Journal
SCHIZOPHRENIA RESEARCH
Volume 138, Issue 2-3, Pages 188-191Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.schres.2012.04.005
Keywords
Amygdala; MRI; Psychotic bipolar disorder; Schizophrenia
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Funding
- National Institute of Health [R01 MH064838, R01 EB000975, P41 RR015241]
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Meta-analyses report larger amygdala in subjects with bipolar disorder compared to schizophrenia. However, few studies have compared the size of amygdala in psychotic bipolar disorder with schizophrenia. Here we examine size of amygdala in a sample of 36 patients with psychotic bipolar disorder, 31 patients with schizophrenia and 27 healthy comparison subjects. Patients with schizophrenia had smaller amygdala compared with patients with psychotic bipolar disorder (p=0.014). These results suggest that change in volume of amygdala may represent a morphologic feature distinguishing psychotic bipolar disorder from schizophrenia. (C) 2012 Elsevier B.V. All rights reserved.
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