor immune microenvironment, resulting in enhanced therapeutic effect.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Zhengxiang Gu, Yechuan Zhang, Xuelian Wei, Zhenyu Duan, Qiyong Gong, Kui Luo
Summary: In this study, copper-doped cobalt selenide nanosheets with selenium vacancies were developed as a robust and efficient electrocatalyst for the reduction of nitrate to ammonia. The introduction of Cu dopants and Se vacancies enhanced the electron transfer and led to the formation of electron-deficient Cu sites, accelerating the dissociation of NO3- and stabilizing the *NO2 intermediates, ultimately achieving selective catalysis in the entire NO3RR process.
ADVANCED MATERIALS
(2023)
Article
Psychiatry
Xiqin Liu, Yajun Zhao, Xueling Suo, Xun Zhang, Nanfang Pan, Graham J. J. Kemp, Qiyong Gong, Song Wang
Summary: This study aimed to identify functional brain markers of COVID-specific vicarious traumatization (VT) and explore the psychological mechanism underlying the brain-VT link. The results revealed that VT was negatively correlated with functional connectivity density (FCD) in the right inferior temporal gyrus (ITG), and psychological resilience mediated the associations of ITG FCD and ITG-default mode network (DMN) functional connectivity with VT. This study provides new evidence on the brain basis of VT and underscores the importance of psychological resilience in the brain-VT relationship.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Medicine, Research & Experimental
Wenjing Zhang, Naici Liu, Youjin Zhao, Chenyang Yao, Dan Yang, Chengmin Yang, Hui Sun, Xia Wei, John A. Sweeney, Huilou Liang, Miaoqi Zhang, Qiyong Gong, Su Lui
Summary: Repetitive transcranial magnetic stimulation (rTMS) is increasingly used to treat neuropsychiatric disorders. However, the exact mechanism of action remains unclear. In this study, the impact of inhibitory and excitatory rTMS on laminar diffusion profiles of neocortex was investigated. Different patterns of changes were observed, with increased fractional anisotropy (FA) in inhibitory rTMS and decreased FA in excitatory rTMS. Laminar analysis revealed the specific effects of rTMS on different cortical layers. These findings provide novel insights into the acute neurobiological effects of rTMS and its potential applications.
Article
Neurosciences
Simin Zhang, Xibiao Yang, Qiaoyue Tan, Huaiqiang Sun, Di Chen, Yinying Chen, Hongjing Zhang, Yuan Yang, Qiyong Gong, Qiang Yue
Summary: This study investigated the changes in whole-brain cortical myelin and thickness induced by diffuse midline glioma and found significant differences among different groups. Additionally, a short-term survival prediction model was constructed using cortical features and tumor radiomics, which showed high accuracy in predicting patient survival.
Article
Biochemistry & Molecular Biology
Shengxiang Fu, Zhongyuan Cai, Li Liu, Xiaomin Fu, Chunchao Xia, Su Lui, Qiyong Gong, Bin Song, Hua Ai
Summary: This study demonstrates the successful synthesis of branched polymer contrast agents with high kinetic stability and T-1 relaxivity by introducing rigid carbon chains and PEG into the structure of Gd-DOTA backbone-bound branched polymers.
Review
Chemistry, Multidisciplinary
Xiuli Zheng, Xiaohai Song, Guonian Zhu, Dayi Pan, Haonan Li, Jiankun Hu, Kai Xiao, Qiyong Gong, Zhongwei Gu, Kui Luo, Weimin Li
Summary: Lung cancer, the second most prevalent cancer and the leading cause of cancer-related death, is often accompanied by drug resistance. Nanomedicine, with its multifunctional and tunable physiochemical properties, holds great promise in overcoming drug resistance in lung cancer treatment.
ADVANCED MATERIALS
(2023)
