Journal
SCHIZOPHRENIA RESEARCH
Volume 119, Issue 1-3, Pages 110-114Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.schres.2009.11.012
Keywords
Schizophrenia; Nicotine; Smoking initiation; Cumulative hazard curves; Survival analysis
Categories
Funding
- Beijing Municipal Natural Science Foundation [7072035]
- Stanley Medical Research Institute [03T-459, 05T-726]
- Department of Veterans Affairs
- VISN 16
- Mental Illness Research, Education and Clinical Center (MIRECC)
- United States National Institute of Health [K05-DA0454, P50-DA18827, U01-MH79639]
- NATIONAL INSTITUTE OF MENTAL HEALTH [U01MH079639] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [K05DA000454] Funding Source: NIH RePORTER
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Schizophrenia is associated with a greater probability of ever smoking daily and with higher rates of initiation of daily smoking after age 20 in Caucasian populations. The aims of the current study were to replicate that schizophrenia is associated with smoking and higher risk of initiating daily smoking before schizophrenia starts among a large sample of male Chinese patients. A survival analysis of onset age for daily smoking compared 776 DSM-IV male inpatients with schizophrenia to 560 male controls. The results showed that the cumulative hazard curves for age of smoking initiation in schizophrenia and controls were significantly different (p<0.001), even after controlling for education (p<0.001). After excluding the patients who started smoking within 5 years before schizophrenia started, the cumulative hazard curve for schizophrenia was significantly different from ever-smoked controls (p<0.001), even after adjusting for education (p<0.001). These findings suggest that schizophrenic patients have a higher risk of starting daily smoking suggesting that vulnerability to schizophrenia may be associated with a higher risk of becoming a daily smoker. (C) 2009 Elsevier B.V. All rights reserved.
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