Article
Biochemistry & Molecular Biology
Amanda J. Croft, Conagh Kelly, Dongqing Chen, Tatt Jhong Haw, Aaron L. Sverdlov, Doan T. M. Ngo
Summary: Obesity is associated with various metabolic disorders and cardiovascular diseases, causing increased hospitalizations, morbidity, and mortality. Dysfunction of adipose tissue due to chronic nutrient stress can lead to oxidative stress, mitochondrial dysfunction, inflammation, hypoxia, and insulin resistance. This study aimed to reduce adipose tissue oxidative stress by overexpressing the antioxidant mitochondrial catalase (mCAT) in adipose tissue to improve systemic metabolic function. The results showed that the AdipoQ-mCAT mice were protected from further metabolic impairment under obesogenic dietary conditions compared to obese wild-type mice, highlighting the critical role of physiological H2O2 signaling in metabolism and adipose tissue function.
Review
Endocrinology & Metabolism
Hubert Kolb, Kerstin Kempf, Stephan Martin
Summary: Experimental studies have shown that reduced levels of insulin or insulin signaling can promote longevity in animal models of aging, but in humans, high insulin and insulin resistance are associated with an increased risk of age-related diseases. These diseases include neurodegenerative diseases, hypertension, cardiovascular disease, and type 2 diabetes. High levels of insulin can lead to increased fat storage and impaired cell function. The synthesis and metabolism of insulin initiate an adaptive response to maintain homeostasis, which has a stronger pro-aging effect in humans compared to short-lived models. Conversely, adopting a lifestyle that promotes low insulin and insulin resistance levels, such as dietary restriction or exercise, can help mitigate these detrimental changes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Immunology
Like Zhao, Xianda Hu, Fei Xiao, Xuan Zhang, Lidan Zhao, Min Wang
Summary: Nucleic acid autoantibodies, increased levels of interferon, and hyperactivation of immune cells are important factors in the development of systemic lupus erythematosus (SLE). Mitochondrial reactive oxygen species (mROS), produced during cellular energy generation, play a crucial role in regulating cell activation and differentiation, as well as the antigenicity of oxidized nucleoids within mitochondria. Recent research has focused on using mROS scavengers and restoring defective mitophagy to address mitochondrial redox imbalance in SLE. However, the underlying mechanisms of how oxidative stress-related mitochondrial molecules influence cell fate at the molecular level are still unknown.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
J. C. Quevedo-Abeledo, M. Hernandez-Diaz, H. Sanchez-Perez, L. Medina-Vega, A. F. Gonzalez-Rivero, C. Almeida-Santiago, L. de Armas-Rillo, M. A. Gonzalez-Gay, I Ferraz-Amaro
Summary: Amylin levels are significantly higher in SLE patients compared to controls, irrespective of insulin resistance that may be present in SLE. The damage caused by the disease and its severity independently explain this upregulation.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Michelle T. Barati, Dawn J. Caster
Summary: Inflammation and oxidative stress play crucial roles in SLE, and Nrf2 is a central regulator of cellular anti-oxidative responses, inflammation, and redox homeostasis. Regulation of Nrf2 has been shown to have important implications in SLE, and Nrf2-inducing agents have demonstrated the potential to alleviate oxidative and inflammatory stress and reduce tissue injury. However, further research is needed to elucidate the specific role of Nrf2 activation in different immune cell types and its mechanisms of action.
Review
Immunology
Wei Sun, Pengchong Li, Jianping Cai, Jie Ma, Xuan Zhang, Yong Song, Yudong Liu
Summary: This article summarizes the altered lipid metabolism and its role in the pathogenesis and progression of SLE. Dysregulated lipid metabolism has complex effects on specific cell types, and may serve as a potential therapeutic target.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Nestor de la Visitacion, Inaki Robles-Vera, Marta Toral, Manuel Gomez-Guzman, Manuel Sanchez, Javier Moleon, Cristina Gonzalez-Correa, Natividad Martin-Morales, Francisco O'Valle, Rosario Jimenez, Miguel Romero, Juan Duarte
Summary: This study demonstrates that alterations in gut microbiota can impact hypertension and vascular inflammation in mice with systemic lupus erythematosus, highlighting the important role of gut microbiota in hypertension.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Rheumatology
Juan C. Quevedo-Abeledo, Hiurma Sanchez-Perez, Beatriz Tejera-Segura, Laura de Armas-Rillo, Soledad Ojeda, Celia Erausquin, Miguel A. Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: In patients with rheumatoid arthritis (RA), insulin sensitivity is lower and beta cell function is higher compared to those with systemic lupus erythematosus (SLE). The impact of traditional insulin resistance factors on insulin resistance indexes is similar in both diseases, suggesting that these differences are disease-related.
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Multidisciplinary Sciences
Qinyao Xu, Xiangzhi Zhang, Shangqing Ge, Chang Xu, Yuanfan Lv, Zongwen Shuai
Summary: This research investigates the therapeutic potential and underlying mechanisms of triptoquinone A and triptoquinone B in addressing bone and joint complications in SLE. It reveals that these compounds can decrease inflammation and cartilage degradation by suppressing NLRC3 expression.
Article
Multidisciplinary Sciences
Neyla S. Al Akl, Olfa Khalifa, Khaoula Errafii, Abdelilah Arredouani
Summary: The study found a significant association between elevated serum ferritin levels and metabolic disorders such as dyslipidemia, diabetes, insulin resistance, and metabolic syndrome. These associations were more pronounced in women, with a greater impact on dyslipidemia, diabetes, and insulin resistance. Elevated serum ferritin levels were identified as a potential risk biomarker for these metabolic abnormalities in Qatari adults.
SCIENTIFIC REPORTS
(2021)
Review
Immunology
Zhu Yan, Qin Chen, Yumin Xia
Summary: Systemic lupus erythematosus (SLE) is a complex autoimmune disease that requires treatment with immunosuppressants. Oxidative stress plays a role in the inflammatory and cellular defects seen in SLE, with oxidative modifications of proteins, lipids, and DNA contributing to immune dysregulation. Detecting inflammatory and cellular markers is crucial for assessing oxidative stress levels accurately. Pharmacological approaches targeting oxidative stress have shown promise in treating SLE. This review examines the involvement of oxidative stress in the pathogenesis and management of SLE.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Changfeng Hu, Jida Zhang, Suzhen Hong, Haichang Li, Lu Lu, Guanqun Xie, Wenqing Luo, Yu Du, Zhijun Xie, Xianlin Han, Chengping Wen
Summary: The close relationships among oxidative stress, dyslipidaemia, inflammation, and autoimmune response in SLE patients contribute to dysfunction and dysregulation of immunocytes. Aberrant lipid metabolism in immunocytes, induced by oxidative stress, may lead to increased production of IgG autoantibodies and cytokines in the early stages of the disease. Treatment with a natural antioxidant can correct the aberrant lipid metabolism and reduce autoimmune reactions, suggesting a potential drug treatment for SLE with fewer adverse effects.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Mattia Carini, Micaela Fredi, Ilaria Cavazzana, Roberto Bresciani, Fabiana Ferrari, Eugenio Monti, Franco Franceschini, Giorgio Biasiotto
Summary: Autoimmune diseases such as RA and SLE are associated with genetic predisposition, iron metabolism, and the inflammatory cytokine system. This study found that the frequency of the IL-6 promoter polymorphism -174G>C was decreased in RA and SLE patients, as well as the p.Cys282Tyr mutation in the HFE gene. Further investigation of these mutations may provide valuable information on the interplay between iron metabolism, inflammation, and immunity in autoimmune diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Paul Curtiss, Amanda M. Walker, Benjamin F. Chong
Summary: This study reviewed patient cohorts and populations to investigate the progression of cutaneous lupus to systemic lupus. The study found variations in the progression rates between adult and pediatric groups, which were attributed to differences in patient populations, study design, diagnostic criteria, and follow-up time. Risk factors associated with the development of systemic lupus included positive anti-nuclear antibodies, hematologic abnormalities, and a higher number of lupus classification criteria at baseline.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, Research & Experimental
Jia-Qin Hu, Yan-Hua Yan, Han Xie, Xue-Bing Feng, Wei-Hong Ge, Hua Zhou, Li-Li Yu, Ling-Yun Sun, Ying Xie
Summary: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the immune system attacking its own tissues and organs. Dyslipidemia, which is closely related to disease activity, is commonly observed in SLE patients and animal models. Manipulating lipid metabolism has the potential to be a therapeutic target for treating SLE, as it plays a role in the dysfunction of T cells in SLE patients.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Ana Lucia Cruz Furstenberger Lehmann, Daniela Frizon Alfieri, Maria Caroline Martins de Araujo, Emanuelle Roberto Trevisani, Maisa Rocha Nagao, Francisco Spessatto Pesente, Jair Roberto Gelinski, Leonardo Bodner de Freitas, Tamires Flauzino, Marcio Francisco Lehmann, Marcell Alysson Batisti Lozovoy, Jose Wander Bregano, Andrea Name Colado Simao, Michael Maes, Edna Maria Vissoci Reiche
Summary: This study evaluated the prognostic validity of a combination of clinical, imaging, and laboratory biomarkers in predicting 1-year mortality of IS, finding that non-survivors showed significant differences in multiple indicators including IS severity, carotid intima-media thickness, coagulation factors, and inflammatory factors.
CLINICAL AND EXPERIMENTAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Tatiane Renata Fagundes, Bruna Taciane da Silva Bortoleti, Fernanda Tomiotto-Pellissier, Virginia Marcia Concato, Manoela Daiele Gonsalves, Nilton Syogo Arakawa, Milena Menegazzo Miranda-Sapla, Carolina Panis, Wander Rogerio Pavanelli
Summary: This study evaluated the anti-tumor activity of grandiflorenic acid (GFA) on breast, liver, and lung tumor cell lines. The treatment using GFA significantly inhibited cell proliferation and induced cell death. The mechanisms of cell death involved the production of reactive oxygen species, exposure of phosphatidylserine, depolarization of the mitochondrial membrane, and decrease in plasma membrane integrity. The study also found the formation of autophagy vacuoles.
Article
Medicine, General & Internal
Emanuele Gustani Gustani-Buss, Carlos E. Buss, Luciane R. Cavalli, Carolina Panis, Felipe F. Tuon, Joao P. Telles, Franciele A. C. Follador, Guilherme W. Wendt, Leia C. Lucio, Lirane E. D. Ferreto, Isabela M. de Oliveira, Emerson Carraro, Lualis E. David, Andrea N. C. Simao, Angelica B. W. Boldt, Maria Luiza Petzl-Erler, Wilson A. Silva, David L. A. Figueiredo
Summary: This study evaluated the prediction factors of COVID-19 mortality in the Brazilian state of Parana. Male gender and age over 35 were associated with increased mortality in different levels of clinical severity. Dyspnea, as well as neurological disorders, neoplastic diseases, and kidney diseases, were linked to higher mortality rates.
Article
Oncology
Janaina Carla da Silva, Thalita Basso Scandolara, Rodrigo Kern, Hellen dos Santos Jaques, Jessica Malanowski, Fernanda Mara Alves, Daniel Rech, Guilherme Ferreira Silveira, Carolina Panis
Summary: This study examines the immunological changes induced by pesticide exposure in breast cancer patients and finds that occupational exposure to pesticides alters the molecular behavior of the disease, which should be considered in risk assessment for breast cancer patients.
Article
Medicine, Research & Experimental
Marcelo Marcos Opolski, Vitor Teixeira Maito, Aedra Carla Bufalo Kawassaki, Janaina Carla da Silva, Rodrigo Kern, Daniel Rech, Stefania Tagliari de Oliveira, Pamela Lonardoni Micheletti, Carolina Panis, Sabrina Grassiolli
Summary: This study evaluated the levels of TNF-alpha in the saliva and plasma of breast cancer and benign breast disease patients, finding higher levels in saliva than in plasma. However, these levels did not correlate with tumor features, indicating that TNF-alpha is not a useful salivary marker for breast cancer patients.
PRECISION MEDICAL SCIENCES
(2022)
Article
Medicine, Research & Experimental
Isis Salviano Soares de Amorim, Isabelle Xavier Dias, Daphne Pinheiro, Simone Nunes de Carvalho, Pedro Nicolau-Neto, Juliana Alves Rodrigues, Priscyanne Barreto Siqueira, Matheus da Silva Oliveira, Carolina Panis, Adenilson de Souza da Fonseca, Andre Luiz Mencalha
Summary: In breast cancer, hypoxia is associated with poor prognosis. The tumor suppressor SAV1 is downregulated in cancer cells, but its expression profile and importance in BC are limited. This study aimed to investigate SAV1 expression under normoxia and hypoxia, and its potential in BC prognosis. The results showed that SAV1 expression is lower in BC samples and tumor cell lines compared to normal samples. Lower levels of SAV1 were associated with worse survival curves and may be a risk factor for BC.
ARCHIVES OF MEDICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Camila Amaral Coracini, Matheus Felipe Zazula, Mariane Okamoto Ferreira, Janaina Carla da Silva, Suellen Ribeiro da Silva Scarton, Carolina Panis, Taciane Stein da Silva Leal, Gladson Ricardo Flor Bertolini
Summary: Gouty arthritis is an inflammatory disease causing pain and joint stiffness. This study aimed to evaluate the effects of photobiomodulation on gouty arthritis using rats as an experimental model. The results showed that photobiomodulation therapy reduced edema, improved joint function, increased pain threshold, activated the antioxidant system, and enhanced the inflammatory response. Therefore, photobiomodulation can be an effective therapeutic option for improving functional status in joint diseases.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Maria Caroline Martins de Araujo, Daniela Frizon Alfieri, Ana Lucia Cruz Furstenberger Lehmann, Tamires Flauzino Luz, Emmanuelle Roberto Trevisani, Maisa Rocha Nagao, Leonardo Bodner de Freitas, Andrea Name Colado Simao, Edna Maria Vissoci Reiche
Summary: This study aimed to investigate the association between cellular adhesion molecules (CAMs) and acute ischemic stroke (IS), as well as to identify biomarkers for predicting short-term mortality after IS. The results showed that a combination of baseline IS severity and soluble vascular cellular adhesion molecule 1 (sVCAM-1) levels could early predict the prognosis of IS patients. Additionally, this study suggests that VCAM-1 might be a potential target for therapeutic strategies in IS.
METABOLIC BRAIN DISEASE
(2023)
Article
Cell Biology
Rodrigo Kern, Janaina Carla da Silva, Fabio Negretti, Mariane Okamoto Ferreira, Matheus Iago Oliveira Coletto, Stefania Tagliari de Oliveira, Fernanda Mara Alves, Thalita Basso Scandolara, Daniel Rech, Carolina Panis
Summary: Recent evidence suggests that CTLA-4 expression is a poor prognosis factor in breast cancer. This study investigated the implications of CTLA-4 expression on circulating inflammatory mediators in breast cancer patients. The results showed that CTLA-4 expression in tumor-infiltrating leukocytes (TILs) correlated with triple-negative breast tumors and was associated with lower levels of IL-12 in plasma. CTLA-4 expression in both tumor and TILs affected the systemic inflammatory status and correlated with more aggressive disease.
Article
Medicine, Research & Experimental
Ellen Mayara Souza Cruz, Virginia Marcia Concato, Juliana Maria Bitencourt de Morais, Taylon Felipe Silva, Fabricio Seidy Ribeiro Inoue, Milena de Souza Cremer, Danielle Lazarin Bidoia, Rayanne Regina Beltrame Machado, Luiz Gustavo de Almeida Chuffa, Mario Sergio Mantovani, Carolina Panis, Wander Rogerio Pavanelli, Fabio Rodrigues Ferreira Seiva
Summary: This study investigated the antitumor effects of melatonin on hepatocellular carcinoma (HCC) using HuH 7.5 cells. The results showed that melatonin reduced cell motility, caused changes in cell structure, and inhibited the Warburg effect by regulating lactate dehydrogenase activity. These findings suggest that melatonin could be a promising candidate for adjuvant therapy in HCC treatment.
Article
Developmental Biology
Fernanda Mithie Ogo, Glaucia Eloisa Munhoz Lion Siervo, Ana Maria Praxedes, Henrique Rodrigues Vieira, Suellen Ribeiro da Silva Scarton, Ana Tereza Guimaraes Bitencourt, Arielle Cristina Arena, Andrea Name Colado Simao, Marina Trevizan Guerra, Paulo Cesar de Freitas Mathias, Glaura Scantamburlo Alves Fernandes
Summary: This study aimed to evaluate the impact of maternal exposure to continuous light during pregnancy on the adult reproductive system in female offspring. The results showed that continuous light exposure during the intrauterine period resulted in reduced LH levels and increased progesterone levels, uterine injuries, increased number of endometrial glands, and reduced antioxidant enzyme activity in the uterus of female offspring.
BIRTH DEFECTS RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Maria Beatriz Madureira, Virginia Marcia Concato, Ellen Mayara Souza Cruz, Juliana Maria Bitencourt de Morais, Fabricio Seidy Ribeiro Inoue, Natalia Concimo Santos, Manoela Daniele Goncalves, Milena Cremer de Souza, Thalita Basso Scandolara, Mariane Fontana Mezoni, Murilo Galvani, Fabio Rodrigues Ferreira Seiva, Carolina Panis, Milena Menegazzo Miranda-Sapla, Wander Rogerio Pavanelli
Summary: Citrus fruits are important sources of bioactive compounds with antioxidant properties, such as flavonoids. Naringenin and hesperidin are emerging compounds with potential anticancer effects, particularly for breast cancer. This review discusses the mechanisms by which naringenin and hesperidin can serve as therapeutic tools and alternative treatment sources for breast cancer.
Article
Medicine, Research & Experimental
Pamella Aparecida Ferreira Fagotti, Matheus Iago Oliveira Colleto, Mariane Okamoto Ferreira, Vitor Teixeira Maito, Bruno Vinicius Campestrini, Thalita Basso Scandolara, Janoario Athanazio de Souza, Daniel Rech, Janaina Carla da Silva, Fernanda Mara Alves, Vanessa Jacob Victorino, Danielle Venturini, Carolina Panis
Summary: This study compared eutrophic and overweight/obese breast cancer patients to investigate the clinical significance of systemic nitric oxide metabolites (NOx) and the factors determining disease prognosis. Plasma samples from 61 women with breast cancer were analyzed using the cadmium-copper-Griess method. The results showed that NOx levels were significantly higher in overweight patients with Luminal B tumors compared to eutrophic patients with the same subtype. Eutrophic postmenopausal patients had significantly lower NOx levels compared to overweight postmenopausal patients. Additionally, eutrophic patients with tumor sizes between 2 and 5 cm had lower NOx levels compared to overweight patients with tumors of the same size range. These findings highlight the impact of trophic-adipose status and prognostic factors on circulating NOx levels in breast cancer patients.
PRECISION MEDICAL SCIENCES
(2023)
Article
Public, Environmental & Occupational Health
Ruan Gabriel Soares da Silva, Mariane Okamoto Ferreira, Isabella Mitsu Suo Komori, Henrique Rodrigues Menezes Oliveira, Murilo Galvani Machado, Julia Fernandes Gois Orrutea, Fernanda Mara Alves, Hellen dos Santos Jaques, Janaina Carla da Silva, Janoario Athanazio de Souza, Daniel Rech, Carolina Panis
Summary: Studies have shown a high incidence of various tumors, including breast cancer, in populations exposed to pesticides. This exposure is not only associated with direct DNA damage but also with epigenetic modifications and inflammation mediators, indicating genomic instability. The present study analyzed the inflammatory changes in the breast tissue of occupationally exposed women without cancer and found an inflammatory signature associated with pesticide exposure, which may trigger genetic mutations and breast carcinogenesis.
FRONTIERS IN PUBLIC HEALTH
(2023)
Meeting Abstract
Clinical Neurology
B. L. Fadel, N. Woldmar, G. Poralla, J. Fontes, L. Giacomin, M. Figueiredo, J. Evaristo, F. Nogueira, C. Panis, A. Rosso, L. Pizzatti
MOVEMENT DISORDERS
(2023)
