Article
Psychiatry
Theodora Stefanidou, Jingyi Wang, Nicola Morant, Brynmor Lloyd-Evans, Sonia Johnson
Summary: This study reveals that loneliness is often overlooked in early intervention services for psychosis, and there is a lack of targeted strategies for addressing it. Mental health practitioners suggest that interventions targeting symptoms, stigma, and negative self-schemas may be beneficial in alleviating loneliness for individuals with early psychosis. Empirical research is needed to develop and test such interventions.
Article
Psychology, Clinical
Joanne S. Carpenter, Jan Scott, Frank Iorfino, Jacob J. Crouse, Nicholas Ho, Daniel F. Hermens, Shane P. M. Cross, Sharon L. Naismith, Adam J. Guastella, Elizabeth M. Scott, Ian B. Hickie
Summary: This study aimed to identify clinical predictors of the onset of bipolar disorder (BD) or psychotic disorder (PD) in youth presenting to early intervention services. The results showed that age, social and occupational functioning, mania-like experiences, suicide attempts, and reduced incidence of physical illness were associated with the emergence of BD, while age, male sex, psychosis-like experiences, suicide attempts, stimulant use, and childhood-onset depression were associated with the emergence of PD.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Nursing
Soontareeporn Meepring, Richard Gray, Xia Li, Wai Tong Chien, Yan Li, Grace W. K. Ho, Preeyakamon Kritkitrat, Daniel Bressington
Summary: This study aimed to investigate the efficacy of the Thai Health Improvement Profile intervention in preventing clinically significant weight gain in individuals with early stage psychosis. The results showed that the intervention group had a lower risk of weight gain compared to the treatment as usual group, although there was a relatively high attrition rate.
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2023)
Article
Psychiatry
Bastian Bertulies-Esposito, Srividya Iyer, Amal Abdel-Baki
Summary: The increased political involvement and funding from the provincial government in Quebec led to widespread implementation of high-quality and accessible early intervention services for psychosis (EIS). Despite some differences between programs founded before and after 2017, the overall impact of the year of implementation was not discernible. Challenges in collecting data may hinder monitoring, data-informed decision-making, and quality improvement.
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2022)
Article
Medicine, General & Internal
Joanna Abraham, Katherine J. Holzer, Emily M. Lenard, Kenneth E. Freedland, Bethany R. Tellor Pennington, Rachel C. Wolfe, Theresa A. Cordner, Ana A. Baumann, Mary Politi, Michael Simon Avidan, Eric Lenze
Summary: This article discusses the high risk of the perioperative period for older adults, specifically the common problems of depression and anxiety. The study aims to design an intervention bundle to improve perioperative mental health, including behavioral activation and medication optimization, and test its feasibility. Quantitative data collection and qualitative feedback analysis will be conducted, and ethical and dissemination plans are in place.
Review
Psychiatry
Alastair Pipkin
Summary: Research shows that delivering Early Intervention in Psychosis teams (EITs) services in rural areas can lead to positive clinical outcomes, especially when using a hub-and-spoke model and stand-alone services. However, adherence to EIT models in rural areas may face challenges such as low overall adherence and issues with funding and managerial support.
EARLY INTERVENTION IN PSYCHIATRY
(2021)
Article
Medicine, General & Internal
Melino Ndayizigiye, Ryan McBain, Collin Whelley, Rorisang Lerotholi, Joalane Mabathoana, Merida Carmona, Joe Curtain, Ermyas Birru, Sara Stulac, Ann C. Miller, Sonya Shin, Nancy Rumaldo, Joia Mukherjee, Adrianne Katrina Nelson
Summary: This study evaluated the integration of a novel early childhood development (ECD) program into the primary healthcare system in Lesotho and found that integrating ECD intervention into a rural primary care platform may be an effective and efficient way to promote ECD outcomes.
Article
Medicine, General & Internal
Xiaojuan Wan, Janita Pak Chun Chau, Ying Wu, Limei Xu, Weijuan Gong
Summary: This study aims to develop a nurse-led peer support intervention for stroke survivors based on the Person-Environment-Occupation-Performance Model and evaluate its effects on the psychosocial outcomes of stroke survivors. The study will recruit 120 stroke survivors for a two-arm randomised controlled trial, with 60 participants in each group. The primary outcomes are social participation and participation self-efficacy.
Review
Medicine, General & Internal
Mikaela Law, Nikita Karulkar, Elizabeth Broadbent
Summary: Viewing visual artworks may have positive effects on reducing stress, with potential moderating factors including setting, individual characteristics, artwork content, and viewing instructions. More robust research with standardized methods and randomized controlled trial designs is needed to further understand the effects.
Article
Psychology, Clinical
Jim van Os, Lotta-Katrin Pries, Margreet ten Have, Ron de Graaf, Saskia van Dorsselaer, Maarten Bak, Gunter Kenis, Bochao D. Lin, Nicole Gunther, Jurjen J. Luykx, Bart P. F. Rutten, Sinan Guloksuz
Summary: Background: Combining the contextual clinical characterization framework with categorical algorithm-based diagnosis can provide more clinical value to patients. Methods: Prospective analysis of data from multiple domains to predict the impact on care needs and healthcare outcomes. Results: The predictive power of the contextual clinical characterization components in joint models exceeded that of any individual component, and the polygenic risk scores did not contribute significantly to the models. Conclusion: The transdiagnostic framework of contextual clinical characterization is more valuable to patients than a categorical system of algorithmic ordering of psychopathology.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Carla Betina Andreucci, Veronique Filippi, Jose Guilherme Cecatti
Summary: This study aims to complement the 2016 WHO antenatal guidelines by systematically reviewing the effects of evidence-based interventions on maternal well-being or functioning. Findings will be disseminated through peer-reviewed publications and scientific events, with a focus on improving maternal outcomes.
Article
Psychiatry
Stephen Puntis, Sofia Pappa, Belinda Lennox
Summary: Early intervention services are effective for individuals with first-episode psychosis, but little is known about care pathways after these services. This study mapped care pathways at the end of early intervention treatment and identified common trajectories of care.
EARLY INTERVENTION IN PSYCHIATRY
(2023)
Review
Medicine, General & Internal
Martin Nwadiugwu
Summary: People with early-onset dementia are at risk of marginalisation due to blame and stigma associated with their condition, leading to limited access to care and social support. Relationship-centred care approaches such as early diagnosis, behavioural therapies, Montessori activities, and community services tailored to their needs can help improve their situation and support their caregivers.
POSTGRADUATE MEDICAL JOURNAL
(2021)
Article
Medicine, General & Internal
Siobhan Hugh-Jones, N. Janardhana, Hareth Al-Janabi, Poornima Bhola, Paul Cooke, Mina Fazel, Kristian Hudson, Prachi Khandeparkar, Tolib Mirzoev, Surendran Venkataraman, Robert M. West, Pavan Mallikarjun
Summary: This article presents the study design for the Safeguarding Adolescent Mental Health in India (SAMA) project, aiming to codesign and feasibility test a suite of interventions to reduce the prevalence of anxiety and depression in Indian adolescents. The interventions will target various systems, including schools, families, and local communities, and incorporate curriculum, social components, mental health literacy, positive behavior practices, and adolescent-led films and social media.
Article
Multidisciplinary Sciences
Maria Ishaq Khattak, Lisa Dikomitis, Muhammad Firaz Khan, Mukhtar Ul Haq, Umaima Saeed, Naila Riaz Awan, Zia Ul Haq, Thomas Shepherd, Christian D. Mallen, Saeed Farooq
Summary: This study aims to explore the perceptions and experiences of schizophrenia from patients, caregivers, healthcare providers, spiritual and traditional healers in Pakistan, in order to develop a community-based intervention for improving treatment adherence. The findings highlight that schizophrenia is not solely a biomedical problem, but influenced by poverty and social disparity. Spiritual and traditional healing methods are seen as integral to the well-being and rehabilitation of schizophrenia patients. The lack of mental health services, training, and necessary medication in primary care is identified as a major issue. Barriers to community-based interventions include multiple pressures on staff, lack of incentives, non-availability of medication, and lack of formal referral pathways.
Article
Psychiatry
G. Paul Amminger, Ashleigh Lin, Melissa Kerr, Amber Weller, Jessica Spark, Charlotte Pugh, Sally O'Callaghan, Maximus Berger, Scott R. Clark, James G. Scott, Andrea Baker, Iain McGregor, David Cotter, Zoltan Sarnyai, Andrew Thompson, Alison R. Yung, Brian O'Donoghue, Eoin Killackey, Cathy Mihalopoulos, Hok Pan Yuen, Barnaby Nelson, Patrick D. McGorry
Summary: This study aims to test the efficacy of CBD in treating subthreshold psychotic symptoms in the at-risk stage of psychotic disorder. Through a randomized controlled trial, CBD will be compared to placebo in improving positive psychotic symptoms in UHR patients, with the hypothesis that CBD will be significantly more effective.
EARLY INTERVENTION IN PSYCHIATRY
(2022)
Article
Psychiatry
Michael Tham, Sarah Bendall, Thomas Carlyon-Stewart, Andrea Polari, Jessica Hartmann, Melissa Kerr, Paul Amminger, Patrick McGorry, Barnaby Nelson, Aswin Ratheesh
Summary: The study found that carers' experiences of their teenagers being identified as at-risk for psychosis varied, with main themes including limited or variable recall of risk information, perceived positive goal of risk disclosure, negative emotions associated with knowledge of risk, relief from uncertainty and helplessness, and effects of risk disclosure mediated by individual circumstance.
EARLY INTERVENTION IN PSYCHIATRY
(2022)
Article
Psychiatry
Sue M. Cotton, Kate M. Filia, Martin Lambert, Michael Berk, Aswin Ratheesh, Benno G. Schimmelmann, Craig Macneil, Melissa Hasty, Patrick D. McGorry, Philippe Conus
Summary: The study found that NEET status in young people with bipolar disorder and psychotic features is associated with premorbid decline, substance use, and forensic issues. NEET status can change during treatment, suggesting a need to further explore the effectiveness of vocational intervention programs specifically for BD.
EARLY INTERVENTION IN PSYCHIATRY
(2022)
Article
Psychiatry
Ellie Brown, Caroline X. Gao, Heather Staveley, Georgia Williams, Simone Farrelly, Debra Rickwood, Nic Telford, Cerissa Papanastasiou, Pat McGorry, Andrew Thompson
Summary: This study analyzed the longitudinal changes in clinical and functional outcomes of individuals with first episode psychosis or at ultra-high risk of psychosis receiving services from headspace in Australia. Results showed significant improvement in both clinical and functional outcomes for all patients, with ultra-high risk patients showing greater reduction in distress symptoms and first episode psychosis patients experiencing greater reduction in positive psychosis symptoms. The study supports the use of real-world data to evaluate outcomes in early psychosis treatment and highlights the importance of ongoing functional recovery focus in these services.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2022)
Article
Psychiatry
Brian O'Donoghue, Hannah Collett, Sophie Boyd, Yuanna Zhou, Emily Castagnini, Ellie Brown, Rebekah Street, Barnaby Nelson, Andrew Thompson, Patrick McGorry
Summary: The study found that the treated incidence of first-episode psychosis increased during the COVID-19 pandemic, especially in the later months of the restrictions. Additionally, the proportion of patients being involuntarily admitted to hospital significantly increased during the pandemic.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2022)
Article
Immunology
Subash Raj Susai, David Mongan, Colm Healy, Mary Cannon, Barnaby Nelson, Connie Markulev, Miriam R. Schafer, Maximus Berger, Nilufar Mossaheb, Monika Schloegelhofer, Stefan Smesny, Ian B. Hickie, Gregor E. Berger, Eric Y. H. Chen, Lieuwe de Haan, Dorien H. Nieman, Merete Nordentoft, Anita Riecher-Roessler, Swapna Verma, Andrew Thompson, Alison Ruth Yung, Patrick D. McGorry, Melanie Focking, David Cotter, G. Paul Amminger
Summary: This study investigated the relationship of erythrocyte omega-3 FAs with plasma immune markers and examined whether the associations between omega-3 FAs and clinical outcomes were mediated via plasma immune markers in CHR individuals. The results indicate a predominantly anti-inflammatory relationship of omega-3 FAs on plasma inflammatory status in CHR individuals, but this did not appear to convey clinical benefits at 6 month and 12 month follow-up. Both immune and non-immune biological effects of omega-3 FAs would be resourceful in understanding the clinical benefits of omega-3 FAs in CHR population.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Psychiatry
John Broughan, Geoff McCombe, Jayleigh Lim, Donal O'Keeffe, Katherine Brown, Mary Clarke, Ciaran Corcoran, David Hanlon, Ned Kelly, John Lyne, Patrick McGorry, Sinead O' Brien, Karen O' Connor, Karen O' Mahony, Seamus Scott, Elizabeth Wycherley, Walter Cullen
Summary: This study evaluated a keyworker-mediated intervention promoting physical health among first episode psychosis patients, finding mixed feasibility outcomes and highlighting challenges such as low recruitment rates, variable linkages between keyworkers and general practitioners, and the impact of COVID-19 restrictions.
EARLY INTERVENTION IN PSYCHIATRY
(2022)
Article
Psychiatry
Jessica A. Hartmann, Barnaby Nelson, Gunther Paul Amminger, Jessica Spark, Hok Pan Yuen, Melissa J. Kerr, Andrea Polari, Nicky Wallis, Julie Blasioli, Lisa Dixon, Cameron Carter, Rachel Loewy, Tara A. Niendam, Martha Shumway, Patrick D. McGorry
Summary: The aim of this study is to determine the most effective type, timing, and sequence of interventions in individuals at ultra-high risk of psychosis, and evaluate the acceptability and feasibility of the treatment approach through the recruitment flow and baseline clinical characteristics.
EARLY INTERVENTION IN PSYCHIATRY
(2022)
Letter
Medicine, General & Internal
Nicole T. M. Hill, Patrick D. McGorry, Jo Robinson
MEDICAL JOURNAL OF AUSTRALIA
(2022)
Editorial Material
Medicine, General & Internal
Patrick D. McGorry
MEDICAL JOURNAL OF AUSTRALIA
(2022)
Review
Psychiatry
Holly Sizer, Ellie Brown, Hellen Geros, Alison Yung, Barnaby Nelson, Patrick McGorry, Brian O'Donoghue
Summary: Limited research suggests similar or superior outcomes for individuals with a first episode of psychosis who present initially via an ARMS clinic. The reduced psychiatric admission rate is an important potential benefit of ARMS clinics that requires further validation.
SCHIZOPHRENIA RESEARCH
(2022)
Article
Psychiatry
Patrick D. McGorry, Cristina Mei, Andrew Chanen, Craig Hodges, Mario Alvarez-Jimenez, Eoin Killackey
Summary: Mental ill-health is the main threat to young people's health and future potential globally. The COVID-19 pandemic has worsened this trend. Despite the immense need, adolescents and emerging adults have limited access to mental health care. Co-designed strategies and innovations have emerged, including integrated primary youth mental health care services, but these need to be scaled up globally to meet the rising demand.
Article
Psychiatry
Tara Burke, Andrew Thompson, Nathan Mifsud, Alison R. Yung, Barnaby Nelson, Patrick McGorry, Brian O'Donoghue
Summary: This study found that a significant proportion of young people initially attended other specialist youth mental health services, and these individuals had lower rates of hospital admission at the time of transition to first-episode psychosis.
SCHIZOPHRENIA RESEARCH
(2022)
Article
Psychiatry
Emily P. Hedges, Hannah Dickson, Stefania Tognin, Gemma Modinos, Mathilde Antoniades, Mark van der Gaag, Lieuwe de Haan, Patrick McGorry, Christos Pantelis, Anita Riecher-Rossler, Rodrigo Bressan, Neus Barrantes-Vidal, Marie-Odile Krebs, Merete Nordentoft, Stephan Ruhrmann, Gabriele Sachs, Bart P. Rutten, Jim van Os, Lucia R. Valmaggia, Philip McGuire, Matthew J. Kempton
Summary: Individuals with clinical high risk for psychosis show deficits in verbal memory and verbal fluency, which are related to longer-term outcomes of the disorder. These cognitive impairments are present even in those not taking antipsychotic medication. Furthermore, impaired immediate verbal recall predicts functional disability and non-remission from the clinical high risk state.
SCHIZOPHRENIA RESEARCH-COGNITION
(2022)
Letter
Psychiatry
Patrick McGorry
AUSTRALASIAN PSYCHIATRY
(2022)