Article
Biochemistry & Molecular Biology
Michal Tomaszewski, Paulina Mertowska, Martyna Janczewska, Agnieszka Styczen, Sebastian Mertowski, Kamil Jonas, Ewelina Grywalska, Grzegorz Kopec
Summary: Pulmonary arterial hypertension (PAH) is a complex disorder where cytokines play a crucial role in deregulation of the immune system. This study found that PAH patients have abnormal immune function with decreased percentages of immune cell subpopulations and changes in cytokine concentration. Furthermore, significant differences were observed between PAH subtypes and immunological parameters, suggesting the important role of the immune system in the pathogenesis of PAH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Li Zhou, Chuangang Tang, Xiaoxin Li, Fang Feng
Summary: There is growing evidence that inflammatory responses play significant roles in malignancies. This study investigated the impact of the pro-inflammatory-to-anti-inflammatory factor ratio in tumor tissues on overall survival in gastric cancer patients. The results showed that the IL-6/IL-10 mRNA expression ratio in tumor tissues was an independent prognostic factor for overall survival and disease-specific survival in gastric cancer patients.
SCIENTIFIC REPORTS
(2022)
Article
Genetics & Heredity
Kalichamy Alagarasu, Himanshu Kaushal, Pooja Shinde, Mahadeo Kakade, Urmila Chaudhary, Vikram Padbidri, Shashikala A. Sangle, Sonali Salvi, Ashish R. Bavdekar, Pradeep D'costa, Manohar Lal Choudhary
Summary: The study investigated the association of SNPs in genes coding for IL6, TNFA, IFNG, IL17A, IL10, and TGFB with disease severity in influenza A(H1N1)pdm09-affected patients. TNFA rs1800629 G/A allele frequency was significantly higher in severe cases, while IL10 rs1800896-rs1800872 G-C haplotype was significantly lower in fatal cases. IL-6 and IL-10 levels were significantly higher in fatal cases compared to survived severe cases.
Article
Rheumatology
Maria-Jose Barrera, Sergio Aguilera, Isabel Castro, Soledad Matus, Patricia Carvajal, Claudio Molina, Sergio Gonzalez, Daniela Jara, Marcela Hermoso, Maria-Julieta Gonzalez
Summary: The study found that the decreased expression of ATG5 in LSG epithelial cells of pSS patients may contribute to increased inflammation. Additionally, activation of the JAK-STAT pathway was associated with clinical manifestations of pSS patients. The research also revealed that tofacitinib has anti-inflammatory effects in the experimental tissues with ATG5 deficiency.
Article
Endocrinology & Metabolism
Wade M. Sanders, Sioban D. Harlow, Kelly R. Ylitalo, Brittney S. Lange-Maia, Aleda M. Leis, Daniel S. McConnell, Carrie A. Karvonen-Gutierrez
Summary: Cardiometabolic factors and inflammation are significantly associated with peripheral neuropathy (PN), independent of diabetes and obesity. C-reactive protein (CRP) mediates the relationship between obesity and MetS with PN.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Anesthesiology
Ericka N. Merriwether, Nilesh M. Agalave, Dana L. Dailey, Barbara A. Rakel, Sandra J. Kolker, Melissa E. Lenert, William H. Spagnola, Ying Lu, Katharine M. Geasland, Lee-Ann H. Allen, Michael D. Burton, Kathleen A. Sluka
Summary: This study found that IL-5 secretion from monocytes was higher in women with FM compared to those without pain, and its levels were significantly associated with pain and other relevant symptoms of FM. Furthermore, in FM patients, higher pain levels were linked to lower percentage of intermediate monocytes and higher percentage of nonclassical monocytes. Animal models also showed that IL-5 could induce analgesia and transform monocytes towards an anti-inflammatory phenotype, suggesting a potential role of IL-5 in managing pain in FM.
Article
Biochemistry & Molecular Biology
Felix Clemens Richter, Matthias Friedrich, Nadja Kampschulte, Klara Piletic, Ghada Alsaleh, Ramona Zummach, Julia Hecker, Mathilde Pohin, Nicholas Ilott, Irina Guschina, Sarah Karin Wideman, Errin Johnson, Mariana Borsa, Paula Hahn, Christophe Morriseau, Bruce D. Hammock, Henk Simon Schipper, Claire M. Edwards, Rudolf Zechner, Britta Siegmund, Carl Weidinger, Nils Helge Schebb, Fiona Powrie, Anna Katharina Simon
Summary: Lipids play a major role in inflammatory diseases through altering inflammatory cell functions. Autophagy, a lysosomal degradation pathway, is found to regulate lipid availability, which affects inflammation. Loss of autophagy gene Atg7 in adipocytes exacerbates intestinal inflammation by causing an imbalance of oxylipins, reducing IL-10 secretion, and exacerbating intestinal inflammation through the cytochrome P450-EPHX pathway.
Article
Pharmacology & Pharmacy
Liping Liao, Wenzhen Dang, Tingting Lin, Jinghua Yu, Tonghai Liu, Wen Li, Senhao Xiao, Lei Feng, Jing Huang, Rong Fu, Jiacheng Li, Liping Liu, Mingchen Wang, Hongru Tao, Hualiang Jiang, Kaixian Chen, Xingxing Diao, Bing Zhou, Xiaoyan Shen, Cheng Luo
Summary: PGK1 plays a role in immunometabolism by influencing metabolic status. The inhibitor DC-PGKI can suppress the activity of PGK1 and alleviate symptoms of inflammatory bowel disease.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Endocrinology & Metabolism
Danny Luan, Benyamin Dadpey, Jessica Zaid, Pania E. Bridge-Comer, Julia H. DeLuca, Wenmin Xia, Joshua Castle, Shannon M. Reilly
Summary: The bidirectional interaction between adipocytes and adipose tissue immune cells is crucial for regulating adipose function, inflammation, and insulin responsiveness. Obesity reduces cAMP-driven IL-6 secretion from adipocytes, but restoring their catecholamine sensitivity can stimulate IL-6 secretion and activate macrophages to promote an anti-inflammatory gene expression pattern.
Article
Immunology
Gergely Tibor Kozma, Tamas Meszaros, Tamas Bakos, Mark Hennies, Daniel Bencze, Barbara Uzonyi, Balazs Gyorffy, Edward Cedrone, Marina A. Dobrovolskaia, Mihaly Jozsi, Janos Szebeni
Summary: The study investigated the relationship between complement activation and cytokine storm using an in vitro model, suggesting a potential anti-CS and anti-inflammatory role of mini-factor H.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Elisa Toppi, Laura Sireno, Micaela Lembo, Nerisa Banaj, Beatrice Messina, Sedigheh Golesorkhtafti, Gianfranco Spalletta, Paola Bossu
Summary: Homotaurine is a potential therapeutic compound for Alzheimer's disease (AD) and has anti-inflammatory properties. This study suggests that supplementation of homotaurine in patients with mild cognitive impairment (MCI) increases the levels of anti-inflammatory cytokines IL-10 and IL-33, while decreasing the levels of pro-inflammatory cytokine IL-18. The elevation of IL-10 and IL-33 is associated with improved episodic memory in treated patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Stefanie Krick, E. Scott Helton, Molly Easter, Seth Bollenbecker, Rebecca Denson, Rennan Zaharias, Phillip Cochran, Shia Vang, Elex Harris, James M. Wells, Jarrod W. Barnes
Summary: This study suggests that the reduced expression of ST6GAL1 and alpha 2-6 sialylation could lead to increased IL-6 expression and secretion in human bronchial epithelial cells (HBECs), and could be associated with poor clinical outcomes in COPD. Exposures to cigarette smoke or BACE1 inhibition resulted in decreased ST6GAL1 secretion, reduced alpha 2-6 sialylation, and increased IL-6 production in HBECs. Plasma ST6GAL1 levels demonstrated an inverse association with prospective acute exacerbations of COPD, while IL-6 was positively associated.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
Xiao Liu, Jingjing Huang, Yuan Jiang, Zhengyu Cao, Maoxiong Wu, Runlu Sun, Zhiteng Chen, Peng Yu, Jianyong Ma, Yangxin Chen, Yuling Zhang, Jingfeng Wang
Summary: This study investigated the inflammatory biomarker profiles of psychological treatment-naive individuals and found that levels of IL-6 and IL-8 were positively correlated with symptoms of depression, suggesting they may play a role in the pathogenesis of psychological disorders. However, these associations were not significant after multiple testing. Larger and longitudinal studies are needed to confirm these findings.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Birte Weber, Ramona Sturm, Dirk Henrich, Ludmila Lupu, Katrin Rottluff, Ingo Marzi, Liudmila Leppik
Summary: Trauma is a major cause of death and disability, and accurate diagnosis is crucial for polytraumatized patients to prevent complications. This study suggests that cytokines in exosomes have a longer half-life and can be used as diagnostic and prognostic markers in these patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Nourin Shakeeb, Prashanth Varkey, Aimy Hynse, Amita Ajit
Summary: This study investigates the expression of inflammatory genes in saliva of COVID-19 patients and compares it with blood samples. The results show that IL-6, TNF-alpha, and IL-10 can be detected in both saliva and blood, and their expression levels are similar. Therefore, saliva may be used as an alternative specimen for monitoring inflammation in COVID-19 patients.
Article
Biochemistry & Molecular Biology
Esther Giraldo, David Palmero-Canton, Beatriz Martinez-Rojas, Maria del Mar Sanchez-Martin, Victoria Moreno-Manzano
Summary: Neural progenitor cell transplantation and optogenetics have great potential in treating disorders and injuries of the central nervous system, with blue-light stimulation showing promise in increasing neuroregeneration and improving cell therapy outcomes for better engraftment and cell identity post transplantation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Paloma Monllor, Esther Giraldo, Mari-Carmen Badia, Jose Garcia de la Asuncion, Maria-Dolores Alonso, Ana Lloret, Jose Vina
Summary: This study aimed to evaluate three serum proteins as potential biomarkers in Alzheimer's disease (AD) patients. Serum clusterin, PKR, and RAGE levels were found to be significantly different in the AD group compared to controls, and showed a significant correlation with CSF A beta(42). These proteins were selected to generate an AD detection model with high sensitivity and specificity.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Nutrition & Dietetics
Carmen Daniela Quero, Pedro Manonelles, Marta Fernandez, Oriol Abellan-Aynes, Daniel Lopez-Plaza, Luis Andreu-Caravaca, Maria Dolores Hinchado, Isabel Galvez, Eduardo Ortega
Summary: The study demonstrated that the synbiotic nutritional supplement significantly improves physical activity, sleep quality, perceived general health, stress, and anxiety levels in professional athletes, while also showing an immunophysiological regulatory effect at the systemic levels involving IL-1 beta, CRH, and dopamine.
Article
Engineering, Biomedical
E. Giraldo, V. J. Nebot, S. Dordevic, R. Requejo-Aguilar, A. Alastrue-Agudo, O. Zagorodko, A. Arminan, B. Martinez-Rojas, M. J. Vicent, V. Moreno-Manzano
Summary: Research shows that improving the stability of fasudil by conjugating it with polymers in a bioresponsive manner can enhance its therapeutic potential in treating spinal cord injuries. The conjugate PGA-SS-F, designed based on the conditions after SCI, significantly promotes neurite elongation and axon growth, reduces early apoptosis, and enhances cell engraftment in a rat model of SCI. This synergistic therapeutic approach may offer a promising clinical strategy for SCI treatment.
Article
Biochemistry & Molecular Biology
Pablo Bonilla, Joaquim Hernandez, Esther Giraldo, Miguel A. Gonzalez-Perez, Ana Alastrue-Agudo, Hoda Elkhenany, Maria J. Vicent, Xavier Navarro, Michael Edel, Victoria Moreno-Manzano
Summary: The combination of PA-C with stem cell transplantation has been shown to protect neural stem cells in vitro, significantly reduce scar formation, promote preservation of neurons and axons, and inhibit inflammatory response in microglia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Maria Coronada Fernandez-Calderon, Maria Dolores Hinchado Sanchez-Moro, Eduardo Ortega Rincon
Summary: This study evaluated the in vitro assimilation of cholesterol by Bifidobacterium animalis subsp. lactis (BPL1) under simulated intestinal conditions. The results showed that the growth of BPL1 was favored in the presence of cholesterol in the culture medium, and up to 44.4% cholesterol assimilation was observed. Therefore, the administration of probiotic bacteria like BPL1 could potentially be an effective option to decrease hypercholesterolemia.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2022)
Review
Environmental Sciences
Sara Cheleschi, Sara Tenti, Iole Seccafico, Isabel Galvez, Antonella Fioravanti, Eduardo Ortega
Summary: Balneotherapy (BT) is commonly used in the treatment of rheumatic diseases, with beneficial effects on inflammation, oxidative stress, cartilage metabolism, and immune responses. Clinical studies have shown the efficacy of BT in reducing pain, inflammation, and improving mobility, as well as in decreasing markers of oxidative stress damage.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Neurosciences
Daniel Esteve, Maria Micaela Molina-Navarro, Esther Giraldo, Noelia Martinez-Varea, Mari-Carmen Blanco-Gandia, Marta Rodriguez-Arias, Jose Manuel Garcia-Verdugo, Jose Vina, Ana Lloret
Summary: Neurogenesis and neuronal migration in the adult brain are impaired in Alzheimer's disease, leading to cell senescence and reduced odor discrimination ability. Studying the APP/PS1 Alzheimer's mouse model may provide insights for new Alzheimer's treatments based on senolytic compounds or pro-neurogenic factors.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Nutrition & Dietetics
Isabel Galvez, Maria Carmen Navarro, Leticia Martin-Cordero, Eduardo Otero, Maria Dolores Hinchado, Eduardo Ortega
Summary: Obesity is associated with low-grade inflammation and increased susceptibility to viral infections, such as COVID-19. Macrophage immunometabolism and metabolic flexibility play a crucial role in this context. Strategies for regulating inflammatory responses while preserving innate defenses are important in obesity and inflammatory diseases. However, the effectiveness of dietary interventions in reducing inflammation, especially in adipose tissue, is still controversial and requires further research.
Article
Environmental Sciences
Carmen Daniela Quero-Calero, Oriol Abellan-Aynes, Pedro Manonelles, Eduardo Ortega
Summary: This investigation examined the effects of a synbiotic in athletes and sedentary individuals, specifically on the immune system, autonomic regulation, and body composition. The results showed significant differences in heart rate variability between sedentary individuals and athletes, but no significant differences between the experimental and control groups. Additionally, there may be differences in the effects of the synbiotic on fat mass and body-fold sum between athletic and sedentary groups due to training. No significant differences were found in cytokines after the study protocol. It is necessary to conduct further research to investigate the chronic effects of the synbiotic on the analyzed biomarkers.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Beatriz Martinez-Rojas, Esther Giraldo, Ruben Grillo-Risco, Marta R. Hidalgo, Eric Lopez-Mocholi, Ana Alastrue-Agudo, Francisco Garcia-Garcia, Victoria Moreno-Manzano
Summary: This study demonstrates the transcriptional dysregulation in spinal cord injury and the impact of neural progenitor cell transplantation on gene expression. The dysregulated transcriptome in injured spinal cord tissue involves cAMP signalling genes, which are rescued by NPC transplantation. However, sustained inhibition of EPAC2 signalling pathway affects the therapeutic mechanisms of NPC-mediated treatment, leading to increased inflammation and hindered neuroplasticity.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Medicine, General & Internal
Maria Dolores Hinchado, Eduardo Otero, Maria del Carmen Navarro, Leticia Martin-Cordero, Isabel Galvez, Eduardo Ortega
Summary: Fibromyalgia (FM) and Chronic Fatigue Syndrome (CFS) are commonly diagnosed diseases with poor tolerance to physical exercise. A study found that patients with FM have worse psychological state and quality of life, but codiagnosis of CFS does not worsen these impairments. Habitual physical exercise can improve stress and anxiety levels in FM patients, regardless of CFS codiagnosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cell Biology
Esther Giraldo, Pablo Bonilla, Mara Mellado, Pablo Garcia-Manau, Carlota Rodo, Ana Alastrue, Eric Lopez, Elena Carreras Moratonas, Ferran Pellise, Snezana Dordevic, Maria J. Vicent, Victoria Moreno Manzano
Summary: Neural precursor cell transplantation is a promising therapy for spinal cord injuries, but its clinical translation remains challenging. A study found that priming human-fetal-spinal-cord-derived NPCs with PGA-SS-FAS improved neuronal differentiation and enhanced migration and survival of transplanted cells in the spinal cord.
Article
Nutrition & Dietetics
Maria Dolores Hinchado, Carmen Daniela Quero-Calero, Eduardo Otero, Isabel Galvez, Eduardo Ortega
Summary: The aim of this research was to analyze the effects of a synbiotic nutritional supplement on patients diagnosed with fibromyalgia (FM) and chronic fatigue syndrome (CFS), focusing on the interaction between inflammatory and stress responses mediated by the cytokine-HPA axis, as well as mental and physical health. The study found that the synbiotic supplement decreased levels of stress, anxiety, and depression, and improved quality of life for FM patients. In addition, it activated the HPA axis to balance the increased inflammation observed in FM patients. The study concludes that synbiotic nutritional supplements can improve the dysregulated immunoneuroendocrine interaction and perceived levels of stress, anxiety, depression, and quality of life in FM patients.
Article
Engineering, Biomedical
Javier Monreal-Trigo, Jose Manuel Terres-Haro, Beatriz Martinez-Rojas, Maria del Mar Sanchez-Martin, Esther Giraldo, Victoria Moreno Manzano, Miguel Alcaniz Fillol
Summary: Optogenetics is a versatile field in neuroscience that has applications in studying neuronal pathways and treating various disorders. However, current instrumentation cannot observe certain phenomena, leading researchers to develop a controllable optogenetic stimulation matrix through a graphical user interface, which was validated in experiments.
IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS
(2022)