Article
Medicine, General & Internal
Seoung Wan Nam, SuMan Kang, Jun Hyeok Lee, Dae Hyun Yoo
Summary: This study evaluated the usefulness of serum interleukin (IL)-37 and IL-18 as disease activity markers of adult-onset Still's disease (AOSD) and found that they can complement each other in reflecting different aspects of AOSD. IL-37 correlated better with CRP while IL-18 correlated with ferritin, AST, and LDH, as well as certain disease manifestations like pleuritis and pneumonitis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Charlotte Girard-Guyonvarc'h, Mathilde Harel, Cem Gabay
Summary: This review summarizes the role and importance of IL-18 and IL-18BP in AOSD and sJIA. It is found that the imbalance of IL-18/IL-18BP is associated with the occurrence of these diseases, and treatment with recombinant IL-18BP shows potential therapeutic effects.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Immunology
Po-Ku Chen, Shiow-Jiuan Wey, Der-Yuan Chen
Summary: Adult-onset Still's disease (AOSD) is a rare and clinically heterogeneous disease with delayed diagnosis and lack of consensus on treatment. This review summarizes the current research evidence on the pathogenic role and clinical implications of interleukin (IL)-18 in AOSD.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Po-Ku Chen, Joung-Liang Lan, Po-Hao Huang, Jye-Lin Hsu, Ching-Kun Chang, Ni Tien, Hui-Ju Lin, Der-Yuan Chen
Summary: This study found that AOSD patients and severe COVID-19 patients have significantly higher levels of galectins and cytokines compared to healthy controls. Active AOSD patients showed elevated IFN-gamma and IL-17A compared to healthy controls. IL-18 is a key discriminator between active AOSD and severe COVID-19.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Toshihiko Shiga, Yuji Nozaki, Daisuke Tomita, Kazuya Kishimoto, Yasuaki Hirooka, Koji Kinoshita, Masanori Funauchi, Itaru Matsumura
Summary: The study suggests that IL-18 could be a useful biomarker for the differential diagnosis of AOSD and adult HLH. Serum IL-18 levels were significantly higher in the AOSD group compared to the adult HLH group, and were closely correlated with ferritin, soluble interleukin-2 receptor (sIL-2R), and other laboratory data.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Kenji Saito, Tomoyuki Asano, Haruki Matsumoto, Yuya Fujita, Naoki Matsuoka, Hiroshi Ohkawara, Yuya Sumichika, Shuhei Yoshida, Jumpei Temmoku, Makiko Yashiro-Furuya, Shuzo Sato, Hiroshi Watanabe, Kiyoshi Migita
Summary: This article reports a case of a 63-year-old male patient with AOSD complicated with monoclonal gammopathy of undetermined significance. The patient exhibited high fever, rash, hyperferritinemia, and M proteinemia. Treatment with tocilizumab successfully suppressed the AOSD activity.
Article
Multidisciplinary Sciences
Jae Ho Han, Mi-Hyun Ahn, Ju-Yang Jung, Ji-Won Kim, Chang-Hee Suh, Ji Eun Kwon, Hyunee Yim, Hyoun-Ah Kim
Summary: This study investigated the role of Toll-like receptors (TLRs) in patients with adult-onset Still's disease (AOSD) and found higher expression levels of TLR2 and TLR7 in AOSD patients compared to healthy controls. TLR2 expression correlated with systemic scores, biochemical markers, and cytokine levels. The percentage of TLR2-positive cells and TLR9-positive inflammatory cell counts were higher in skin lesions of AOSD patients. Additionally, TLR1, TLR4, TLR7, and TLR9 expression levels were higher in lymph nodes of AOSD patients compared to other lymphadenopathy conditions. Circulating TLR2- and TLR7-positive cells may play a role in AOSD pathogenesis, and immunohistochemical staining for TLRs in skin lesions and lymph nodes may aid in differentiating AOSD from similar conditions.
SCIENTIFIC REPORTS
(2022)
Article
Obstetrics & Gynecology
Carolina Martinez-King, Sarah H. Chung, Stephen A. McCartney
Summary: Adult-onset Still's disease (AOSD), a rare autoinflammatory disorder, can lead to life-threatening complications during pregnancy. Limited data is available on the treatment of AOSD in pregnancy, despite the increasing use of biologic therapeutics. In this case report, a 23-year-old primigravid patient with AOSD was successfully treated with tocilizumab, an interleukin-6 receptor antagonist, to prevent AOSD flare during pregnancy. This highlights the potential effectiveness of tocilizumab in reducing the risk of AOSD flare in pregnant women.
REPRODUCTIVE SCIENCES
(2023)
Article
Multidisciplinary Sciences
Ju-Yang Jung, Mi-Hyun Ahn, Ji-Won Kim, Chang-Hee Suh, Jae Ho Han, Hyoun-Ah Kim
Summary: Adult-onset Still's disease (AOSD) is a systemic inflammatory disease characterized by the activation of monocyte-derived cells and the release of neutrophil extracellular traps (NET). The upregulation of the CCL2-CCR2 axis may contribute to the clinical and inflammatory characteristics of AOSD. Higher levels of CCL2 and CCR2 were found in AOSD patients compared to patients with rheumatoid arthritis and healthy controls.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Dai Kishida, Takanori Ichikawa, Ryota Takamatsu, Shun Nomura, Masayuki Matsuda, Wataru Ishii, Tatsuo Nagai, Sadahiro Suzuki, Ken-ichi Ueno, Naoki Tachibana, Yasuhiro Shimojima, Yoshiki Sekijima
Summary: This study retrospectively analyzed the data of 62 elderly AOSD patients and compared them with younger-onset patients. The findings showed notable differences in clinical symptoms, complications, and laboratory results between elderly AOSD patients and younger-onset patients. The study emphasizes the importance of promptly controlling disease activity and managing infections in elderly AOSD.
SCIENTIFIC REPORTS
(2022)
Review
Medicine, General & Internal
Stylianos Tomaras, Carl Christoph Goetzke, Tilmann Kallinich, Eugen Feist
Summary: Adult-onset Still's disease is a rare systemic autoinflammatory disease characterized by arthritis, spiking fever, skin rash, and elevated ferritin levels. Immune dysregulation plays a central role in the disease, involving pathogenic involvement of both arms of the immune system. Extensive research has led to a better understanding of AoSD and revolutionary advances in treatment.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Luana Andreea Macovei, Alexandra Burlui, Ioana Bratoiu, Ciprian Rezus, Anca Cardoneanu, Patricia Richter, Andreea Szalontay, Elena Rezus
Summary: Adult-onset Still's disease is a systemic inflammatory disorder with unknown etiology, characterized by symptoms such as high fever, lymphadenopathy, hepatosplenomegaly, hyperferritinemia, and leukocytosis. Treatment options include NSAIDs, corticosteroids, csDMARDs, and biological therapy targeting various inflammatory cytokines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Rheumatology
Xinyue Hong, Haoyu Pan, Yutong Su, Qiongyi Hu, Yue Sun, Honglei Liu, Xiaobing Cheng, Junna Ye, Hui Shi, Jianfen Meng, Zhuochao Zhou, Jinchao Jia, Tingting Liu, Mengyan Wang, Xia Chen, Yuning Ma, Zihan Tang, Fan Wang, Hao Zhang, Yijun You, Dehao Zhu, Longfang Chen, Chengde Yang, Jialin Teng, Huihui Chi
Summary: This study investigated the impact of inactivated SARS-CoV-2 vaccines on disease activity in patients with inactive AOSD. The results showed that there was no significant increase in relapse rate in vaccinated patients compared to unvaccinated patients, and no relapse occurred within 1 month after vaccination. In addition, adverse reactions reported by vaccinated patients were mild and self-limiting.
Review
Rheumatology
Bruno Fautrel, Jacoby Patterson, Catherine Bowe, Mick Arber, Julie Glanville, Stuart Mealing, Viviam Canon-Garcia, Laura Fagerhed, Hilde Rabijns, Roberto Giacomelli
Summary: This systematic review evaluated the efficacy and safety of biologic disease modifying anti-rheumatic drugs (bDMARDs) for adult-onset Still's disease (AOSD). The review included three randomized controlled trials, one retrospective case series, and 17 case series. Limited data from randomized controlled trials showed that bDMARDs may be effective compared to conventional DMARDs or placebo. However, the lack of standardized assessment criteria hindered comparisons between studies. Uncontrolled retrospective case series suggested that bDMARDs were effective in AOSD, but no comparative data were available. Standardization of therapeutic response definition and larger comparative studies are needed to determine the most effective bDMARDs for AOSD.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Medicine, General & Internal
Azusa Ogita, Shin-ichi Ansai, Hidehisa Saeki
Summary: This study investigated the serum IL-18 levels along with IL-6, ferritin, and C-reactive protein in 6 Japanese patients with adult-onset Still's disease (AOSD). The results showed that serum IL-18 levels were significantly elevated in AOSD patients and could be a clue for diagnosis. CRP was also found to be a useful biomarker for monitoring disease activity compared to IL-6 and IL-18.
JOURNAL OF NIPPON MEDICAL SCHOOL
(2022)