Article
Psychiatry
Guillermo Pardo-de-Santayana, Maria Juncal-Ruiz, Javier Vazquez-Bourgon, Laura Riesco-Davila, Victor Ortiz-Garcia de la Foz, Jose Maria Pelayo-Teran, Marcos Lopez-Hoyos, Benedicto Crespo-Facorro
Summary: Research shows that first episode psychosis (FEP) patients have higher levels of pro-inflammatory cytokines in their serum, which may contribute to neural harm, and prolonged active psychosis at the early stages of the illness is associated with poorer functional outcomes. The study suggests that the change in serum levels of MIP-3 alpha and scores of negative psychotic symptoms in the early months of treatment could predict the time to initial remission of positive psychotic symptoms.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Piotr Szpakowski, Dominika Ksiazek-Winiarek, Malgorzata Turniak-Kusy, Ilona Pacan, Andrzej Glabinski
Summary: Astrocytes, once considered passive brain cells, have been found to play a more active role in the central nervous system. This study aimed to evaluate the production of inflammatory chemokines and neurotrophic factors by primary human astrocytes after inflammatory or anti-inflammatory stimulation. The results showed that only astrocytes induced by inflammatory mediators produced certain chemokines, and pro-inflammatory conditions decreased the release of a neurotrophic factor while anti-inflammatory cytokines increased its production.
Article
Chemistry, Medicinal
Kalu K. Asanka Sanjeewa, Kalahe H. I. N. M. Herath, Hye-Won Yang, Cheol Soo Choi, You-Jin Jeon
Summary: Fucoidans are sulfated heteropolysaccharides found in brown seaweeds and some marine invertebrates, with promising bioactive properties such as antioxidant, immunomodulatory, anti-inflammatory, antiobesity, antidiabetic, and anticancer properties. Controlled inflammatory responses are beneficial, but chronic inflammatory responses are often associated with the pathogenesis of various diseases.
Article
Biochemistry & Molecular Biology
David M. M. Cauvi, Dennis Hawisher, Julia Derunes, Antonio De Maio
Summary: Phospholipids play important roles in cellular membranes, vesicles, and lipid nanoparticles. The presence of phospholipids can alter the transcriptome and proteome of cells, as well as modulate signaling pathways, leading to changes in cellular functions.
Review
Cardiac & Cardiovascular Systems
Bryce R. Evans, Anais Yerly, Emiel P. C. van der Vorst, Iris Baumgartner, Sarah Maike Bernhard, Marc Schindewolf, Yvonne Doering
Summary: Atherosclerotic vascular disease is the most common cause of ischemia, myocardial infarction, and stroke. The structure and function of the arterial vessel wall, consisting of the adventitia, media, and intima, determine vascular function. Vascular smooth muscle cells and endothelial cells are key in shaping the vascular wall and maintaining proper function. Atherosclerosis, initiated by endothelial dysfunction, leads to pathological alterations known as vascular remodeling, ultimately causing insufficient vascular function and cardiovascular events.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Anders Larsson, Johanna Helmersson-Karlqvist, Lars Lind, Johan Arnlov, Tobias Rudholm Feldreich
Summary: The study revealed significant associations between plasma osteopontin and multiple biomarkers, while no significant associations were found between urine osteopontin and the studied plasma cytokine biomarkers. This suggests that circulating osteopontin plays a role in a protein-protein interaction network involving chemokines, cytokines, and growth factors.
Article
Rheumatology
Marc Corbera-Bellalta, Roser Alba-Rovira, Sujatha Muralidharan, Georgina Espigol-Frigole, Roberto Rios-Garces, Javier Marco-Hernandez, Amanda Denuc, Farah Kamberovic, Patricia Perez-Galan, Alexandra Joseph, Annalisa D'Andrea, Kent Bondensgaard, Maria C. Cid, John F. Paolini
Summary: The study found increased expression of GM-CSF and its receptor alpha in GCA lesions. Enhanced JAK2/STAT5A expression/phosphorylation and increased expression of target genes CD83 and Spi1/PU.1 were observed in GCA lesions. Treatment with mavrilimumab in ex vivo cultured GCA arteries resulted in reduced expression of cell markers CD3 epsilon, CD20, CD14, and CD16, as well as reduced infiltration of CD16 and CD3 epsilon cells. Mavrilimumab also reduced the expression of molecules related to T cell activation, Th1 differentiation, pro-inflammatory cytokines, and vascular injury. Additionally, mavrilimumab reduced CD34+ cells and neoangiogenesis in GCA lesions.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Review
Cell Biology
Lavanya Goodla, Xiang Xue
Summary: This brief review discusses the involvement of three representative cytokines (TNF-alpha, IL-6 and IL-1 beta), a lipid molecule PGE2 and two chemokines (CXCL1 and CXCL2) in the process of CRC liver metastases.
Review
Immunology
Priscilla Vilela dos Santos, Debora Nonato Miranda de Toledo, Debora Maria Soares de Souza, Tatiana Prata Menezes, Luiza Oliveira Perucci, Zolder Marinho Silva, Daniela Caldas Teixeira, Ed Wilson Rodrigues Vieira, Valter Ferreira de Andrade-Neto, Nathalia Sernizon Guimaraes, Andre Talvani
Summary: This study evaluated the available information on inflammatory and regulatory plasma mediators in pregnant women diagnosed with toxoplasmosis. Eight studies were included in the analysis, and the results showed that infected pregnant women had higher levels of IL-5, IL-6, IL-8, IL-17, CCL5, and IL-10 in their plasma. These findings suggest that the immune status of pregnant women determines the course of T. gondii infection, and the balance between inflammatory and regulatory cytokines mitigates the adverse effects on the placenta and fetus.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Rheumatology
Aaron Z. Reyes, Kelly A. Hu, Jacob Teperman, Theresa L. Wampler Muskardin, Jean-Claude Tardif, Binita Shah, Michael H. Pillinger
Summary: The search for effective COVID-19 management strategies is ongoing, with colchicine showing promise in targeting multiple mechanisms associated with excessive inflammation. Outpatient treatment with colchicine could potentially reduce the need for hospitalization and mortality due to COVID-19, benefiting both resource-replete and resource-poor regions by reducing the demand for rare or expensive care resources.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Medicine, General & Internal
Briana K. Clifford, Nadeem O. Kaakoush, Nicodemus Tedla, David Goldstein, David Simar
Summary: This study aimed to compare the effects of high-intensity and low-intensity aerobic exercise on the inflammatory profile of cancer survivors. It found that both low-intensity and high-intensity exercise can positively modulate inflammatory markers. Scaling up low-intensity exercise over time may be more applicable and achievable for cancer survivor cohorts while still eliciting beneficial effects on systemic inflammation.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Immunology
Timothy J. Liu, Lynlee L. Lin, Erin McMeniman, Jason Wu, Yung-Ching Kao, Snehlata Kumari, Glen M. Boyle, James W. Wells, H. Peter Soyer, Jazmina L. Gonzalez-Cruz
Summary: In this pilot study, the possibility of diagnosing inflammatory skin diseases from an immunological perspective was explored. Significant differences in the expression of inflammatory markers were detected between lesional and perilesional biopsies, indicating the potential of inflammatory signatures as diagnostic differentiators and alternative targets in anti-inflammatory treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ivan K. Domingo, Asna Latif, Amit P. Bhavsar
Summary: Cisplatin, a widely used chemotherapeutic drug, is effective against various solid cancers but limited by its adverse drug reactions. The most common reactions include nephrotoxicity, peripheral neuropathy, and ototoxicity. Previous studies focused on oxidative stress as the cause of these toxicities, but recent evidence suggests that inflammation may be the main driving force. This review summarizes the common and distinct inflammation characteristics among different adverse reactions, as well as current treatments targeting pro-inflammatory signaling pathways to improve the use of cisplatin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
David H. Adamowicz, Tsung-Chin Wu, Rebecca Daly, Michael R. Irwin, Dilip Jeste, Xin M. Tu, Lisa T. Eyler, Ellen E. Lee
Summary: This study aimed to explore the relationship between executive functioning and inflammatory biomarkers in people with schizophrenia. The results showed that systemic inflammation did not predict long-term declines in executive functioning. This suggests the need for further research to better understand the relationship and mechanisms between inflammation and cognition in schizophrenia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Plant Sciences
Gugulethu P. Khumalo, Thanh Nguyen, Ben-Erik Van Wyk, Yunjiang Feng, Ian E. Cock
Summary: In this study, the immunomodulatory and anti-inflammatory properties of bark from ten important southern African plants were evaluated. It was found that most of these plants exhibited cytokine inhibitory effects, providing new insights into the mechanisms by which they regulate inflammation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Psychology, Clinical
Rosa Ayesa-Arriola, Margarita Miguel-Corredera, Victor Ortiz-Garcia de la Foz, Karl D. Neergaard, Patricia Correa-Ghisays, Esther Setien-Suero, Benedicto Crespo-Facorro
Summary: Lower levels of education are associated with the development of psychosis, while higher education is linked to better initial conditions and outcomes in first episode of psychosis (FEP) patients.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Rosa Ayesa-Arriola, Victor Ortiz-Garcia de la Foz, Nancy Murillo-Garcia, Javier Vazquez-Bourgon, Maria Juncal-Ruiz, Marcos Gomez-Revuelta, Paula Suarez-Pinilla, Esther Setien-Suero, Benedicto Crespo-Facorro
Summary: This study found that cognitive reserve (CR) plays a role in the variability of clinical and neurocognitive outcomes in first-episode psychosis patients. Patients with low CR had more severe symptoms, while those with high CR had better cognitive functioning.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Psychology, Developmental
Nathalia Garrido-Torres, Karem Guzman-Torres, Susana Garcia-Cerro, Gladys Pinilla Bermudez, Claudia Cruz-Baquero, Hansel Ochoa, Diego Garcia-Gonzalez, Manuel Canal-Rivero, Benedicto Crespo-Facorro, Miguel Ruiz-Veguilla
Summary: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social interaction deficiencies, restricted interests, and repetitive behaviors. MicroRNAs (miRs/miRNAs) are implicated in the development of ASD, with miR-451a being the most relevant marker for impaired social interaction. Other dysregulated miRNAs, such as miR-19a-3p, miR-494, and miR-142-3p, are expressed differently in various tissues and body fluids of ASD patients, suggesting their potential as biomarkers. Saliva is considered the optimal biological fluid for miRNA measurements due to its easy collection from children.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Psychiatry
Cinta Gas, Rosa Ayesa-Arriola, Javier Vazquer-Bourgon, Benedicto Crespo-Facorro, Jesus Garcia-Gavilan, Javier Labad, Lourdes Martorell, Gerard Muntane, Vanessa Sanchez-Gistau, Elisabet Vilella
Summary: Recent evidence suggests that DDR1 plays a role in myelination and is associated with decreased cognitive processing speed in schizophrenia. This study investigated the association between DDR1 variants and cognitive processing speed in early psychosis patients. The results showed that SZ-risk combined genotypes were associated with increased cognitive processing speed in early psychosis patients.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychiatry
Manuel Canal-Rivero, Miguel Ruiz-Veguilla, Victor Ortiz-Garcia de la Foz, Alvaro Lopez-Diaz, Nathalia Garrido-Torres, Rosa Ayesa-Arriola, Javier Vazquez-Bourgon, Jacqueline Mayoral-van Son, Paolo Brambilla, Tilo Kircher, Rafael Romero-Garcia, Benedicto Crespo-Facorro
Summary: This study used a long-term longitudinal design to investigate the evolution of negative symptoms in first-episode psychosis and their associated brain changes. The results identified stable, decreasing, and increasing trajectories in three factors of negative symptoms (expressivity, experiential, and attention). Furthermore, patients with an increasing trajectory in expressivity showed cortical thinning in certain brain regions, which could be used as a biomarker of poor symptom outcome.
BRITISH JOURNAL OF PSYCHIATRY
(2023)
Correction
Biochemistry & Molecular Biology
Sean R. McWhinney, Katharina Brosch, Vince D. Calhoun, Benedicto Crespo-Facorro, Nicolas A. Crossley, Udo Dannlowski, Erin Dickie, Lorielle M. F. Dietze, Gary Donohoe, Stefan Du Plessis, Stefan Ehrlich, Robin Emsley, Petra Furstova, David C. Glahn, Alfonso Gonzalez-Valderrama, Dominik Grotegerd, Laurena Holleran, Tilo T. J. Kircher, Pavel Knytl, Marian Kolenic, Rebekka Lencer, Igor Nenadic, Nils Opel, Julia-Katharina Pfarr, Amanda L. Rodrigue, Kelly Rootes-Murdy, Alex J. Ross, Kang Sim, Antonin Skoch, Filip Spaniel, Frederike Stein, Patrik Svancer, Diana Tordesillas-Gutierrez, Juan Undurraga, Javier Vaquez-Bourgon, Aristotle Voineskos, Esther Walton, Thomas W. Weickert, Cynthia Shannon Weickert, Paul M. Thompson, Theo G. M. van Erp, Jessica A. Turner, Tomas Hajek
MOLECULAR PSYCHIATRY
(2023)
Correction
Psychiatry
Nathalia Garrido-Torres, Luis Alameda, Maria Luisa Suarez Suarez, Idalino Rocha Gonzalez, Manuel Canal-Rivero, Benedicto Crespo-Facorro, Miguel Ruiz-Veguillaabc
PSYCHIATRY RESEARCH
(2023)
Letter
Psychiatry
Nathalia Garrido-Torres, Luis Alameda, Idalino Rocha-Gonzalez, Manuel Canal-Rivero, Benedicto Crespo-Facorro, Miguel Ruiz-Veguilla
PSYCHIATRY RESEARCH
(2023)
Article
Psychiatry
Nancy Murillo-Garcia, Victor Ortiz-Garcia de la Foz, Margarita Miguel-Corredera, Javier Vazquez-Bourgon, Esther Setien-Suero, Karl Neergaard, Jorge Moya-Higueras, Benedicto Crespo-Facorro, Rosa Ayesa-Arriola
Summary: This study aimed to analyse whether intelligence quotient (IQ) improves, declines, or remains stable over 10 years among First Episode Psychosis (FEP) patients and healthy subjects. Cluster analysis revealed that FEP patients showed intellectual improvement or stability, but no decline post-onset of psychosis. However, the profiles of intellectual change among FEP patients are more heterogeneous than that of healthy controls over 10 years.
SCHIZOPHRENIA RESEARCH
(2023)
Article
Psychiatry
Manuel Canal-Rivero, Javier Vazquez-Hernandez, Marta Leon-Gomez, Silvia Maraver-Ayala, Luis Fernandez-Portes, Soraya Sanhez-Benitez, Nathalia Garrido-Torres, Miguel Ruiz-Veguilla, Benedicto Crespo-Facorro
Summary: The study aimed to explore the prevalence and temporal pattern of COVID-19 in long-term mental health facilities in Spain, as well as estimate the impact of severe mental health diagnosis on COVID-19 outcomes. The findings showed that workers had a higher risk of testing positive for COVID-19 compared to mental health users. However, after adjusting for age and gender, the risk of testing positive for COVID-19 was similar for mental health users. The study concluded that the lower prevalence of COVID-19 among mental health users could be attributed to preventive measures and the possible role of antipsychotic treatment in preventing SARS-CoV-2 infection.
SCHIZOPHRENIA RESEARCH
(2023)
Article
Psychiatry
Edward Millgate, Sophie E. Smart, Antonio F. Pardinas, Eugenia Kravariti, Olesya Ajnakina, Adrianna P. Kapinska, Ole A. Andreassen, Thomas R. E. Barnes, Domenico Berardi, Benedicto Crespo-Facorro, Giuseppe D'Andre, Arsime Demjaha, Marta Di Forti, Gillian A. Doody, Laura Kassoumeri, Aziz Ferchiou, Lorenzo Guidi, Eileen M. Joyce, Ornella Lastrina, Ingrid Melle, Baptiste Pignon, Jean-Romain Richard, Carmen Simonsen, Andrei Szoke, Ilaria Tarricone, Andrea Tortelli, Javier Vazquez-Bourgon, Robin M. Murray, James T. R. Walters, James H. MacCabe
Summary: This study aimed to determine whether cognitive impairment at first episode significantly differs between future antipsychotic responders and resistant cases. The findings showed that patients who were future classified as treatment resistant reported poorer performance across most cognitive domains at baseline. These results indicate that deficits in IQ/general cognitive functioning at first episode are associated with future treatment resistance.
SCHIZOPHRENIA RESEARCH
(2023)
Article
Psychiatry
J. M. Lopez-Villatoro, M. Diaz-Marsa, A. de la Torre-Luque, K. S. MacDowell, C. Prittwitz, J. C. Leza, J. L. Carrasco
Summary: This study aimed to identify clusters of BPD patients based on inflammatory/oxidative biomarker profiles and investigate their association with phenotypic features. Two clusters were identified: Cluster 1 patients had higher levels of antioxidant and anti-inflammatory biomarkers, longer disease duration, milder anxiety symptoms, and lower prescription of antipsychotic drugs compared to Cluster 2 patients.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2023)
Article
Behavioral Sciences
Celia Martin-Cuevas, Victor Dario Ramos-Herrero, Benedicto Crespo-Facorro, Ana C. Sanchez-Hidalgo
Summary: This paper systematically reviews prenatal environmental alterations and adolescent cannabis consumption associated with an increased risk of SCZ, focusing on dual animal models where prenatal environmental exposure and postnatal cannabis exposure are the two hits.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Psychiatry
Inge Winter-van Rossum, Mark Weiser, Silvana Galderisi, Stefan Leucht, Istvan Bitter, Birte Glenthoj, Alkomiet Hasan, Jurjen Luykx, Marina Kupchik, Georg Psota, Paola Rocca, Nikos Stefanis, Alexander Teitelbaum, Mor Bar Haim, Claudia Leucht, Georg Kemmler, Timo Schurr, Michael Davidson, Rene S. Kahn, W. Wolfgang Fleischhacker
Summary: This study aimed to compare the efficacy of long-acting injectable (LAI) antipsychotics and oral medication in preventing medication discontinuation in patients with early-phase schizophrenia. The findings showed no substantial advantage of LAI treatment over oral treatment regarding time to discontinuation.
Article
Psychiatry
Gerard Muntane, Javier Vazquez-Bourgon, Ester Sada, Lourdes Martorell, Sergi Papiol, Elena Bosch, Arcadi Navarro, Benedicto Crespo-Facorro, Elisabet Vilella
Summary: Individuals with a first episode of psychosis experience rapid weight gain in the initial months of treatment, which is influenced by genetics. Genetic factors play a significant role in determining weight gain during the first episode of psychosis, highlighting the importance of genetic pleiotropy in predicting future outcomes.
EUROPEAN PSYCHIATRY
(2023)