Article
Immunology
Natalia Egri, Chelsea Bentow, Laura Rubio, Gary L. Norman, Susana Lopez-Sanudo, Michael Mahler, Albert Perez-Isidro, Ricard Cervera, Odette Vinas, Gerard Espinosa, Estibaliz Ruiz-Ortiz
Summary: The study found that persistently positive results for aPS/PT IgG antibodies were significantly associated with APS classification, thrombosis, triple aPL positivity, LA positive result, and the Global APS Score (GAPSS) > than 9 points, but not with pregnancy morbidity and SLE.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Bowen Li, Qian Ren, Jizu Ling, Zhongbin Tao, Xuemei Yang, Yuning Li
Summary: A meta-analysis was conducted to evaluate the relationship of neutrophil-to-lymphocyte ratio (NLR) and mean platelet volume (MPV) with severe gastrointestinal involvement in pediatric Henoch-Schonlein Purpura (HSP). The results indicated that NLR was significantly higher and MPV was lower in HSP patients with severe GI involvement. These markers may be used for predicting or diagnosing severe GI involvement in children with HSP, but further studies with larger sample sizes are needed for validation.
Article
Immunology
Yuanzhen Zhang, Guizhi Xia, Xiaojing Nie, Yugui Zeng, Yi Chen, Yifang Qian, Guangming Chen, Jun Huang, Chengfeng Wang, Chuanyin Zhang, Xiaoli Huang, Yuen Yang, Xiaojian Qiu, Fang Yang, Jie Chen, Jun Hu
Summary: This study investigated the gut microbiota in children with Henoch-Schonlein Purpura (HSP) and found significant differences in microbial community compared to healthy controls. The abundance of certain bacteria, such as Escherichia-Shigella, Bacteroides, Lachnoclostridium, Faecalibacterium, Streptococcus, and Fusobacteria, was found to be associated with HSP characteristics, including recurrence, IgG levels, complement C3 levels, and GI symptoms. The findings suggest a potential role of gut microbiota in the pathogenesis of HSP.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Rheumatology
Can Liu, Lingli Luo, Min Fu, Zhengqiu Li, Jianlong Liu
Summary: This study identified the most common infectious agent in children with Henoch-Schonlein purpura (HSP) and determined that mean platelet volume (MPV) is an important predictor of renal involvement in HSP patients with Mycoplasma pneumoniae (MP) infection. This discovery has significant implications for clinical treatment and cost reduction.
CLINICAL RHEUMATOLOGY
(2022)
Article
Immunology
Ke Wang, Xiaomei Sun, Shuolan Jing, Li Lin, Yao Cao, Xin Peng, Lina Qiao, Liqun Dong
Summary: This study developed and validated a nomogram for predicting severe kidney disease outcomes in hospitalized Henoch-Schonlein purpura (HSP) children. The nomogram, based on LASSO regression and Cox proportional hazards analysis, showed good performance in both the training and validation datasets, indicating its potential clinical usefulness.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Min Wen, Xiqiang Dang, Shipin Feng, Qingnan He, Xiaoyan Li, Taohua Liu, Xiaojie He
Summary: Recent studies have shown that intestinal microbes and metabolites are involved in the pathogenesis of many diseases. This study aimed to detect gut microbes and metabolites in children with HSP in order to understand the etiology and pathogenesis of the disease. The results showed that the composition of gut microbes and metabolites differed significantly between the HSP group and the control group, suggesting a possible role of unsaturated fatty acid metabolism in the occurrence and development of HSP.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Maria Maddalena Sirufo, Martina Raggiunti, Lina Maria Magnanimi, Lia Ginaldi, Massimo De Martinis
Summary: This case report describes a female who developed HSP after receiving the COVID-19 vaccine ChAdOx1 nCoV-19 AZD1222, which is the first report of its kind. No similar cases were reported in the ChAdOx1 nCoV-19 AZD1222 trial with 23,848 participants.
Article
Medical Laboratory Technology
Marta Tonello, Elisa Bison, Maria Grazia Cattini, Elena Pontara, Luca Iaccarino, Gentian Denas, Chunyan Cheng, Vittorio Pengo
Summary: The study found a high positivity rate of aPS/PT antibodies, especially of the IgM subtype, in patients with isolated LA. There is an association between LA diagnosis based on two positive coagulation tests and the presence of aPS/PT antibodies, suggesting the evaluation method of isolated LA may impact the measurement of aPS/PT antibodies.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2021)
Review
Pediatrics
Valentina M. L. Montorfani-Janett, Gabriele E. Montorfani, Camilla Lavagno, Gianluca Gualco, Mario G. Bianchetti, Gregorio P. Milani, Sebastiano A. G. Lava, Marirosa Cristallo Lacalamita
Summary: The involvement of external male genitalia in Henoch-Schonlein vasculitis is not well categorized. This systematic review analyzed 85 reports and found that the genital involvement mostly appeared concurrently with or after the cutaneous features of Henoch-Schonlein syndrome. Scrotal involvement can result from skin inflammation, epididymitis, orchitis, or testicular ischemia.
Article
Immunology
Shuang Pang, Shuan Zhao, Xiaohong Bai, Nana Song, Shengzhi Wang, Jiawei Yu, Jun Zhang, Xiaoqiang Ding
Summary: The study revealed substantial differences in tongue coating microbiota between children with Henoch-Schonlein purpura nephritis (HSPN) and healthy controls, including microbial diversity and specific bacterial orders. Further metabolic function analysis also showed significant differences between the two groups.
MICROBIAL PATHOGENESIS
(2021)
Article
Medicine, General & Internal
Qian Zhang, Ling-Yun Lai, Yuan-Yuan Cai, Ma-Jie Wang, Gaoxiang Ma, Lian-Wen Qi, Jun Xue, Feng-Qing Huang
Summary: Metabolic markers were screened using serum-urine matched metabolomics to predict the progression of Henoch-Schonlein purpura nephritis (HSPN). Choline and cis-vaccenic acid were identified as potential biomarkers for predicting HSPN progression based on metabolic differences between HSPN patients with and without severe kidney damage.
FRONTIERS IN MEDICINE
(2021)
Article
Pediatrics
Ning Zhang, Ge Tian, Yuanyuan Sun, Jing Pan, Wei Xu, Zhe Li
Summary: Our study revealed altered B-cell subsets in children with Henoch-Schonlein purpura, characterized by increased total B cells, decreased plasma cells and naive B cells, and increased memory nonswitched B cells. Additionally, significant correlations between Tfh cells and various B-cell subsets were observed.
Article
Hematology
Tessa Noordermeer, Jessica E. Molhoek, Roger E. G. Schutgens, Silvie A. E. Sebastian, Sandra Drost-Verhoef, Annet C. W. van Wesel, Philip G. de Groot, Joost C. M. Meijers, Rolf T. Urbanus
Summary: Anti-beta 2GPI and anti-prothrombin antibodies cause lupus anticoagulant (LA) through different mechanisms: anti-beta 2GPI antibodies interfere with FV activation by FXa through a direct interaction, while anti-prothrombin antibodies compete with FXa for phospholipid binding sites.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Medicine, General & Internal
Maria Francesca Gicchino, Dario Iafusco, Maria Maddalena Marrapodi, Rosa Melone, Giovanna Cuomo, Angela Zanfardino, Emanuele Miraglia del Giudice, Alma Nunzia Olivieri
Summary: Henoch-Schonlein Purpura is a common vasculitis in children that is usually self-limited. Immunosuppressive treatment is used for severe renal involvement, but there is limited literature on immunosuppressive treatment for severe HSP without kidney involvement. In cases with gastrointestinal involvement, Mycophenolate Mofetil treatment has shown to be effective in inducing and maintaining remission.
Article
Medicine, General & Internal
Oguz Catal, Bahri Ozer, Mustafa Sit
Summary: Henoch-Schonlein Purpura (HSP) is an autoimmune vasculitis characterized by leukocytoclastic vasculitis of small vessels and deposition of IgA-containing immune complexes. Adults with HSP have a higher risk of complications and death, while most cases only require supportive care. Corticosteroids can help relieve arthritis and abdominal pain, but aggressive therapy does not effectively reduce renal damage except in cases of crescentic nephritis.
JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
(2021)
