4.6 Article

Similar Age-Related Decline in Cortical Activity Over Frontotemporal Regions in Schizophrenia: A Multichannel Near-Infrared Spectroscopy Study

Journal

SCHIZOPHRENIA BULLETIN
Volume 41, Issue 1, Pages 268-279

Publisher

OXFORD UNIV PRESS
DOI: 10.1093/schbul/sbu086

Keywords

schizophrenia; near infrared spectroscopy; age effect; NIRS

Categories

Funding

  1. Ministry of Health, Labour, and Welfare [H23-seishin-ippan-002]
  2. Japan Society for the Promotion of Science/Ministry of Education, Culture, Sports, Science and Technology [21249064]
  3. Intramural Research Grant for Neurological and Psychiatric Disorders of NCNP [23-10]
  4. Japan Research Foundation for Clinical Pharmacology
  5. Takeda Science Foundation
  6. [23118001]
  7. [23118004]
  8. [23791309]

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Although recent studies have demonstrated that patients with schizophrenia and healthy controls did not differ in the speed of age-related decline in cortical thickness and performances on cognitive tests, hemodynamic changes assessed by functional neuroimaging remain unclear. This study investigated age effects on regional brain cortical activity to determine whether there is similar age-related decline in cortical activity as those observed in cortical thickness and cognitive test performance. A total of 109 patients with schizophrenia (age range: 16-59 y) and 106 healthy controls (age range: 16-59 y) underwent near-infrared spectroscopy (NIRS) while performing a verbal fluency test (VFT). Group comparison of cortical activity was examined using 2-tailed t tests, adopting the false discovery rate method. The relationship between age and cortical activity was investigated using correlational and multiple regression analyses, adjusting for potential confounding variables. A 2-way ANOVA was conducted to investigate differences in the age effects between diagnostic groups. The patient group exhibited significantly decreased cortical activity in several regions of the frontotemporal cortices. However, slopes of age-dependent decreases in cortical activity were similar between patients and healthy individuals at the bilateral frontotemporal regions. Our study showed no significant between-group differences in the age-related decline in cortical activity, as measured by NIRS, over the frontotemporal regions during a VFT. The results of our study may indicate a decrease in cortical activity in a relatively limited period around illness onset rather than continuously progressing over the course of the illness.

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