Article
Clinical Neurology
Margo W. Menkes, Carolyn M. Andrews, Takakuni Suzuki, Jinsoo Chun, Lisa O'Donnell, Tyler Grove, Wisteria Deng, Melvin G. McInnis, Patricia J. Deldin, Ivy F. Tso
Summary: This study aimed to investigate the impaired impulsivity control in individuals with bipolar I disorder (BD) and whether similar difficulties are present in schizophrenia spectrum disorders (SZ). The results suggest that both BD and SZ patients have difficulties in discriminating emotional faces from neutral faces, which may contribute to difficulties in appropriate behavioral responding in social-affective contexts.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Andrea J. Wood, Amber R. Carroll, Ann K. Shinn, Dost Ongur, Kathryn E. Lewandowski
Summary: Psychiatric diagnosis is not always stable, as evidenced by a diagnostic change rate of 25.4% in individuals with psychosis over time. Initial diagnoses of certain disorders, such as schizophrenia-spectrum disorders, were more likely to lead to diagnostic changes, highlighting the natural instability of some diagnoses.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychiatry
Daniel Guinart, Renato de Filippis, Stella Rosson, Bhagyashree Patil, Lara Prizgint, Nahal Talasazan, Herbert Meltzer, John M. Kane, Robert D. Gibbons
Summary: The study developed CAT-Psychosis test, which can quickly and reliably assess the severity of psychosis and discriminate psychotic patients from healthy controls. The development and calibration study included 649 psychotic patients, while the validation study involved 160 patients and 40 healthy controls.
SCHIZOPHRENIA BULLETIN
(2021)
Article
Psychiatry
Sophie-Kathrin Kirchner, Michael Lauseker, Kristina Adorjan, Heike Anderson-Schmidt, Ion-George Anghelescu, Bernhardt T. Baune, Monika Budde, Udo Dannlowski, Detlef E. Dietrich, Andreas J. Fallgatter, Peter Falkai, Christian Figge, Katrin Gade, Urs Heilbronner, Lena Hiendl, Georg Juckel, Janos L. Kalman, Farahnaz Kloehn-Saghatolislam, Carsten Konrad, Fabian U. Lang, Mojtaba Oraki Kohshour, Sergi Papiol, Daniela Reich-Erkelenz, Jens Reimer, Eva Z. Reininghaus, Sabrina K. Schaupp, Max Schmauss, Andrea Schmitt, Eva Christina Schulte, Simon Senner, Carsten Spitzer, Thomas Vogl, Joerg Zimmermann, Alkomiet Hasan, Thomas G. Schulze, Fanny Senner
Summary: This study comprehensively evaluates the association of sociodemographic, clinical, personality, and quality of life related factors with medication adherence by analyzing data from the PsyCourse study. The results show that never having used illicit drugs, the number of prescribed antipsychotics, the personality trait conscientiousness, and the environmental domain of quality of life have the strongest association with medication adherence.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Johan Ahti, Tuula Kieseppa, Jaana Suvisaari, Kimmo Suokas, Minna Holm, Asko Wegelius, Ari Ahola-Olli, Katja Hakkinen, Olli Kampman, Markku Lahteenvuo, Tiina Paunio, Jari Tiihonen, Annamari Tuulio-Henriksson, Erkki Isometsa
Summary: This study compared psychosocial functioning between schizophrenia, schizoaffective disorder, bipolar disorder, and major depressive disorder with psychotic features. The results showed that schizophrenia had the worst level of functioning, while bipolar disorder had the best. Gender and number of hospitalizations were strongly associated with marriage, employment, and independent living across all diagnostic categories.
SCHIZOPHRENIA RESEARCH
(2022)
Article
Neurosciences
Emma E. M. Knowles, Juan M. Peralta, Laura Almasy, Vishwajit Nimgaonkar, Francis J. McMahon, Andrew M. McIntosh, Pippa Thomson, Samuel R. Mathias, Ruben C. Gur, Joanne E. Curran, Henriette Raventos, Javier Contreras, Assen Jablensky, Johanna Badcock, John Blangero, Raquel E. Gur, David C. Glahn
Summary: The study found significant genetic overlap between psychotic disorders and cognitive measures, while the genetic overlap between bipolar disorder and cognition is specific to different ascertainment strategies and ethnicities. Patients with affective disorders show enhanced performance in working and face memory.
BIOLOGICAL PSYCHIATRY
(2021)
Article
Psychiatry
Ambreen Kanwal, Sohail A. Sheikh, Amina Iftikhar, Sadaf Naz, Jose Pardo
Summary: By visiting outpatient departments in multiple hospitals in Lahore, Pakistan and conducting clinical assessments, we identified eight families with multiple affected individuals with psychiatric disorders. This highlights an alternative approach to discovering rare genetic variants causing psychiatric disorders.
Article
Psychiatry
Mariesa Cay, Virginie-Anne Chouinard, Mei-Hua Hall, Ann K. Shinn
Summary: This study aimed to examine the reliability of self-reports of childhood trauma in psychotic disorders. The study found that patients with schizophrenia and psychotic bipolar disorder can provide reliable self-reports, especially related to physical and emotional abuse.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Soili Tormalehto, Tanja Svirskis, Timo Partonen, Erkki Isometsa, Sami Pirkola, Marianna Virtanen, Reijo Sund
Summary: This study examines the seasonal patterns of hospital admissions in patients with mood and psychotic disorders and investigates whether the admission rates vary according to the seasonal daylength. The findings indicate that manic episodes peak in summer and have the lowest rates in winter. Unipolar depressive episodes peak in autumn and spring and have lower rates in summer. There is a similar seasonal pattern between schizophrenia and manic episodes, as well as between unipolar depressive, bipolar depressive, and mixed episodes.
CLINICAL EPIDEMIOLOGY
(2022)
Article
Psychiatry
Sang Jin Rhee, Dongyoon Shin, Daun Shin, Yoojin Song, Eun-Jeong Joo, Hee Yeon Jung, Sungwon Roh, Sang-Hyuk Lee, Hyeyoung Kim, Minji Bang, Kyu Young Lee, Se Hyun Kim, Minah Kim, Jihyeon Lee, Jaenyeon Kim, Yeongshin Kim, Jun Soo Kwon, Kyooseob Ha, Youngsoo Kim, Yong Min Ahn
Summary: Data-driven approaches are crucial for understanding the heterogeneity and overlap in transdiagnostic samples. This study used plasma proteomics-based clustering to subtype patients with psychotic-affective disorders. Significant differences were found between patients and healthy controls in terms of pathologic peptides. Latent class analysis revealed distinct classes of patients, with the negative symptom factor being significantly different between the classes. This highlights the significance of negative symptoms in understanding the heterogeneity and overlap of psychotic-affective disorders.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Psychiatry
Yong Qiu, Jiamin Dai, Yan Zou, Ling Zhao, Xiaowei Xia, Leijun Li, Jiaoshi Zhao, Tong Liu, Yichen Zhang, Junyan Wu, Zhinan Li, Zhuang Kang, Zili Han, Jinbei Zhang, Ruiwang Huang, Qinling Wei
Summary: Comparing white matter structural connectomic alterations between first episode SZ and BDP, this study found specific differences in brain regions that may help distinguish between the two disorders. Identifying shared and distinct WM networks may improve the understanding of the neuroanatomy of mental diseases.
ASIAN JOURNAL OF PSYCHIATRY
(2021)
Article
Psychiatry
Emma M. Parrish, Samantha A. Chalker, Mayra Cano, Raeanne C. Moore, Amy E. Pinkham, Philip D. Harvey, Thomas Joiner, Amy Lieberman, Eric Granholm, Colin A. Depp
Summary: This study used ecological momentary assessment to investigate the relationship between perceived burdensomeness (PB) and thwarted belonginess (TB) with suicidal ideation (SI) in individuals with psychotic disorders. The results showed that burdensomeness varied less within participants compared to belongingness, and participants with SI had higher burdensomeness ratings and lower belongingness ratings. Social context, psychotic symptoms, mood, and SI were all found to be related to these interpersonal suicide-related risk factors.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Psychiatry
Tuyen T. Le, Joshua D. Di Vincenzo, Kayla M. Teopiz, Yena Lee, Danielle S. Cha, Leanna M. W. Lui, Nelson B. Rodrigues, Roger C. Ho, Bing Cao, Kangguang Lin, Flora Nasri, Hartej Gill, Orly Lipsitz, Mehala Subramaniapillai, Rodrigo B. Mansur, Joshua D. Rosenblat, Roger S. McIntyre
Summary: Psychotic depression is a severe subtype of major depressive disorder with high relapse and mortality rates. Ketamine may be an alternative pharmacotherapy, but its efficacy and safety in patients with psychotic depression have not been established.
PSYCHIATRY RESEARCH
(2021)
Review
Psychiatry
Mark L. Vickers, Yoon Kwon Choi, Lars Eriksson, Yekaterina Polyakova-Nelson, Zorica Jokovic, Stephen D. Parker, Vikas Moudgil, Judith A. Dean, Joseph Debattista, James G. Scott
Summary: Research and clinical practice addressing sexual and reproductive health in young people with psychosis, including issues such as pregnancy, sexual violence, and gender, are crucial.
SCHIZOPHRENIA BULLETIN
(2023)
Review
Psychiatry
Nina Vindegaard, Helene Speyer, Merete Nordentoft, Simon Rasmussen, Michael Eriksen Benros
Summary: This review article explores alterations in gut microbiota of patients with psychotic disorders, bipolar disorder or depression compared to healthy controls. The findings suggest specific changes in microbiota composition in these patients, but caution is advised due to biases and methodological variability in the included studies. Larger studies are needed to further investigate the relationship between gut microbiota and mental disorders, while also considering various factors that may influence the results.
SCHIZOPHRENIA RESEARCH
(2021)
Article
Psychology, Clinical
Naici Liu, Rebekka Lencer, Zhipeng Yang, Wenjing Zhang, Chengmin Yang, Jiaxin Zeng, John A. Sweeney, Qiyong Gong, Su Lui
Summary: The study found that schizophrenia patients showed reductions in white matter functional activity, particularly in the genu of the corpus callosum. Additionally, there were correlations between white matter and gray matter functional activity, as well as white matter microstructure changes. These findings provide valuable evidence for functional alterations in schizophrenia.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Psychology, Clinical
Ling-Yu Huang, Brooke S. Jackson, Amanda L. Rodrigue, Carol A. Tamminga, Elliot S. Gershon, Godfrey D. Pearlson, Matcheri S. Keshavan, Sarah S. Keedy, S. Kristian Hill, John A. Sweeney, Brett A. Clementz, Jennifer E. McDowell
Summary: Antisaccade tasks can be used to assess cognitive control processes in individuals with psychotic disorders, showing differences in cognitive deficits across schizophrenia, schizoaffective disorder, and bipolar disorder with psychosis. Higher error rates and longer latencies on correctly performed antisaccade trials in psychosis cases indicate deficits specific to higher-order cognitive aspects of saccade generation.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Psychology, Developmental
Lauren M. Schmitt, John A. Sweeney, Craig A. Erickson, Rebecca Shaffer
Summary: This study evaluated the feasibility, reproducibility, and sensitivity of the probabilistic reversal learning task (PRL) as an outcome measure for cognitive flexibility in autism spectrum disorder (ASD) intervention trials. The results demonstrated that PRL is highly feasible, shows test-retest reproducibility, and is sensitive to detect change following interventions, suggesting it may be a useful measure for future ASD intervention trials focusing on cognitive flexibility.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2022)
Article
Neurosciences
Rebecca J. Lepping, Walker S. McKinney, Grant C. Magnon, Sarah K. Keedy, Zheng Wang, Stephen A. Coombes, David E. Vaillancourt, John A. Sweeney, Matthew W. Mosconi
Summary: Research indicates that individuals with autism spectrum disorder exhibit increased force variability and reduced entropy during visuomotor behavior, along with greater brain activation and decreased functional connectivity. Additionally, delayed maturation is observed in the functional connectivity between cerebellar-cortical sensorimotor and nonsensorimotor networks.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
Jordan E. Norris, Suzanne H. Kimball, Danna C. Nemri, Lauren E. Ethridge
Summary: Misophonia is a condition characterized by hypersensitivity and strong emotional reactivity to specific auditory stimuli. A study found that there are three types of symptom presentations in individuals with misophonia, ranging from severe symptoms with few co-occurring psychiatric conditions to a more complex presentation involving sensory hypersensitivities, tinnitus, and increased incidence of social and psychiatric symptoms.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biology
Ernest Pedapati, Lauren M. Schmitt, Lauren E. Ethridge, Rui Liu, Elizabeth Smith, John A. Sweeney, Rebecca C. Shaffer, Kelli C. Dominick, Donald L. Gilbert, Steve W. Wu, Paul S. Horn, Devin Binder, Martine Lamy, Megan Axford, Makoto Miyakoshi, Craig A. Erickson
Summary: This study analyzes electroencephalography data from 70 patients with Fragile X syndrome and discovers unique changes in neural activity, highlighting the role of disrupted thalamocortical modulation in local hyperexcitability.
COMMUNICATIONS BIOLOGY
(2022)
Article
Psychology, Developmental
Kevin Bell, Keegan McMillin, Lauren E. Ethridge
Summary: Being isolated from a group can lead to health risks and depressive symptomology, but the way an individual experiences isolation can moderate these negative effects. Individual perception of loneliness is influenced by social environment and attachment style. This paper reviews research on loneliness and attachment, highlighting the bidirectional relationships between them.
DEVELOPMENTAL REVIEW
(2022)
Article
Psychology, Multidisciplinary
Adon F. G. Rosen, Emma Auger, Nicholas Woodruff, Alice Mado Proverbio, Hairong Song, Lauren E. Ethridge, David Bard
Summary: This study highlights the introduction of parameter bias from the application of two-stage approaches and the manifestation of differential item functioning (DIF) in cognitive neuroscience data. The use of the multiple indicator multiple cause (MIMIC) model is shown to identify and remove items with DIF and model brain-behavior relationships with greater sensitivity. The results suggest that the MIMIC model can derive complex item-level brain-behavior relationships.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Clinical Neurology
Carrie R. Jonak, Ernest Pedapati, Lauren M. Schmitt, Samantha A. Assad, Manbir S. Sandhu, Lisa DeStefano, Lauren Ethridge, Khaleel A. Razak, John A. Sweeney, Devin K. Binder, Craig A. Erickson
Summary: In this study, EEG biomarkers were identified in both mouse model and human with FXS. The use of baclofen was associated with the suppression of abnormal gamma power and increase in low-frequency power at rest in both groups. This finding shows promise for the development of drugs for FXS using translational medicine approaches.
JOURNAL OF NEURODEVELOPMENTAL DISORDERS
(2022)
Article
Neurosciences
Lei Ding, Guofa Shou, Yoon-Hee Cha, John A. Sweeney, Han Yuan
Summary: Resting-state functional magnetic resonance imaging (fMRI) reveals brain-wide coordinated patterns of spontaneous neural activity in the human brain. However, understanding the fast brain-wide networks at the timescales of neuronal events remains limited due to temporal constraints. In this study, using scalp-based electroencephalography (EEG), researchers reconstructed cortical neural tomography and identified brain-wide intrinsic networks and their dynamics.
Article
Psychiatry
Maolin Hu, Yan Xia, Xiaofen Zong, John A. Sweeney, Jeffrey R. Bishop, Yanhui Liao, Gina Giase, Bingshan Li, Leah H. Rubin, Yunpeng Wang, Zongchang Li, Ying He, Xiaogang Chen, Chunyu Liu, Chao Chen, Jinsong Tang
Summary: This study suggests that short-term treatment with risperidone leads to changes in DNA methylation (DNAm) in drug-naive patients with schizophrenia. Risperidone therapy has a beneficial effect on DNAm, and these changes are related to changes in brain physiology, cognition, and symptom severity.
PSYCHIATRY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jordan E. Norris, Lisa A. DeStefano, Lauren M. Schmitt, Ernest V. Pedapati, Craig A. Erickson, John A. Sweeney, Lauren E. Ethridge
Summary: Fragile X syndrome (FXS) is a neurodevelopmental disorder characterized by intellectual disability, sensory hypersensitivity, executive function difficulties, and social anxiety. This study aimed to investigate the temporal and hemispheric dynamics supporting alpha phenotypes in FXS and their relationship with neural phenotypes related to auditory processing. The findings suggest that individuals with FXS show more differences in alpha power, primarily in the right hemisphere. The study also revealed sex differences in alpha hemisphere outcomes, with males displaying more bursts of alpha activity and females spending longer periods of time in sustained high alpha states.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Jordan E. Norris, Lauren M. Schmitt, Lisa A. De Stefano, Ernest V. Pedapati, Craig A. Erickson, John A. Sweeney, Lauren E. Ethridge
Summary: This study examined different subgroups of FMR1 premutation carriers and found varying sensory processing characteristics that have been previously understudied. The findings further validate the clinical subgroups and provide valuable information for identifying mechanisms supporting specific risk factors and divergent therapeutic needs.
FRONTIERS IN INTEGRATIVE NEUROSCIENCE
(2023)
Article
Neurosciences
Kathryn E. Unruh, James Bartolotti, Walker S. McKinney, Lauren M. Schmitt, John A. Sweeney, Matthew W. Mosconi
Summary: Sensorimotor issues in autism spectrum disorder (ASD) involve deficits in multimodal sensory feedback integration and reduced reliance on error-monitoring processes. This study found that individuals with ASD showed reduced functional connectivity in specific brain regions during a visuomotor task at high force levels. Additionally, reduced connectivity was associated with more severe ASD symptoms. These findings suggest that parietal-cerebellar connectivity may serve as a neural marker underlying both core and comorbid features of ASD.
Article
Biochemistry & Molecular Biology
Suheyla Cetin-Karayumak, Amanda E. E. Lyall, Maria A. A. Di Biase, Johanna Seitz-Holland, Fan Zhang, Sinead Kelly, Doron Elad, Godfrey Pearlson, Carol A. A. Tamminga, John A. A. Sweeney, Brett A. A. Clementz, David Schretlen, Katharina Stegmayer, Sebastian Walther, Jungsun Lee, Tim Crow, Anthony James, Aristotle Voineskos, Robert W. W. Buchanan, Philip R. R. Szeszko, Anil K. K. Malhotra, Matcheri Keshavan, Martha E. E. Shenton, Yogesh Rathi, Ofer Pasternak, Marek Kubicki
Summary: Studies using Free Water Imaging have consistently found increased extracellular free water in individuals with early psychosis, but the time course of these elevations and their relationship with illness duration have not been extensively studied. Our multi-site analysis of diffusion magnetic resonance imaging scans from individuals with schizophrenia at different illness stages and ages reveals that average whole brain free water is higher in individuals with schizophrenia across all ages, with the greatest values observed in early adulthood. Additionally, free water is negatively associated with illness duration.
MOLECULAR PSYCHIATRY
(2023)