Article
Multidisciplinary Sciences
Jian-xiong Wang, Yue Shen, Xi-le Wang, Lin-li Ma, Sheng-qian Xu
Summary: This study used mendelian randomized analysis (MR) to investigate the causal relationship between clinical phenotypes of endometriosis and ankylosing spondylitis (AS). The study found a causal relationship between infertile endometriosis and AS, but no causal relationship between ovarian endometriosis, pelvic peritoneum endometriosis, rectovaginal endometriosis and AS.
SCIENTIFIC REPORTS
(2023)
Editorial Material
Rheumatology
Juergen Braun, Robert B. M. Landewe
Summary: Three monoclonal antibodies targeting interleukin-23 have been approved for psoriasis treatment, with two also approved for psoriatic arthritis. However, they have shown to be ineffective in axial spondyloarthritis and may be due to generic effects rather than specific inflammation.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Multidisciplinary Sciences
Sahar Gelfman, Arden Moscati, Santiago Mendez Huergo, Rujin Wang, Veera Rajagopal, Neelroop Parikshak, Vijay Kumar Pounraja, Esteban Chen, Michelle Leblanc, Ralph Hazlewood, Jan Freudenberg, Blerta Cooper, Ann J. Ligocki, Charles G. Miller, Tave Van Zyl, Jonathan Weyne, Carmelo Romano, Botir Sagdullaev, Olle Melander, Aris Baras, Eli A. Stahl, Giovanni Coppola
Summary: In this study, the authors performed genome-wide association analysis and whole-exome analysis to uncover the underlying genetics of HLA-B*27 positive and negative forms of anterior uveitis (AU).
NATURE COMMUNICATIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Yan Zhong, Yingwen Chen, Xinyue Zhang, Wenjun Cai, Changwei Zhao, Wenhai Zhao
Summary: This Mendelian randomization study found no evidence to support a causal relationship between ankylosing spondylitis and cardiovascular disease. Further research is needed to confirm this association.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Ozlem Daltaban, Ayse Unal Enginar, Kemal Ustun, Mukerrem Hatipoglu, Cahit Kacar, Tiraje Tuncer
Summary: This study aimed to investigate the relationship between periodontal disease and ankylosing spondylitis (AS) by evaluating clinical periodontal measurements and gingival crevicular fluid (GCF) levels. The results showed that patients with AS had lower GCF sclerostin levels and the periodontal measurements were strongly correlated with AS-related parameters, indicating a potential interrelationship between inflammatory periodontal disease and AS.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Medicine, General & Internal
Milad Baniaamam, Sjoerd C. Heslinga, Laura Boekel, Thelma C. Konings, M. Louis Handoko, Otto Kamp, Vokko P. van Halm, Irene E. van der Horst-Bruinsma, Mike T. Nurmohamed
Summary: The study revealed that the prevalence of diastolic left ventricular dysfunction and conduction disorders in elderly ankylosing spondylitis patients was similar to controls and not clinically relevant. However, ankylosing spondylitis patients had up to five times increased odds of developing aortic valve regurgitation compared to controls.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Jian Mei, Hongxin Hu, Haiqi Ding, Ying Huang, Wenming Zhang, Xiaoqing Chen, Xinyu Fang
Summary: The study using bidirectional Mendelian randomization analysis found no evident causal association between genetic liability to Ankylosing Spondylitis (AS) and the risk of osteoporosis (OP) or lower bone mineral density (BMD) in the European population, highlighting the second effect of AS on OP. However, genetically predicted decreased BMD/OP is a risk factor for AS with a causal relationship, suggesting that patients with OP should be aware of the potential risk of developing AS. Moreover, OP and AS share similar pathogenesis and pathways.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Ophthalmology
Nazife Sule Yasar Bilge, Umut Kalyoncu, Pamir Atagunduz, Ediz Dalkilic, Yavuz Pehlivan, Orhan Kucuksahin, Cemal Bes, Servet Akar, Muhammet Cinar, Hakan Emmungil, Duygu Ersozlu, Askin Ates, Ridvan Mercan, Gezmis Kimyon, Suleyman Serdar Koca, Emel Gonullu, Veli Yazisiz, Emre Tekgoz, Nilufer Alpay-Kanitez, Abdulsamet Erden, Sedat Kiraz, Belkis Nihan Coskun, Burcu Yagiz, Ufuk Ilgen, Omer Karadag, Levent Kilic, Ihsan Ertenli, Timucin Kasifoglu
Summary: The study aimed to analyze the frequency and factors associated with acute anterior uveitis (AAU) in different forms of Spondyloarthritis (SpA) in a large Turkish cohort. It was found that older age, smoking history, delayed diagnosis, longer disease duration, arthritis, positive HLA-B27, family history of SpA, and radiographic damage were associated with a higher prevalence of uveitis in SpA patients. Psoriasis and psoriatic arthritis patients had a lower prevalence of uveitis. Early detection of uveitis can aid in the diagnosis of SpA.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Rheumatology
Marta Arevalo Salaet, Clementina Lopez-Medina, Mireia Moreno, Victoria Navarro-Compan, Joan Calvet Fontova, Maria Llop, Maxime Dougados, Jordi Gratacos
Summary: This study analyzed the influence of HLA-B27 in the phenotypical expression of pSpA. The results showed that HLA-B27-positive patients had an earlier disease onset and higher axial involvement, tarsitis, and uveitis, but no association with other EMM, fibromyalgia, or peripheral structural damage was observed.
Article
Immunology
Ta-hsin Tsung, Ke-Hao Huang, Wu-Chien Chien, Yi-Hao Chen, I-Chuan Yen, Chi-Hsiang Chung, Jiann-Torng Chen, Ching-Long Chen
Summary: This study found that uveitis is a risk factor for stroke development in patients with AS, and both anterior uveitis and posterior segment involvement increase the risk of stroke.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Nutrition & Dietetics
Mingyi Yang, Xianjie Wan, Haishi Zheng, Ke Xu, Jiale Xie, Hui Yu, Jiachen Wang, Peng Xu
Summary: This study analyzed the genetic relationship between ankylosing spondylitis (AS) and gut microbiota, and found that the four common gut microbiotas (Bacteroides, Streptococcus, Proteobacteria, and Lachnospiraceae) associated with AS have no causal relationship with the disease at the genetic level.
Article
Nutrition & Dietetics
Stefan Lucian Popa, Dinu Iuliu Dumitrascu, Vlad Dumitru Brata, Traian Adrian Duse, Maria Delia Florea, Abdulrahman Ismaiel, Laura Mirela Muntean, Simona Grad
Summary: Recent research on spondyloarthritis and immune-mediated diseases associated with HLA-B27 has made significant progress in understanding the pathogenesis and treatment options. The genetic background of spondyloarthritis has been shown to be linked to inflammatory bowel diseases and gut microbiota. The role of diet in these diseases is important and has potential applications in personalized medicine.
Article
Medicine, General & Internal
Gerhard Schmalz, Markus Bartl, Jan Schmickler, Susann Patschan, Daniel Patschan, Dirk Ziebolz
Summary: This cross-sectional study aimed to investigate the potential associations between periodontal inflamed surface area (PISA) and tooth loss with disease-related parameters in rheumatoid arthritis (RA) and ankylosing spondylitis (AS) patients. The study found that tooth loss is associated with disease activity, especially in RA individuals, while no associations were found between PISA and disease-related parameters in both groups.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Orthopedics
Zhiwei Luan, Yansong Wang
Summary: This study investigated the association between ankylosing spondylitis (AS) and m6A methylation. By analyzing 72 samples from the GSE73754 dataset, AS-related m6A genes were identified and found to be negatively correlated with the incidence of AS. The study also suggested a potential relationship between AS and immunity, providing further insights into AS treatment.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Rheumatology
Denis Poddubnyy, Fabian Proft, Laura Spiller, Mikhail Protopopov, Valeria Rios Rodriguez, Burkhard Muche, Judith Rademacher, Murat Torgutalp, Janis Lucas Vahldiek, Joachim Sieper, Imke Redeker
Summary: The diagnostic value of SpA features varies in different patient populations, which should be considered in the diagnostic approach.
Letter
Rheumatology
Ronald F. van Vollenhoven, Sander W. Tas, Michael T. Nurmohamed
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
J. Koers, N. I. L. Derksen, W. J. J. Falkenburg, P. Ooijevaar-de Heer, M. T. Nurmohamed, G. J. Wolbink, T. Rispens
Summary: This study found that anti-hinge antibodies (AHAs) and elevated levels of Fab glycosylation are present not only in patients with rheumatoid arthritis (RA), but also in healthy controls (HCs). These results suggest that extensive Fab glycosylation may develop in response to an inflammatory proteolytic microenvironment, but is not restricted to RA.
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
T. Rusman, M. A. C. van der Weijden, M. T. Nurmohamed, C. J. van Denderen, R. B. M. Landewe, P. M. Bet, C. M. A. van der Bijl, C. J. Van der Laken, I. E. van der Horst-Bruinsma
Summary: The study found that 16 weeks of etanercept treatment did not have an impact on disease activity, the chance of biological treatment, or radiographic progression in patients with suspected non-radiographic axial spondyloarthritis.
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Maria Konsta, Michael T. Nurmohamed, Alexios Iliopoulos, Petros P. Sfikakis, J. Christiaan van Denderen, Ingrid Visman, Grigorios T. Sakelariou, Irene E. van der Horst-Bruinsma
Summary: The study aims to examine the prevalence of hip involvement in patients with ankylosing spondylitis (AS) treated with tumor necrosis factor inhibitors (TNFi) and estimate the effect of TNFi on radiographic progression of hip involvement compared to the spine. The results showed that approximately one-third of AS patients had hip involvement, which seemed to stabilize with TNFi treatment. There were no sex differences in the prevalence or progression of this manifestation.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Laure Gossec, Stefan Siebert, Paul Bergmans, Kurt de Vlam, Elisa Gremese, Beatriz Joven-Ibanez, Tatiana Korotaeva, Frederic Lavie, Wim Noel, Michael T. Nurmohamed, Petros P. Sfikakis, Mohamed Sharaf, Elke Theander, Josef S. Smolen
Summary: This study evaluated the real-world persistence and effectiveness of the IL-12/23 inhibitor ustekinumab or a tumour necrosis factor inhibitor (TNFi) for psoriatic arthritis over 3 years. The results showed that the proportion of patients still on their initial treatments after 3 years was similar with ustekinumab and TNFi, but ustekinumab had a lower rate of adverse events.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Pharmacology & Pharmacy
Renske C. F. Hebing, Imke H. Bartelink, Helen R. Gosselt, Sandra G. Heil, Mauritis C. F. J. de Rotte, Pascal H. P. de Jong, Mike T. Nurmohamed, Robert de Jonge, Ron A. A. Mathot
Summary: This study investigated the association between red blood cell methotrexate polyglutamates (MTX-PG) concentrations and response in rheumatoid arthritis patients starting methotrexate (MTX) therapy. The results showed that there was an association between RBC-MTX-PG concentrations and Disease Activity Score in 28 joints (DAS28). Based on the findings, it is suggested to increase the dose if MTX-PG concentration is below 9.15 nmol/L at month 1, continue with the same dose if the concentration is above 47 nmol/L, and consider other treatment options if the concentration is above 78 nmol/L from 3 months onwards.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Pharmacology & Pharmacy
Helen R. R. Gosselt, Jette A. A. van Lint, Leanne J. J. Kosse, Phyllis I. I. Spuls, Harald E. E. Vonkeman, Sander W. W. Tas, Frank Hoentjen, Michael T. T. Nurmohamed, Bart J. F. van den Bemt, Martijn B. A. van Doorn, Naomi T. T. Jessurun
Summary: Sex differences exist in the frequency and nature of ADRs in patients with inflammatory rheumatic diseases, but not in ADR burden.
EXPERT OPINION ON DRUG SAFETY
(2023)
Article
Rheumatology
A. B. Blanken, M. Korteweg, L. van Boheemen, R. F. van Vollenhoven, M. T. Nurmohamed, C. J. van der Laken
Summary: The study aimed to investigate the performance and factors of influence of optical spectral transmission (OST) imaging as a new technique for measuring joint inflammation in rheumatoid arthritis (RA). The results showed significant differences in OST scores between RA patients and the control group, and moderate correlations between OST scores and ultrasound and clinical disease activity.
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2023)
Review
Rheumatology
M. Sobejana, M. van der Esch, J. van den Hoek, G. Kitas, M. van der Leeden, M. T. Nurmohamed, G. S. Metsios
Summary: In addition to DMARD treatment, exercise is increasingly promoted in patients with RA, but few studies have investigated the combined effects of these interventions on disease activity. This scoping review summarized the evidence on whether a combined effect can be detected in studies where exercise intervention was performed in addition to DMARD treatment. Eleven studies were included, and although some showed significant reductions in disease activity outcomes for the exercise + medication group compared with the medication-only group, most studies had weak methodological quality.
CURRENT RHEUMATOLOGY REPORTS
(2023)
Article
Rheumatology
Mikkel Ostergaard, Ronald F. van Vollenhoven, Anna Rudin, Merete Lund Hetland, Marte Schrumpf Heiberg, Dan C. Nordstrom, Michael T. Nurmohamed, Bjorn Gudbjornsson, Lykke Midtboll Ornbjerg, Pernille Boyesen, Kristina Lend, Kim Horslev-Petersen, Till Uhlig, Tuulikki Sokka, Gerdur Grondal, Simon Krabbe, Joakim Lindqvist, Inger Gjertsson, Daniel Glinatsi, Meliha Crnkic Kapetanovic, Anna-Birgitte Aga, Francesca Faustini, Pinja Parmanne, Tove Lorenzen, Cagnotto Giovanni, Johan Back, Oliver Hendricks, Daisy Vedder, Tuomas Rannio, Emma Grenholm, Maud Kristine Ljosa, Eli Brodin, Hanne Lindegaard, Annika Soderbergh, Milad Rizk, Alf Kastbom, Per Larsson, Line Uhrenholt, Soren Andreas Just, David J. Stevens, Trine Bay Laurbjerg, Gunnstein Bakland, Inge Christoffer Olsen, Espen A. Haavardsholm, Jon Lampa, NORD-STAR Study Grp
Summary: This study compared the clinical and radiographic outcomes of different biological treatments with active conventional therapy in patients with early rheumatoid arthritis (RA). The results showed that abatacept and certolizumab pegol had higher clinical remission rates compared to active conventional therapy, while tocilizumab did not show significant differences. Radiographic progression was low and similar across treatments.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
J. van den Hoek, M. Sobejana, F. van Nes, G. Metsios, G. Kitas, M. van der Leeden, M. T. Nurmohamed, M. van der Esch
Summary: The objective of this study was to gain insight into the perceptions and experiences of patients with rheumatoid arthritis and a high cardiovascular disease risk (CVD-RA) undergoing an exercise intervention. The study analyzed data from six patients through face-to-face interviews and identified seven themes related to perceptions and experiences. The findings highlighted the importance of being viewed as a person and feeling safe.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Rheumatology
Jimmy Wiegel, Bart F. Seppen, Michael T. Nurmohamed, Marieke M. ter Wee, Wouter H. Bos
Summary: Routine collection of ePROs prior to consultations can improve clinical care, but a low response rate may limit its benefits. This study found that patients between 55 and 73 years of age and with higher socio-economic status were more likely to complete the ePROs, while patients living in urban areas had lower odds.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Rheumatology
Bart F. F. Seppen, Jimmy Wiegel, Michael T. T. Nurmohamed, Wouter H. H. Bos, Marieke M. M. ter Wee
Summary: Telemonitoring disease activity with ePROs can reduce rheumatic care workload by cutting down on outpatient clinic visits, but low adherence to reporting ePROs is common. This study aimed to identify facilitators and barriers to weekly monitoring of disease activity. Focus group discussions were held with patients who had recently participated in telemonitoring studies using a smartphone app for ePRO completion. Thematic analysis revealed five themes related to adherence: questionnaire frequency, discussing results, physical consultations, patient insight, and user experience. Both barriers and facilitators were found within these themes. The results suggest that maximizing the perceived benefits of completing ePROs and tailoring their frequency based on patients' disease activity or preference, along with training clinicians to discuss the completed ePROs, may improve adherence.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Rheumatology
Reinder Raadsen, Romy Hansildaar, Lianne C. Pouw, Femke Hooijberg, Laura Boekel, Gerrit Jan Wolbink, Arno W. R. van Kuijk, Michael T. Nurmohamed
Summary: This study evaluates the cardiovascular disease risk and prevalence of risk factors in patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA), and axial spondyloarthritis (SpA). The results show that the traditional cardiovascular risk factors are significantly elevated in these patients compared to healthy controls. However, after adjusting for traditional risk factors, the cardiovascular risk was not increased in these patients.
