Article
Oncology
Ye-Ling Liu, Xue-Lin Wang, Xiao-Hui Yang, Xiao-Huan Wu, Guo-Xin He, Li-Min Xie, Xun-Jie Cao, Xu-Guang Guo
Summary: Xpert Bladder Cancer demonstrates high accuracy and specificity in diagnosing bladder cancer compared to cystoscopy. Further research is needed to confirm these findings.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Urology & Nephrology
Matthew Zibelman, Aeen M. Asghar, Daniel C. Parker, John O'Neill, Shuanzeng Wei, Richard E. Greenberg, Marc C. Smaldone, David Y. T. Chen, Rosalia Viterbo, Robert G. Uzzo, Evan Bloom, Rutika Kokate, Daniel M. Geynisman, Pooja Ghatalia, Mengying Deng, Eric A. Ross, Elizabeth Plimack, Philip H. Abbosh, Alexander Kutikov
Summary: This study aimed to evaluate the reliability and limitations of cystoscopic evaluation in candidates for radical cystectomy, showing that systematic endoscopic evaluation was unable to accurately predict post-operative pathology results. Further research is needed to explore novel imaging and biomarker strategies to optimize decision making regarding bladder preservation.
JOURNAL OF UROLOGY
(2021)
Article
Oncology
Rahul Krishnatry, Priyamvada Maitre, Anuj Kumar, Tejshri Telkhade, Ganesh Bakshi, Gagan Prakash, Mahendra Pal, Amit Joshi, Santosh Menon, Vedang Murthy
Summary: This study aimed to evaluate urinary symptoms and urine cytology as screening tools for cystoscopic detection of local recurrence after bladder-preserving trimodality treatment (TMT). The results showed that urinary symptoms and urine cytology were effective in predicting local recurrence in cystoscopic biopsy. The combination of cystoscopy and urine cytology was particularly sensitive in detecting muscle-invasive recurrence, while alternate cystoscopy may be more optimal for detecting any local recurrence.
Article
Urology & Nephrology
Hu Chen, Yang Hong, Bai Yu, Li Ruiqian, Li Jun, Wu Hongyi, Wang Ziyong, Jiang Haiyang, Zhang Chongjian, Bi Ying, Wang Qilin
Summary: Bladder tumor morphology is moderately correlated with invasion depth and outer invasive depth is significantly associated with inferior overall survival and progression-free survival in patients with bladder urothelial carcinoma.
Article
Urology & Nephrology
Abhishek Bhat, Deukwoo Kwon, Nachiketh Soodana-Prakash, Ali Mouzannar, Sanoj Punnen, Mark L. Gonzalgo, Dipen J. Parekh, Chad R. Ritch
Summary: The study aimed to determine the optimal cystoscopic interval for intermediate risk, nonmuscle invasive bladder cancer. Results showed that moderate intensity (6-month) surveillance intervals in this patient population allow for timely detection without compromising oncological outcomes, and are less costly with fewer cystoscopies compared to high intensity (3-month) intervals.
JOURNAL OF UROLOGY
(2021)
Article
Urology & Nephrology
Taylor Parisse, Katy Reines, Ramsankar Basak, Dana Mueller, Randall Teal, Maihan B. Vu, Jessica Carda-Auten, Kathryn Stein, Kara Giannone, Robert Lipman, Angela B. Smith
Summary: This study aimed to explore the perspectives of patients and providers on repeat transurethral resection of bladder tumors, in order to improve counseling and treatment options for nonmuscle-invasive bladder cancer. The findings showed differences in treatment preferences and emphasized the need for better communication and counseling in this area.
JOURNAL OF UROLOGY
(2023)
Article
Urology & Nephrology
Arighno Das, Jason E. Cohen, Oliver S. Ko, Brian J. Jordan, Alexander P. Glaser, Gregory B. Auffenberg, Joshua J. Meeks
Summary: The creation and distribution of individual surgeon scorecards improved detrusor muscle sampling during transurethral resection, leading to a decreased risk of disease recurrence in patients with nonmuscle invasive bladder cancer.
JOURNAL OF UROLOGY
(2021)
Review
Oncology
Honglin Li, Yubin Cao, Pingchuan Ma, Zhongkai Ma, Chunjie Li, Wenbin Yang, Lingyun Zhou
Summary: The study found that the novel visualization method assisted transurethral resection (VA-TUR) could significantly improve recurrence-free survival (RFS) and progression-free survival (PFS) in non-muscle-invasive bladder cancer (NMIBC) patients, but the effect was not significant in muscle-invasive bladder cancer (MIBC) patients.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Alison Schulz, Justin Loloi, Luis Pina Martina, Alexander Sankin
Summary: Bladder cancer is a challenging disease with high recurrence rates, leading to invasive surveillance methods. Non-invasive urinary tests have gained attention for early detection and to reduce unnecessary procedures; however, there is a need for improved sensitivity and specificity. Recent advancements in technology and research offer novel detection systems and biomarkers that show promise in clinical practice.
ONCOTARGETS AND THERAPY
(2022)
Article
Medicine, General & Internal
Anne M. Neilan, Raphael J. Landovitz, Mylinh H. Le, Beatriz Grinsztejn, Kenneth A. Freedberg, Marybeth McCauley, Nattanicha Wattananimitgul, Myron S. Cohen, Andrea L. Ciaranello, Meredith E. Clement, Krishna P. Reddy, Emily P. Hyle, A. David Paltiel, Rochelle P. Walensky
Summary: The study found that although CAB-LA offers more benefits over F/TDF, effective oral PrEP limits the additional price society should be willing to pay for CAB-LA.
ANNALS OF INTERNAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Takahito Kawano, Yoko Tachibana, Junichi Inokuchi, Jeong-Hun Kang, Masaharu Murata, Masatoshi Eto
Summary: This study aimed to investigate the presence of activated protein kinase C alpha (PKC alpha) in urine samples and the possibility of PKC alpha as a urinary biomarker for bladder cancer diagnosis. Results showed that activated PKC alpha was present at higher levels in bladder cancer tissues than in normal bladder tissues, and also observed at higher levels in urine samples collected from orthotopic xenograft mice carrying human bladder cancer cells. These findings suggest that activated PKC alpha can potentially serve as a urinary biomarker for diagnosing bladder cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Surgery
Zhinan Fan, Hongjin Shi, Jiayu Luo, Xinquan Guo, Bo Wang, Yao Liu, Junjie Yu
Summary: Fluorescence cystoscopy and narrow-band imaging (NBI) are advantageous for treating and diagnosing patients with nonmuscle-invasive bladder cancer.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Biophysics
Melanie MacGregor, Hanieh Safizadeh Shirazi, Kit Man Chan, Kola Ostrikov, Kym McNicholas, Alex Jay, Michael Chong, Alexander H. Staudacher, Thomas D. Michl, Aigerim Zhalgasbaikyzy, Michael P. Brown, Moein Navvab Kashani, Adam Di Fiore, Alex Grochowski, Stephen Robb, Simon Belcher, Jordan Li, Jonathan M. Gleadle, Krasimir Vasilev
Summary: The non-invasive diagnostic platform presented in this study combines microfluidic technology with PDD principles and immunocapture technology to detect shed bladder cancer cells in patient urine, achieving highly specific capture rates. In a pilot study, it successfully differentiated bladder cancer patients from non-cancer controls, showing potential for post-treatment surveillance and cancer detection in suspected bladder cancer patients.
BIOSENSORS & BIOELECTRONICS
(2021)
Review
Medicine, Research & Experimental
Ovidiu Bratu, Dragos Marcu, Radu Anghel, Dan Spinu, Lucian Iorga, Irina Balescu, Nicolae Bacalbasa, Camelia Diaconu, Cornel Savu, Carmen Savu, Alexandru Cherciu
Summary: Bladder tumors are commonly diagnosed urologic malignant diseases with high recurrence rates, and urinary biomarkers could potentially improve diagnosis accuracy. However, due to the heterogeneous nature of bladder cancer, a single marker test with reduced cost is unlikely, necessitating the use of a panel of markers for valuable information.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Review
Urology & Nephrology
Yanish Soorojebally, Yann Neuzillet, Mathieu Roumiguie, Pierre-Jean Lamy, Yves Allory, Francoise Descotes, Sophie Ferlicot, Diana Kassab-Chahmi, Stephane Oudard, Xavier Rebillard, Catherine Roy, Thierry Lebret, Morgan Roupret, Francois Audenet
Summary: This systematic review evaluated the clinical validity and utility of eleven urinary biomarkers for bladder cancer diagnosis and NMIBC follow-up. The results suggested that urinary biomarkers may have a complementary role in bladder cancer diagnosis and NMIBC surveillance, but further confirmation of their clinical benefit is needed.
WORLD JOURNAL OF UROLOGY
(2023)