Article
Neurosciences
Divesh Thaploo, Stefanie Zelder, Thomas Hummel
Summary: The study concludes that CNV is a useful electrophysiological measure of cognition, but odors of different hedonic tones have only minor effects on CNV in the present context.
Review
Behavioral Sciences
Michal Pieniak, Anna Oleszkiewicz, Vittoria Avaro, Federico Calegari, Thomas Hummel
Summary: Olfactory training (OT) has been shown to benefit olfactory recovery and is debated for its potential to improve psychological functioning. Research focuses on its utility in clinical practice and the accompanying changes in olfactory loss patients and animal models. Challenges lie in methodological issues in OT research and areas requiring further scientific attention.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Multidisciplinary Sciences
Behzad Iravani, Martin Schaefer, Donald A. Wilson, Artin Arshamian, Johan N. Lundstrom
Summary: Through two experiments, it was found that negative odors elicit specific neural activity in the human olfactory bulb and lead to rapid motor avoidance responses.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Otorhinolaryngology
Anna Oleszkiewicz, Laura Bottesi, Michal Pieniak, Shuji Fujita, Nadejda Krasteva, Gabriele Nelles, Thomas Hummel
Summary: This study found that performing OT twice a day was more effective in supporting olfactory rehabilitation and interventions targeted to verbal semantic fluency, especially in subjects with lower baseline scores.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Medicine, Research & Experimental
David T. Liu, Maha Sabha, Michael Damm, Carl Philpott, Anna Oleszkiewicz, Antje Haehner, Thomas Hummel
Summary: The study found that the presence of parosmia is associated with clinically relevant recovery in olfactory discrimination and identification function in patients with PIOD receiving olfactory training, with patients who have lower baseline olfactory function being more likely to show significant improvements.
Article
Biology
Kyung Soo Kim, Il-Youp Kwak, Hyun Jin Min
Summary: This study aimed to evaluate the PEA-based sniffing bead test as a screening tool for olfactory dysfunction. Significant correlations were found between the PEA bead test and conventional psychophysical olfactory function testing. The PEA bead test showed high sensitivity and specificity for discriminating olfactory dysfunction. These results suggest that the PEA bead test could be a valuable screening tool for olfactory dysfunction.
Review
Neurosciences
Charlotte Bontempi, Laurence Jacquot, Gerard Brand
Summary: Studies suggest that there are no clear differences in odor hedonic judgment between men and women, with gender effects being more pronounced in body odors than in non-specific odors.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Bontempi Charlotte, Jacquot Laurence, Brand Gerard
Summary: This study proposes a model of odor hedonic profile (OHP) based on everyday odors without stimulus, which can accurately estimate the pleasantness of odors. The OHP can be a useful tool in various contexts and pathologies.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Computer Science, Cybernetics
Simon Niedenthal, William Fredborg, Peter Lunden, Marie Ehrndal, Jonas K. Olofsson
Summary: The development of a compact and low-cost olfactory display for virtual reality systems has the potential to enhance the olfactory experience in virtual environments. Through user studies and gas sensor analysis, the researchers have shown the clear and consistent output of the device, as well as its intuitive usability and support for gameplay interaction. A virtual wine tasting game served as a demonstration of the device's capabilities in recreating an olfactory experience and facilitating training and gameplay interactions.
INTERNATIONAL JOURNAL OF HUMAN-COMPUTER STUDIES
(2023)
Article
Geriatrics & Gerontology
Vidyulata Kamath, Kening Jiang, Kevin J. Manning, R. Scott Mackin, Keenan A. Walker, Danielle Powell, Frank R. Lin, Honglei Chen, Willa D. Brenowitz, Kristine Yaffe, Eleanor M. Simonsick, Jennifer A. Deal
Summary: This study examined the relationship between baseline olfactory performance and the development of significant depressive symptoms and longitudinal depression trajectories in older adults. The results showed that individuals with poorer olfaction had a higher risk of developing depression symptoms and being in higher depression trajectory groups over time. The relationship between olfaction and incident depression symptom severity was partially mediated by cognitive status.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Otorhinolaryngology
Giancarlo B. Cherobin, Roberto E. S. Guimaraes, Marcia C. de Paula Gomes, Luis O. G. Vasconcelos, Ligia A. N. de Abreu
Summary: This study aimed to investigate the effectiveness of intranasal insulin as a treatment for recalcitrant olfactory dysfunction in patients with COVID-19. The study included 16 volunteers with persistent olfactory dysfunction, and their olfactory function was assessed before and after the intervention. The results showed that intranasal insulin treatment significantly improved the sense of smell in these patients.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Medicine, Research & Experimental
Ayaho Yoshino, Goekhan Goektas, Mehmet K. Mahmut, Yunmeng Zhu, Oender Goektas, Taro Komachi, Kimihiro Okubo, Thomas Hummel
Summary: The study developed a test for assessing retronasal olfaction in healthy individuals and patients with olfactory disorders using tasteless powders. Results showed high correlation between retronasal and orthonasal olfaction, with 16 stimuli effectively differentiating patients from controls.
Article
Medicine, General & Internal
Taesik Jung, Bo Yoon Choi, Minho Jang, Taehee Kim, Eunhye Seo, Jin Kook Kim
Summary: This study compared the olfactory and gustatory characteristics of COVID-19 patients with olfactory dysfunction and postinfectious olfactory dysfunction patients without COVID-19. The COVID-19 group had better initial olfactory and gustatory function. After olfactory training, both groups showed an increase in olfactory function test scores.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Otorhinolaryngology
Min-Seok Rha, Hyung-Ju Cho, Joo-Heon Yoon, Seok Jun Moon, Chang-Hoon Kim
Summary: This study found that GD is significantly associated with OD, especially in patients with PTOD. Age ≥55 years and PTOD are factors associated with a higher frequency of GD among patients with OD.
Article
Psychiatry
Francois Kazour, Boriana Atanasova, Marc Mourad, Charline El Hachem, Thomas Desmidt, Sami Richa, Wissam El-Hage
Summary: Patients in manic episodes showed deficits in identifying positive odors. They evaluated these smells as less pleasant and less emotional compared to remitted bipolar subjects and healthy controls. Mania was associated to higher emotion rating of negative smells compared to remitted subjects and controls. There was no difference between the 3 groups in the ratings of intensity and familiarity of smells, as well as in the olfactory threshold testing. The 3 groups showed no difference in the identification of negative smells.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Psychology, Developmental
Stirling T. Argabright, Elina Visoki, Tyler M. Moore, Dallas T. Ryan, Grace E. DiDomenico, Wanjiku F. M. Njoroge, Jerome H. Taylor, Sinan Guloksuz, Ruben C. Gur, Raquel E. Gur, Tami D. Benton, Ran Barzilay
Summary: Youth suicide rates have been increasing in the United States, especially among Black Americans. This study aimed to investigate the unique contribution of racial/ethnic discrimination to childhood suicidal ideation and attempts. The findings showed that racial/ethnic discrimination is disproportionately experienced by Black children and is associated with preadolescent suicidality, emphasizing the need to address discrimination in suicide prevention strategies.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2022)
Article
Neurosciences
Aaron F. Alexander -Bloch, Rahul Sood, Russell T. Shinohara, Tyler M. Moore, Monica E. Calkins, Casey Chertavian, Daniel H. Wolf, Ruben C. Gur, Theodore D. Satterthwaite, Raquel E. Gur, Ran Barzilay
Summary: This study is one of the first brain imaging studies of OCS in a large adolescent sample. The results show robust connectome-wide differences related to OCS, as well as specific abnormalities involving known functional systems. These findings support the potential for OCS as an early marker of psychiatric risk.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2022)
Article
Neurosciences
Semra Etyemez, Zui Narita, Marina Mihaljevic, Koko Ishizuka, Vidyulata Kamath, Kun Yang, Akira Sawa
Summary: Olfactory dysfunction is predictive in psychotic disorders and specifically associated with deficits in social cognition in early-stage psychosis.
NEUROSCIENCE RESEARCH
(2022)
Review
Primary Health Care
Lauren E. Claus, Evelyn M. Leland, Katherine Y. Tai, Rodney J. Schlosser, Vidyulata Kamath, Andrew P. Lane, Nicholas R. Rowan
Summary: Olfaction, gustation, and chemesthesis are important senses that can be affected by dysfunction. Chemosensory dysfunction can have implications on various aspects of patients' lives and may even be an early indicator of underlying medical conditions. There is a growing need for improved awareness and care for patients with chemosensory dysfunction, and psychophysical assessment tools can provide more accurate evaluations.
JOURNAL OF THE AMERICAN BOARD OF FAMILY MEDICINE
(2022)
Article
Nutrition & Dietetics
Varun Vohra, Evelyn M. Leland, Rodney J. Schlosser, Vidyulata Kamath, Nicholas R. Rowan
Summary: The study shows that dietary patterns high in protein/selenium and beta-carotene/vitamin A are associated with lower frailty prevalence in adults with olfactory dysfunction. These findings suggest that dietary patterns are uniquely associated with frailty in older adults with olfactory dysfunction.
Article
Neurosciences
Vidyulata Kamath, Matthew L. Senjem, Anthony J. Spychalla, Honglei Chen, Priya Palta, Thomas H. Mosley, B. Gwen Windham, Michael Griswold, David S. Knopman, Rebecca F. Gottesman, Clifford R. Jack, A. Richey Sharrett, Andrea L. C. Schneider
Summary: Impaired olfactory identification is associated with smaller neuroanatomical regions in individuals without dementia, which are the primary targets of AD pathogenic processes.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Psychology, Clinical
Oscar W. H. Wong, Ran Barzilay, Angela M. W. Lam, Sandra Chan, Monica E. Calkins, Raquel E. Gur, Ruben C. Gur
Summary: Executive function is uniquely associated with the severity of comorbid psychopathology in individuals with autism spectrum disorder (ASD), and could be a potential target for interventions.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Semra Etyemez, Zui Narita, Marina Mihaljevic, Jennifer M. Coughlin, Gerald Nestadt, Frederick C. Nucifora, Thomas W. Sedlak, Nicola G. Cascella, Finn-Davis Batt, Jun Hua, Andreia Faria, Koko Ishizuka, Vidyulata Kamath, Kun Yang, Akira Sawa
Summary: Significant correlations were found between the left SFG volume and odour discrimination, as well as rs-fMRI connectivity involving the left SFG and odour discrimination in first episode psychosis (FEP) patients, but not in healthy controls (HCs). The data-driven approach did not observe any significant correlations, possibly due to insufficient statistical power.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2023)
Article
Otorhinolaryngology
Andrea L. C. Schneider, Rebecca F. Gottesman, Thomas H. Mosley, Srishti Shrestha, Nicholas R. Rowan, A. Richey Sharrett, Honglei Chen, Vidyulata Kamath
Summary: The study found an association between head injury and olfactory dysfunction, particularly in individuals with multiple prior head injuries and more severe head injury. The findings also suggested that individuals with prior head injury were more likely to underestimate or overestimate their olfactory deficits compared to objective olfactory testing.
JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2022)
Article
Anesthesiology
Charles H. Brown, Alexandria Lewis, Julia Probert, Michelle Parish, Jing Tian, Kaushik Mandal, Allen Everett, Elizabeth Colantuoni, Vidyulata Kamath, Charles Hogue, Abhay Moghekar
Summary: Changes in neurofilament light after cardiac surgery are associated with postoperative cognitive function. Higher baseline neurofilament light concentration is associated with worse baseline cognition but can lead to improvements in cognition at 1 year.
Article
Computer Science, Artificial Intelligence
Hongming Li, Dhivya Srinivasan, Chuanjun Zhuo, Zaixu Cui, Raquel E. Gur, Ruben C. Gur, Desmond J. Oathes, Christos Davatzikos, Theodore D. Satterthwaite, Yong Fan
Summary: A novel self-supervised DL method is developed to compute personalized brain functional networks based on fMRI. The DL model, trained without external supervision, optimizes functional homogeneity of personalized FNs using an end-to-end architecture. The identified personalized FNs are found to be informative for predicting individual differences in behavior, brain development, and schizophrenia status, demonstrating the effectiveness of this approach.
MEDICAL IMAGE ANALYSIS
(2023)
Article
Nutrition & Dietetics
Srishti Shrestha, Xiaoqian Zhu, Vidyulata Kamath, Kevin J. Sullivan, Jennifer A. Deal, A. Richey Sharrett, Andrea L. C. Schneider, Priya Palta, Rebecca F. Gottesman, B. Gwen Windham, Thomas H. Mosley, Michael E. Griswold, Honglei Chen, Antonios Dakanalis
Summary: Through analyzing 6053 participants in the Atherosclerosis Risk in Communities (ARIC) Neurocognitive Study, it is found that factors such as age, sex, education level, race, and APOE epsilon 4 are associated with olfactory status and decline. Older age, male sex, lower education, Black race, APOE epsilon 4, etc. increase the probability of olfactory errors and anosmia, while factors such as physical activity and hypertension benefit olfaction. Long-term follow-up studies are needed in the future.
Article
Nutrition & Dietetics
Varun Vohra, Sahar Assi, Vidyulata Kamath, Zachary M. Soler, Nicholas R. Rowan
Summary: This study, using data from the NHANES, found an independent association between poor dietary habits and cognitive and olfactory dysfunctions. It also discovered that adherence to a specific diet partially mediated the relationship between olfactory dysfunction and cognitive decline. The findings highlight the importance of nutritional interventions in mitigating cognitive decline.
Article
Medicine, General & Internal
Lydia Kogler, Veronika I. Mueller, Ewald Moser, Christian Windischberger, Ruben C. Gur, Ute Habel, Simon B. Eickhoff, Birgit Derntl
Summary: Testosterone levels modulate resting-state functional connectivity between brain regions involved in affective processing and executive functions. Significant sex differences were found, with higher testosterone levels associated with lower connectivity between the amygdala and the superior frontal gyrus in women. Testosterone may have sex-specific patterns in affect and cognition networks, as well as in the frontal down-regulation of the amygdala.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Psychology, Clinical
Susan S. Kuo, David R. Roalf, Konasale M. Prasad, Christie W. Musket, Petra E. Rupert, Joel Wood, Ruben C. Gur, Laura Almasy, Raquel E. Gur, Vishwajit L. Nimgaonkar, Michael F. Pogue-Geile
Summary: This study investigates the effects of schizophrenia genetic variation on brain structure phenotypes across the lifespan. The results suggest that schizophrenia genetic risk impacts different brain regions at different developmental stages, with frontal and insula regions being affected before the peak age of onset, and frontal, parietal, occipital regions being affected after the peak age of onset. These findings highlight the dynamic nature of schizophrenia genetic effects and the importance of integrating neuroimaging methods with developmental behavior genetic approaches in understanding risk processes in psychopathology.
JOURNAL OF PSYCHOPATHOLOGY AND CLINICAL SCIENCE
(2022)