Article
Endocrinology & Metabolism
L. E. Flores, S. Nelson, N. Waltman, K. Kupzyk, J. Lappe, L. Mack, L. D. Bilek
Summary: This study found that bone structure in post-menopausal women is closely related to levels of physical activity. Increasing physical activity can improve bone structure, particularly in the lower leg.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Nutrition & Dietetics
Mariah Kay Jackson, Laura D. Bilek, Nancy L. Waltman, Jihyun Ma, James R. Hebert, Sherry Price, Laura Graeff-Armas, Jill A. Poole, Lynn R. Mack, Didier Hans, Elizabeth R. Lyden, Corrine Hanson
Summary: Little is known about the relationship between diet and inflammation and its impact on bone health. This cross-sectional study examined the association between diet's inflammatory potential and bone-related outcomes in midwestern post-menopausal women. The results showed that there was no significant association between the inflammatory potential of diet and bone density or structure in this cohort.
Review
Physiology
Santosh Thapa, Ananya Nandy, Elizabeth Rendina-Ruedy
Summary: Osteoporosis is a common endocrinologic disorder characterized by chronic bone loss, with post-menopausal women being most affected. Gonadal sex hormones, particularly estrogen, play a crucial role in regulating bone mass, impacting bone formation and resorption, and potentially contributing to osteoporosis through alterations in bone cell metabolism potential.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Nutrition & Dietetics
Sabrina Paolino, Elvis Hysa, Sabrina Atena Stoian, Emanuele Gotelli, Andrea Casabella, Paolo Vittoriano Clini, Greta Pacini, Carmen Pizzorni, Alberto Sulli, Elena Nikiphorou, Vanessa Smith, Maurizio Cutolo
Summary: Bone quantity and quality do not significantly differ between MetS+ and MetS- RA patients. However, MetS+ RA patients show higher disease activity and lower vitamin D levels. Furthermore, metabolic parameter alterations are correlated with bone quality changes, suggesting potential bone microarchitecture impairments despite unchanged BMD values.
Article
Biochemistry & Molecular Biology
Yen-Huai Lin, Yu-Tai Shih, Michael Mu Huo Teng
Summary: The study found a significant association between osteosarcopenia and fragility fractures, especially when considering high-fracture-risk osteopenia and osteoporosis. Women with osteosarcopenia were more likely to have previously sustained a fracture compared to those without osteosarcopenia, with sarcopenia alone, and with osteoporosis alone.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Nutrition & Dietetics
Thais R. Silva, Karen Oppermann, Fernando M. Reis, Poli Mara Spritzer
Summary: Nutritional habits are crucial for postmenopausal women's health, with low-fat, plant-based diets showing beneficial effects on body composition. The Mediterranean diet pattern and other healthy habits may contribute to the prevention of bone, metabolic, and cardiovascular diseases during the postmenopausal period.
Article
Endocrinology & Metabolism
Victor G. Canuas-Landero, Christopher N. George, Diane V. Lefley, Hannah Corness, Munitta Muthana, Caroline Wilson, Penelope D. Ottewell
Summary: This study investigated the role of estradiol in modulating the antitumor effects of Zol using mouse models. The results showed that estradiol contributes to the differential effects of Zol in pre- and post-menopausal women. Additionally, other immunological and microenvironmental factors may also play a role in this phenomenon.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Natalia Yumi Noronha, Guilherme da Silva Rodrigues, Isabella Harumi Yonehara Noma, Camila Fernanda Cunha Brandao, Karine Pereira Rodrigues, Alexandre Colello Bruno, Chanachai Sae-Lee, Ligia Moriguchi Watanabe, Marcela Augusta de Souza Pinhel, Isabelle Mello Schineider, Mariana Luciano de Almeida, Fernando Barbosa Junior, Deborah Araujo Morais, Wellington Tavares de Sousa Junior, Torsten Plosch, Carlos Roberto Bueno Junior, Carla Barbosa Nonino
Summary: This study found that physical exercise can modify the epigenetic patterns of post-menopausal women with poor glycemic control, and it plays an important role in treating hyperglycemia and preventing diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Physiology
Jorge Perez-Gomez, Nicolai Rytter, Camilla Mandrup, Jon Egelund, Bente Stallknecht, Michael Nyberg, Ylva Hellsten
Summary: This study evaluated the effect of 12 weeks of intense aerobic exercise training on skeletal muscle angiogenesis in late pre- and recent postmenopausal women with <4 years of age difference. The training had a significant impact on capillary per fiber ratio, capillary density, and muscle VEGF protein content, with no difference observed between the two groups. The loss of estrogen at menopause did not influence the capillary growth response to intense aerobic training.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mohammed. G. A. Ansari, Abdul Khader Mohammed, Kaiser A. Wani, Syed D. Hussain, Abdullah M. Alnaami, Saba Abdi, Naji J. Aljohani, Nasser M. Al-Daghri
Summary: The study found that VDR gene variants were significantly associated with increased risk of osteoporosis in Saudi postmenopausal women, suggesting a close relationship between specific gene variations and decreased bone density leading to osteoporosis.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2021)
Review
Public, Environmental & Occupational Health
Hagar E. E. Lialy, Malak A. A. Mohamed, Latifa A. A. AbdAllatif, Maria Khalid, Abdulrahman Elhelbawy
Summary: This systematic review examines the effects of different physiotherapy modalities on insomnia and depression in perimenopausal, menopausal, and post-menopausal women. The results show that reflexology, yoga, walking, and aromatherapy massage have a significant impact on reducing insomnia and depression in menopausal women.
Article
Biochemistry & Molecular Biology
Marion Courtalin, Nicolas Bertheaume, Sammy Badr, Alexandrine During, Daniela Lombardo, Valerie Deken, Bernard Cortet, Aline Clabaut, Julien Paccou
Summary: This study aimed to determine the relationship between circulating sclerostin and bone marrow adiposity. It was found that serum sclerostin was positively correlated with bone mineral density and negatively correlated with renal function and visceral adiposity. However, there was no evidence of a relationship between serum sclerostin and bone marrow adiposity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Sangeeta Huidrom, Mirza Atif Beg, Tariq Masood
Summary: Postmenopausal osteoporosis is a disease characterized by low bone mass and increased risk of fracture in postmenopausal women, caused by estrogen deficiency leading to bone loss. Current therapies have unwanted side effects, prompting the search for a safe and effective alternative. Probiotics, as dietary supplements with beneficial microbes, have shown potential benefits for bone health and are being studied for their role in postmenopausal osteoporosis.
CURRENT DRUG TARGETS
(2021)
Article
Cardiac & Cardiovascular Systems
Kate A. Wickham, Line B. Norregaard, Mikkel Oxfeldt, Stephen S. Cheung, Lasse Gliemann, Mette Hansen, Ylva Hellsten
Summary: The decline in estrogen at menopause poses challenges to cardiovascular and metabolic health, but phytoestrogens like isoflavones may have similar effects as endogenous estrogen. This study found that supplementation with fermented red clover extract reduced vascular inflammation in early post-menopausal women.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Nutrition & Dietetics
Abbigail Tan, Rebecca L. Thomas, Matthew D. Campbell, Sarah L. Prior, Richard M. Bracken, Rachel Churm
Summary: This study aimed to investigate the effects and efficacy of exercise training on metabolic syndrome (MetS) risk factors in post-menopausal women. A systematic review and meta-analysis of randomized controlled studies were conducted, showing that exercise training significantly improved MetS risk factors, including waist circumference, triglycerides, high-density lipoprotein, fasting glucose, systolic blood pressure, and diastolic blood pressure. Moderate intensity and combined training were found to be the most effective in improving MetS risk factors.
CLINICAL NUTRITION
(2023)